Abstract：
:The lack of the glycine transporter 1 (GlyT1) leads to early postnatal death due to failure of respiratory network activity. Here we demonstrate a segregated expression of GlyT1 on different astroglial cell populations of the ventral respiratory group. In TgN(hGFAP-EGFP) mice a combined immunohistochemical and electrophysiological approach was used to define the cellular expression of GlyT1 in the respiratory network. EGFP-labeled cells with outwardly rectifying current-voltage relationship did not express glycine transporter 1, while GlyT1 was abundantly expressed in mature protoplasmic astrocytes, which are electrophysiologically characterized by a large potassium conductance, a more negative membrane potential and the expression of glutamate transporters. Taken together, the vital capacity for the clearance of extracellular glycine is restricted to a subpopulation of astroglial cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Szoke K,Härtel K,Grass D,Hirrlinger PG,Hirrlinger J,Hülsmann Sdoi
10.1016/j.brainres.2006.08.089subject
Has Abstractpub_date
2006-11-13 00:00:00pages
182-9issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)02438-3journal_volume
1119pub_type
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