Vicia villosa lectin-positive neurones in human cerebral cortex. Loss in Alzheimer-type dementia.

Abstract:

:Frontal and temporal sections of 4 normal human brains and 3 brains from patients with a diagnosis of Alzheimer-type dementia (ATD) were stained with Vicia villosa lectin conjugated to biotin to localize glycoproteins containing terminal N-acetylgalactosamine. These lectin binding sites were localized at the surface of a population of non-pyramidal interneurones. Examination of the co-existence of calbindin D28K or parvalbumin (PVA) with the lectin-binding material revealed that in the human cerebral cortex the lectin labelled only the PVA-immunoreactive neurones. Cell counts of the number of lectin-staining cells revealed that these cells are lost in ATD. The few remaining lectin-staining cells in ATD are shrunken and showed reduced expression of the lectin-staining material.

journal_name

Brain Res

journal_title

Brain research

authors

Kobayashi K,Emson PC,Mountjoy CQ

doi

10.1016/0006-8993(89)90416-2

subject

Has Abstract

pub_date

1989-09-25 00:00:00

pages

170-4

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(89)90416-2

journal_volume

498

pub_type

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