Abstract:
:Results from clinical studies provide evidence that cognitive changes relatively late in life may be traced to antecedent conditions including diabetes, obesity, a sedentary lifestyle, and an atherogenic diet. As such, several traits of Type 2 diabetes (T2DM) could be considered pathogenic factors of aging, contributing to age-dependent cognitive decline and our susceptibility to Alzheimer's disease. It appears that both the duration of metabolic condition and the age of the individual, together can contribute to the potential impact on peripheral as well as brain health. Because of robust evidence that in animal models of aging, Ca(2+) dysregulation alters neuronal health, synaptic plasticity, and learning and memory processes, we tested the hypothesis that peripheral metabolic dysregulation could exacerbate Ca(2+) dysfunction in hippocampal CA1 neurons. Using intracellular/ extracellular electrophysiological and Ca(2+) imaging techniques, we show that Ca(2+)levels at rest or during synaptic stimulation, the Ca(2+)-dependent afterhyperpolarization, baseline field potentials, and short-term synaptic plasticity were not significantly altered in young-adult male Zucker diabetic fatty rats compare to their lean counterparts. Our observations suggest that early phases of T2DM characterized by high levels of glucose and insulin may be too transient to alter hippocampal CA1 physiology in this animal model of diabetes. These results are supported by clinical data showing that longer T2DM duration can have greater negative impact on cognitive functions. This article is part of a Special Issue entitled SI: Brain and Memory.
journal_name
Brain Resjournal_title
Brain researchauthors
Maimaiti S,DeMoll C,Anderson KL,Griggs RB,Taylor BK,Porter NM,Thibault Odoi
10.1016/j.brainres.2014.10.052subject
Has Abstractpub_date
2015-09-24 00:00:00pages
214-21eissn
0006-8993issn
1872-6240pii
S0006-8993(14)01474-7journal_volume
1621pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::To test the hypothesis that stimulation of glial peroxidase activity by estrogens may play a role in the pathogenesis of the previously reported degenerative changes in the hypothalamic arcuate nucleus that occur in female rats treated with a long-acting estrogen preparation, the cellular localization and number of pe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90273-e
更新日期:1990-01-22 00:00:00
abstract::A combined retrograde transport and immunocytochemical study was carried out to determine the projections of the large glycine-immunoreactive neurons in the ventral cochlear nucleus of the guinea pig. Horseradish peroxidase (HRP) was injected into the contralateral cochlear nucleus, and cochlear nucleus sections were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90285-x
更新日期:1987-07-07 00:00:00
abstract::Injection of a potent, cholinergic muscarinic antagonist, [3H]3-quinuclidinyl benzilate ([3H]QNB), results in a localization of the drug to muscarinic receptors in rat brain. The distribution of these drug receptors was examined in various brain regions previously thought to contain cholinergic neurons. They were loca...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90399-1
更新日期:1976-07-09 00:00:00
abstract::The regional hemodynamic basis of the cardiovascular response to acute noise stress in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats and the role of the central amygdaloid nucleus in mediating this response was investigated. Using the pulsed Doppler flow probe technique it was determined that in respons...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91257-5
更新日期:1984-01-23 00:00:00
abstract::Secretion of calcitonin gene-related peptide (CGRP) was studied with the model system of dispersed adult rat trigeminal ganglion cells. Veratridine stimulated secretion of CGRP immunoreactivity. Tetrodotoxin and local anesthetics inhibited veratridine-stimulated peptide secretion. These observations implicate sodium c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91441-1
更新日期:1986-08-13 00:00:00
abstract::The synaptic protein alpha-synuclein is found throughout the brain, although its function remains ill-defined. Abnormal accumulations of alpha-synuclein have been recognised to be associated with a number of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Nevertheless, little is know...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.10.072
更新日期:2004-04-09 00:00:00
abstract::Given a hypothesised role for CCK in the anterior cingulate cortex (ACC) for the sensation of pain, the aim of the present study was to investigate whether the increased CCK release could be affected by two different analgesic drugs, morphine and the non-selective cyclooxygenase inhibitor diclofenac. Since opioids sti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.12.006
更新日期:2007-03-09 00:00:00
abstract::The vascular changes in the hippocampus and neocortex during kainic acid-induced seizures were investigated in control rats and in rats with chronic, bilateral, cervical sympathectomy. Seizures were induced in unanesthetized, spontaneously breathing rats. The increase in blood flow in the hippocampus of the sympathect...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91782-c
更新日期:1990-11-05 00:00:00
abstract::A detailed study of the distribution of neuropeptide Y (NPY) in the striatum of squirrel monkey (Saimiri sciureus) and cat was undertaken by means of indirect immunofluorescence and peroxidase-antiperoxidase (PAP) methods. In monkey, the NPY-immunoreactivity is homogeneously distributed along the entire extent of the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91131-5
更新日期:1986-05-07 00:00:00
abstract::Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00751-3
更新日期:1998-10-05 00:00:00
abstract::We describe a method to produce frog olfactory epithelium with a population of developmentally synchronized receptor cells suitable for electrophysiological studies. The epithelium is ablated with ZnSO4 and allowed to regenerate for 10 days. Generation of new cells is then blocked by continuous treatment with hydroxyu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90122-2
更新日期:1987-02-01 00:00:00
abstract::Simultaneous extracellular recordings from one electrode of 'local' groups of 3-6 neurons were obtained from the auditory cortex of unanesthetized, paralyzed cats. The activity and functional connectivity of local microenvironments were examined under various auditory stimuli. Single cell response patterns were examin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90567-x
更新日期:1983-08-08 00:00:00
abstract::Altered expression of neurotrophins may contribute to the pathogenesis of schizophrenia. Several studies suggest sex steroid hormones may be involved in the regulation of brain-derived neurotrophic factor (BDNF) signaling, as well as the symptoms of schizophrenia. This study aimed to identify sex differences in BDNF-T...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.01.060
更新日期:2011-04-12 00:00:00
abstract::The effects of injecting cholecystokinin (CCK) into the third ventricle or into selected hypothalamic sites on electrical firing rate of sympathetic nerves to interscapular brown fat (IBAT) has been investigated in anesthetized rats. The hypothesis for these experiments was that there was a reciprocal relationship bet...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91486-x
更新日期:1992-12-04 00:00:00
abstract::The effects of oral administration of the neuroleptic, haloperidol, on regional brain concentrations of cholecystokinin (CCK) and neurotensin were examined in the rat. Both short-term (3 weeks) and long-term (8 months) haloperidol administration increased the concentration of CCK in the substantia nigra. While short-t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91580-1
更新日期:1989-02-20 00:00:00
abstract::The suprachiasmatic nuclei (SCN) contain the major pacemaker for mammalian circadian rhythms. The SCN receive photic input both directly, via the retinohypothalamic tract (RHT), and indirectly, via the geniculohypothalamic tract (GHT), which originates in cells in the intergeniculate leaflet (IGL) and anterior portion...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91163-3
更新日期:1989-07-31 00:00:00
abstract::The aim of this study was to investigate the relationship between serum metabolomic biomarkers and brain in vivo magnetic resonance spectroscopy (MRS) biomarkers in patients with Parkinson's disease (PD) as well as to investigate compound concentration changes by comparing the results with healthy control subjects. Un...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147118
更新日期:2020-12-01 00:00:00
abstract::The aim of the present work was to study the effects of hyperammonemia on brain energy metabolism in neonatal rats. Rats were rendered hyperammonemic by ammonium acetate administration. This decreased brain ATP concentrations but enhanced brain ammonia and lactate levels in both adult and neonatal rats. In adult rats,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02529-0
更新日期:2003-05-23 00:00:00
abstract::Concurrent activation of dopamine D1 and D2 receptors (D1 and D2) is required for the expression of certain dopamine (DA)-mediated responses, such as climbing and stereotyped behaviors. Such interactions between D1 and D2 (i.e. D1/D2 synergism) represent an important aspect of dopaminergic function and plasticity. The...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04277-4
更新日期:2003-03-28 00:00:00
abstract::Spontaneous and drug-induced interictal and post-ictal locomotor behavior of rats was investigated following electrical 'kindling' of different limbic structures at 3 brain sites which differ in the relative amount of innervation from dopamine cells of the ventral tegmentum: nucleus accumbens (N.Acc.), amygdala (AMYG)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91385-x
更新日期:1985-02-04 00:00:00
abstract::The incidence of amyotrophic lateral sclerosis (ALS) is higher among men than women but rises in women after the menopause. Estrogens may play a protective role. Treatment with estrogens has been shown to be neuroprotective in models of several neurodegenerative diseases. We therefore determined the effect of ovariect...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.06.024
更新日期:2004-09-17 00:00:00
abstract::The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.058
更新日期:2007-01-12 00:00:00
abstract::The effect of valproic acid (VPA) on synaptic transmission was investigated at the frog neuromuscular junction using electrophysiological methods. The drug caused a dose-dependent decrease in the quantal content of the endplate potential (EPP) and a significant reduction in the input resistance of the postjunctional m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90393-7
更新日期:1984-07-23 00:00:00
abstract::Applications of acetylcholine to hippocampal slices maintained in vitro resulted in slow depolarizations and simultaneous increases in membrane resistance (RN)in hippocampal pyramidal neurons. Increases in RN had both voltage dependent and voltage independent components. These effects were associated with increases in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90089-5
更新日期:1981-04-27 00:00:00
abstract::In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy fr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90819-x
更新日期:1986-04-16 00:00:00
abstract::In albino rats the deep layers of the superior colliculus were stimulated, and climbing fiber responses of Purkinje cells were explored in the medial region of the lobulus simplex. They were identified in a strip (ca. 0.7-1.0 mm wide) in the most medial region of folium b. In the tectorecipient zone of the medial acce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90467-7
更新日期:1987-08-11 00:00:00
abstract::Male rats were treated with barbital in their drinking fluid for about 40 weeks (daily dose 200 mg/kg). The treatment was stopped on day 0 and the number of muscarinic binding sites was measured in 3 brain parts (striatum; cortex and hippocampus; medulla oblongata and midbrain) during the abstinence with labeled quinu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90146-9
更新日期:1982-08-19 00:00:00
abstract::A series of experiments were performed to study the effects of learning upon proteins in the split-brain pigeon. With this preparation, one side of the brain was trained in a color discrimination task while the other side served as a naive control. Proteins from both sides of the brain were separated by one- and two-d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90349-2
更新日期:1980-09-29 00:00:00
abstract::The mesolimbic dopamine (DA) system has long been known to be involved in reward behaviors. As with other substances of abuse, it has been extensively reported that ethanol influences the dopaminergic system. The present study examined whether selectively bred Sardinian-alcohol-preferring (sP) and Sardinian alcohol no...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03296-6
更新日期:2002-01-11 00:00:00
abstract::The first phase of this study involves injecting a different fluorescent retrograde axonal tracer into the subthalamic nucleus, the substantia nigra, and the mesopontine tegmentum. Multiple labeled cells are found within the caudal third of the globus pallidus. The entopeduncular nucleus and adjacent basal forebrain s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90948-7
更新日期:1989-05-15 00:00:00