Cardiovascular effects of acetylcholine microinjection into the ventrolateral and dorsal periaqueductal gray of rats.

Abstract:

:In the present study, we describe the cardiovascular effects of local acetylcholine (Ach) microinjection into both the ventrolateral (vlPAG) and dorsal (dPAG) periaqueductal gray areas of anesthetized rats and the possible local receptors involved with these responses. Microinjection of Ach (9, 27, 45 or 81 nmol/50 nL) into the vlPAG caused dose-related depressor responses. These hypotensive responses were blocked by local pretreatment with increasing doses of the nonselective muscarinic antagonist atropine (1, 3 or 9 nmol/50 nL)(.) The microinjection of Ach into the dPAG caused no significant cardiovascular responses in anesthetized rats. In conclusion, the present findings suggest that a cholinergic system present in the vlPAG, but not in the dPAG, is involved with cardiovascular system control. Moreover, these cardiovascular responses evoked by Ach are mediated by muscarinic receptors.

journal_name

Brain Res

journal_title

Brain research

authors

Deolindo MV,Pelosi GG,Busnardo C,Resstel LB,Corrêa FM

doi

10.1016/j.brainres.2010.11.051

subject

Has Abstract

pub_date

2011-01-31 00:00:00

pages

74-81

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(10)02564-3

journal_volume

1371

pub_type

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