Abstract：
:In the present study, we describe the cardiovascular effects of local acetylcholine (Ach) microinjection into both the ventrolateral (vlPAG) and dorsal (dPAG) periaqueductal gray areas of anesthetized rats and the possible local receptors involved with these responses. Microinjection of Ach (9, 27, 45 or 81 nmol/50 nL) into the vlPAG caused dose-related depressor responses. These hypotensive responses were blocked by local pretreatment with increasing doses of the nonselective muscarinic antagonist atropine (1, 3 or 9 nmol/50 nL)(.) The microinjection of Ach into the dPAG caused no significant cardiovascular responses in anesthetized rats. In conclusion, the present findings suggest that a cholinergic system present in the vlPAG, but not in the dPAG, is involved with cardiovascular system control. Moreover, these cardiovascular responses evoked by Ach are mediated by muscarinic receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Deolindo MV,Pelosi GG,Busnardo C,Resstel LB,Corrêa FMdoi
10.1016/j.brainres.2010.11.051subject
Has Abstractpub_date
2011-01-31 00:00:00pages
74-81eissn
0006-8993issn
1872-6240pii
S0006-8993(10)02564-3journal_volume
1371pub_type
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