Effect of phenytoin on intracellular calcium and intracellular protein changes during pentylenetetrazole-induced bursting activity in snail neurons.

abstract：:Two high molecular weight surface glycoproteins of cerebellar cells which are selectively labeled by lactoperoxidase-catalyzed iodination of monolayer cultures from the developing mouse cerebellum, have been identified and partially characterised. Both molecules, called peak 2 and peak 3 proteins, were the major glyco...

journal_title：Brain research

authors： Goridis C,Hirsch M,Dossetto M,Baechler E

更新日期：1980-01-27 00:00:00

abstract：:Using a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD), this study investigated on the neuroprotective effects of acupuncture by examining whether acupuncture contributed to inhibiting microglial activation and inflammatory events. C57BL/6 mice were treated with MPT...

journal_title：Brain research

authors： Kang JM,Park HJ,Choi YG,Choe IH,Park JH,Kim YS,Lim S

更新日期：2007-02-02 00:00:00

abstract：:Previous evidence suggests that preterm newborns with intrauterine growth restriction (IUGR) have specific neurostructural and neurodevelopmental anomalies, but it is unknown whether these effects persist in early childhood. We studied a sample of 18 preterm IUGR, 15 preterm AGA - born between 26 and 34 weeks of gesta...

journal_title：Brain research

authors： Padilla N,Falcón C,Sanz-Cortés M,Figueras F,Bargallo N,Crispi F,Eixarch E,Arranz A,Botet F,Gratacós E

更新日期：2011-03-25 00:00:00

abstract：:Previous studies have found that the primary change in the brain of chronic alcoholics is a selective loss of white matter in cerebral hemispheres. It is unknown whether the loss of white matter is due to alcohol-induced degeneration of axons in white matter, and this hypothesis has never been tested. We used a newly ...

journal_title：Brain research

authors： Tang Y,Pakkenberg B,Nyengaard JR

更新日期：2004-12-17 00:00:00

abstract：:Dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, has been localized in light and electron microscopic preparations of rat brain by an immunocytochemical method using a peroxidase--anti-peroxidase Fab complex. In light microscopic preparations, DBH-specific reaction product was obse...

journal_title：Brain research

authors： Cimarusti DL,Saito K,Vaughn JE,Barber R,Roberts E,Thomas PE

更新日期：1979-02-16 00:00:00

abstract：:Neuronal degeneration was detected in the tenia tecta and other regions of the anterior limbic system of male weanling rats 3 days after four doses of 5 mg/kg d-amphetamine (4 x 5 mg/kg AMPH) when seizures occurred during AMPH exposure. Neurodegeneration in the parietal cortex, loss of tyrosine hydroxylase immunoreact...

journal_title：Brain research

authors： Bowyer JF

更新日期：2000-12-08 00:00:00

abstract：:Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and m...

journal_title：Brain research

authors： Li S,Chen X,Mao L,Zahid KR,Wen J,Zhang L,Zhang M,Duan J,Duan J,Yin X,Wang Y,Zhao L,Tang X,Wang X,Xu G

更新日期：2018-08-01 00:00:00

abstract：:Cortistatin (CST) is a recently described neuropeptide with high structural homology with somatostatin. Its mRNA is restricted to gamma amino butyric acid (GABA)-containing cells in the cerebral cortex and hippocampus. CST modulates the electrophysiology of the hippocampus and cerebral cortex of rats; hence, it may be...

journal_title：Brain research

authors： Sánchez-Alavez M,Gómez-Chavarín M,Navarro L,Jiménez-Anguiano A,Murillo-Rodríguez E,Prado-Alcalá RA,Drucker-Colin R,Prospéro-García O

更新日期：2000-03-06 00:00:00

abstract：:In the present study, we report the localization of the Rev-ErbA alpha and beta nuclear orphan receptors, two closely related members of the nuclear hormone receptor superfamily, in the brain. Both Rev-ErbA variant mRNAs were highly expressed in the olfactory bulb, the hippocampus, and in the granular cells of the cer...

journal_title：Brain research

authors： Kainu T,Enmark E,Gustafsson JA,Pelto-Huikko MP

更新日期：1996-12-16 00:00:00

abstract：:The aim of this study was to evaluate the effects of hypothermia on bilirubin-induced alterations in brain cell membrane function and energy metabolism in the developing brain. Thirty-seven newborn piglets were divided randomly into four groups: normothermic control (NC, n=9); hypothermic control (HC, n=7); normotherm...

journal_title：Brain research

authors： Park WS,Chang YS,Chung SH,Seo DW,Hong SH,Lee M

更新日期：2001-12-20 00:00:00

abstract：:The senescence-accelerated mouse prone 8 (SAMP8) is a novel aging model characterized by early onset and rapid advancement of senescence. In the present study, 6-month-old male SAMP8 mice were orally administered icariin (75, 150mg/kg) for 15weeks. Mice were submitted to passageway water maze test and step-down passiv...

journal_title：Brain research

authors： He XL,Zhou WQ,Bi MG,Du GH

更新日期：2010-06-02 00:00:00

abstract：:After traumatic brain injury, extracellular K(+) in brain can dramatically increase. We studied the effects of increased K(+) on the isolated pressurized rat middle cerebral artery (MCA). MCAs (200-250 microm OD) were isolated, cannulated with glass micropipettes, and pressurized. K(+) was increased in the extralumina...

journal_title：Brain research

authors： Golding EM,Steenberg ML,Johnson TD,Bryan RM Jr

更新日期：2000-10-13 00:00:00

abstract：:Neurons located in the nucleus raphe magnus (NRM), a region important in the control of nociception, appear to be tonically inhibited by noradrenergic (NA) neurons. Anatomical studies have suggested that the A5 catecholamine nucleus may be the primary source of noradrenergic neurons whose terminals are located in the ...

journal_title：Brain research

authors： Sagen J,Proudfit HK

更新日期：1986-04-02 00:00:00

abstract：:The subunit composition of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs) is an important determinant of AMPAR biophysical properties and trafficking. To date, AMPAR subunit composition has been quantitatively evaluated only for the hippocampus, where different experimental approaches have yield...

journal_title：Brain research

authors： Reimers JM,Milovanovic M,Wolf ME

更新日期：2011-01-07 00:00:00

abstract：:The effect of intrathecal (i.t.) galanin (GAL) on the prolonged increase of spinal reflex excitability produced by conditioning stimulation (CS) of unmyelinated muscle afferents was studied in decerebrate, spinalized, unanesthetized rats. A CS train (1 Hz, 20 s) applied to the unmyelinated fibers in the gastrocnemius ...

journal_title：Brain research

authors： Xu XJ,Wiesenfeld-Hallin Z,Hökfelt T

更新日期：1991-02-15 00:00:00

abstract：:There is evidence that heme oxygenase plays a role in cellular defense against reactive oxygen species and thereby has neuroprotective effects. We examined the interaction of Neotrofin, a cognitive-enhancing and neuroprotective drug, with the heme oxygenase system. In adult rats, both a single administration or seven ...

journal_title：Brain research

authors： Wang X,Hauptmann N,Taylor E,Foreman M,Khawli LA,Maines MD

更新日期：2003-02-07 00:00:00

abstract：:In monkeys (Macaca fuscata and mulatta), horseradish peroxidase (HRP) was injected in the cerebral cortices, areas 4 (medial and lateral parts), 5, 6 and 9 (a part just rostral to area 6), in which stimulation of cerebellar nuclei was known to elicit superficial or deep thalamocortical responses. Retrogradely labelled...

journal_title：Brain research

authors： Miyata M,Sasaki K

更新日期：1983-09-12 00:00:00

abstract：:Sprague-Dawley dams were treated with 3 v/v % ethanol in liquid diet from the 8th day gestation through 3 weeks nursing period. Offsprings, ages 1, 2 and 3 weeks, and their dams were studied. Brain weights and their total proteins were not affected by this ethanol treatment. Total enolase activity/mg protein and its i...

journal_title：Brain research

authors： Harada K,Adams V,Okamoto M

更新日期：1992-05-15 00:00:00

abstract：:Hyperprolinemia type II is an autosomal recessive disorder caused by the severe deficiency of delta(1)-pyrroline-5-carboxylate dehydrogenase activity leading to tissue accumulation of proline (Pro). Most patients detected so far show neurological manifestations including epilepsy and mental retardation, whose pathophy...

journal_title：Brain research

authors： Delwing D,Bavaresco CS,Chiarani F,Wannmacher CM,Wajner M,Dutra-Filho CS,de Souza Wyse AT

更新日期：2003-11-21 00:00:00

abstract：:Beta-amyloid peptide (Aβ) has a causal role in the pathophysiology of Alzheimer's disease (AD). Recent studies indicate that Aβ can disrupt excitatory glutamatergic synaptic function at synaptic level. However, the underlying mechanisms remain obscure. In this study, we recorded evoked and spontaneous EPSCs in hippoca...

journal_title：Brain research

authors： Yao W,Zou HJ,Sun D,Ren SQ

更新日期：2013-06-17 00:00:00

abstract：:Axonal injury of the dorsal root ganglion (DRG) neurons may alter the synthesis of certain membrane proteins that are responsible for the development of abnormal hyperexcitability. The external domains of most of these membrane proteins are sialylated. Because sialic acid carries heavy negative charges, the increase o...

journal_title：Brain research

authors： Peng XQ,Zhang XL,Fang Y,Xie WR,Xie YK

更新日期：2004-11-12 00:00:00

abstract：:The distribution of AMPA-type glutamate receptor (GluR) subunits was studied in the Edinger-Westphal nucleus (EW) of chicks and pigeons. GluR1, GluR2, GluR3 and GluR4 subunits appeared to be present in EW neurons of both species, but interspecific differences were observed in the abundance of the different types of su...

journal_title：Brain research

authors： Toledo CA,Britto LR,Pires RS,Veenman CL,Reiner A

更新日期：2002-08-23 00:00:00

abstract：:Social defeat is a powerful experience that often leads to drastic physiological and behavioral changes in many animal species. An example of such a change is conditioned defeat in Syrian hamsters. The neurophysiological mechanisms that underlie such changes are not yet fully understood, however, there is evidence tha...

journal_title：Brain research

authors： Jasnow AM,Huhman KL

更新日期：2001-11-30 00:00:00

abstract：:An endogenous asymmetry in striatal dopaminergic function has been identified in rats, and related to spontaneous and drug-induced circling (rotation, turning). We have developed an electronic device for measuring in humans the same kinds of rotational movements observed in rats. Our data indicate that, without being ...

journal_title：Brain research

authors： Bracha HS,Seitz DJ,Otemaa J,Glick SD

更新日期：1987-05-19 00:00:00

abstract：:Growth hormone releasing factor (GRF) applied by iontophoresis, pressure, and in the perfusate, increased (14.81%) or decreased (45.92%) the firing of paraventricular neurons extracellularly recorded from guinea-pig hypothalamic slices. Effects were similar whatever the mode of application and were elicited in the nan...

journal_title：Brain research

authors： Poulain P,Carette B

更新日期：1986-04-23 00:00:00

abstract：:The ventral tegmental area has been suggested as a possible site of action for the rewarding effect of opiates on the basis of the fact that local morphine injections in this but not other regions are rewarding. That this is a necessary and not just a sufficient site of opiate rewarding action was suggested by the fac...

journal_title：Brain research

authors： Britt MD,Wise RA

更新日期：1983-01-03 00:00:00

abstract：:At present severe damage to hair cells and sensory neurons in the inner ear results in non-treatable auditory disorders. Cell implantation is a potential treatment for various neurological disorders and has already been used in clinical practice. In the inner ear, delivery of therapeutic substances including neurotrop...

journal_title：Brain research

authors： Palmgren B,Jin Z,Jiao Y,Kostyszyn B,Olivius P

更新日期：2011-03-04 00:00:00

abstract：:The opiate antagonist, naloxone, produces dose-dependent biphasic changes in clinical pain. The mechanism of the analgesia produced by low dose naloxone is unknown. To study the analgesic effect of naloxone, we have used a programmable infusion pump, which eliminates placebo-induced endorphin-mediated analgesia, to ad...

journal_title：Brain research

authors： Levine JD,Gordon NC

更新日期：1986-02-19 00:00:00

abstract：:Semaphorins constitute a family of signaling molecules with functions in axon pathfinding and neuronal migration. Neuropilins 1 and 2 have been identified as the ligand-binding component of semaphorin receptors. Both ligands and receptors are expressed in embryonic and adult organs in complementary and sometimes redun...

journal_title：Brain research

authors： Meléndez-Herrera E,Varela-Echavarría A

更新日期：2006-01-05 00:00:00

abstract：:A microdialysis technique for the in vivo assessment of the monoaminergic and GABAergic levels in the ventromedial (VMN) and paraventricular nuclei (PVN) of the hypothalamus was used in order to examine the activities of neurons that project to the hypothalamic regions and are implicated in the regulation of ingestive...

journal_title：Brain research

authors： Ohtani N,Sugano T,Ohta M

更新日期：1999-09-18 00:00:00