Abstract:
:In intracellular recordings from the CA1 region of the hippocampal slice preparation, an infrequent cell type different from the predominant pyramidal cell has been characterized. The cells have very brief spikes, hyperpolarizing after-potentials, and tend to fire at a high spontaneous rate; unitary synaptic potentials are visible in the baseline. Stimulation in stratum radiatum evokes an EPSP which often triggers a short burst of spikes; an IPSP invariably follows the initial excitation. Intracellular injection of HRP into these cells shows them to be a non-pyramidal cell type with extensive local axon ramification; however, they do not resemble the classical basket cell. These cells are, nevertheless, candidates for an interneuron in hippocampus.
journal_name
Brain Resjournal_title
Brain researchauthors
Schwartzkroin PA,Mathers LHdoi
10.1016/0006-8993(78)90991-5subject
Has Abstractpub_date
1978-11-17 00:00:00pages
1-10issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(78)90991-5journal_volume
157pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::A study of complex I (NADH:ubiquinone oxidoreductase) activity in Parkinson's disease (PD) brain has identified loss of activity only in substantia nigra although loss of activity of this enzyme has been identified in a number of non-brain tissues. We investigated this paradox by studying complex I and other complexes...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.061
更新日期:2008-01-16 00:00:00
abstract::Human arachnoid villi were studied ultrastructurally to clarify the mechanism of cerebrospinal fluid absorption. Arachnoid villi of humans showed quite different features from those of animals. The former were not always invested with endothelial linings as previously reported in the latter. Instead, there was a cover...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91220-5
更新日期:1986-10-01 00:00:00
abstract::Monoclonal antibody N210 (mabN210) recognizes the 210 kdalton neurofilament protein in mammals and gives characteristic immunocytochemical staining of neurofilament-rich processes. For example, in the cerebellum it recognizes myelinated axons and the calyx formed by basket cell axon collaterals. The distribution of ma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90937-6
更新日期:1986-07-23 00:00:00
abstract::We have explored the potential neuroprotective effect of local lentiviraly-mediated overexpression of nerve growth factor (NGF) on in vivo long-term potentiation (LTP) in the rat hippocampus under pathological conditions. The suspension of lentiviral particles was prepared using a genetic construct containing the huma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.07.051
更新日期:2015-10-22 00:00:00
abstract::Patients with sickle cell disease (SCD) can develop strokes and as a result, present neurologic and neurocognitive deficits. However, recent studies show that even without detectable cerebral parenchymal abnormalities on imaging studies, SCD patients can have significant cognitive and motor dysfunction, which can pres...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146968
更新日期:2020-11-01 00:00:00
abstract::Using psychophysical techniques, the ability of human subjects to discriminate the velocity of brush movement across the glabrous skin of the hand was determined. The same stimulus was then used in a series of neurophysiological experiments designed to determine the ability of neurons in the primary somatosensory cort...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90746-5
更新日期:1980-10-06 00:00:00
abstract::alpha(1)-Adrenoceptors are concentrated in the locus coeruleus (LC) where they appear to regulate various active behaviors but have been difficult to stimulate effectively. The present study examined the behavioral, pharmacological and neural effects of possible stimulation of these receptors with 6-fluoronorepinephri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.07.049
更新日期:2009-09-29 00:00:00
abstract::Projections to the rostral ventrolateral medulla (RVLM) and nucleus raphe magnus (NRM) appear to originate from neurones with overlapping distributions in the periaqueductal grey (PAG) as demonstrated by the retrograde transport of red and green fluorescent latex microspheres. Furthermore, double-labelling studies dem...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00784-6
更新日期:1996-09-09 00:00:00
abstract::The blood-brain barrier (BBB) permeability primarily increases in cerebral venules during acute hypertension. Methyl-β-cyclodextrin (MβCD), a cholesterol-depleting agent, decreases the expression of caveolins disrupting caveolar structures. We aimed to determine the effects of MβCD on the BBB permeability of angiotens...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.03.024
更新日期:2019-07-15 00:00:00
abstract::The responses of single alpha motoneurons to various "natural' stimuli were recorded from dissected ventral root filaments in lightly anesthetized control and recently decerebellate cats. The identity of the motoneurons was established by recording the unitary responses to orthodromic stimulation of nerves innervating...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90208-5
更新日期:1975-09-12 00:00:00
abstract::We describe a method to produce frog olfactory epithelium with a population of developmentally synchronized receptor cells suitable for electrophysiological studies. The epithelium is ablated with ZnSO4 and allowed to regenerate for 10 days. Generation of new cells is then blocked by continuous treatment with hydroxyu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90122-2
更新日期:1987-02-01 00:00:00
abstract::Administration of either Tyr-D-Ala-Gly-MePhe-Gly(ol) (DAGO), a mu-opioid agonist, or nicotine into the VTA (A10) caused an increase in both dopamine (DA) and its metabolite levels in both the A10 region and DA nerve terminals in the nucleus accumbens of rats when assessed with dual probe brain dialysis. These findings...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90087-4
更新日期:1993-10-08 00:00:00
abstract::The localization of adenosine receptors labelled with [3H]cyclohexyladenosine ([3H]CHA) and adenosine transport sites labelled with [3H]nitrobenzylthioinosine ([3H]NBI) was examined in striatum and superior colliculus (SC) using radioligand binding and lesioning methods. Striatal kainic acid lesions significantly redu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91033-4
更新日期:1986-01-22 00:00:00
abstract::Amitriptyline, a representative tricyclic antidepressant, has been widely used for the treatment of neuropathic pain, such as post-herpetic and trigeminal neuralgia. In the present study, we investigated the effect of amitriptyline on glycinergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) in acute...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.03.030
更新日期:2012-05-21 00:00:00
abstract::Nasal and temporal microexplants from the retina of the chicken embryo (E6; White Leghorn) were cultured on a collagen gel in the presence of extract from anterior or posterior E18 optic tectum. After 4 days of incubation maximum neurite lengths were measured as a function of protein concentration (1-500 micrograms/ml...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90085-x
更新日期:1987-01-01 00:00:00
abstract::In neonates, ventilatory responses to hypoxia are 'biphasic,' with an augmentation followed by a decline. The hypoxia-induced augmentations in ventilation are attenuated and the depressions are accentuated following denervation of the peripheral chemoreceptors. Piglets that were decerebrated at a rostral mesencephalic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01310-9
更新日期:1999-02-20 00:00:00
abstract::Using the hippocampal slice preparation, extracellular recordings of CA3 field excitatory postsynaptic potentials (fEPSPs) were performed to assess the effects of adenosine on the induction of mossy fiber long-term potentiation (LTP). When present during tetanization, adenosine (50 microM) significantly suppressed mos...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91061-5
更新日期:1991-03-08 00:00:00
abstract::Activation of kappa-opioid receptors (KOR) in the medial prefrontal cortex (mPFC) modulates excitatory transmission, which may involve interactions with N-methyl-D-aspartate (NMDA) glutamate receptors. We investigated possible anatomical correlates of this modulation by using dual labeling electron microscopy to exami...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02894-9
更新日期:2002-08-16 00:00:00
abstract::Two selectively bred lines of mice, one responding with high (HA) and the other with low analgesia (LA) to 3 min swims at 20 degrees C were compared with respect to naloxone ability to reverse such swim induced pain threshold elevation. Also, the analgesic effect of morphine was tested in both lines of mice. Naloxone ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91380-6
更新日期:1986-11-05 00:00:00
abstract::Peripheral nerve injury in animals can cause neuropathic pain often expressed in the form of hyperalgesia and allodynia. Spinal nerve ligation, in which the fifth and sixth lumbar (L5 and L6) or only the L5 spinal nerve is ligated and cut, is a model commonly used to produce neuropathic pain. The purpose of the presen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.02.089
更新日期:2008-05-07 00:00:00
abstract::The N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor is linked to an ion channel that is blocked by the phencyclidine analog N-(1-[thienyl]cyclohexyl)piperidine (TCP). Previous studies have shown that NMDA and glycine act together to increase the access of [3H]TCP to its binding site, presumably b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90918-2
更新日期:1990-05-21 00:00:00
abstract::High cell density, with attendant aggregation, selectively increases expression of substance P (SP) and choline acetyltransferase (ChAT) in virtually pure neonatal sympathetic neuronal cultures. To investigate the specific role of cell contact in selective transmitter expression, SP content and ChAT activity were exam...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(86)80202-5
更新日期:1986-12-01 00:00:00
abstract::The blockade of the lateral parabrachial nucleus (LPBN) with GABA(A) receptor agonist muscimol induces robust hypertonic NaCl and water intake by rats. In the present study we investigated the effects of previous injections of losartan (AT(1) angiotensin receptor antagonist) into the LPBN on 0.3M NaCl and water intake...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.06.004
更新日期:2011-07-27 00:00:00
abstract::Vanilloid (capsaicin) receptors were visualized by [3H]resiniferatoxin (RTX) autoradiography in the brain of newborn as well as adult (both control and colchicine-treated) rats. Specific labelling was seen in the brain stem only, in the nucleus of the solitary tract extending into the area postrema and the spinal sens...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01094-7
更新日期:1995-12-12 00:00:00
abstract::Glial cell line derived neurotrophic factor (GDNF) is a potent survival factor for several types of neurons. GDNF binds with high affinity to GDNF-family receptor alpha-1 (GFR alpha-1). This receptor is expressed in different areas of the brain, including the hippocampus and dentate gyrus. By using in situ hybridizati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02682-2
更新日期:2000-09-22 00:00:00
abstract::Adenosine, agmatine and kynurenic acid are endogenous ligands acting on different (e.g. adenosine, NMDA, alpha(2)-adrenergic and imidazoline) receptors with a potential role in nociception at the spinal level. Their antinociceptive effects have already been investigated as monotherapy, but only a few studies have repo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.09.039
更新日期:2004-12-10 00:00:00
abstract::Explicit memory is widely assumed to reflect the conscious processes of recollection and familiarity. However, familiarity has been hypothesized to be supported by nonconscious processing. In the present functional magnetic resonance imaging (fMRI) experiment, we assessed whether familiarity is mediated by some of the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.12.008
更新日期:2016-02-01 00:00:00
abstract::Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.12.058
更新日期:2009-03-09 00:00:00
abstract::Ongoing electrical activity was recorded from the axons of neurosecretory cells from the brain of 5th instar Rhodnius prolixus throughout the moulting cycle. Dramatic changes in both the frequency and pattern of electrical activity occur at specific times during the cycle, enabling the timing of release of neurohormon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90314-5
更新日期:1980-06-02 00:00:00
abstract:BACKGROUND:Cerebral ischemia is a major leading cause of death and at the first place cause of disability all over the world. There are a lot of drugs that are in experimental stage for treatment of stroke. Among them are calcium channel blockers (CCBs) that have, in animal models, different effectiveness in healing of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.038
更新日期:2007-10-24 00:00:00