Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development.

abstract：:In vitro quantitative autoradiography of high-affinity [3H]desmethylimipramine (DMI) binding sites was performed on 24 human brains postmortem. Highest densities of binding sites were found in portions of the amygdala, the granular layer of the dentate gyrus, the pyramidal layer of CA4. Next, in descending order were ...

journal_title：Brain research

authors： Gross-Isseroff R,Israeli M,Biegon A

更新日期：1988-07-19 00:00:00

abstract：:Treatment with thyrotropin-releasing hormone (TRH) significantly improved survival following induction of fatal systemic anaphylaxis in mice. The protective effect was mediated centrally since survival was increased by intracerebroventricular (i.c.v.) administration of TRH at doses which had no effect when given syste...

journal_title：Brain research

authors： Amir S,Harel M,Schachar A

更新日期：1984-04-30 00:00:00

abstract：:The postnatal development of acetylcholinesterase (AChE, EC 3.1.1.7) and NADH-diaphorase was examined in the caudate-putamen nucleus and substantia nigra of rats ranging from 3 to 90 days in age. From 3 to 15 days post partum islands of AChE and NADH-diaphorase activity were observed in the caudate-putamen nucleus. In...

journal_title：Brain research

authors： Butcher LL,Hodge GK

更新日期：1976-04-23 00:00:00

abstract：:Two distinct families of low-molecular-weight toxins (argiotoxins) have been isolated from the venom of the orb-web spider. Argiope trifasciata. The toxins have been purified to homogeneity and characterised by spectroscopic, mass spectrometric and microchemical analysis. The major biologically active member of the fi...

journal_title：Brain research

authors： Budd T,Clinton P,Dell A,Duce IR,Johnson SJ,Quicke DL,Taylor GW,Usherwood PN,Usoh G

更新日期：1988-05-10 00:00:00

abstract：:Intracellular recordings of the spontaneous activity were obtained from neurons in long-term cultures from the area of the supraoptic nucleus of rats. The effects of various substances known from in situ studies to cause vasopressin release were analyzed. Application of nicotine or acetylcholine induced a transition f...

journal_title：Brain research

authors： Gähwiler BH,Dreifuss JJ

更新日期：1980-07-14 00:00:00

abstract：:We have examined the afferent and efferent projections between the claustrum and visual cortex in the Long-Evans rat using anterograde and retrograde axonal transport techniques. Injections of either wheat germ agglutinin/horseradish peroxidase (WGA/HRP) or Fast Blue were made into each of the main visual regions (17,...

journal_title：Brain research

authors： Carey RG,Neal TL

更新日期：1985-03-11 00:00:00

abstract：:Distribution of somatostatin (SS) immunoreactivity was observed in the preoptic-anterior hypothalamus (PO-AH) of the female rat brain. Six specific rabbit antibodies A (SS-14), B (SS-28), C (SS-28 complete), D (SS 14 and SS-28 both), E (SS preprohormone) and F (GHRH) were used for immunostaining using Avidin-Biotin Co...

journal_title：Brain research

authors： Bhatnagar M

更新日期：2001-05-11 00:00:00

abstract：:Diabetes mellitus can lead to functional and structural deficits in both the peripheral and central nervous system. The pathogenesis of these deficits is multifactorial, probably involving, among others, microvascular dysfunction and alterations in intracellular calcium homeostasis. The present study examined the effe...

journal_title：Brain research

authors： Biessels GJ,ter Laak MP,Kamal A,Gispen WH

更新日期：2005-02-21 00:00:00

abstract：:Mild cognitive impairment (MCI) is considered the transitional stage between normal cognition and dementia. The aim of this study was to use tractography based analysis to elucidate alterations in subjects with MCI compared with subjects with early Alzheimer's disease (AD) and controls. Seventeen subjects with early A...

journal_title：Brain research

authors： Kiuchi K,Morikawa M,Taoka T,Nagashima T,Yamauchi T,Makinodan M,Norimoto K,Hashimoto K,Kosaka J,Inoue Y,Inoue M,Kichikawa K,Kishimoto T

更新日期：2009-09-01 00:00:00

abstract：:We hypothesized that abnormal activity and adrenergic sensitivity in injured dorsal root ganglion (DRG) neurons are due to an intrinsic alteration of the cell body membrane. We investigated the effects of adrenergic stimulus on the activities of Ca2+ and K+ channels of DRG neurons in a rat chronic constriction injury ...

journal_title：Brain research

authors： Honma Y,Yamakage M,Ninomiya T

更新日期：1999-06-19 00:00:00

abstract：:Increases in extracellular potassium concentrations reliably increase burst rates in cultured fetal murine spinal cord networks. This effect could be mimicked by either blocking voltage-gated potassium conductances or facilitating excitatory synaptic interactions, but not by blocking specific calcium-dependent potassi...

journal_title：Brain research

authors： Rhoades BK,Gross GW

更新日期：1994-04-18 00:00:00

abstract：:Prostaglandins are now thought to play an important role in nociceptive information transmission in the spinal cord. Prostaglandins are known to be produced by cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid. Two forms of COX have been identified: COX-1, which is constitutively expressed in mo...

journal_title：Brain research

authors： Yamamoto T,Nozaki-Taguchi N

更新日期：1996-11-11 00:00:00

abstract：:The postnasal development of the Na-independent [3H]glutamate binding sites, which exhibit some characteristics of postsynaptic glutamate receptors, has been studied in rat hippocampal membranes. The amount of binding sites (expressed in pmol/hippocampus) represents 4% of the adult level at postnatal day (PND) 4, incr...

journal_title：Brain research

authors： Baudry M,Arst D,Oliver M,Lynch G

更新日期：1981-01-01 00:00:00

abstract：:Recent radioligand binding studies demonstrated an increase in the density of dopamine D2 receptors in the nucleus accumbens ipsilateral to the stimulating electrode in amygdala- or hippocampal-kindled rats. In the present study we examined the anticonvulsant effect of dopamine agonists by unilateral microinjections i...

journal_title：Brain research

authors： Wahnschaffe U,Löscher W

更新日期：1991-07-12 00:00:00

abstract：:The ability of the monoclonal antibody, 192-IgG, directed against the rat nerve growth factor (NGF) receptor to mimic or inhibit the actions of NGF was examined in vitro and in vivo. 192-IgG had no effect on morphology, survival, or protein synthesis rates of sympathetic neuronal cultures. When injected into newborn r...

journal_title：Brain research

authors： Johnson EM Jr,Osborne PA,Taniuchi M

更新日期：1989-01-23 00:00:00

abstract：:Using an immunocytochemical technique we have analyzed changes in substance P, somatostatin, calcitonin gene-related peptide, and galanin immunoreactivity pattern in the rat dorsal root ganglia. After 7 days of adrenalectomy, sham operated rats were compared with adrenalectomized animals either receiving a daily intra...

journal_title：Brain research

authors： Coveñas R,DeLeón M,Chadi G,Cintra A,Gustafsson JA,Narvaez JA,Fuxe K

更新日期：1994-03-21 00:00:00

abstract：:The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI). Four daily intr...

journal_title：Brain research

authors： Mao J,Price DD,Hayes RL,Lu J,Mayer DJ,Frenk H

更新日期：1993-03-05 00:00:00

abstract：:The autoradiographic [14C]2-deoxyglucose (2-DG) method was used to map ascending pathways which are influenced by arousing electrical stimulation of the midbrain reticular formation (RET) in alert rats. The major finding was that RET stimulation produces selective patterns of metabolic activation and suppression in di...

journal_title：Brain research

authors： Gonzalez-Lima F,Scheich H

更新日期：1985-09-30 00:00:00

abstract：:The senescence-accelerated mouse prone 8 (SAMP8) is a novel aging model characterized by early onset and rapid advancement of senescence. In the present study, 6-month-old male SAMP8 mice were orally administered icariin (75, 150mg/kg) for 15weeks. Mice were submitted to passageway water maze test and step-down passiv...

journal_title：Brain research

authors： He XL,Zhou WQ,Bi MG,Du GH

更新日期：2010-06-02 00:00:00

abstract：:The development from primary to augmenting responses of somatosensory (SI) cortical area to low-frequency stimulation of the ventrobasal (VB) thalamus or white matter (WM) beneath SI in VB-lesioned preparations was studied by field potential analysis and extracellular unit recording. Compared to the major postsynaptic...

journal_title：Brain research

authors： Morin D,Steriade M

更新日期：1981-01-26 00:00:00

abstract：:The immunocytochemical localization of L-glutamate decarboxylase (GAD), the enzyme which which forms gamma-aminobutyric acid (GABA), has been studied in developing rodent cerebellum. During the first 3-4 postnatal days, GAD is distributed along non-terminal portions of axonal processes in close association with small ...

journal_title：Brain research

authors： McLaughlin BJ,Wood JG,Saito K,Roberts E,Wu JY

更新日期：1975-03-07 00:00:00

abstract：:Tyrosine kinase B (TrkB) levels in the adult guinea pig cochlear nucleus (CN) were determined from Western blots for up to 60 days after unilateral cochlear ablation (UCA). Compared to TrkB levels on the intact side, those on the lesioned side were elevated in the anteroventral CN (AVCN) at 7 and 60 days and in the po...

journal_title：Brain research

authors： Suneja SK,Potashner SJ

更新日期：2002-12-13 00:00:00

abstract：:The response properties of neurons in the region of striate cortex subserving central retina (0 degrees-2 degrees) and in a region of representation of parafoveal retina (4 degrees-7 degrees) were studied in unanesthetized paralyzed macaque monkeys. Neurons sensitive to the orientation of the stimulus in the visual fi...

journal_title：Brain research

authors： Poggio GF,Baker FH,Mansfield RJ,Sillito A,Grigg P

更新日期：1975-12-12 00:00:00

abstract：:Following acute intracerebroventricular injections of 1 ng of apamin and chronic apamin infusion (0.4 ng/microl, 0.5 microl/h, 14 days), the rat brains exhibited bilateral damage only in the cerebellum. The argyrophilic cells were Purkinje cells in copula pyramis, flocculus, paraflocculus, and paramedian lobules. Thes...

journal_title：Brain research

authors： Mourre C,Fournier C,Soumireu-Mourat B

更新日期：1997-12-19 00:00:00

abstract：:Medial basal hypothalamic (MBH) 5 alpha-reductase activity was significantly blocked with a known inhibitor, Proscar (Finasteride), in pregnant rats while their open-field behavior was quantified during the last week of pregnancy. In control animals, open-field behavior significantly decreased (in a stair-step fashion...

journal_title：Brain research

authors： Lephart ED,Ladle DR,Jacobson NA,Rhees RW

更新日期：1996-11-11 00:00:00

abstract：:Rab3A is a small GTP-binding synaptic vesicle protein, shown to dissociate from synaptic vesicle membranes upon depolarization-induced exocytosis. Using an antiserum raised against rab3A, we found that the antigen was localized to the neuropil of specific brain regions, but was not present in major fiber tracts or mos...

journal_title：Brain research

authors： Moya KL,Tavitian B,Zahraoui A,Tavitian A

更新日期：1992-09-11 00:00:00

abstract：:We have investigated the influence of central noradrenergic and dopaminergic systems on the susceptibility of rats to seizures in the kainic acid (KA)-model of epilepsy. In the dose range of 0.75 to 10 mg/kg s.c., KA dose-dependently induced characteristic behavioural changes. Partial depletion of noradrenaline (NA) a...

journal_title：Brain research

authors： Baran H,Hörtnagl H,Hornykiewicz O

更新日期：1989-08-28 00:00:00

abstract：:Recent evidence suggests that the primary visual cortex (V1) of rodents expresses surprisingly high levels of plasticity into adulthood. For example, long-term potentiation (LTP) is readily induced in the mature V1 of adult rodents in vivo. Here, adult, urethane-anesthetized rats were used for a detailed characterizat...

journal_title：Brain research

authors： Kuo MC,Dringenberg HC

更新日期：2012-12-07 00:00:00

abstract：:Aspartame (L-aspartyl-L-phenylalanine methyl ester), an artificial low-calorie sweetener, was shown to dose-dependently inhibit L-[3H]glutamate binding to its N-methyl-D-aspartate-specific receptors. L-Aspartic acid, a major endogenous metabolite of aspartame, inhibited the binding more stronger than aspartame, while ...

journal_title：Brain research

authors： Pan-Hou H,Suda Y,Ohe Y,Sumi M,Yoshioka M

更新日期：1990-06-18 00:00:00

abstract：:The localization of the methionine-enkephalin-Arg6-Gly7-Leu8 (Met-Enk-Arg-Gly-Leu)-like immunoreactivity-containing neurons in the rat lumbosacral spinal cord was immunohistochemically examined by an antiserum very specific to Met-Enk-Arg-Gly-Leu. The immunoreactive neurons occupied the positions corresponding to the ...

journal_title：Brain research

authors： Shimosegawa T,Koizumi M,Toyota T,Goto Y,Yanaihara C,Yanaihara N

更新日期：1987-03-17 00:00:00