Abstract：
:Central administration of CRH results in endocrinological, cardiovascular, and behavioral effects that suggest stress or anxiety. Among these is a marked pressor response. Parenteral administration of CRH, however, results in hypotension. We used parenteral administration of antalarmin, a novel, small molecule CRH1 receptor antagonist, and alpha-helical CRH(9-41), a peptidic CRHR1/CRHR2 antagonist to attempt to determine the receptor mechanisms through which CRH is acting in both of these situations. Our results suggest that the hypertension produced by central CRH administration is mediated through central CRHR1 receptors, whereas the hypotension produced by parenteral CRH administration is mediated through peripheral CRHR2 receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Briscoe RJ,Cabrera CL,Baird TJ,Rice KC,Woods JHdoi
10.1016/s0006-8993(00)02742-6subject
Has Abstractpub_date
2000-10-27 00:00:00pages
204-7issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02742-6journal_volume
881pub_type
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