Cardiovascular effects of acetylcholine microinjection into the ventrolateral and dorsal periaqueductal gray of rats.


:In the present study, we describe the cardiovascular effects of local acetylcholine (Ach) microinjection into both the ventrolateral (vlPAG) and dorsal (dPAG) periaqueductal gray areas of anesthetized rats and the possible local receptors involved with these responses. Microinjection of Ach (9, 27, 45 or 81 nmol/50 nL) into the vlPAG caused dose-related depressor responses. These hypotensive responses were blocked by local pretreatment with increasing doses of the nonselective muscarinic antagonist atropine (1, 3 or 9 nmol/50 nL)(.) The microinjection of Ach into the dPAG caused no significant cardiovascular responses in anesthetized rats. In conclusion, the present findings suggest that a cholinergic system present in the vlPAG, but not in the dPAG, is involved with cardiovascular system control. Moreover, these cardiovascular responses evoked by Ach are mediated by muscarinic receptors.


Brain Res


Brain research


Deolindo MV,Pelosi GG,Busnardo C,Resstel LB,Corrêa FM




Has Abstract


2011-01-31 00:00:00












  • Effect of chronic pre- and post-natal low-dose ethanol exposure on brain enolase isoenzyme activities.

    abstract::Sprague-Dawley dams were treated with 3 v/v % ethanol in liquid diet from the 8th day gestation through 3 weeks nursing period. Offsprings, ages 1, 2 and 3 weeks, and their dams were studied. Brain weights and their total proteins were not affected by this ethanol treatment. Total enolase activity/mg protein and its i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Harada K,Adams V,Okamoto M

    更新日期:1992-05-15 00:00:00

  • Resistance to anoxic injury in the dorsal columns of adult rat spinal cord following demyelination.

    abstract::In order to examine the relationship between myelination and sensitivity to anoxia in adult white matter, we studied action potential conduction in the spinal cord dorsal column of adult rats in which focal demyelinating lesions had been produced using ethidium bromide/X-irradiation. Acutely isolated spinal cords from...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Imaizumi T,Kocsis JD,Waxman SG

    更新日期:1998-01-01 00:00:00

  • Effect of hyperbaric oxygenation on intracranial pressure elevation rate in rats during the early phase of severe traumatic brain injury.

    abstract::Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO(2)) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO(2) treatment has a therapeutic effect on ICP dynamics and survival following seve...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rogatsky GG,Kamenir Y,Mayevsky A

    更新日期:2005-06-21 00:00:00

  • Spatial frequency-dependent feedback of visual cortical area 21a modulating functional orientation column maps in areas 17 and 18 of the cat.

    abstract::The feedback effect of activity of area 21a on orientation maps of areas 17 and 18 was investigated in cats using intrinsic signal optical imaging. A spatial frequency-dependent decrease in response amplitude of orientation maps to grating stimuli was observed in areas 17 and 18 when area 21a was inactivated by local ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Huang L,Chen X,Shou T

    更新日期:2004-02-20 00:00:00

  • Amphetamine injected into the ventral tegmental area sensitizes the nucleus accumbens dopaminergic response to systemic amphetamine: an in vivo microdialysis study in the rat.

    abstract::Different groups of rats received three injections of either D-amphetamine (2.5 micrograms/0.5 microliters/side) or saline into the ventral tegmental area (VTA), one injection every third day. Two weeks following the last injection, dopamine (DA) neurotransmission in the nucleus accumbens (N. Acc.) was assessed with i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vezina P

    更新日期:1993-03-12 00:00:00

  • Elimination of inappropriate axonal branches of regenerating cockroach motor neurons as detected by the retrograde transport of horseradish peroxidase conjugated wheat germ agglutinin.

    abstract::A procedure is described for identifying the motor neurons innervating individual cockroach muscles by use of the retrograde transport of extracellularly injected horseradish peroxidase and the staining of cells in whole mount preparations. A modification of this procedure using wheat germ agglutinin covalently conjug...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Denburg JL

    更新日期:1982-09-23 00:00:00

  • WITHDRAWN: Transplantation of bone mesenchymal stem cells containing the nerve growth factor gene in adult rat brain with Fimbria Fornix lesion.

    abstract::Bone marrow-derived mesenchymal stem cells (BMSCs) are a promising source for cell-based treatment of brain injury, but the therapy of BMSCs is restricted by low cell survival. We examined whether nerve growth factor (NGF) improve BMSCs viability in the brain with Fimbria-Fornix lesion (FF). After transduction of NGF ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Leng SL,Fan WG,Qu HG,Xu SC,Zhong WY,Zhang WY,Zeng JQ,Long DH,He HW

    更新日期:2009-01-19 00:00:00

  • Extracellular levels of neuropeptide Y are markedly increased in the dorsal hippocampus of freely moving rats during kainic acid-induced seizures.

    abstract::In this microdialysis study we measured the extracellular neuropeptide Y (NPY) levels in the dorsal hippocampus of conscious rats. During potassium-induced depolarisations, a 93% increase in extracellular levels of NPY was observed. NPY has been demonstrated to reduce kainic acid-induced convulsions in rats, but it is...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Husum H,Mikkelsen JD,Mørk A

    更新日期:1998-01-19 00:00:00

  • Cardiovascular responses to microinjection of L-glutamate into the NTS in AV3V-lesioned rats.

    abstract::The excitatory amino acid L-glutamate injected into the nucleus of the solitary tract (NTS) in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure (MAP) and reduces heart rate. In this study, we investigated the effects of acute (1 day) and chronic (15 days) electrolytic...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vieira AA,Colombari E,De Luca LA Jr,de Almeida Colombari DS,Menani JV

    更新日期:2004-10-29 00:00:00

  • Non-oriented cells of the striate cortex activated during smooth pursuit eye movements and steady fixations in behaving monkeys.

    abstract::Extracellular recordings were carried out in the primary visual cortex of behaving monkeys. Neurons were activated by moving a visual stimulus on their receptive fields during periods of steady fixation and by moving their receptive fields (smooth pursuit eye movements) on a motionless visual stimulus. Regarding non-o...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Galletti C,Squatrito S,Battaglini PP,Maioli MG

    更新日期:1983-01-31 00:00:00

  • Immunocytochemical staining of neuropeptide Y (NPY) in the insular lobe of the monkey: a light microscopic study.

    abstract::Neuropeptide Y (NPY) has been detected immunocytochemically in cerebral cortex and subcortical white matter of the primate frontal, parietal, temporal, and occipital lobes. Because little is known about NPY in the primate insular lobe and because peptides play an important role in normal neuronal functioning and alter...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Augustine JR,Mascagni F,McDonald AJ,Blake CA

    更新日期:1993-02-19 00:00:00

  • Olfactory bulbectomy prevents short photoperiod-induced anestrus in female golden hamsters.

    abstract::When female golden hamsters are maintained on a photoperiod of less than 12.5 h of light per day, they go into a pineal gland-induced anestrus in 6-10 weeks. This acyclicity is similar in certain respects to the testicular regression which occurs in male golden hamsters maintained on a short photoperiod. A recent stud...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pieper DR,Samyn MM,Heverly RN

    更新日期:1986-08-13 00:00:00

  • Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study.

    abstract::An expanding body of data has indicated that the seizure prone state in genetically epilepsy-prone rats (GEPRs) is partially caused by deficits in central nervous system noradrenergic transmission. Several lines of evidence suggest that the noradrenergic terminals in the superior colliculus (SC) may act as determinant...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yan QS,Dailey JW,Steenbergen JL,Jobe PC

    更新日期:1998-01-12 00:00:00

  • Effects of sulpiride and apomorphine on prolactin release in adrenalectomized animals. Role of sodium ions.

    abstract::The present experiments were performed to demonstrate in vivo the existence of a modulatory role of Na+ in the inhibitory control of prolactin (PRL) secretion. Groups of adult male rats were either adrenalectomized (adrenex) or sham-operated (normals) and implanted in the right atrium with a chronic cannula for the in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Collu R,Bouvier C

    更新日期:1987-01-13 00:00:00

  • Immunoreactive avian pancreatic polypeptide in the chicken retina: overall distribution.

    abstract::The distribution of avian pancreatic polypeptide (APP)-like immunoreactivity (APP-IR) in the chicken retina was investigated by means of immunohistochemistry. The observation from frozen sections showed that APP-IR is localized in the stratified amacrine cells of the first sublayer. Examination of whole-mounts reveale...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Katayama Y,Kiyama H,Arai Y,Tohyama M

    更新日期:1984-09-17 00:00:00

  • The taste reactivity test. II. Mimetic responses to gustatory stimuli in chronic thalamic and chronic decerebrate rats.

    abstract::The taste reactivity test described in the preceding paper was used to begin determining the capacity of brain stem structures to execute and regulate ingestive behavior. Both chronic thalamic and chronic decerebrate rat preparations were examined repeatedly, and their gustatory mimetic responses compared through fram...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Grill HJ,Norgren R

    更新日期:1978-03-24 00:00:00

  • Casein kinase II is associated with neurofibrillary tangles but is not an intrinsic component of paired helical filaments.

    abstract::Neurofibrillary tangles (NFT) are pathological cytoskeletal structures composed of paired helical filaments (PHF), and are found in neurons of patients afflicted with many neurodegenerative disorders, including Alzheimer's disease (AD). We previously found that an antiserum against casein kinase II (CK-II) stained NFT...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Baum L,Masliah E,Iimoto DS,Hansen LA,Halliday WC,Saitoh T

    更新日期:1992-02-21 00:00:00

  • The action of MPTP on synaptic transmission is affected by changes in Ca2+ concentrations.

    abstract::1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes a disruption of nigrostriatal dopaminergic function which resembles parkinsonism. On the cellular level, the disruption involves a Ca2+ independent release of dopamine, depletion of nigral and striatal dopamine, and the death of dopaminergic neurons. We have p...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wilson JA,Lau YS,Gleeson JG,Wilson JS

    更新日期:1991-02-15 00:00:00

  • Remote astrocytic response of prefrontal cortex is caused by the lesions in the nucleus basalis of Meynert, but not in the ventral tegmental area.

    abstract::The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Anezaki T,Yanagisawa K,Takahashi H,Nakajima T,Miyashita K,Ishikawa A,Ikuta F,Miyatake T

    更新日期:1992-03-06 00:00:00

  • Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings.

    abstract::The onset of the daily wheel running bout precedes dark onset by several hours in the early runner genetic variant of mice. Here, we test the hypothesis that timed daily administration of a melatonin agonist, ramelteon, or a benzodiazepine, triazolam, normalizes the timing of daily wheel-running rhythms in early runne...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wisor JP,Jiang P,Striz M,O'Hara BF

    更新日期:2009-11-03 00:00:00

  • Kinetics of phenylalanine transport at the human blood-brain barrier investigated in vivo.

    abstract::In vivo proton magnetic resonance spectroscopy was used to investigate intracerebral phenylalanine (Phe) concentrations in nine patients with classical phenylketonuria (PKU). The study included serial examinations (n = 31; plasma Phe levels: 0.47-2.24 mmol/l) of patients either receiving a Phe-restricted diet (200 mg ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Möller HE,Weglage J,Wiedermann D,Vermathen P,Bick U,Ullrich K

    更新日期:1997-12-19 00:00:00

  • The basis and functional role of the late EMG activity in human forearm muscles following wrist displacement.

    abstract::The present paper examines the hypothesis that the long latency EMG activity produced by muscle stretch is the result of long loop reflex pathways involved in the control of limb stiffness. We recorded the cerebral responses and late EMG activity in agonist and antagonist muscles following sudden stretch of the wrist ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Goodin DS,Aminoff MJ

    更新日期:1992-08-28 00:00:00

  • Postnatal development of rat peripheral nerves: an immunohistochemical study of membrane lipids common to non-myelin forming Schwann cells, myelin forming Schwann cells and oligodendrocytes.

    abstract::Interest in the role of membrane lipids in Schwann cell function prompted this study of lipid antigens on myelin- and non-myelin forming Schwann cells. Using the monoclonal antibodies 07, which recognises galactocerebroside, 08, 09 and 011, the distribution and time course of expression of the 4 membrane lipids have b...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Eccleston PA,Mirsky R,Jessen KR,Sommer I,Schachner M

    更新日期:1987-10-01 00:00:00

  • Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity.

    abstract::We examined the role of the phosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) and cyclic AMP-response element binding protein (CREB) in N-methyl-d-aspartate (NMDA)-induced neurotoxicity in the rat retina. Western blot analysis showed early elevation of phosphorylated CaMKII (p-CaMKII) protein ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Takeda H,Kitaoka Y,Hayashi Y,Kumai T,Munemasa Y,Fujino H,Kobayashi S,Ueno S

    更新日期:2007-12-12 00:00:00

  • The effect of reticular stimulation on spontaneous and evoked activity in the cat visual cortex.

    abstract::The mesencephalic reticular formation (MRF) of cats anesthetized with N2O was stimulated electrically, and the effects of this stimulation on activity in the striate cortex were studied. The variations of intra- and extracellularly recorded unit activity and the changes in the extracellular potassium concentration wer...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Singer W,Tretter F,Cynader M

    更新日期:1976-01-30 00:00:00

  • Brain laterality as a determinant of susceptibility to depression in an animal model.

    abstract::Rats exposed to stressors that cannot be controlled may develop a deficit in their ability to subsequently learn to control a new stressor. This phenomenon is known as 'learned helplessness' and is a well-accepted animal model of depression. Evidence is presented showing that rats having different directional biases o...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Carlson JN,Glick SD

    更新日期:1991-06-07 00:00:00

  • Effect of aminoguanidine on optic nerve involvement in experimental diabetic rats.

    abstract::The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low dose (25 mg kg-1 body...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ino-ue M,Ohgiya N,Yamamoto M

    更新日期:1998-08-03 00:00:00

  • The maintenance of hippocampal pyramidal neuron populations is dependent on the modulation of specific cell cycle regulators by thyroid hormones.

    abstract::The onset of adult hypothyroidism causes neuronal damage in the CA3 hippocampal region, which is attenuated by T(4) administration. We analyzed the expression of molecular proliferation markers (Cyclin D1 and PCNA), cellular damage-arrest (p53 and p21), and apoptosis (Bax/Bcl-2 index) in the hippocampus of hypothyroid...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Alva-Sánchez C,Sánchez-Huerta K,Arroyo-Helguera O,Anguiano B,Aceves C,Pacheco-Rosado J

    更新日期:2009-05-19 00:00:00

  • Delayed behavioral response to antidepressant drugs following selective damage to the hippocampal noradrenergic innervation in rats.

    abstract::The present study was undertaken to investigate in rats the role of the noradrenergic innervation of the hippocampus in the reversal by antidepressant drugs of escape failures caused by previous exposure to inescapable shocks (learned helplessness design). Rats were either sham-operated or given a bilateral infusion o...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Soubrie P,Martin P,el Mestikawy S,Hamon M

    更新日期:1987-12-29 00:00:00

  • Projections to the neostriatum from the cat precruciate cortex. Anatomy and physiology.

    abstract::The projections to the striatum from two cytoarchitectonically and functionally distinct subdivisions of the cat precruciate motor cortex were studied using anatomical and electrophysiological techniques. Our results indicate that the medial precruciate cortex (stimulation of which leads to movements of the axial and ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Garcia-Rill E,Nieto A,Adinolfi A,Hull CD,Buchwald NA

    更新日期:1979-07-20 00:00:00