Ultrastructural observations of non-selective effects of ricin treatment (RCA-120) in the rat dorsal root ganglion.

abstract：:Oxidative stress plays an important role in neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Methamphetamine (METH) is an amphetamine analog that causes degeneration of the dopaminergic system in mammals and subsequent oxidative stress. In our present study, we have used immortalized hu...

journal_title：Brain research

authors： Zhang X,Banerjee A,Banks WA,Ercal N

更新日期：2009-06-12 00:00:00

abstract：:Avian circadian rhythms are regulated by a multiple oscillatory system consisting of the pineal, the suprachiasmatic nucleus (SCN) and the eye. In the present study, ontogeny of circadian clock in the pineal and the SCN of chick embryo was examined using Per2 expression as a marker. A daily rhythmicity of Per2 express...

journal_title：Brain research

authors： Okabayashi N,Yasuo S,Watanabe M,Namikawa T,Ebihara S,Yoshimura T

更新日期：2003-11-14 00:00:00

abstract：:While genetic predisposition is a major factor, it is not known how development of attention-deficit/hyperactivity disorder (ADHD) is modulated by early life stress. The spontaneously hypertensive rat (SHR) displays the behavioral characteristics of ADHD (poorly sustained attention, impulsivity, hyperactivity) and is ...

journal_title：Brain research

authors： Sterley TL,Howells FM,Russell VA

更新日期：2016-06-15 00:00:00

abstract：:Human truncated tau protein is an active constituent of the neurofibrillary degeneration in sporadic Alzheimer's disease. We have shown that modified tau protein, when expressed as a transgene in rats, induced AD characteristic tau cascade consisting of tau hyperphosphorylation, formation of argyrophilic tangles and s...

journal_title：Brain research

authors： Hrnkova M,Zilka N,Minichova Z,Koson P,Novak M

更新日期：2007-01-26 00:00:00

abstract：:The rostral projection of A delta and C primary afferents in Lissauer's tract (LT) was studied by assessing how far, rostrally, axons entering at a given level could be activated by electrical stimulation. Sural A delta primary afferents in LT exhibited a rostral projection at least as far as the L3/L4 border, 4 segme...

journal_title：Brain research

authors： Traub RJ,Sedivec MJ,Mendell LM

更新日期：1986-12-03 00:00:00

abstract：:Central administration of CRH results in endocrinological, cardiovascular, and behavioral effects that suggest stress or anxiety. Among these is a marked pressor response. Parenteral administration of CRH, however, results in hypotension. We used parenteral administration of antalarmin, a novel, small molecule CRH1 re...

journal_title：Brain research

authors： Briscoe RJ,Cabrera CL,Baird TJ,Rice KC,Woods JH

更新日期：2000-10-27 00:00:00

abstract：:It has been suggested that thiolic groups are essential for cytochrome c oxidase (COX) activity and other respiratory mitochondrial enzymes. Recent experiments showed that the thiolic antioxidant N-acetylcysteine (NAC) can protect against age-related impairment in COX activity in mice hepatic mitochondria. The present...

journal_title：Brain research

authors： Martínez Banaclocha M,Martínez N

更新日期：1999-09-18 00:00:00

abstract：:The effects of 17 beta-estradiol benzoate (EB), ethynodioldiacetate and ovine prolactin on dopamine (DA) turnover have been studied. As an index for a change in turnover, differences in DA depletion following tyrosine hydroxylase inhibition with alpha-methyl-tyrosine methylester were observed. DA was measured by means...

journal_title：Brain research

authors： Wiesel FA,Fuxe K,Hökfelt T,Agnati LF

更新日期：1978-06-16 00:00:00

abstract：:The retrogradely-transported tracer, rhodamine-tagged microspheres was injected into the pressor region of the rostral ventrolateral medulla (RVLM) to enable detection of paraventricular neurons in the hypothalamus that project to the RVLM. The protein, Fos, was detected immunohistochemically and used to highlight neu...

journal_title：Brain research

authors： Badoer E

更新日期：1998-08-10 00:00:00

abstract：:To achieve a better understanding of the parallel information processing that takes place in the nervous system, many researchers have recently begun to use multielectrode techniques to obtain high spatial- and temporal-resolution recordings of the firing patterns of neural ensembles. Apart from the complexities of ac...

journal_title：Brain research

authors： Fernández E,Ferrandez J,Ammermüller J,Normann RA

更新日期：2000-12-22 00:00:00

abstract：:The purpose of this study was to identify the functional fields activated in relation to the self-paced proximal and distal arm movements. The regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) and 15O-labelled H2O (H2(15)O) in eight healthy subjects. All subjects performed the fo...

journal_title：Brain research

authors： Kawashima R,Itoh H,Ono S,Satoh K,Furumoto S,Gotoh R,Koyama M,Yoshioka S,Takahashi T,Takahashi K,Yanagisawa T,Fukuda H

更新日期：1996-04-15 00:00:00

abstract：:Simultaneous extracellular recordings from one electrode of 'local' groups of 3-6 neurons were obtained from the auditory cortex of unanesthetized, paralyzed cats. The activity and functional connectivity of local microenvironments were examined under various auditory stimuli. Single cell response patterns were examin...

journal_title：Brain research

authors： Frostig RD,Gottlieb Y,Vaadia E,Abeles M

更新日期：1983-08-08 00:00:00

abstract：:Hydroxyl free radical production seems to play an important role in the pathogenesis of Parkinson's disease. In the present study, we investigated the dopamine agonists pramipexole and pergolide as well as the nitrone compound S-PBN (N-tert-butyl-alpha-(2-sulfophenyl)nitrone) to reduce hydroxyl radical formation. Micr...

journal_title：Brain research

authors： Ferger B,Teismann P,Mierau J

更新日期：2000-11-17 00:00:00

abstract：:Basic FGF has recently been shown to produce systemic and cerebral vasodilation. To test the hypothesis that bFGF increases regional cortical blood flow (rCBF), rCBF and brain pHi were measured while bFGF or vehicle was superperfused onto the cortex of rabbits. The results of this study demonstrate that topical applic...

journal_title：Brain research

authors： Regli L,Anderson RE,Meyer FB

更新日期：1994-11-28 00:00:00

abstract：:Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. Previous MRI studies have revealed that POAG can be associated with alterations in hippocampal function. Thus, the aim of this study was to investigate a relationship between chronic high intraocular pressure (IOP) and hippocamp...

journal_title：Brain research

authors： Yuan Y,Chen Z,Li L,Li X,Xia Q,Zhang H,Duan Q,Zhao Y

更新日期：2017-11-15 00:00:00

abstract：:Neonatal rat superior cervical ganglia were mechanically dissociated, and the sympathetic neurons grown in dispersed cell cultures. Intracellular microelectrodes were used to study the effects of tetraethylammonium (TEA+), a blocker of outward K+ currents, on the excitable properties of these neurons. Addition of TEA+...

journal_title：Brain research

authors： Suppes T

更新日期：1984-02-20 00:00:00

abstract：:Voltage-activated calcium channel currents were recorded from differentiated human neuroblastoma cells. SK-N-SH-SY5Y (SH-SY5Y) line, using patch-clamp techniques. Experimental solutions were designed to suppress sodium and potassium channel currents, and barium ions were used as the charge carrier. Two distinct types ...

journal_title：Brain research

authors： Reuveny E,Narahashi T

更新日期：1993-02-12 00:00:00

abstract：:Homer1a is implicated in depression in humans and depression-like behavior in mice. To further understand the role of Homer1a in stress-induced emotional changes, we applied very mild stress to Homer1a knockout (H1a KO) mice. The wild-type (WT) and H1a KO mice were restrained for 2h daily for 7 consecutive days at the...

journal_title：Brain research

authors： Shui Y,Wang L,Luo X,Uchiumi O,Yamamoto R,Sugai T,Kato N

更新日期：2015-04-24 00:00:00

abstract：:The effect of chronic administration of morphine to rats on the N-methyl-D-aspartate (NMDA) receptors labeled with [3H]MK-801, a non-competitive antagonist, was determined in brain regions and spinal cord. Male Sprague-Dawley rats were rendered tolerant to and physically dependent on morphine by subcutaneous implantat...

journal_title：Brain research

authors： Gudehithlu KP,Reddy PL,Bhargava HN

更新日期：1994-03-14 00:00:00

abstract：:A comparison was made of the effects of left and right cerebral decortication on cytotoxic activity of natural killer and natural cytotoxic lymphocytes in the mouse. Natural killer cytotoxic activity was significantly reduced after right decortication, whereas left decortication led to a less pronounced, though still ...

journal_title：Brain research

authors： Belluardo N,Mudò G,Cella S,Bindoni M

更新日期：1990-08-06 00:00:00

abstract：:The default mode network (DMN) is characterised by coherent very low frequency (VLF) neural oscillations in the resting brain. The attenuation of this activity has been demonstrated following the transition from rest to performance of a broad range of cognitive goal-directed tasks. Whether the activity of resting stat...

journal_title：Brain research

authors： Hsu CF,Broyd SJ,Helps SK,Benikos N,Sonuga-Barke EJ

更新日期：2013-08-02 00:00:00

abstract：:To examine the hypothesis that the increased adrenocortical activity during lactation induced the loss of the prolactin (PRL) -releasing effect of morphine, we studied the effect of morphine in adrenalectomized (ADX) and sham-operated primiparous lactating Wistar rats. Animals were adrenalectomized 4 days after delive...

journal_title：Brain research

authors： Kiem DT,Fekete MI,Bartha L,Nagy G,Makara GB

更新日期：1991-11-01 00:00:00

abstract：:We have previously found that the amyloid precursor protein (APP) of Alzheimer's disease is present on the surface of rat cortical neurons in culture, in a segmental pattern which first becomes evident after 24 hours and is fully developed by five days. As APP has previously been reported to have a short half-life in ...

journal_title：Brain research

authors： Storey E,Spurck T,Pickett-Heaps J,Beyreuther K,Masters CL

更新日期：1996-09-30 00:00:00

abstract：:The localization of [3H]corticosterone in the brain and pituitary of the adrenalectomized rat was studied by autoradiography. Corticosterone was concentrated preferentially by neurons in the hippocampus, septum, amygdala, and neocortex, with the hippocampal and septal neurons having the greatest concentration. [3H]-Co...

journal_title：Brain research

authors： Rhees RW,Grosser BI,Stevens W

更新日期：1975-01-10 00:00:00

abstract：:The hypothalamic response area for electrically induced locomotion was determined using moveable electrodes and discriminant analysis as an appropriate statistical technique. At 241 out of 641 stimulated sites locomotion was induced. The distribution of locomotion sites is relatively diffuse. Discriminant analysis of ...

journal_title：Brain research

authors： Lammers JH,Kruk MR,Meelis W,van der Poel AM

更新日期：1988-05-24 00:00:00

abstract：:Results from clinical studies provide evidence that cognitive changes relatively late in life may be traced to antecedent conditions including diabetes, obesity, a sedentary lifestyle, and an atherogenic diet. As such, several traits of Type 2 diabetes (T2DM) could be considered pathogenic factors of aging, contributi...

journal_title：Brain research

authors： Maimaiti S,DeMoll C,Anderson KL,Griggs RB,Taylor BK,Porter NM,Thibault O

更新日期：2015-09-24 00:00:00

abstract：:The hallucinogen d-lysergic acid diethylamide (d-LSD) evokes dramatic somatic and psychological effects. In order to analyze the neural activation induced by this unique psychoactive drug, we tested the hypothesis that expression of the immediate-early gene product c-Fos is induced in specific regions of the rat foreb...

journal_title：Brain research

authors： Frankel PS,Cunningham KA

更新日期：2002-12-27 00:00:00

abstract：:Using nerve growth factor (NGF), anti-NGF sera and dissociated neonatal mouse dorsal root ganglionic neurons we present a microculture assay methodology for (1) the titration of neurotrophic factor (NTF) activity in monolayer culture, (2) the titration of NTF antibodies which 'block' NTF biological activity, (3) the t...

journal_title：Brain research

authors： Manthorpe M,Skaper SD,Varon S

更新日期：1981-12-28 00:00:00

abstract：:Involvement of N-methyl-D-aspartate (NMDA) receptor complex and 5-hydroxytryptamine3 (5-HT3) receptors in state-dependent learning (SDL) induced by ethanol (EtOH) was investigated in the step-through passive avoidance task in rats. Pre-training injections of EtOH or MK-801 reduced step-through latency in the test sess...

journal_title：Brain research

authors： Nakagawa Y,Iwasaki T

更新日期：1996-01-15 00:00:00

abstract：:Stroke is the major cause of acquired epilepsy in the adult population. The mechanisms of ischemia-induced epileptogenesis are not completely understood, but glutamate is associated with both ischemia-induced injury and epileptogenesis. The objective of this study was to develop an in vitro model of epileptogenesis in...

journal_title：Brain research

authors： Ziobro JM,Deshpande LS,Delorenzo RJ

更新日期：2011-01-31 00:00:00