Population coding in spike trains of simultaneously recorded retinal ganglion cells.

Abstract:

:To achieve a better understanding of the parallel information processing that takes place in the nervous system, many researchers have recently begun to use multielectrode techniques to obtain high spatial- and temporal-resolution recordings of the firing patterns of neural ensembles. Apart from the complexities of acquiring and storing single unit responses from large numbers of neurons, the multielectrode technique has provided new challenges in the analysis of the responses from many simultaneously recorded neurons. This paper provides insights into the problem of coding/decoding of retinal images by ensembles of retinal ganglion cells. We have simultaneously recorded the responses of 15 ganglion cells to visual stimuli of various intensities and wavelengths and analyzed the data using discriminant analysis. Models of stimulus encoding were generated and discriminant analysis used to estimate the wavelength and intensity of the stimuli. We find that the ganglion cells we have recorded from are non-redundant encoders of these stimulus features. While single ganglion cells are poor classifiers of the stimulus parameters, examination of the responses of only a few ganglion cells greatly enhances our ability to specify the stimulus wavelength and intensity. Of the parameters studied, we find that the rate of firing of the ganglion cells provides the most information about these stimulus parameters, while the timing of the first action potential provides almost as much information. While we are not suggesting that the brain is using these variables, our results show how a population of sensory neurons can encode stimulus features and suggest that the brain could potentially deduce reliable information about stimulus features from response patterns of retinal ganglion cell populations.

journal_name

Brain Res

journal_title

Brain research

authors

Fernández E,Ferrandez J,Ammermüller J,Normann RA

doi

10.1016/s0006-8993(00)03072-9

subject

Has Abstract

pub_date

2000-12-22 00:00:00

pages

222-9

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006899300030729

journal_volume

887

pub_type

杂志文章
  • Effects of intraventricular substantia nigra allografts as a function of donor age.

    abstract::Transplantation of fetal substantia nigra into the brain can alleviate some of the manifestations of animal models of Parkinson's disease. The purpose of the present experiment was to determine the optimal embryonic donor age for solid tissue substantia nigra grafts. Rats with unilateral substantia nigra lesions were ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90652-r

    authors: Simonds GR,Freed WJ

    更新日期:1990-10-15 00:00:00

  • Phosphorylation of beta-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis.

    abstract::Secretion and progressive cerebral accumulation of beta-amyloid peptides (Abeta) derived by endoproteolytic ("amyloidogenic") processing of beta-amyloid precursor protein (APP) represent collectively an early and necessary event in the pathogenesis of Alzheimer's disease. We previously demonstrated that secretion of t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.01.031

    authors: Sodhi CP,Perez RG,Gottardi-Littell NR

    更新日期:2008-03-10 00:00:00

  • Calbindin-like immunoreactivity in two peripheral chemosensory tissues of the rat: taste buds and the vomeronasal organ.

    abstract::In the rat, calbindin-like immunoreactivity was observed at both the light and electron microscopic levels within the chemoreceptor neurons of the vomeronasal organ (VNO) and both intragemmal cells and associated nerve fibers of the circumvallate taste buds. All VNO neurons were immunoreactive. Only a subset of intrag...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90493-s

    authors: Johnson EW,Eller PM,Jafek BW,Norman AW

    更新日期:1992-02-14 00:00:00

  • Chronic corticotropin-releasing hormone and vasopressin regulate corticosteroid receptors in rat hippocampus and anterior pituitary.

    abstract::Corticotropin-releasing hormone (CRH) and vasopressin (AVP) participate in the endocrine, autonomic, immunological and behavioral response to stress. CRH and AVP receptors are found in hippocampus and anterior pituitary, where mineralocorticoid (MR) and glucocorticoid (GR) receptors are abundant. We investigated the p...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02585-x

    authors: Hügin-Flores ME,Steimer T,Schulz P,Vallotton MB,Aubert ML

    更新日期:2003-06-27 00:00:00

  • Temperature and amiloride alter taste nerve responses to Na+, K+, and NH+4 salts in rats.

    abstract::The effects of adaptation/stimulus temperature (25 degrees C vs. 35 degrees C) on taste nerve responses to salt stimulation and amiloride suppression were assessed in rats. We measured the integrated responses of the chorda tympani nerve to 500 mM concentrations of NaCl, Na2SO4, sodium acetate (NaAc), KCl, K2SO4, pota...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/S0006-8993(96)01118-3

    authors: Lundy RF Jr,Contreras RJ

    更新日期:1997-01-09 00:00:00

  • Amyloid precursor protein is localized in growing neurites of neonatal rat brain.

    abstract::Previous studies have indicated that amyloid precursor protein (APP) might be a trophic agent in the nervous system, possibly through the regulation of cell adhesion and the protease/protease inhibitor activity. Additionally, APP is upregulated during the development of the nervous system. In order to further study th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91329-d

    authors: Masliah E,Mallory M,Ge N,Saitoh T

    更新日期:1992-10-16 00:00:00

  • The time course of implicit processing of erotic pictures: an event-related potential study.

    abstract::The current study investigated the time course of the implicit processing of erotic stimuli using event-related potentials (ERPs). ERPs elicited by erotic pictures were compared with those by three other types of pictures: non-erotic positive, negative, and neutral pictures. We observed that erotic pictures evoked enh...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.10.019

    authors: Feng C,Wang L,Wang N,Gu R,Luo YJ

    更新日期:2012-12-13 00:00:00

  • Gene expression in the presence or absence of myelin assembly.

    abstract::Regulation of myelin protein gene expression in the presence and absence of myelin assembly can be assessed using crushed or permanently transected adult sciatic nerves of rats. The P0 glycoprotein and the myelin basic protein (MBP) are the major myelin-specific proteins of the peripheral nervous system. The steady-st...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0169-328x(87)90021-0

    authors: LeBlanc AC,Poduslo JF,Mezei C

    更新日期:1987-04-01 00:00:00

  • Alterations of steroid receptor coactivator-1 (SRC-1) immunoreactivities in specific brain regions of young and middle-aged female Sprague-Dawley rats.

    abstract::Previous studies have shown that steroid receptor coactivator-1 (SRC-1) is involved in the regulation of Purkinje cell development and motor learning, neural stem cell differentiation and reproductive-related plasticity. It is widely distributed in the adult brain, but the aging-related changes in the brain remain unc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.01.024

    authors: Zhang D,Guo Q,Bian C,Zhang J,Lin S,Su B

    更新日期:2011-03-25 00:00:00

  • Dopamine-containing amacrine cells of rhesus monkey retina parallel rods in spatial distribution.

    abstract::Dopamine-containing amacrine cells of rhesus monkey were found everywhere outside of the foveola in whole, flat retinas by the formaldehyde-glutaraldehyde fluorescent method. There were about 7500 such cells in a single retina and their density, determined by cell counts and measured by a nearest neighbor method, was ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91174-0

    authors: Mariani AP,Kolb H,Nelson R

    更新日期:1984-11-19 00:00:00

  • The use of the regenerating frog sciatic nerve for pharmacological studies of orthograde and retrograde axonal transport.

    abstract::The outgrowth region of the regenerating frog sciatic nerve shows an increased permeability for various drugs, which has been utilized for pharmacological studies of axonal transport. Six days after a bilateral crush lesion, the nerves, including the spinal ganglia, were incubated in a compartmented chamber. Orthograd...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91160-7

    authors: Edström A,Ekström P,Kanje M,Sjöberg J

    更新日期:1987-01-13 00:00:00

  • Peripheral input pathways projecting to the motor cortex in the cat.

    abstract::The possibility that the motor cortex receives peripheral input directly from the thalamus was examined using the evoked potential method and the following results were obtained. Potentials in the motor cortex evoked by stimulation of superficial radial (SR) or group II deep radial (DR) nerve were neither abolished no...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90532-8

    authors: Asanuma H,Larsen KD,Zarzecki P

    更新日期:1979-08-24 00:00:00

  • Gangliosides modulate Schwann cell proliferation and morphology.

    abstract::We examined the effect of gangliosides on Schwann cell cultures isolated from neonatal rat sciatic nerves. Addition of gangliosides (GM1, GM3, and ganglioside mixture) at concentrations between 0.25 and 2 mg/ml significantly diminished both the baseline rate of proliferation of the Schwann cells and their response to ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90442-8

    authors: Sobue G,Taki T,Yasuda T,Mitsuma T

    更新日期:1988-12-06 00:00:00

  • Development of cytochrome oxidase staining in the retina and lateral geniculate nucleus: a possible correlate of ON- and OFF-center channel maturation.

    abstract::A histochemical stain for cytochrome oxidase (CO) activity was used to examine the maturation of a neurochemical correlate of ON and OFF channels in the retina and dorsal lateral geniculate nucleus (LGN) of the tree shrew. In the adult tree shrew, the CO staining pattern can be used as a histochemical marker of segreg...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(87)90217-3

    authors: Lachica EA,Condo GJ,Casagrande VA

    更新日期:1987-08-01 00:00:00

  • Unilateral kainic acid lesions reveal dominance of right archistriatum in avian fear behavior.

    abstract::Unilateral injections of 1 microgram of kainic acid in the archistriatum of 5-day-old domestic chicks reduced fear, as expressed by distress calls (peeps), significantly more than did identical injections in the same structure on the left side. This result adds affective behavior to the growing list of functions that ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90861-9

    authors: Phillips RE,Youngren OM

    更新日期:1986-07-09 00:00:00

  • Sex differences in the rat forebrain.

    abstract::In the first postnatal month, the thickness of the cerebral cortex has different patterns of development in the male and female Long-Evans rat. All areas of the male cortex appear to develop at similar rates, very rapidly for the first 10 days, then more gradually reaching a peak somewhere between 30 and 40 days of ag...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/0165-0173(87)90014-2

    authors: Diamond MC

    更新日期:1987-05-01 00:00:00

  • Noradrenergic effects on olfactory perception and learning.

    abstract::We here review modulation of olfactory guided behavioral tasks by noradrenaline. In this review we focus on modulation of the main olfactory system in adult rodents. We detail behavioral paradigms commonly used and discuss how sensory perception and learning can be measured using these paradigms. We then describe neur...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2018.03.021

    authors: Linster C,Escanilla O

    更新日期:2019-04-15 00:00:00

  • Phosphatidylcholine protects neurons from toxic effects of amyloid β-protein in culture.

    abstract::Amyloid β-protein (Aβ) is the major component of extracellular plaques in the brains of patients with Alzheimer's disease. It has been suggested that the interaction of Aβ with membrane cholesterol is essential for Aβ to exert neurotoxicity; however, the effect of phospholipids, another major membrane lipid component,...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.04.035

    authors: Ko M,Hattori T,Abdullah M,Gong JS,Yamane T,Michikawa M

    更新日期:2016-07-01 00:00:00

  • Postnatal development of the inferior olivary complex in the rat. III. A morphometric analysis of volumetric growth and neuronal cell number.

    abstract::The overall volume of the three main inferior olivary (ION) subnuclei increases four-fold between the day of birth (PO) and P21. The rate of this increase is uneven; between P10 and P15 there is an abrupt acceleration which parallels the period of intense synaptogenesis and maturation of the neuropil. The growth of th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(84)90029-4

    authors: Bourrat F,Sotelo C

    更新日期:1984-11-01 00:00:00

  • Cysteamine-induced depletion of central somatostatin-like immunoactivity: effects on behavior, learning, memory and brain neurochemistry.

    abstract::The effects of a wide range of doses of systemically administered cysteamine were studied on locomotor behavior, passive avoidance memory, cortical and cerebrospinal fluid somatostatin-like immunoactivity and cortical levels of dopamine and norepinephrine. High doses of cysteamine (200 and 250 mg/kg s.c.) led to susta...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90060-6

    authors: Haroutunian V,Mantin R,Campbell GA,Tsuboyama GK,Davis KL

    更新日期:1987-02-17 00:00:00

  • ADAM12 is expressed by astrocytes during experimental demyelination.

    abstract::A disintegrin and metalloproteinase (ADAM) 12 represents a member of a large family of similarly structured multi-domain proteins. In the central nervous system (CNS), ADAM12 has been suggested to play a role in brain development, glioblastoma cell proliferation, and in experimental autoimmune encephalomyelitis. Furth...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.02.049

    authors: Baertling F,Kokozidou M,Pufe T,Clarner T,Windoffer R,Wruck CJ,Brandenburg LO,Beyer C,Kipp M

    更新日期:2010-04-22 00:00:00

  • Evidence for the functional compartmentalization of spike generating regions of rat midbrain dopamine neurons recorded in vitro.

    abstract::The regulation of spike generation in rat midbrain dopamine (DA) neurons was investigated using in vitro intracellular recordings. DA neurons fired long (greater than 1.8 ms) action potentials that exhibited comparatively depolarized spike thresholds (approx. -35 to -45 mV). Depolarization of the DA neuron increased t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90488-w

    authors: Grace AA

    更新日期:1990-07-30 00:00:00

  • The effects of axotomy and preganglionic denervation on the expression of pituitary adenylate cyclase activating peptide (PACAP), galanin and PACAP type 1 receptors in the rat superior cervical ganglion.

    abstract::The effects of axotomy, chemical sympathectomy and preganglionic denervation on the expression of the neuropeptides, pituitary adenylate cyclase-activating peptide (PACAP), galanin (GAL), and the PACAP type 1 receptor in the rat superior cervical ganglion (SCG) were investigated by immunocytochemistry, in situ hybridi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00923-2

    authors: Moller K,Reimer M,Ekblad E,Hannibal J,Fahrenkrug J,Kanje M,Sundler F

    更新日期:1997-11-14 00:00:00

  • Assessment of different induction protocols to elicit long-term depression (LTD) in the rat visual cortex in vivo.

    abstract::Changes in synaptic efficacy, including long-term potentiation (LTP) and long-term depression (LTD), provide mechanisms for experience-induced plasticity of cortical and subcortical circuits. LTP is readily induced under drastically different experimental conditions (e.g., in vitro and in vivo). However, few studies h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.12.063

    authors: Hager AM,Dringenberg HC

    更新日期:2010-03-08 00:00:00

  • Apparent sprouting of striatal serotonergic terminals after dopamine-depleting brain lesions in neonatal rats.

    abstract::Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90665-6

    authors: Stachowiak MK,Bruno JP,Snyder AM,Stricker EM,Zigmond MJ

    更新日期:1984-01-16 00:00:00

  • Effects of short-term portacaval anastomosis on the peripheral and brain disposition of the blood-brain barrier permeability marker sodium fluorescein in rats.

    abstract::Contradictory results have been reported with regard to the effects of various models of hepatic encephalopathy on the blood-brain barrier (BBB) permeability, which may be due partly to the use of brain concentrations of BBB markers without attention to their peripheral pharmacokinetics. The purpose of the current stu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.07.040

    authors: Shaik IH,Miah MK,Bickel U,Mehvar R

    更新日期:2013-09-19 00:00:00

  • Kindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. II. Effects of the NMDA antagonist MK-801.

    abstract::The effect of the non-competitive N-methyl-D-aspartate antagonist MK-801 on the early development of kindling-induced potentiation was examined in the rabbit hippocampal dentate gyrus. MK-801 (0.5 mg/kg) was administered 2 h before each daily kindling stimulation was applied to the perforant path. This treatment conti...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91182-z

    authors: Robinson GB

    更新日期:1991-10-18 00:00:00

  • Differential effects of the N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors of the excitatory amino acids system on LH and FSH secretion. Its effects on the hypothalamic luteinizing hormone releasing hormone during maturation in male rats.

    abstract::The present experiments describe the effect of NMDA and kainate agonists of the NMDA and non-NMDA subtype of receptors respectively of the excitatory amino acids (EAAs) system in prepubertal (16 days of age) and peripubertal (30-day-old rats) male rats on the in vitro hypothalamic release of GnRH, and on the in vivo L...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)01216-8

    authors: Carbone S,Szwarcfarb B,Rondina D,Feleder C,Moguilevsky JA

    更新日期:1996-01-29 00:00:00

  • Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats.

    abstract::Stroke-prone spontaneously hypertensive rats (SHRSP) are a well-characterized, genetic model for stroke. We showed earlier that the structure and function of the tight junctions in SHRSP blood-brain barrier endothelial cells is disturbed prior to stroke. To investigate the molecular events leading to endothelial dysfu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02670-1

    authors: Kirsch T,Wellner M,Luft FC,Haller H,Lippoldt A

    更新日期:2001-08-10 00:00:00

  • Diffusion kurtosis imaging study on temporal lobe after nasopharyngeal carcinoma radiotherapy.

    abstract:PURPOSE:Diffusion kurtosis imaging (DKI) is a MRI technique which can measure alterations in the diffusion of water molecules to reflect tissue changes in both white and grey matter. This study evaluated the potential of DKI for the early diagnosis of radiation-induced temporal lobe changes in the grey and white matter...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.07.041

    authors: Wang D,Li YH,Fu J,Wang H

    更新日期:2016-10-01 00:00:00