Abstract:
:The astrocyte-derived protein S100B stimulates production of inducible nitric oxide synthase and nitric oxide (NO) in astrocytes [Hu et al., 1996, J. Biol. Chem. 271:2543], but its effect on microglia is not known. In addition, S100B's ability to modulate the activity of other glial activating agents has not been defined. In this study, we compared the ability of S100B to stimulate NO in cultures of rat primary astrocytes and the BV-2 murine microglial cell line, and investigated the effect of the combined action of S100B and other stimuli known to activate glial cells. S100B itself stimulated the production of NO in astrocytes, and did not modify or potentiated only weakly the NO production induced by interleukin-1 beta, tumor necrosis factor alpha, dibutyryl cyclic AMP, zymosan A or lipid A. In contrast, S100B alone did not induce NO in BV-2 cells but strongly potentiated NO production in the presence of lipid A but not zymosan A. The deletion of eight C-terminal amino acid residues in S100B leads to a loss of the effect of S100B on microglia but not on astrocytes. These results demonstrate that responses of glial cells to extracellular S100B can vary depending on the cell type, and suggest that different structural features of S100B are important for the protein's effects on microglia and astrocytes.
journal_name
Brain Resjournal_title
Brain researchauthors
Petrova TV,Hu J,Van Eldik LJdoi
10.1016/s0006-8993(99)02251-9subject
Has Abstractpub_date
2000-01-17 00:00:00pages
74-80issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(99)02251-9journal_volume
853pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Converging evidence implicates alterations in multiple signaling pathways in the etiology of schizophrenia. Previously, these studies were limited to the analysis of one or a few phosphoproteins at a time. Here, we use a novel kinase array platform to simultaneously investigate the convergence of multiple signaling ca...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.04.029
更新日期:2014-06-03 00:00:00
abstract::The parabrachial nucleus consists of several subnuclei which contains autonomic, gustatory, visceral sensory, nociceptive, and respiratory related neurons. We have investigated the direct projections from the rat parabrachial region, including the K olliker-Fuse nucleus, to the pharyngeal motoneurons with an anterogra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01127-5
更新日期:1999-01-23 00:00:00
abstract::Cytosolic phospholipase A2 (cPLA2) catalyzes the selective release of arachidonic acid from the sn-2 position of membrane phospholipids and has been suggested as an effector in the receptor-mediated release of arachidonic acid in signal transduction. The potential role of cPLA2 as an effector in muscarinic acetylcholi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00806-3
更新日期:1998-10-26 00:00:00
abstract::To date, few treatment strategies applying cellular transplantation to the chronically injured spinal cord have yielded significant functional improvement in animal experiments. Here we report that significant improvement of locomotor function was achieved in rats with chronic spinal cord injury (SCI) by the applicati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.03.054
更新日期:2012-05-25 00:00:00
abstract::A comparison was made of the effects of left and right cerebral decortication on cytotoxic activity of natural killer and natural cytotoxic lymphocytes in the mouse. Natural killer cytotoxic activity was significantly reduced after right decortication, whereas left decortication led to a less pronounced, though still ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90704-f
更新日期:1990-08-06 00:00:00
abstract::The main purpose of the present study was to determine whether specific regions of the mouse brain exhibit different age-related changes in oxidative stress, as indicated by glutathione redox state and the level of protein-glutathionyl mixed disulfides. Comparison of 3- and 21-month-old mice indicated an age-related d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.040
更新日期:2007-01-05 00:00:00
abstract::The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90333-6
更新日期:1985-01-28 00:00:00
abstract::Ia synapses in laminae VI and IX of the cat's spinal cord were examined in the electron microscope following iontophoretic injection of horseradish peroxidase (HRP) into single, identified, Ia afferent fibers from gastrocnemius muscles. Ia boutons contacting motoneuron dendrites in lamina IX contained spherical synapt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90831-x
更新日期:1984-05-23 00:00:00
abstract::This study examined the projection from the rostral nucleus of the solitary tract (rNST) to the medial parabrachial nucleus (mPBN) in male Wistar rats using DiI as a retrograde tracer and biotinylated dextran as an anterograde tracer. Following successful unilateral injection of DiI into the mPBN (n = 8), retrogradely...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00736-6
更新日期:1996-10-21 00:00:00
abstract::Tubulin immunostaining of semi-thin sections after polyethylene glycol embedding was used in the tectal plate of the embryonic mouse at 10 days postmating to analyze the effects of cold treatment on the microtubules of the different cell types seen at this stage. Three sets of microtubules are observed. In the radiall...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90021-6
更新日期:1987-12-01 00:00:00
abstract::Binding of cyclic AMP to the regulatory subunit of cyclic AMP-dependent protein kinase (PKA) is an essential step in cyclic AMP-mediated intracellular signal transduction. This binding is, however, rapidly inhibited in the acute phase of cerebral ischemia, indicating that the signal transduction via PKA is very vulner...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03231-0
更新日期:2002-01-04 00:00:00
abstract::The kinetic properties of the testosterone-metabolizing enzymes were studied in the hypothalamus of adult and young zebra finches of both sexes. Estradiol, 5 alpha-dihydrotestosterone, 5 beta-dihydrotestosterone and 5 beta-androstane-3 alpha,17 beta-diol were identified as metabolites of testosterone in males and fema...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90406-4
更新日期:1988-11-01 00:00:00
abstract::It has been well established that the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) opener, diazoxide, has protective effects on the heart and brain following ischemia/reperfusion injury. However, the mechanism of the neuroprotective effects of diazoxide remains unclear. This study highlights the anti-apo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.11.019
更新日期:2011-01-25 00:00:00
abstract::A decline in the magnitude of the summated responses evoked by taste solutions began about 1 h following IXth nerve transection. In 41 IXth nerves transected at different lengths we found a linear relationship between the length of the IXth nerve stump remaining attached to the tongue and the time for the taste respon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91331-1
更新日期:1980-07-21 00:00:00
abstract::Stanniocalcin (STC-1), a 50 kDa glycoprotein hormone that regulates calcium/phosphate homeostasis in bony fish and mammals, has been shown to be expressed in central neurons and choroid plexus, and to exert a protective effect against hypercalcemic and hypoxic damage to neurons. Circumventricular organs are known to f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.04.070
更新日期:2008-07-07 00:00:00
abstract::In Parkinson disease (PD), the subthalamic nucleus (STN) becomes hyperactive (disinhibited), which is reported to cause excitotoxic damage to midbrain dopaminergic neurons. Here, we examined whether silencing of the hyperactive STN by chronic bilateral deep brain stimulation (DBS) increased the survival of midbrain do...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.08.082
更新日期:2006-11-20 00:00:00
abstract::Spinal cord patterns of metabolic activity in a model of neuropathic pain were assessed in unanesthetized rats by the [14C]-2-deoxyglucose (2-DG) technique. Rats used in this procedure had demonstrable thermal hyperalgesia ipsilateral to sciatic nerve ligation and ipsilateral hindpaws that were lifted in a guarded pos...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91468-g
更新日期:1991-11-15 00:00:00
abstract::Nitric oxide synthase (NOS) activity was examined in forebrain, cerebellum and optic lobes of adult domestic fowl, having a hereditary primary generalized convulsive disorder. NOS was approximately 2-fold higher in only the forebrain of adult epileptic fowl compared to non-epileptic (carrier) hatchmates. A significant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00595-1
更新日期:1996-10-07 00:00:00
abstract::Extracellular recordings were conducted in the paraflocculus of anesthetized Long-Evans pigmented rats to determine how ionotophoresis of norepinephrine (NE) affects the responsiveness of individual Purkinje cells and interneurons to presentations of visual stimuli within their visual receptive fields. Presentations o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91421-c
更新日期:1990-04-30 00:00:00
abstract::Wild red foxes, proverbially cunning carnivores, are investigated for adult hippocampal neurogenesis and morphological characteristics of the dentate gyrus. Adult red foxes harbor almost 15-times more young, doublecortin-positive neurons in their dentate gyrus than domesticated dogs. The number of doublecortin-positiv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.02.075
更新日期:2010-04-30 00:00:00
abstract::YM-14673 is a thyrotropin-releasing hormone (TRH) analog that has a modification of the N-terminal (pyroglutamyl) moiety of the tripeptide. It is longer acting than TRH and has substantially greater potency with regard to central facilitatory activity. In the present studies, the effect of YM-14673 was examined in rat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90509-x
更新日期:1989-05-08 00:00:00
abstract::This study aimed to identify sites and mechanisms of long-term plasticity following lower limb muscle training. Two groups performing either a postural stability maintenance training (SMT) or a ballistic ankle strength training (BST) were compared to a non-training group. The hypothesis was that practicing of a self-i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.08.048
更新日期:2007-11-07 00:00:00
abstract::The distribution of NK(1) receptor immunoreactivity in the amygdaloid complex, induction of NK(1) receptor endocytosis in the amygdala following immobilisation stress, and the ability of pretreatment with the substance P antagonist L-760,735 or imipramine to block this response were examined in gerbils, a species with...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01976-9
更新日期:1999-11-27 00:00:00
abstract::In the central nervous system (CNS) insulin mediates a variety of effects including feeding, metabolism and cognition. The cognitive enhancing effects of insulin are proposed to be mediated through activation of insulin receptors in the hippocampus, an important integration center for learning and memory in the mammal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.005
更新日期:2009-11-03 00:00:00
abstract::A study of brains of 16 dogs from one to 19 years of age showed a structure- and cell-type- specific pattern of tau protein phosphorylation at mAb Tau-1 site and the absence of phosphorylation at the mAb AT8 site. Strong immunolabeling with mAb Tau-1 of the mossy fibers and perikarya of neurons in sectors CA3 and CA4 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00542-3
更新日期:1998-08-17 00:00:00
abstract::Adenylate cyclase activity accumulated proximal to a constriction placed around the frog sciatic nerve. The rate of accumulation was linear between 8 and 24 h following placement of the constriction; accumulation rate declined substantially after 24 h. Accumulation of activity distal to the constriction in normal nerv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90284-0
更新日期:1982-01-28 00:00:00
abstract::Ouabain binds to the catalytic subunit of Na+,K+-ATPase and specific [3H]ouabain binding can be used as a measure of the number of active enzyme molecules present in a given tissue. Specific [3H]ouabain binding can be demonstrated in frozen, cryostat sections from rat brain and pineal and these sites have the characte...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90719-0
更新日期:1987-04-21 00:00:00
abstract::Protein kinase C (PKC) is a family of serine/threonine kinases comprised of 10 isoforms. Although commercial antibodies are available for all 10 isoforms, the specificity of these antibodies has been questioned. We have identified immunoblot conditions in which commercially purchased PKC antibodies are specific for th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.110
更新日期:2006-04-14 00:00:00
abstract::We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-d-aspartate receptor (NMDAR). NMDAR inhibition by Pb(2+) during synaptogenesis disrupts downstream trans-synaptic signaling of brain-derived neuro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.12.037
更新日期:2012-02-23 00:00:00
abstract::A cluster of trigeminal nociceptive neurons was located in the lateral sulcus on the upper bank of the frontoparietal operculum in a region bordering between cortical areas SII and 7b. These neurons were isolated in cortical cell layers IV and V-VI. All nociceptive neurons responded exclusively to noxious mechanical s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90375-2
更新日期:1989-04-10 00:00:00