Abstract:
:Frontal and temporal sections of 4 normal human brains and 3 brains from patients with a diagnosis of Alzheimer-type dementia (ATD) were stained with Vicia villosa lectin conjugated to biotin to localize glycoproteins containing terminal N-acetylgalactosamine. These lectin binding sites were localized at the surface of a population of non-pyramidal interneurones. Examination of the co-existence of calbindin D28K or parvalbumin (PVA) with the lectin-binding material revealed that in the human cerebral cortex the lectin labelled only the PVA-immunoreactive neurones. Cell counts of the number of lectin-staining cells revealed that these cells are lost in ATD. The few remaining lectin-staining cells in ATD are shrunken and showed reduced expression of the lectin-staining material.
journal_name
Brain Resjournal_title
Brain researchauthors
Kobayashi K,Emson PC,Mountjoy CQdoi
10.1016/0006-8993(89)90416-2subject
Has Abstractpub_date
1989-09-25 00:00:00pages
170-4issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)90416-2journal_volume
498pub_type
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