Abstract:
:Following infection with influenza virus, animals display decreased locomotor activity and feeding behavior and loss of body weight. It has been suggested that these effects may be mediated by cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), induced by the infection. To assess the potential role of IL-1, we tested the ability of a naturally occurring IL-1-receptor antagonist (IL-1ra) to antagonize the changes in feeding behavior induced by IL-1, endotoxin (lipopolysaccharide, LPS), and infection with influenza virus. Feeding behavior was assessed by measuring the daily intake of food pellets and sweetened milk in a 30-min period. Acute injection of IL-1 beta decreased milk intake, but mouse IL-6 and mouse TNF-alpha did not. However, TNF-alpha decreased food pellet intake slightly, especially when it was injected at the beginning of the dark phase. The reductions in milk intake induced by mouse IL-1 beta were largely prevented by IL-1ra pretreatment (100 micrograms/mouse i.p.). The LPS-induced reductions in milk intake were attenuated, but not blocked, by IL-1ra treatment (300 micrograms/mouse). LPS still induced significant decrements in the presence of the antagonist. In influenza virus-infected mice, IL-1ra was administered either by repeated subcutaneous (s.c.) injections, or by continuous s.c. infusion from osmotic minipumps. These IL-1ra treatments produced small, but statistically significant, attenuations of the depression in milk and food pellet intake in the virus-infected mice. In several experiments, IL-1ra treatment increased the survival of influenza virus-infected mice. Thus the attenuation of the hypophagia may have been caused by this IL-1ra-induced increase in survival. The results suggest that IL-1 contributes to sickness behavior induced by LPS and influenza virus infection, but it is not the only factor involved.
journal_name
Brain Resjournal_title
Brain researchauthors
Swiergiel AH,Smagin GN,Johnson LJ,Dunn AJdoi
10.1016/s0006-8993(97)01009-3subject
Has Abstractpub_date
1997-11-21 00:00:00pages
96-104issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)01009-3journal_volume
776pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::In a recent study in the tiger salamander, Ambystoma tigrinum, were demonstrated topographic patterns of responsivity across the olfactory epithelium which were characteristic for each odorant. The present study was initiated to investigate whether these patterns remain constant when odorant concentration is varied. O...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90562-6
更新日期:1984-04-16 00:00:00
abstract::A disintegrin and metalloproteinase (ADAM) 12 represents a member of a large family of similarly structured multi-domain proteins. In the central nervous system (CNS), ADAM12 has been suggested to play a role in brain development, glioblastoma cell proliferation, and in experimental autoimmune encephalomyelitis. Furth...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.02.049
更新日期:2010-04-22 00:00:00
abstract::A direct, although transient, projection from the sensorimotor cortex to the cerebellum has been described previously in the neonatal kitten. The present report demonstrates that this pathway can be induced to persist into juvenile stages of the cat by partially denervating the deep cerebellar nuclei. Most of the cere...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(86)80021-x
更新日期:1986-11-01 00:00:00
abstract::The 'commissural' innervation of the dentate gyrus molecular layer has been analyzed in normal adult rats and in those in which the ipsilateral entorhinal cortex had been removed by aspiration at 14 days post-natal. This ablation severely deafferents the distal two-thirds of the molecular layer and induces 'sprouting'...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90512-2
更新日期:1979-10-12 00:00:00
abstract::Choline is an essential nutrient whose availability during the second half of gestation produces long-lasting cognitive effects. Rats that obtain supplemental choline during embryonic day (E) 11-17 have enhanced depolarization-evoked acetylcholine (ACh) release from hippocampal slices, whereas choline deficiency durin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.08.046
更新日期:2008-10-27 00:00:00
abstract::The distribution of cerebellar [3H]flunitrazepam binding sites was studied autoradiographically in Purkinje cell degeneration (pcd/pcd), weaver (wv/wv), staggerer (sg/sg) and reeler (rl/rl) mutant mice. In the normal 78-day-old C57BL/6J mouse cerebellum, the highest concentration of [3H]flunitrazepam binding sites was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90920-1
更新日期:1988-03-15 00:00:00
abstract::Five pairs of neurosecretory cells in the subesophageal ganglion of the silkmoth Bombyx mori discharge action potentials in (near) synchrony to release a pheromone biosynthesis-activating neuropeptide (PBAN). Waveforms of compound action potentials recorded extracellularly from axonal tracts were analyzed to determine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03349-2
更新日期:2002-03-08 00:00:00
abstract::Because previous studies have emphasized the importance of the amygdala in the therapeutic actions of benzodiazepines and described differences in benzodiazepine receptor distribution between human and rat, this study examined the distribution of multiple benzodiazepine receptors in normal human amygdala by light micr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90730-8
更新日期:1983-10-16 00:00:00
abstract::Terminal fibers anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) were observed in the locus coeruleus in the brainstem of the cat and the cynomolgus monkey following injections in lamina I of the spinal or medullary dorsal horn. Thus, thermoreceptive- or nociceptive-specific lamina I cells that pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90915-v
更新日期:1992-07-03 00:00:00
abstract::Cerebellum is involved in the motion coordination and working memory, to which spike programming at Purkinje neurons are essential. The development of Purkinje neurons in the embryonic stage has been well studied. However, it is not clear about the maturation of their intrinsic property related to spike programming du...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.092
更新日期:2006-06-30 00:00:00
abstract::In recent years microvillar cells (MVC) have been identified in the olfactory epithelium of numerous species, including rodents, canines, and primates. However, there is no consensus on the morphologic or histochemical features of this cell, nor is the function of these cells currently known. Previous studies have exa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01144-7
更新日期:1995-01-09 00:00:00
abstract::Hippocampal CA1 pyramidal cell neurons are sensitized to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4) following exposure to L-quisqualic acid (QUIS). It has been proposed that induction of this 'QUIS-effect' involves uptake of L-QUIS by hippocampal cells. We have used o-phthaldialdehyde (OPA) derivatiz...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91359-z
更新日期:1993-03-05 00:00:00
abstract::Neonatal rats were exposed to lead from parturition to weaning via the milk of dams drinking 0.2% lead acetate solution. The alterations of long-term potentiation (LTP) and paired-pulse facilitation (PPF) of hippocampal dentate gyrus in adult rats (90-115 days) following developmental lead exposure were studied in viv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00739-2
更新日期:1998-09-28 00:00:00
abstract::The postnatal development of soma size and cytochrome oxidase activity was examined in the perigeniculate nucleus (PGN) and reticular nucleus of the thalamus (RNT). Neurons in the PGN and RNT exhibited a rapid increase in soma size between 2 and 4 weeks of age. During this period of cell growth there is an increase in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90047-2
更新日期:1987-10-01 00:00:00
abstract::The current study explored the effects of prolonged antidepressant treatment on mRNA levels of two nuclear receptors in specific brain regions of an animal model of depression, the Wistar-Kyoto (WKY) rat. Both nuclear receptors have been implicated in the development or treatment of depression. The expression of nucle...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.09.041
更新日期:2010-11-29 00:00:00
abstract::Equivalent antiinflammatory doses of steroids including betamethasone, methylprednisolone and dexamethasone were administered in the neonatal period in a rat model. In situ cell death in hippocampus quantified by Terminal Deoxynucleated Transferase Nick-End Labeling and on ratio of brain to body weight was investigate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.10.051
更新日期:2009-01-23 00:00:00
abstract::In the sea hare, Aplysia californica, consummatory feeding behavior is selectively abolished by bilateral crushes of the cerebral-buccal connectives and recovers by postlesion day 13. Recovered biting responses are initially weak and increase in magnitude gradually with time. The lesions do not affect appetitive feedi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91217-3
更新日期:1992-07-10 00:00:00
abstract::In the present study, we characterized the evoked electrical activity from T(13) to S(2) dorsal roots (DRs) during glass probe-stimulation of the vagina-cervix-uterus junction (VCUJ) of female Wistar rats. The results showed that gentle stimulation of VCUJ evoked high-amplitude electrical activity in L(3) and L(6) DRs...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.12.023
更新日期:2013-02-16 00:00:00
abstract::Unilateral microinjections (0.20 microliter) of the excitatory amino acids (EAA), L-aspartate (ASP), D,L-homocysteate (DLH) or kainate (KA) were made into the midbrain of freely moving cats. Injections of DLH (20 nmol) or ASP (200 nmol) made within the midbrain periaqueductal grey matter (PAG) consistently elicited a ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91465-5
更新日期:1988-01-26 00:00:00
abstract::To investigate the role of the amygdala in central regulation of pancreatic exocrine secretion, the effects of electrolytic lesions on pancreatic secretion were studied in rats. Small bilateral electrolytic lesions in amygdaloid body restricted to basolateral, medial and central nuclei were produced. Eight days after ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90770-x
更新日期:1985-08-05 00:00:00
abstract::The influence of glutamate and aspartate on the time course of decay of excitatory currents at neuromuscular junctions of locust skeletal muscle was examined. Both aspartate (up to 10 mM) and glutamate (up to 0.3 mM) had little influence on the decay time of the synaptic currents, whether measured intracellularly by v...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91020-3
更新日期:1980-06-16 00:00:00
abstract::In this study we present data supporting a heterogeneous distribution of the brain-specific S-100 protein on nerve cell plasma membranes from isolated neurons. This has been shown in a previous study by immunoelectron microscopy using peroxidase-conjugated anti-S-100 antiserum and in this study by immunofluorescence u...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90161-4
更新日期:1975-12-26 00:00:00
abstract::The amplitude of the acoustic startle reflex can be modulated by exposure to aversive stimuli or other conditions which evoke a state of fear. The neurotransmitters involved in this modulation are currently being investigated. Unilateral local infusion of corticotropin-releasing hormone (CRH; 0, 10, 20, 40 and 80 ng) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01309-7
更新日期:1998-01-26 00:00:00
abstract::The objective of this study was to further investigate neurochemicals which might modulate congenital differences in sensitivity to the acute and chronic effects of ethanol. Catecholamine levels were measured in the cortex, hippocampus, midbrain and cerebellum of long-sleep (LS) and short-sleep (SS) mice. These measur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91513-z
更新日期:1991-11-01 00:00:00
abstract::The onset of the daily wheel running bout precedes dark onset by several hours in the early runner genetic variant of mice. Here, we test the hypothesis that timed daily administration of a melatonin agonist, ramelteon, or a benzodiazepine, triazolam, normalizes the timing of daily wheel-running rhythms in early runne...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.07.103
更新日期:2009-11-03 00:00:00
abstract::Systemic endothelin-1 (ET-1) enhances the activity of subfornical organ (SFO) neurons with identified projections to the paraventricular nucleus of the hypothalamus (PVN). The present electrophysiological experiments were undertaken to examine the mechanisms through which systemic ET influences vasopressin secretion. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91378-r
更新日期:1992-07-17 00:00:00
abstract::Intracellular staining of neurons located in the superficial layers of the superior colliculus (SC) of the cat was carried out through an intracellular recording micropipette with which responses to stimulation of the optic chiasm (OX) and the optic tract (OT) ipsilateral to the explored SC were recorded. :A total of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90180-3
更新日期:1981-07-27 00:00:00
abstract::The feedback effect of activity of area 21a on orientation maps of areas 17 and 18 was investigated in cats using intrinsic signal optical imaging. A spatial frequency-dependent decrease in response amplitude of orientation maps to grating stimuli was observed in areas 17 and 18 when area 21a was inactivated by local ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.024
更新日期:2004-02-20 00:00:00
abstract::In the present study, we performed immunohistochemical studies to investigate the changes of Bcl-2 and Bax in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation. In contrast to the controls, a high density of Bcl-2-IR astrocytes were detected all around the gray matter of the spina...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03014-6
更新日期:2000-12-29 00:00:00
abstract::Cats acquired a conditioned eyeblink (CR) in a situation where the conditioned stimulus (CS) was a click and the unconditioned stimulus (US) was unilateral electrical stimulation of the zygomatic orbital branch of the facial nerve, which is a motor nerve. In a discrimitive training program, cats received both a click ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90681-2
更新日期:1975-06-06 00:00:00