Enkephalin-like immunoreactivity levels increase in the motor nucleus after an intramedullar axotomy of motoneurons in the adult cat spinal cord.

abstract：:Dendritic spines are actin-rich protrusions from the dendritic shaft, considered to be the locus where most synapses occur, as they receive the vast majority of excitatory connections in the central nervous system (CNS). Interestingly, hippocampal spines are plastic structures that contain a dense array of molecules i...

journal_title：Brain research

authors： Bellot A,Guivernau B,Tajes M,Bosch-Morató M,Valls-Comamala V,Muñoz FJ

更新日期：2014-07-21 00:00:00

abstract：:Previous examination of binge cocaine self-administration and 2 week withdrawal from cocaine self-administration on ionotropic glutamate receptor subunit (iGluRs) protein levels revealed significant alterations in iGluR protein levels that differed between the mesocorticolimbic and nigrostriatal pathways. The present ...

journal_title：Brain research

authors： Hemby SE,Horman B,Tang W

更新日期：2005-12-07 00:00:00

abstract：:Three hours after administration of the pro-oxidant 2-cyclohexen-1-one, calpain activity was significantly reduced in the brain of young rats, but not in the brain of adult rats, and cathepsin D activity remained unchanged. Addition of isovalerylcarnitine to the incubation medium increased calpain activity 5-7-fold, c...

journal_title：Brain research

authors： Benuck M,Banay-Schwartz M,Ramacci MT,Lajtha A

更新日期：1992-11-20 00:00:00

abstract：:Hypoxia markedly depresses synaptic transmission in hippocampal slices of the rat. This depression is attributed to presynaptic inhibition of glutamate release and is largely mediated by adenosine released during hypoxia acting through presynaptic adenosine A(1) receptors. Paired pulse facilitation studies allowed us ...

journal_title：Brain research

authors： Coelho JE,de Mendonça A,Ribeiro JA

更新日期：2000-06-30 00:00:00

abstract：:Currently there are no uniform standard treatments for newborn suffering from cerebral hypoxia-ischemia (HI) and to find new and effective strategies for treating the HI injury remains a key direction for future research. Present study was designed to demonstrate that optimal dose (1 or 3%) of creatine monohydrate (Cr...

journal_title：Brain research

authors： Allah Yar R,Akbar A,Iqbal F

更新日期：2015-01-21 00:00:00

abstract：:Results from clinical studies provide evidence that cognitive changes relatively late in life may be traced to antecedent conditions including diabetes, obesity, a sedentary lifestyle, and an atherogenic diet. As such, several traits of Type 2 diabetes (T2DM) could be considered pathogenic factors of aging, contributi...

journal_title：Brain research

authors： Maimaiti S,DeMoll C,Anderson KL,Griggs RB,Taylor BK,Porter NM,Thibault O

更新日期：2015-09-24 00:00:00

abstract：:We have examined the question of whether alpha-tubulin is detyrosylated during axonal transport in retinal ganglion cell axons and axons of spinal motor neurons. The degree of tyrosylation of alpha-tubulin was estimated from immunocytochemistry and immunoblotting with two anti-alpha-tubulin monoclonals, one of which (...

journal_title：Brain research

authors： Burgoyne RD,Norman KM

更新日期：1986-08-27 00:00:00

abstract：:Pregnenolone sulfate (PS) is an endogenous neurosteroid known to antagonize GABA(A) receptor-mediated inhibitory responses and potentiate NMDA receptor-mediated excitatory responses in vitro. To assess the actions of the steroid as a modulator of seizure susceptibility in vivo, PS (30-300 nmol) was administered intrac...

journal_title：Brain research

authors： Kokate TG,Juhng KN,Kirkby RD,Llamas J,Yamaguchi S,Rogawski MA

更新日期：1999-06-12 00:00:00

abstract：:Muscarinic and NMDA receptors contribute to post-traumatic hypersensitivity to secondary ischemia. However, the effect of these receptor antagonists on behavior and CA1 neuronal death after traumatic brain injury (TBI) with acute (1 h after TBI) forebrain ischemia has not been systematically assessed. We examined cogn...

journal_title：Brain research

authors： Jenkins LW,Lu Y,Johnston WE,Lyeth BG,Prough DS

更新日期：1999-01-30 00:00:00

abstract：:Adult male guinea pigs were castrated and 24 h later injected with [3H]dihydrotestosterone. Their pituitary glands were then processed for autoradiographic and immunocytochemical analyses. Three percent of the parenchymal cells in the pars distalis were radiolabelled. These cells were primarily gonadotrophs; a small p...

journal_title：Brain research

authors： Herbert DC,Sheridan PJ

更新日期：1986-01-08 00:00:00

abstract：:Met5-enkephalin- (Met-ENK), Leu5-enkephalin-, Met5-enkephalin-Arg6-Phe7-, metorphamide- and BAM 22P-like peptides could be detected in the lumbar spinal cord of the chicken by immunocytochemistry and/or high performance liquid chromatography. However, a peptide identical to Met5-enkephalin-Arg6-Gly7-Leu8 could not be ...

journal_title：Brain research

authors： Maderdrut JL,Merchenthaler I,Sundberg DK,Okado N,Oppenheim RW

更新日期：1986-07-02 00:00:00

abstract：:The innervation of the tensor tympani muscle of the middle ear in Macaca fascicularis (cynomolgus monkey) was studied using the horseradish peroxidase (HRP) neural tracing technique. A compact column of small trigeminal motoneurons was labeled ipsilaterally following intramuscular application of HRP to the tensor tymp...

journal_title：Brain research

authors： Gannon PJ,Eden AR

更新日期：1987-02-24 00:00:00

abstract：:The effect of gamma-aminobutyric acid (GABA)receptor stimulation on norepinephrine (NE)-induced metabolism of polyphosphoinositides (PIPs) was studied in rat hippocampal slices. Inositol phosphates (IPs), PIPs, and phosphatidic acid were measured. NE induced formation of IPs and phosphatidic acid in a dose-dependent m...

journal_title：Brain research

authors： Corradetti R,Ruggiero M,Chiarugi VP,Pepeu G

更新日期：1987-05-12 00:00:00

abstract：:Glioblastoma stem cells (GSCs) are thought to contribute to the diffuse invasiveness of malignant gliomas. Emerging evidence supports a role for a disintegrin and metalloproteinase 17 (ADAM17) in proteolytic ectodomain shedding of several EGFR-binding ligands, which subsequently activate PI3K/AKT and MEK/ERK pathways ...

journal_title：Brain research

authors： Chen X,Chen L,Chen J,Hu W,Gao H,Xie B,Wang X,Yin Z,Li S,Wang X

更新日期：2013-11-13 00:00:00

abstract：:Neuronal activity in the nucleus parabrachialis medialis (NPBM) was examined in unanesthetized, unrestrained cats during each sleep-waking state. Discharge related to the cardiac cycle was assessed by calculating cross-correlation functions between neuronal and cardiac events (using the peak of the EKG 'R' wave as a r...

journal_title：Brain research

authors： Sieck GC,Harper RM

更新日期：1980-10-20 00:00:00

abstract：:Whole cell and perforated patch clamp experiments were conducted on cultured cortical rat neurones (7-21 days in vitro) in order to determine the effects of the anticonvulsant and glutamate release inhibitor Lamotrigine (10-100 microM), on CNS receptors and ion channels. The compound inhibited, indiscriminately, both ...

journal_title：Brain research

authors： Lees G,Leach MJ

更新日期：1993-05-28 00:00:00

abstract：:In the brain, the neuropeptide cholecystokinin (CCK) appears to be involved in the mediation of stress responses. Here we provide new evidence that mild stress induces long-term changes in CCK-like immunoreactivity (CCK-LI) in the prefrontal cortex (PFC). The changes in CCK-LI show a biphasic pattern, with a decrease ...

journal_title：Brain research

authors： Radu D,Brodin E,Weber G,Lindefors N

更新日期：2001-07-27 00:00:00

abstract：:We studied the short- and long-term epileptogenic effects of massed stimulation (MS) of the piriform cortex. Sprague-Dawley rats with electrodes implanted bilaterally in the anterior piriform cortex and the dorsal and ventral hippocampi underwent MS: electrical stimulation of the left piriform cortex every 5 min for 6...

journal_title：Brain research

authors： Timofeeva OA,Peterson GM

更新日期：1997-04-18 00:00:00

abstract：:Binge-like ethanol treatment of septal neurons blunts GABAAR-mediated miniature postsynaptic currents (mPSCs), suggesting it arrests synaptic development. Ethanol may disrupt postsynaptic maturation by blunting feedback signaling through immature GABAARs. Here, the impact of ethanol on the sensitivity of mPSCs to zolp...

journal_title：Brain research

authors： DuBois DW,Trzeciakowski JP,Parrish AR,Frye GD

更新日期：2006-05-17 00:00:00

abstract：:A monospecific antibody against tyrosine hydroxylase (TH), purified from a transplantable rat pheochromocytoma, was produced in rabbits. Immunohistochemical techniques were employed in order to determine if a relationship exists between the subcellular distribution of TH and the level of activation of the enzyme in th...

journal_title：Brain research

authors： Stephens JK,Masserano JM,Vulliet PR,Weiner N,Nakane PK

更新日期：1981-03-30 00:00:00

abstract：:Using the acetylthiocholine staining method, it was possible to visualize acetylcholinesterase (AChE)-stained neuronal cell bodies and nerve endings as well as AChE-positive vesicles in the rat duodenum. AChE-reactive perikarya were seen with certainty only in the myenteric plexus. They were 40 micron in diameter and ...

journal_title：Brain research

authors： Wolter HJ

更新日期：1985-07-29 00:00:00

abstract：:The administration of alpha 2-adrenoreceptor antagonists SKF 64139 or SKF 72223 (TIQ derivatives) elicits an increase in striatal DOPA synthesis. The findings that the enhanced DOPA synthesis is reversed by pretreatment of the animals with clonidine or with the D beta H inhibitor FLA-63 suggest that action of the TIQ ...

journal_title：Brain research

authors： Rabey JM,Passeltiner P,Bystritsky A,Engel J,Goldstein M

更新日期：1981-12-28 00:00:00

abstract：:DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] is a potent neurotoxicant in both vertebrate and invertebrate species. We have previously reported that neonatal exposure to DDT affects the muscarinic cholinergic receptors (MAChR) in the cerebral cortex in the neonatal mouse, leading to permanent disturbances in th...

journal_title：Brain research

authors： Eriksson P,Ahlbom J,Fredriksson A

更新日期：1992-06-12 00:00:00

abstract：:Aspartame (L-aspartyl-L-phenylalanine methyl ester), an artificial low-calorie sweetener, was shown to dose-dependently inhibit L-[3H]glutamate binding to its N-methyl-D-aspartate-specific receptors. L-Aspartic acid, a major endogenous metabolite of aspartame, inhibited the binding more stronger than aspartame, while ...

journal_title：Brain research

authors： Pan-Hou H,Suda Y,Ohe Y,Sumi M,Yoshioka M

更新日期：1990-06-18 00:00:00

abstract：:Intracerebroventricular (i.c.v.) administration of corticotropin-releasing factor (CRF) biphasically affects performance in tests of learning and memory. In the present study, we used CRF, urocortin (Ucn), a recently cloned CRF homologue, and CRF receptor antagonists, to determine which CRF receptor subtype(s) mediate...

journal_title：Brain research

authors： Zorrilla EP,Schulteis G,Ormsby A,Klaassen A,Ling N,McCarthy JR,Koob GF,De Souza EB

更新日期：2002-10-18 00:00:00

abstract：:Levodopa (L-DOPA) is widely used for symptomatic management in Parkinson's disease. We recently showed that (-)-epigallocatechin-3-gallate, a tea polyphenol, not only inhibits L-DOPA methylation, but also protects against oxidative hippocampal neurodegeneration. In the present study, we sought to determine several oth...

journal_title：Brain research

authors： Kang KS,Yamabe N,Wen Y,Fukui M,Zhu BT

更新日期：2013-02-25 00:00:00

abstract：:Arg8-vasopressin (AVP), a circadian clock-controlled gene product, is released from the hypothalamic suprachiasmatic nuclei (SCN) in mice in a circadian fashion. Previously reported differences in two mouse lines, initially selected for thermoregulatory nest-building behavior (building small nests (S-mice) or big nest...

journal_title：Brain research

authors： Van der Veen DR,Castillo MR,Van der Zee EA,Jansen K,Gerkema MP,Bult-Ito A

更新日期：2005-10-26 00:00:00

abstract：:The aim of this study was (i) to compare the immunocytochemical distribution of the calcium-binding protein calbindin-D28k (CB) in the hippocampus of rats with the pattern of neurodegeneration following adrenalectomy (ADX) using silver impregnation, and (ii) to investigate the CB-immunoreactivity in the hippocampus fo...

journal_title：Brain research

authors： Krugers HJ,Medema RM,Postema F,Korf J

更新日期：1995-10-23 00:00:00

abstract：:At various times after spinal nerve injury, dorsal root ganglia (DRGs) from injured segments were removed with attached dorsal roots and spinal nerves. In an in vitro recording chamber, spontaneously active units were recorded from teased dorsal root fascicles. Sustained spontaneous activity could first be recorded at...

journal_title：Brain research

authors： Liu X,Chung K,Chung JM

更新日期：1999-12-04 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) immunoreactivity in rat tissue was assayed using a new reversed-phase, ion-pair, high-pressure liquid chromatography (HPLC) method for separating TRH from its analogs. Virtually all of the TRH immunoreactivity in hypothalamus, brain stem, preoptic area, septum, striatum, frontal cor...

journal_title：Brain research

authors： Spindel E,Wurtman RJ

更新日期：1980-11-17 00:00:00