Abstract:
:It has been demonstrated previously that kappa opioid receptor agonists, such as dynorphin, inhibit oxytocin secretion in the rat. To determine whether kappa agonists act directly on oxytocin-containing magnocellular neurons to inhibit hormone secretion, we utilized immunofluorescence to examine the cellular localization of kappa opioid receptors in the rat paraventricular and supraoptic nuclei. kappa Opioid receptor immunoreactivity co-localized with oxytocin-containing cell bodies, their axons and axon terminals. Thus, our results suggest that kappa opioid receptor agonists can exert direct inhibitory actions on oxytocin magnocellular neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Smith MJ,Wise PMdoi
10.1016/s0006-8993(01)02154-0subject
Has Abstractpub_date
2001-04-13 00:00:00pages
162-5issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(01)02154-0journal_volume
898pub_type
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