Abstract：
:Neurotensin (NT) is an endogenous peptide which has been hypothesized to function in the central nervous systems as a neurotransmitter. Injection of NT into the cerebral ventricular system of rodents produces antinociception in a variety of analgesia tests. In the hot plate test, direct microinjection of NT into the central nucleus of the amygdala (AC) produced a significant increase in the nociceptive threshold of the rat, while injections into tissue adjacent to the AC were generally ineffective. Antinociception following intra-AC injection of NT occurred at an ED50 dose of 2.4 micrograms NT, and was significantly lower than the ED50 dose observed when NT was given into the lateral ventricles (93.2 micrograms NT). Lesions of the stria terminalis totally abolished the antinociceptive effect of intra-AC administration of NT, indicating that AC efferent or afferent fibers within the stria terminalis are necessary for the observed increase in nociceptive threshold.
journal_name
Brain Resjournal_title
Brain researchauthors
Kalivas PW,Gau BA,Nemeroff CB,Prange AJ Jrdoi
10.1016/0006-8993(82)90251-7subject
Has Abstractpub_date
1982-07-15 00:00:00pages
279-86issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(82)90251-7journal_volume
243pub_type
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