Aβ induces acute depression of excitatory glutamatergic synaptic transmission through distinct phosphatase-dependent mechanisms in rat CA1 pyramidal neurons.

abstract：:Aspartame (L-aspartyl-L-phenylalanine methyl ester), an artificial low-calorie sweetener, was shown to dose-dependently inhibit L-[3H]glutamate binding to its N-methyl-D-aspartate-specific receptors. L-Aspartic acid, a major endogenous metabolite of aspartame, inhibited the binding more stronger than aspartame, while ...

journal_title：Brain research

authors： Pan-Hou H,Suda Y,Ohe Y,Sumi M,Yoshioka M

更新日期：1990-06-18 00:00:00

abstract：:It has been accepted that the descending system from the nucleus locus coeruleus (LC)/nucleus subcoeruleus (SC) plays a significant role in spinal nociceptive processing. The present study was designed to examine modulation of nociceptive processing in the caudal part of the trigeminal sensory nuclear complex, the tri...

journal_title：Brain research

authors： Tsuruoka M,Matsutani K,Maeda M,Inoue T

更新日期：2003-12-12 00:00:00

abstract：BACKGROUND:An important part of the medical treatment of many cerebrovascular diseases is the occlusion of brain supplying arteries. Until now, the risk of this intervention can only be estimated by invasive diagnostics including the risk of cerebrovascular accidents. METHODS AND RESULTS:As a supporting tool, a comput...

journal_title：Brain research

authors： Roessler FC,Reith W,Siegel G

更新日期：2006-11-06 00:00:00

abstract：:GABA-A receptors mediate both phasic synaptic inhibition and more recently appreciated tonic currents in the vertebrate central nervous system. We addressed discrepancies in the literature regarding the pharmacology of tonic currents by examining tonic currents in a controlled environment of dissociated, solitary glut...

journal_title：Brain research

authors： Eisenman LN,Kress G,Zorumski CF,Mennerick S

更新日期：2006-11-06 00:00:00

abstract：:SBA and NADPH-d histochemistries allow identification of functionally distinct components of the amphibian primary olfactory system. In Pipa, a secondarily aquatic frog, combination of both methodologies, using alternate sets of histological sections, reveals that, apart from Jacobson's organ, this species has a "wate...

journal_title：Brain research

authors： Meyer DL,Fackler IR,Jadhao AG,D'Aniello B,Kicliter E

更新日期：1997-07-11 00:00:00

abstract：:To learn whether there are developmental changes in salt and acid taste responses from the posterior tongue, we recorded from the glossopharyngeal nerve, which innervates taste buds in circumvallate papillae, in sheep fetuses, lambs and adults. Multifiber responses to NH4Cl, KCl, NaCl, LiCl, citric and hydrochloric ac...

journal_title：Brain research

authors： Mistretta CM,Bradley RM

更新日期：1983-12-01 00:00:00

abstract：:Previous research has demonstrated that in the Siberian hamster, both photoperiod and estrous cyclicity alter the profile of noradrenergic activity with the paraventricular nucleus of the hypothalamus (PVN), and that noradrenergic activity is correlated with changes in circulating levels of prolactin. Work from our la...

journal_title：Brain research

authors： Dodge JC,Badura LL

更新日期：2004-08-06 00:00:00

abstract：:Activity produced by direct microelectrophoretic application of glutamate onto 19 convergent neurones in trigeminal nucleus caudalis, was strongly depressed during and after the application of heterotopic noxious conditioning stimuli: noxious heat (52 degrees C) applied to the tail, noxious pinches applied to the tail...

journal_title：Brain research

authors： Villanueva L,Cadden SW,Le Bars D

更新日期：1984-10-29 00:00:00

abstract：:Neonatal destruction of nigrostriatal dopamine neurons by cerebroventricular injection of 6-hydroxydopamine (6-OHDA) results in a serotonin (5-HT) hyperinnervation of the rostral neostriatum in adult rat. Quantitative ligand-binding autoradiography was used to compare the density of various 5-HT receptor subtypes in t...

journal_title：Brain research

authors： Radja F,Descarries L,Dewar KM,Reader TA

更新日期：1993-03-26 00:00:00

abstract：:Kernicterus is a bilirubin-induced encephalopathy in newborn. Its spectrum ranges from subtle extrapyramidal to acute encephalopathy and chronic posticteric sequelae. Current treatment of this serious problem is far from optimal. Taurine has been documented to have protective effects on neuronal cells against ischemia...

journal_title：Brain research

authors： Zhang B,Yang X,Gao X

更新日期：2010-03-12 00:00:00

abstract：:Evidence is provided that carbonic anhydrase-II is localized in the central nervous system to wide spread systems of oligodendrocytes and restricted astroglia populations, involving both fiber bundles and neuropil. It is suggested that CO2 formed in activated axons may, via carbonic anhydrase-II, give rise to protons ...

journal_title：Brain research

authors： Agnati LF,Tinner B,Staines WA,Väänänen K,Fuxe K

更新日期：1995-04-03 00:00:00

abstract：:The presence of calretinin and calbindin immunoreactivity is studied in the retina of larval and adult lamprey and their respective distributions are compared. Calretinin distribution is also studied in the retina of transforming stages. Western blot analysis in brain extracts showed a 29-kDa band with both polyclonal...

journal_title：Brain research

authors： Villar-Cheda B,Abalo XM,Anadón R,Rodicio MC

更新日期：2006-01-12 00:00:00

abstract：:A selective 5-HT reuptake inhibitor, fluvoxamine (10 and 30 mg/kg, i.p.) suppressed long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP was completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by th...

journal_title：Brain research

authors： Kojima T,Matsumoto M,Togashi H,Tachibana K,Kemmotsu O,Yoshioka M

更新日期：2003-01-03 00:00:00

abstract：:At present, the ability of polyunsaturated fatty acids (PUFAs) to regulate individual glutamate transporter subtypes is poorly understood and very little information exists on the mechanism(s) by which PUFAs achieve their effects on the transport process. Here we investigate the effect of cis-4,7,10,13,16,19-docosahex...

journal_title：Brain research

authors： Berry CB,Hayes D,Murphy A,Wiessner M,Rauen T,McBean GJ

更新日期：2005-03-10 00:00:00

abstract：:Samples of 14 brains of autopsied patients suffering from dementia of the Alzheimer type were examined. In Congo red-hemalum stained 14-microns-thick sections of the hippocampus 15 tangle-bearing and 25-30 unaffected nerve cells of area CA1 per case were measured for cell size and nucleolar size utilizing an interacti...

journal_title：Brain research

authors： Gertz HJ,Schoknecht G,Krüger H,Cervos-Navarro J

更新日期：1989-05-22 00:00:00

abstract：:The localization of a GTP-binding protein (G(o)) in the cerebellar and cerebral cortex and hippocampus of the normal and reeler mutant mouse was immunohistochemically examined using affinity-purified antibody raised against the alpha subunit of G(o). Although the general distribution pattern of G(o)-immunoreactive pro...

journal_title：Brain research

authors： Terashima T,Katada T,Ichikawa R,Ui M,Inoue Y

更新日期：1993-01-22 00:00:00

abstract：:Pregabalin is useful for treating neuropathic pain, but known to increase body weight as a side effect. To investigate the mechanism of this increase in body weight, we focused on dopamine in the lateral hypothalamus (LH) and examined the effects of pregabalin on dopamine levels in the LH and food intake. The dopamine...

journal_title：Brain research

authors： Ikeda H,Yonemochi N,Ardianto C,Yang L,Kamei J

更新日期：2018-12-15 00:00:00

abstract：:A short-acting non-barbiturate intravenous general anaesthetic, etomidate, when administered i.v. lowered serum prolactin levels in the rat. The effect was evident at rest, after surgical stress or after injection of 5-hydroxytryptophan. Haloperidol-induced hyperprolactinaemia was not modified. Administered via the in...

journal_title：Brain research

authors： Preziosi P,Cerrito F,Vacca M

更新日期：1983-07-25 00:00:00

abstract：:Although the role of cAMP-response-element-binding protein (CREB) binding protein (CBP) in the neuroprotective mechanisms has been the focus of many studies, very little is known about the expression or function of CBP in aged brains. We have therefore examined age-related changes in CBP expression in the cerebral cor...

journal_title：Brain research

authors： Chung YH,Kim EJ,Shin CM,Joo KM,Kim MJ,Woo HW,Cha CI

更新日期：2002-11-29 00:00:00

abstract：:The influence of the superficial layers of the superior colliculus (SC) on responses of the lateral geniculate nucleus was studied in anesthetized and paralyzed rabbits. Fifty to one hundred nanoliters of inactivating drugs were injected through a micropipette positioned in the SC in register with the geniculate cells...

journal_title：Brain research

authors： Molotchnikoff S,Delaunais D,Casanova C,Lachapelle P

更新日期：1986-06-04 00:00:00

abstract：:The lack of the glycine transporter 1 (GlyT1) leads to early postnatal death due to failure of respiratory network activity. Here we demonstrate a segregated expression of GlyT1 on different astroglial cell populations of the ventral respiratory group. In TgN(hGFAP-EGFP) mice a combined immunohistochemical and electro...

journal_title：Brain research

authors： Szoke K,Härtel K,Grass D,Hirrlinger PG,Hirrlinger J,Hülsmann S

更新日期：2006-11-13 00:00:00

abstract：:Previous work has demonstrated that 3 pharmacologically and neuroanatomically distinct analgesia systems can be sequentially activated by increasing numbers of transcutaneous tail-shock. To date, the categorization of the early (after 2 tail-shocks) and late (after 80-100 tail-shocks) analgesias as opiate-mediated has...

journal_title：Brain research

authors： Watkins LR,Wiertelak EP,Maier SF

更新日期：1992-06-05 00:00:00

abstract：:A subset of olfactory receptor neurons of the Caribbean spiny lobster Panulirus argus possesses receptors for L-glutamate that can mediate both excitatory and inhibitory responses (P.C. Daniel, M.F. Burgess, C.D. Derby, Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable usi...

journal_title：Brain research

authors： Burgess MF,Derby CD

更新日期：1997-10-17 00:00:00

abstract：:In order to establish the cellular and subcellular localization of the chemokine protein, vascular endothelial growth factor (VEGF) or vascular permeability factor, in adult human retina, we employed immunocytochemistry with double immunolabeling, using a primary antibody to amino acids 1-10 of VEGF, together with ant...

journal_title：Brain research

authors： Famiglietti EV,Stopa EG,McGookin ED,Song P,LeBlanc V,Streeten BW

更新日期：2003-04-18 00:00:00

abstract：:The effect of dopamine (DA) on the calcium-activated potassium conductance underlying the slow afterhyperpolarization (AHP) which follows a train of action potentials in hippocampal pyramidal cells was studied utilizing the in vitro hippocampal slice preparation. Bath-applied DA (1-100 microM) significantly reduced th...

journal_title：Brain research

authors： Malenka RC,Nicoll RA

更新日期：1986-08-06 00:00:00

abstract：:Neuromuscular patterns associated with the development of hindlimb stepping behaviors were studied from birth to postnatal day 60 in normal kittens. Hindlimb muscles were chronically implanted with EMG electrodes at birth to characterize interlimb coordination and intralimb synergies during development of overground a...

journal_title：Brain research

authors： Bradley NS,Smith JL

更新日期：1988-01-01 00:00:00

abstract：:In this study, we examined the immunohistochemical occurrence and distribution of glial cell line-derived neurotrophic factor (GDNF) in autoptic specimens of normal human hippocampus at different ages, from 22 weeks of gestation (w.g.) to adult life. Two different anti-GDNF polyclonal antibodies were used. Western blo...

journal_title：Brain research

authors： Pina Serra M,Quartu M,Ambu R,Follesa P,Del Fiacco M

更新日期：2002-02-22 00:00:00

abstract：:Two D-amino acid substitution angiotensin analogues were compared against native angiotensin II (AII) and angiotensin III (AIII) for their resistance to brain tissue-induced degradation and for pressor potency when intracerebroventricularly (i.c.v.) infused in Sprague-Dawley rats. The in vitro results indicate that [D...

journal_title：Brain research

authors： Wright JW,Roberts KA,Cook VI,Murray CE,Sardinia MF,Harding JW

更新日期：1990-04-23 00:00:00

abstract：:Interactive-activation models posit that visual word recognition involves co-activation of orthographic neighbors (e.g., note, node) and competition among them via lateral inhibitory connections. Behavioral evidence of this lexical competition comes from masked priming paradigms, in which target words elicit slower re...

journal_title：Brain research

authors： Meade G,Grainger J,Midgley KJ,Emmorey K,Holcomb PJ

更新日期：2018-04-15 00:00:00

abstract：:The extraction and utilization of sound level changes in acoustic-autonomic reflex systems were studied on a vasoconstriction response in the tail of nonanesthetized rats. The vasoconstriction was found to depend on sound level and changes of level in the following ways. (a) It increased as a linear function of sound ...

journal_title：Brain research

authors： Borg E

更新日期：1980-04-21 00:00:00