Locomotor behavior following kindling in three different brain sites.

abstract：:Until recently, the bulk of research on the human reward system was focused on studying the dopaminergic and opioid neurotransmitter systems. However, extending the initial data from animal studies on reward, recent pharmacological brain imaging studies on human participants bring a new line of evidence on the key rol...

journal_title：Brain research

authors： Macoveanu J

更新日期：2014-03-27 00:00:00

abstract：:Diurnal changes in the intranuclear release of vasopressin (VP) and oxytocin (OT) in the suprachiasmatic (SCN), paraventricular (PVN) and supraoptic nuclei (SON) of the rat were studied by means of brain microdialysis. A significant diurnal variation in VP release in the SCN was detected, with the highest levels occur...

journal_title：Brain research

authors： Kalsbeek A,Buijs RM,Engelmann M,Wotjak CT,Landgraf R

更新日期：1995-06-05 00:00:00

abstract：:The neurobiology of autism spectrum disorders (ASDs) has become increasingly understood since the advent of magnetic resonance imaging (MRI). Initial observations of an above-average head circumference were supported by structural MRI studies that found evidence of increased total brain volume and early rapid brain ov...

journal_title：Brain research

authors： Stigler KA,McDonald BC,Anand A,Saykin AJ,McDougle CJ

更新日期：2011-03-22 00:00:00

abstract：:Decision making is commonly conceived to reflect the interplay of mutually antagonistic systems: executive processes must inhibit affective information to make adaptive choices. Consistent with this interpretation, prior studies have shown that the dorsolateral prefrontal cortex (dlPFC) is activated by executive proce...

journal_title：Brain research

authors： Mullette-Gillman OA,Detwiler JM,Winecoff A,Dobbins I,Huettel SA

更新日期：2011-06-13 00:00:00

abstract：:Repeated administration of subconvulsant doses of lidocaine or cocaine results in the development of an increased susceptibility to seizures induced by the two drugs (pharmacological kindling). It has been hypothesized that the local anesthetic properties of cocaine are responsible for its convulsant and epileptogenic...

journal_title：Brain research

authors： Marley RJ,Witkin JM,Goldberg SR

更新日期：1991-10-25 00:00:00

abstract：:There are sex differences in the neurochemistry of brainstem nuclei that participate in the control of breathing as well as sex differences in respiratory responses to hypoxia. Central chemoreception refers to the detection within the brain of minute changes in carbon dioxide (CO(2)) levels and the subsequent modulati...

journal_title：Brain research

authors： Niblock MM,Gao H,Li A,Jeffress EC,Murphy M,Nattie EE

更新日期：2010-01-22 00:00:00

abstract：:The dipeptide N-acetylaspartylglutamate (NAAG) may be involved in the process of glutamatergic signaling by both acting at glutamate receptors and as a glutamate protransmitter. In the present study we determined the cellular localization and distribution of NAAG-like immunoreactivity (NAAG-LI) in normal human brain a...

journal_title：Brain research

authors： Passani LA,Vonsattel JP,Coyle JT

更新日期：1997-10-24 00:00:00

abstract：:The influence of osmotic stimulation on the density of beta-adrenoceptor binding sites in the rat supraoptic nucleus (SON) was studied by quantitative autoradiography using 125I-cyanopindolol (ICYP). Increased density of beta-adrenoceptor binding sites was observed in osmotically stimulated rats and also after the sup...

journal_title：Brain research

authors： Lafarga M,Berciano MT,Del Olmo E,Andres MA,Pazos A

更新日期：1992-08-21 00:00:00

abstract：:The regulation of circadian rhythms changes with age. In humans, changes in the timing of sleep and wakefulness are especially common. In Syrian hamsters Mesocricetus auratus the free running period of the activity/rest rhythm shortens with age. The present study tested the hypothesis that critical age-related changes...

journal_title：Brain research

authors： Viswanathan N,Davis FC

更新日期：1995-07-17 00:00:00

abstract：:Aging is accompanied by an impairment of associative memory. The medial temporal lobe and fronto-striatal network, both involved in associative memory, are known to decline functionally and structurally with age, leading to the so-called associative binding deficit and the resource deficit. Because the MTL and fronto-...

journal_title：Brain research

authors： Meulenbroek O,Kessels RP,de Rover M,Petersson KM,Rikkert MG,Rijpkema M,Fernández G

更新日期：2010-02-22 00:00:00

abstract：:The conduction velocity of frog ischiadic nerves incubated in vitro in osmolarities between 220 and 1000 mOsm decreased with the degree of fiber shrinkage. The latter (non-circularity factor) was determined from computer-assisted measurements in freeze-substituted or in chemically fixed fibers. Freeze-substituted norm...

journal_title：Brain research

authors： Minwegen P,Friede RL

更新日期：1984-04-09 00:00:00

abstract：:To test the hypothesis that functional metabolic deficits observed following surgical brain injury are associated with changes in cognitive performance in rodents, we performed serial imaging studies in parallel with behavioral measures in control animals and in animals with surgical implants. Memory function was asse...

journal_title：Brain research

authors： Frumberg DB,Fernando MS,Lee DE,Biegon A,Schiffer WK

更新日期：2007-05-04 00:00:00

abstract：:The Leu-enkephalin dalargin does not normally penetrate the blood brain barrier when given intravenously. Drug targeting to the brain was investigated by using poly(butylcyanoacrylate) nanoparticles which were coated with polysorbate 80. When injected intravenously in mice, dalargin-loaded nanoparticles coated with th...

journal_title：Brain research

authors： Schröder U,Sabel BA

更新日期：1996-02-26 00:00:00

abstract：:Current and voltage responses elicited by increasing or decreasing the concentration of L-glutamate or its analog kainate around isolated cone horizontal cells were measured with patch pipettes using the whole cell recording configuration. Application of these photoreceptor transmitter agonists induced inward currents...

journal_title：Brain research

authors： Perlman I,Knapp AG,Dowling JE

更新日期：1989-05-15 00:00:00

abstract：:Although nitric oxide (NO) has been shown to play an important role in the pathophysiology of cerebral ischemia, its contribution to the pathogenesis of experimentally induced thromboembolic stroke is unknown. In this study, we pharmacologically manipulated NO levels in the acute post-thrombotic stage and determined t...

journal_title：Brain research

authors： Stagliano NE,Dietrich WD,Prado R,Green EJ,Busto R

更新日期：1997-06-06 00:00:00

abstract：:Regulation of myelin protein gene expression in the presence and absence of myelin assembly can be assessed using crushed or permanently transected adult sciatic nerves of rats. The P0 glycoprotein and the myelin basic protein (MBP) are the major myelin-specific proteins of the peripheral nervous system. The steady-st...

journal_title：Brain research

authors： LeBlanc AC,Poduslo JF,Mezei C

更新日期：1987-04-01 00:00:00

abstract：:Opioid-binding cell adhesion molecule (OBCAM) is the member of the IgLON family, a subgroup of the immunoglobulin superfamily. In the present study, the functions and dynamics of OBCAM were investigated in hippocampal neurons in vitro. Western blotting revealed that OBCAM expression was low at early stages of culture ...

journal_title：Brain research

authors： Yamada M,Hashimoto T,Hayashi N,Higuchi M,Murakami A,Nakashima T,Maekawa S,Miyata S

更新日期：2007-08-24 00:00:00

abstract：:Monoamine oxidase A and B (MAO A and B; EC 1.4.3.4) are integral proteins of the outer mitochondrial membrane that degrade monoamines including the neurotransmitters norepinephrine, dopamine, and serotonin. In this study, monoclonal antibodies that recognize rat or monkey MAO A were used in immunocytochemical studies ...

journal_title：Brain research

authors： Westlund KN,Krakower TJ,Kwan SW,Abell CW

更新日期：1993-05-28 00:00:00

abstract：:Zinc-enriched (ZEN) neurons are distributed widely throughout the brain and spinal cord. Synaptic vesicle zinc in these neurons is thought to function as a neuromodulator upon its release into the synaptic cleft. Consistent with this possibility, zinc or zinc chelators can alter spatial learning, working memory, and n...

journal_title：Brain research

authors： Cole TB,Martyanova A,Palmiter RD

更新日期：2001-02-09 00:00:00

abstract：:Hippocampal slices were taken from 7-day-old rats and maintained in vitro for 1-3 weeks. The organization of intrahippocampal connections in these explants was studied by placing onto the tissue small crystals of horseradish peroxidase (HRP) soaked with the detergent Nonidet. Antero- and retrograde transport of HRP wa...

journal_title：Brain research

authors： Keller F,Lipp HP,Waser PG

更新日期：1986-08-13 00:00:00

abstract：:Functional magnetic resonance imaging studies on episodic memory (EM) retrieval have used a variety of paradigms/contrasts to yield many diverse findings, which raises the need for an integrative multifactorial view. To address this need, I begin by proposing a fourstage, quasi-sequential model of network activity dur...

journal_title：Brain research

authors： Kim H

更新日期：2020-11-15 00:00:00

abstract：:The density of specific prostaglandin E2 (PGE2) binding sites was quantitatively mapped in the rat brain using in vitro autoradiography. The anterior wall of the third ventricle and the nucleus solitary tract were found to have a very high density of binding sites (greater than 15 fmol/mg tissue). Two thalamic nuclei ...

journal_title：Brain research

authors： Matsumura K,Watanabe Y,Imai-Matsumura K,Connolly M,Koyama Y,Onoe H,Watanabe Y

更新日期：1992-05-29 00:00:00

abstract：:The present study investigated the effect of locally infused guanfacine, an alpha2A-adrenergic agonist, into the ventral prefrontal cortex (PFv) on visuomotor associative learning. Two monkeys were well trained on a two-problem visuomotor associative task: the monkeys performed movement A if presented with a circle pa...

journal_title：Brain research

authors： Wang M,Tang ZX,Li BM

更新日期：2004-10-22 00:00:00

abstract：:Cerebral ischemia initiates an inflammatory response in the brain that is associated with the induction of a variety of cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1alpha/beta (IL-1alpha/beta) that contributes to stroke injury. Transient middle cerebral artery occlusion (tMCAO) in spon...

journal_title：Brain research

authors： Adibhatla RM,Hatcher JF

更新日期：2007-02-23 00:00:00

abstract：:The generation of oscillatory activity may be crucial to brain function. The coordination of individual neurons into rhythmic and coherently active populations is thought to result from interactions between excitatory and inhibitory cells mediated by local feedback connections. By using extracellular recording wires a...

journal_title：Brain research

authors： Ahrens KF,Freeman WJ

更新日期：2001-08-24 00:00:00

abstract：:We have used magnetic resonance imaging (MRI) of the living rat brain to longitudinally analyze the ontogenesis of an ibotenic acid lesion targeted at the piriform cortex. The MRI data were systematically compared with data obtained from a battery of histopathological techniques, including Nissl stain, hematoxylin sta...

journal_title：Brain research

authors： Ben-Horin N,Hazvi S,Bendel P,Schul R

更新日期：1996-04-29 00:00:00

abstract：:The aim of this work was to investigate the modulation of the cardiovascular effects of neuropeptide Y (NPY) in the nucleus tractus solitarii (NTS) by angiotensin II (Ang II) and to determine the NPY receptor subtype involved in this modulation. Anesthesized Sprague-Dawley rats received microinjections in the NTS of A...

journal_title：Brain research

authors： Díaz-Cabiale Z,Fuxe K,Coveñas R,González-Barón S,Narváez JA

更新日期：2003-09-05 00:00:00

abstract：:In the electrophysiologic test of the hindlimb withdrawal reflex where the long latency component is found to be dependent on noradrenaline (NA), implants of fetal NA tissue in lesioned animals result in a recovery of NA dependent function proportional to the number of catecholamine fluorescent cells in the implants. ...

journal_title：Brain research

authors： Moorman SJ,Whalen LR,Nornes HO

更新日期：1990-02-05 00:00:00

abstract：:The alpha-2 adrenergic agonist dexmedetomidine (Dex), 3-300 microg/kg, i.p., decreased cerebellar cGMP in a dose-dependent manner. Fentanyl (F), an opioid agonist, increased cerebellar cGMP at 0.3 mg/kg, s.c., and decreased it at doses >/=1 mg/kg. The inhibitory effect was receptor specific, that of Dex being blocked ...

journal_title：Brain research

authors： Vulliemoz Y,Virag L,Whittington RA

更新日期：1998-11-30 00:00:00

abstract：:The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...

journal_title：Brain research

authors： Anezaki T,Yanagisawa K,Takahashi H,Nakajima T,Miyashita K,Ishikawa A,Ikuta F,Miyatake T

更新日期：1992-03-06 00:00:00