Abstract：
:Cortistatin (CST) is a recently described neuropeptide with high structural homology with somatostatin. Its mRNA is restricted to gamma amino butyric acid (GABA)-containing cells in the cerebral cortex and hippocampus. CST modulates the electrophysiology of the hippocampus and cerebral cortex of rats; hence, it may be modulating mnemonic processes. In this study, we have evaluated the effect of CST and somatostatin (SS) on short- and long-term memory (STM and LTM, respectively), as well as on the extinction of the behavior by using the footshock passive avoidance behavioral test. In addition, we tested the ability of both neuropeptides to affect the generation of cAMP in hippocampal neurons in culture. Results showed that the administration of either CST or SS into the hippocampal CA1 deteriorates memory consolidation in a dose-response fashion and facilitates the extinction of the learned behavior. CST was more potent than SS. Likewise, CST increases cAMP while SS decreases it. These results strongly support a modulatory role for CST in memory processes.
journal_name
Brain Resjournal_title
Brain researchauthors
Sánchez-Alavez M,Gómez-Chavarín M,Navarro L,Jiménez-Anguiano A,Murillo-Rodríguez E,Prado-Alcalá RA,Drucker-Colin R,Prospéro-García Odoi
10.1016/s0006-8993(99)02336-7subject
Has Abstractpub_date
2000-03-06 00:00:00pages
78-83issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(99)02336-7journal_volume
858pub_type
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