Hypothalamic substrates for brain stimulation-induced patterns of locomotion and escape jumps in the rat.

Abstract:

:The hypothalamic response area for electrically induced locomotion was determined using moveable electrodes and discriminant analysis as an appropriate statistical technique. At 241 out of 641 stimulated sites locomotion was induced. The distribution of locomotion sites is relatively diffuse. Discriminant analysis of both positive and negative electrode localizations yields areas with high, intermediate or low probability of inducing the response. The response is considered to be mediated by fibres of the subpallido-pedunculopontine system, which includes the mesencephalic locomotor region. Different categories of exploratory and flight-directed locomotion were distinguished, and response areas for both categories were determined. In addition the response area for escape jumps was delimited. Exploratory locomotion is mainly induced from the lateral hypothalamus, while flight-directed locomotion and escape jumps are evoked from the medial hypothalamus. The response area for exploratory locomotion reflects the lateral hypothalamic distribution of the subpallidal projection to the mesencephalic locomotor region. A diffuse substrate for flight behavior seems to occupy almost the entire medial hypothalamus. It is concluded that a locomotor subroutine subserving different behavioural mechanisms can be activated at many hypothalamic sites.

journal_name

Brain Res

journal_title

Brain research

authors

Lammers JH,Kruk MR,Meelis W,van der Poel AM

doi

10.1016/0006-8993(88)91045-1

subject

Has Abstract

pub_date

1988-05-24 00:00:00

pages

294-310

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(88)91045-1

journal_volume

449

pub_type

杂志文章
  • Intra-axonal mechanisms driving axon regeneration.

    abstract::Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate. Axotomized neurons in the periphery can spontaneously m...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2020.146864

    authors: Smith TP,Sahoo PK,Kar AN,Twiss JL

    更新日期:2020-08-01 00:00:00

  • Enhancement of current induced by superfusion of GABA in locus coeruleus neurons by pentobarbital, but not ethanol.

    abstract::gamma-Aminobutyric acid (GABA), pentobarbital and ethanol were applied by bath superfusion to rat locus coeruleus (LC) neurons in a brain slice preparation. The GABA-induced current and conductance increase was measured with single-electrode voltage clamp. Pentobarbital potentiated the GABA-induced current and conduct...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91044-h

    authors: Osmanović SS,Shefner SA

    更新日期:1990-05-28 00:00:00

  • Localization of D1 dopamine receptors on live cultured striatal neurons by quantitative fluorescence microscopy.

    abstract::Single neurons in culture express a heterogeneity of neurotransmitter receptor subtypes. The study of the effects of neurotransmitters on neuronal function is complicated by this heterogeneity. It would therefore be useful to be able to identify live neurons that express the receptors of interest and then use these ne...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00436-2

    authors: Hoyt KR,Reynolds IJ

    更新日期:1996-08-26 00:00:00

  • Perineuronal microglial reactivity following proximal and distal axotomy of rat rubrospinal neurons.

    abstract::Microglial reactivity in the red nucleus of rats was studied following upper cervical and lower thoracic rubrospinal tractotomy using the lectin binding method. Following axotomy, the contralateral nucleus containing the axotomized neurons was identified using the retrograde tracer Fast blue. It was subdivided into do...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01418-7

    authors: Tseng GF,Wang YJ,Lai QC

    更新日期:1996-04-09 00:00:00

  • Three-dimensional morphology and distribution of pallidal axons projecting to both the lateral region of the thalamus and the central complex in primates.

    abstract::This study presents a three-dimensional analysis of pallido-thalamic axons and axonal endings in the monkey (Macaca mulatta and M. irus). Injections of the anterograde tracer biocytin were made in the dorsal, associative region of the medial pallidum. Numerous axonal endings were observed within the pallidal territory...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00181-9

    authors: Arecchi-Bouchhioua P,Yelnik J,François C,Percheron G,Tandé D

    更新日期:1997-04-18 00:00:00

  • cFos induction during conditioned taste aversion expression varies with aversion strength.

    abstract::Fos-like immunoreactivity (FLI) can indicate the location of neurons activated following expression of conditioned taste aversion (CTA). After one conditioning trial FLI has been identified in the intermediate nucleus of the solitary tract (iNTS) with little expression in other brain regions. The present study assesse...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)03032-8

    authors: Navarro M,Spray KJ,Cubero I,Thiele TE,Bernstein IL

    更新日期:2000-12-29 00:00:00

  • Pentylenetetrazole-induced bursting activity and cellular protein phosphorylation in snail neurons.

    abstract::To elucidate the intracellular mechanism of seizure discharge, phosphorylation of cellular protein during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. PTZ markedly enhanced the phosphorylation of proteins of 34,000 and 50,000 molecular weight. Similar effects were observed by a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91395-8

    authors: Onozuka M,Imai S,Sugaya E

    更新日期:1986-01-01 00:00:00

  • Calcium dependency of excitatory chemical synaptic transmission in the frog cerebellum in vitro.

    abstract::Chemical synaptic transmission was studied with microelectrode techniques in isolated frog cerebella maintained in vitro. Purkinje cell (PC) EPSPs, elicited by selective monosynaptic electrical stimulation of both the parallel fiber (PF) and climbing fiber (CF) inputs, could be inverted by depolarizing (outward) curre...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)91005-2

    authors: Hackett JT

    更新日期:1976-09-10 00:00:00

  • Galectin-3 mediates post-ischemic tissue remodeling.

    abstract::Galectin-3 (Gal-3) is a member of a class of carbohydrate-binding proteins and plays a role in a number of cellular functions such as cell proliferation, angiogenesis and differentiation. We observed an up-regulated expression of Gal-3 in the ischemic brain following transient middle cerebral artery occlusion in rats....

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.06.073

    authors: Yan YP,Lang BT,Vemuganti R,Dempsey RJ

    更新日期:2009-09-08 00:00:00

  • Noradrenergic regulation of prolactin secretion at the level of the paraventricular nucleus of the hypothalamus: functional significance of the alpha-1b and beta-adrenergic receptor subtypes.

    abstract::Previous research has demonstrated that in the Siberian hamster, both photoperiod and estrous cyclicity alter the profile of noradrenergic activity with the paraventricular nucleus of the hypothalamus (PVN), and that noradrenergic activity is correlated with changes in circulating levels of prolactin. Work from our la...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.05.009

    authors: Dodge JC,Badura LL

    更新日期:2004-08-06 00:00:00

  • Concerted and predictable acquisition of glial fibrillary acidic protein filaments by a cohort of astroblasts in culture.

    abstract::Primary cultures of the 21 day foetal rat brain contain a cohort of astroblasts that concertedly acquire glial fibrillary acidic protein (GFAP) filaments between the 16th and 18th hour after plating. This burst of cytoskeletal differentiation is not observed in cultures initiated from the 18 day foetal brain and is no...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90637-7

    authors: Wilson J,Malloch G,Joiner M,Burnet F

    更新日期:1985-07-22 00:00:00

  • Studies on the relationship of binding affinity to psychoactive and anticholingergic potency of a group of psychotomimetic glycolates.

    abstract::A study was undertaken of the possible relationship of the binding affinity of a series of anticholinergic psychotomimetic drugs to their psychopharmacological and anticholinergic effects. Binding was measured to brain homogenates and nerve endings using [3H]quinuclidinyl benzilate (QB), a highly potent psychotomimeti...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90889-7

    authors: Baumgold J,Abood LG,Aronstam R

    更新日期:1977-03-25 00:00:00

  • Enhancement of REM sleep with auditory stimulation in young and old rats.

    abstract::Auditory stimulation applied during rapid eye movement (REM) sleep enhances the duration of REM sleep in cats and humans. The present experiment investigated whether auditory stimulation would enhance REM sleep in young (3-6 months) rats, and also in old (22-24 months) rats which have impaired REM sleep. Baseline slee...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91299-t

    authors: Arankowsky-Sandoval G,Stone WS,Gold PE

    更新日期:1992-09-04 00:00:00

  • Abnormal resting-state functional connectivity patterns of the putamen in medication-naïve children with attention deficit hyperactivity disorder.

    abstract::Structural and functional alterations of the putamen have been reported in patients with attention deficit hyperactivity disorder (ADHD), but the functional relationships between this area and other brain regions are seldom explored. In the present study, seed-based correlation analyses were performed in the resting-s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.08.029

    authors: Cao X,Cao Q,Long X,Sun L,Sui M,Zhu C,Zuo X,Zang Y,Wang Y

    更新日期:2009-12-15 00:00:00

  • Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87.

    abstract::BW 1003C87, 5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid, has been tested for its in vitro and in vivo effects on glutamate release in rat brain tissue, and for its cerebro-protective action in two rodent models of cerebral ischemia. In rat brain slices the release of glutamate evoked by verat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91254-c

    authors: Meldrum BS,Swan JH,Leach MJ,Millan MH,Gwinn R,Kadota K,Graham SH,Chen J,Simon RP

    更新日期:1992-10-09 00:00:00

  • Developmental and age-related changes of dopamine transporter, and dopamine D1 and D2 receptors in human basal ganglia.

    abstract::The developmental and age-related changes of the dopamine transporter (DAT), and the dopamine D1 and D2 receptor (D1R and D2R) subtypes were investigated in basal ganglia (BG) of human brain. DAT immunostaining was mainly observed in the neuropil, neurons, and glia of the striatum. The DAT-positive neuropil was detect...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01933-2

    authors: Meng SZ,Ozawa Y,Itoh M,Takashima S

    更新日期:1999-10-02 00:00:00

  • The influence of chronic stress on multiple opioid peptide systems in the rat: pronounced effects upon dynorphin in spinal cord.

    abstract::Recurrent exposure to intermittent electrical foot-shock (30 min, twice daily) for 7 days caused an increase in immunoreactive (ir) dynorphin and ir-alpha-neo-endorphin in lumbar and cervical (but not thoracic) spinal cord as measured 16 h following the final session. At this time the level of ir-Met-enkephalin-Arg6-G...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91012-2

    authors: Przewlocki R,Lasoń W,Höllt V,Silberring J,Herz A

    更新日期:1987-06-16 00:00:00

  • Interaction between descending paraventricular neurons and vagal motor neurons.

    abstract::The hypothalamic paraventricular nucleus is known to send projections to the dorsal medullary area where it appears to innervate the nucleus tractus solitarius and the dorsal motor nucleus of the vagus. Experiments were carried out in urethane anesthetized rats to identify single vagal motor neurons identified by anti...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90399-3

    authors: Lawrence D,Pittman QJ

    更新日期:1985-04-15 00:00:00

  • Functional and metabolic correlates of long series of cortical spreading depression waves in rats.

    abstract::Repetitive generation of spreading depression (SD) waves may induce metabolic and functional disturbances in the invaded brain regions. In order to better characterize this state, up to 60 SD waves were elicited in the cerebral cortex of anesthetized rats by intracortical injections of 2 microliters of isotonic K-acet...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91399-0

    authors: Gorelova NA,Krivánek J,Bures J

    更新日期:1987-02-24 00:00:00

  • The motor units of cat medial gastrocnemius: speed-size relations and their significance for the recruitment order of mortor units.

    abstract::The interrelationships between axonal conduction velocity, tetanic tension, twitch contraction time and rate of force development during a tetanus have been studied in 126 motor units from 12 cat medial gastrocnemius muscles. While the range of axonal conduction velocities for slow- (contraction time greater than 45 m...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(75)90542-9

    authors: Stephens JA,Stuart DG

    更新日期:1975-06-27 00:00:00

  • IGFBP2 promotes neural stem cell maintenance and proliferation differentially associated with glioblastoma subtypes.

    abstract::Neural stem cells (NSCs) give rise to the central nervous system (CNS) and persist in certain areas of adult brains for replenishing damaged differentiated cells. The loss of the balance between NSC self-renewal and differentiation could lead to tumor formation such as the occurrence of glioblastoma (GBM), the most co...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2018.10.018

    authors: Shen F,Song C,Liu Y,Zhang J,Wei Song S

    更新日期:2019-02-01 00:00:00

  • Differential expression of cocaine- and amphetamine-regulated transcript and agouti related-protein in chronically food-restricted sheep.

    abstract::Recently, much attention has focused on the role of the melanocortin system in the regulation of energy homeostasis, especially the satiety effects of the pro-opiomelanocortin (POMC)-derived peptide alpha-melanocyte stimulating hormone (alpha-MSH). We have found that POMC mRNA levels are similar in fat and thin sheep ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02918-3

    authors: Henry BA,Rao A,Ikenasio BA,Mountjoy KG,Tilbrook AJ,Clarke IJ

    更新日期:2001-11-09 00:00:00

  • Impact of circulating estradiol on melatonin binding sites in discrete areas of the female rat brain.

    abstract::The distribution of 125I-melatonin binding sites in 6 discrete brain regions of female rats at the estrous stage and the effects of ovariectomy and subsequent 17 beta-estradiol treatment on these binding sites were studied. Specific binding of 125I-melatonin was found in the hypothalamus, medulla-pons, hippocampus, ce...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91057-2

    authors: Laudon M,Zisapel N

    更新日期:1987-01-27 00:00:00

  • Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release.

    abstract::A common feature of many neurodegenerative disorders is an abundance of activated glial cells (astrocytes and microglia). In Alzheimer's disease (AD), activated astrocytes are in close apposition to and surrounding the amyloid plaques. The mechanisms by which the astrocytes become activated in AD and the consequences ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01318-8

    authors: Hu J,Akama KT,Krafft GA,Chromy BA,Van Eldik LJ

    更新日期:1998-03-02 00:00:00

  • Glia-dependent neurotoxicity and neuroprotection in mesencephalic cultures.

    abstract::Dopaminergic neurotoxicities of 6-hydroxydopamine (6-OHDA) and the lipopolysaccharide (LPS) were compared in rat mesencephalic cultures plated on poly-L-lysine or on glial monolayers. In the neuron-enriched cultures plated on polylysine, 6-OHDA killed 89% of the tyrosine hydroxylase (TH)-immunopositive neurons, but LP...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01189-7

    authors: Bronstein DM,Perez-Otano I,Sun V,Mullis Sawin SB,Chan J,Wu GC,Hudson PM,Kong LY,Hong JS,McMillian MK

    更新日期:1995-12-15 00:00:00

  • Ca2+ and pH affect the neurite formation in cultured mollusc isolated neurones.

    abstract::Neurite formation in neurones isolated from adult molluscs in culture has been shown to depend on the total content of Ca in the cells, intracellular Ca2+ concentration, intracellular acid-alkaline balance, extracellular pH, and the capacity and composition of buffers. The neurones with a low total Ca content prior to...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90546-2

    authors: Kostenko MA,Musienko VS,Smolikhina TI

    更新日期:1983-10-03 00:00:00

  • Tachykinins protect cholinergic neurons from quinolinic acid excitotoxicity in striatal cultures.

    abstract::The neuroprotective effect of tachykinins against excitotoxic death of cholinergic neurons was studied in rat striatal cell cultures. Quinolinic acid (QUIN) and kainic acid (KA) produced a dose dependent decrease in choline acetyltransferase activity, but KA was more potent. Our results show that substance P (SP) tota...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)00879-7

    authors: Calvo N,Reiriz J,Pérez-Navarro E,Alberch J

    更新日期:1996-11-18 00:00:00

  • Anesthesia influences the outcome from experimental spinal cord injury.

    abstract::The effect of anesthesia upon the functional outcome after experimental spinal cord injury (SCI) was studied in 221 rats subjected to graded weight drop contusion in the thoracic cord. Neurologic function was assessed in a blinded fashion for one week after injury using a modification of the method of Tarlov. The post...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91521-h

    authors: Salzman SK,Mendez AA,Sabato S,Lee WA,Ingersoll EB,Choi IH,Fonseca AS,Agresta CA,Freeman GM

    更新日期:1990-06-25 00:00:00

  • Met-enkephalin-like immunoreactivity in microdialysates from nucleus tractus solitarii in piglets during normoxia and hypoxia.

    abstract::Met-enkephalin-like immunoreactivity in microdialysates from the respiratory-related nucleus tractus solitarii was determined simultaneously with ventilatory responses in seven, spontaneously breathing, developing swine under conditions of normoxia, hypoxia and recovery from hypoxia for 30 min each. Assayed levels of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00541-w

    authors: Yan S,Zhang C,Laferrière,Moss IR

    更新日期:1995-07-31 00:00:00

  • Induction of c-fos in rat brain by acute cocaine and fenfluramine exposure: a comparison study.

    abstract::Although cocaine shares the ability of fenfluramine to inhibit the synaptic reuptake of serotonin, previous observations from our group suggest that the genomic effects of fenfluramine in the rat striatum are primarily mediated by dopaminergic rather than serotonergic mechanisms. To compare and further understand the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91391-9

    authors: Torres G,Rivier C

    更新日期:1994-05-30 00:00:00