Enhanced visuomotor associative learning following stimulation of alpha 2A-adrenoceptors in the ventral prefrontal cortex in monkeys.

Abstract:

:The present study investigated the effect of locally infused guanfacine, an alpha2A-adrenergic agonist, into the ventral prefrontal cortex (PFv) on visuomotor associative learning. Two monkeys were well trained on a two-problem visuomotor associative task: the monkeys performed movement A if presented with a circle pattern, or movement B if presented with a triangle pattern. For learning of new visuomotor associations, the monkeys were presented with a new set of four patterns in each and every daily session, two of which instructed movement A and the other two movement B. Bilaterally infused guanfacine (2.5 microg/microl; 3 microl on each side) improved the monkeys' ability to learn new visuomotor associations: trials and errors to learning criterion of 90% correct decreased significantly. The monkeys showed an enhanced capability to use win-stay/lose-shift strategy on 'repeat trials' and change-stay/change-shift strategy on 'change trials.' The present results indicate that alpha2A-adrenoceptor in the PFv is involved in regulating visuomotor associative learning.

journal_name

Brain Res

journal_title

Brain research

authors

Wang M,Tang ZX,Li BM

doi

10.1016/j.brainres.2004.07.062

subject

Has Abstract

pub_date

2004-10-22 00:00:00

pages

176-82

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(04)01248-X

journal_volume

1024

pub_type

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