Abstract:
:The axonal arborizations of the basket cells in the cerebral neocortex have long been considered as the source of the presynaptic terminals contacting the cell bodies of pyramidal cells. Given that the concept of the cortical basket cell is based upon indirect evidence only, it was deemed worthwhile to re-investigate this problem using the Golgi-EM technique. This approach permits one to trace the presynaptic terminals back to their parent cell body, so that it allows for a positive identification of basket cells, i.e. cells which produce axosomatic synapses by preference. A type of interneuron in layer II-III of the cat visual cortex is described. Its axon treminals form multiple synaptic contacts, of the symmetrical type, on cell bodies and proximal dendrites of pyramidal and non-pyramidal cells. On the basis of this efferent synaptic pattern, this interneuron is considered to be a basket cell. The possible correspondence of this interneuronal type with other putative basket cells described in previous Golgi studies is discussed. In addition, a simple re-section method for semithin sections is described, which has been used to identify individual Golgi-impregnated axonal boutons in electron microscopy.
journal_name
Brain Resjournal_title
Brain researchauthors
DeFelipe J,Fairén Adoi
10.1016/0006-8993(82)90898-8subject
Has Abstractpub_date
1982-07-22 00:00:00pages
9-16issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(82)90898-8journal_volume
244pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Although much is known regarding the modulation of ion channels through protein phosphorylation, little is known about their dephosphorylation by protein phosphatases (PrPs). To address this issue we examined the effects of a phosphatase inhibitor, okadaic acid (OA), and protein phosphatases obtained from rabbit skele...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90611-x
更新日期:1991-05-17 00:00:00
abstract::We previously observed that substance P (SP) levels in the rat superior cervical ganglion (SCG) rise sharply when the ganglion is maintained in vitro. To define the cellular localization of SP, sections of cultured SCG were stained for the possible dual presence of SP and tyrosine hydroxylase (TOH). Immunoreactivity t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91442-2
更新日期:1984-04-30 00:00:00
abstract::The effect of an extended program of perforant path or amygdala kindling on paired-pulse suppression in the dentate gyrus was studied in male hooded rats. Repeated kindling stimulations were delivered twice or three times daily until either 300 stimuli had been delivered or generalized convulsions had been observed to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01277-o
更新日期:1995-01-23 00:00:00
abstract::The effect of the xanthine derivative propentofylline (HWA 285) on metabolic and functional recovery in rabbit spinal cord after 20 and 30 min ischemia and 4 days of reperfusion was investigated. Pre-treatment with 20 mg/kg significantly improved recovery of the energy state in the spinal cord, however, without signif...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91114-t
更新日期:1992-09-11 00:00:00
abstract::We examined the effects of chronic social stress and social rank on monamine concentrations in the prefrontal cortex (PFC) in adult male cynomolgus macaques (Macaca fascicularis). Seventy-five animals were housed in five-member social groups for 28 months and were exposed to three experimental conditions. A 'no-stress...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01146-3
更新日期:1995-12-24 00:00:00
abstract::Ethanol administration in long-sleep (LS) and short-sleep (SS) mice results in a large number of Fos-IR neurons in the supraoptic nucleus (SON) in LS, and almost no Fos-IR neurons in the same nucleus in SS mice. In contrast, isotonic saline, hypertonic saline, with or without ethanol, resulted in a similar pattern of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02453-8
更新日期:2002-05-10 00:00:00
abstract::The present study combined masked priming with electrophysiological recordings to investigate orthographic priming effects with nonword targets. Targets were pronounceable nonwords (e.g., STRENG) or consonant strings (e.g., STRBNG), that both differed from a real word by a single letter substitution (STRONG). Targets ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.050
更新日期:2011-04-22 00:00:00
abstract::Injection of a potent, cholinergic muscarinic antagonist, [3H]3-quinuclidinyl benzilate ([3H]QNB), results in a localization of the drug to muscarinic receptors in rat brain. The distribution of these drug receptors was examined in various brain regions previously thought to contain cholinergic neurons. They were loca...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90399-1
更新日期:1976-07-09 00:00:00
abstract::Chemokine receptors, and in particular CXCR4 and CCR5 play a key role in the neuropathogenesis of Human Immunodeficiency Virus-1 (HIV)4 associated dementia (HAD). Thus, new insight into the expression of CXCR4 in the central nervous system may help develop therapeutic compounds against HAD. Brain-derived neurotrophic ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.05.086
更新日期:2008-08-28 00:00:00
abstract::The effect of different dose, mode and duration of estradiol administration was examined in the different brain catecholaminergic areas in ovariectomized (OVX) female rats. We determined changes in mRNA levels of tyrosine hydroxylase (TH), rate-limiting enzyme in catecholamine (CA) biosynthesis of GTP cyclohydrolase I...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.04.002
更新日期:2004-07-23 00:00:00
abstract::The suprachiasmatic nuclei receive photic input information directly through a retinohypothalamic tract (RHT) and indirectly through a projection from the intergeniculate leaflet of the lateral geniculate complex, the geniculohypothalamic tract (GHT). Prior work has established that the RHT is sufficient for entrainme...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90374-5
更新日期:1988-09-20 00:00:00
abstract::The response of two populations of neurones in the substantia nigra (nigro-striatal compacta neurones and reticulata neurones) to microelectrophoretically administered putative neurotransmitters and stimulation of the ipsilateral striatum has been investigated in anaesthetized rats. There were marked differences betwe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90467-4
更新日期:1981-05-18 00:00:00
abstract::The globus pallidus plays a critical role in movement regulation. Morphological studies have shown that group I mGluRs including mGluR1 and mGluR5 are expressed in the globus pallidus. Up to now, little is known about the in vivo electrophysiological effects of group I mGluRs on the pallidal neurons. The present study...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.08.027
更新日期:2012-10-05 00:00:00
abstract::We compared the laminar location and morphology of superior colliculus cells projecting to the dorsal and ventral lateral geniculate nuclei (LGd, LGv), the pretectum (PT), the parabigeminal nucleus (Pb), and nucleus lateralis posterior (LP) in the ground squirrel Spermophilus tridecemlineatus. Horseradish peroxidase w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90432-x
更新日期:1987-11-17 00:00:00
abstract::The pretectal olivary nucleus of the squirrel monkey was examined in both normal and autoradiographic material. In the Nissl- and fiber-stained tissue the nucleus appears as a laminated structure. The distribution of retinal terminals within the nucleus was examined by the autoradiographic tracing method. These data r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91125-2
更新日期:1981-11-09 00:00:00
abstract::The present study was undertaken in order to study the rate of maturation of the cochlear action potential sensitivity, latency, and tuning curves for various stimulus frequencies and to correlate the development of latency and frequency selectivity with threshold development. This study showed a two-stage model of ma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90239-2
更新日期:1987-12-15 00:00:00
abstract::A special feature of the extracellular matrix in adult brains of various species is the concentration of certain components around different sub-populations of neurones, giving rise to net-like structures termed perineuronal nets. Recently, some of these components have been identified but the function of these nets h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01596-6
更新日期:1999-07-10 00:00:00
abstract::The present study gives a detailed description of the functional characteristics and of the topographic distribution of responses mediated through the climbing fiber (CF) pathway in the cerebellum of adult rats which have been repeatedly irradiated from birth so that the Purkinje cells (PCs) in the adult remained inne...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91291-1
更新日期:1987-09-22 00:00:00
abstract::Recently mutations in ubiquilin-2 were identified in patients with amyotrophic lateral sclerosis (ALS) and ALS/dementia providing direct evidence for the importance of this protein in neurodegenerative diseases. Histological studies have suggested that ubiquilin-1/-2 are associated with various pathological inclusions...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.06.006
更新日期:2013-08-02 00:00:00
abstract::It has been hypothesized on the basis of animal models of epilepsy that abnormal neural activity in epilepsy may be related to reorganized neural circuits that facilitate epileptogenesis. Little evidence of this was available for human epilepsy. This paper provides the first evidence of such reorganization of a hippoc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90234-5
更新日期:1989-08-28 00:00:00
abstract::Alterations in the membraneous organelles were studied in two experimental neuropathies: 2,5-hexanedione (2,5-HD) and beta,beta'-iminodiproprionitrile (IDPN), both of which exhibit massive neurofilamentous accumulation. The membranous organelles were stained using the diaminobenzidine potassium ferrocyanide (DPF) meth...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90489-4
更新日期:1983-06-06 00:00:00
abstract::We previously described a rat model where the injection of formalin in the tail induced a facilitation of the hindpaw withdrawal reflexes (hyperalgesia). In the present work, after injecting formalin in the tail, we measured the levels of pro-nociceptive mediators tumor necrosis factor-alpha (TNF) and substance P (SP)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.06.007
更新日期:2004-09-03 00:00:00
abstract::Regeneration of descending supraspinal projections were identified in adult goldfish following administration of HRP to different levels of the spinal cord. While in the untreated normal fish 17 nuclei were shown to project into the spinal cord, only 11 of them seem to have participated in the process of regeneration....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90159-k
更新日期:1993-08-27 00:00:00
abstract::In the present study, we describe the cardiovascular effects of local acetylcholine (Ach) microinjection into both the ventrolateral (vlPAG) and dorsal (dPAG) periaqueductal gray areas of anesthetized rats and the possible local receptors involved with these responses. Microinjection of Ach (9, 27, 45 or 81 nmol/50 nL...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.11.051
更新日期:2011-01-31 00:00:00
abstract::This study attempted to ascertain whether heatstroke-induced ischemia is associated with augmented striatal glutamate release and can be attenuated by NMDA receptor antagonists. Mean arterial pressure (MAP), striatal cerebral blood flow (CBF), striatal glutamate release and striatal neuronal damage score were assessed...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00282-0
更新日期:1998-06-08 00:00:00
abstract::We examined the distribution of choline acetyltransferase (ChAT) mRNA in the brain of six autopsied individuals by in situ hybridization with 35S-labeled human ChAT riboprobes. Neurons containing hybridization signal for ChAT mRNA were observed in the nucleus of the diagonal band of Broca, the basal nucleus of Meynert...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00677-5
更新日期:1998-09-21 00:00:00
abstract::Painful experience is a complex entity made up of sensory, affective, motivational and cognitive dimensions. The neural mechanisms involved in pain perception acts in a serial and a parallel way, discriminating and locating the original stimulus and also integrating the affective feeling, involved in a special situati...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2003.10.073
更新日期:2004-03-12 00:00:00
abstract::To verify whether microtubules are involved in the mechanism of axoplasmic transport in vivo, [3H]leucine was injected into ventral horns of rats, and 3 h later Ca2+ or other drugs injected into sciatic nerves. The injection of 50-200 mM Ca2+, raising intra-axoplasmic Ca2+ levels, blocked transport above the intraneur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90514-7
更新日期:1986-03-26 00:00:00
abstract::We previously reported that reactive oxygen species (ROS) in paraventricular nucleus (PVN) modulated cardiac sympathetic afferent reflex (CSAR) and mediated the effect of angiotensin II (Ang II) in the PVN on the CSAR. In the present study, we investigated whether the NAD(P)H oxidase in the PVN was a key source of ROS...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.113
更新日期:2006-04-12 00:00:00
abstract::Despite a blood-brain barrier for norepinephrine, the concentration of norepinephrine in plasma and cerebrospinal fluid has been observed to be similar. This relationship between plasma and cerebrospinal fluid norepinephrine levels suggest that peripheral sympathetic neurons innervating blood vessels to brain and spin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91600-8
更新日期:1986-03-05 00:00:00