Abstract：
:A study of complex I (NADH:ubiquinone oxidoreductase) activity in Parkinson's disease (PD) brain has identified loss of activity only in substantia nigra although loss of activity of this enzyme has been identified in a number of non-brain tissues. We investigated this paradox by studying complex I and other complexes of the mitochondrial electron transport chain in frontal cortex from PD and aged control brain using a variety of assay conditions and tissue preparations. We found increasingly significant losses of complex I activity in PD frontal cortex as increasingly pure mitochondria were studied. Complexes II, III, and IV were comparable in PD and controls. Inclusion of bovine serum albumin in the assay increased enzyme activity but lessened discrimination between PD and controls. Complex I deficiency in PD brain is not confined to substantia nigra. Methodological issues are critical in demonstrating this loss of activity.
journal_name
Brain Resjournal_title
Brain researchauthors
Parker WD Jr,Parks JK,Swerdlow RHdoi
10.1016/j.brainres.2007.10.061subject
Has Abstractpub_date
2008-01-16 00:00:00pages
215-8eissn
0006-8993issn
1872-6240pii
S0006-8993(07)02581-4journal_volume
1189pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:When observing bistable stimuli, the percept can change in the absence of changes in the stimulus itself. When intermittently presenting a bistable stimulus, the number of perceptual alternations can increase or decrease, depending on the duration of the period that the stimulus is removed from screen between stimulus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.078
更新日期：2009-02-03 00:00:00
abstract：:We previously reported a model of acute cochlear energy failure using a mitochondrial toxin, 3-nitropropionic acid (3-NP), to study mechanisms of inner ear disorders such as inner ear ischemia. In this model, the main cause of hearing loss is apoptosis of fibrocytes in the cochlear lateral wall. Here, we analyzed the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.08.062
更新日期：2011-10-24 00:00:00
abstract：:Changes in synaptic efficacy, including long-term potentiation (LTP) and long-term depression (LTD), provide mechanisms for experience-induced plasticity of cortical and subcortical circuits. LTP is readily induced under drastically different experimental conditions (e.g., in vitro and in vivo). However, few studies h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.063
更新日期：2010-03-08 00:00:00
abstract：:Oral ENA713 (0.5, 1.5 and 4.5 mg/kg), an acetylcholinesterase inhibitor (AChEI), dose-dependently enhanced extracellular acetylcholine concentrations in the hippocampus of freely moving rats. This effect was paralleled by changes in both noradrenergic and dopaminergic transmission. In particular, ENA713 significantly ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02266-6
更新日期：2000-05-26 00:00:00
abstract：:Two myelin sheaths sharing a common outer tongue process are illustrated in a thin section electron micrograph from mouse optic nerve. Although they derive from the same outer tongue process, and therefore from the same oligodendrocyte, the two sheaths are of different thicknesses (6 and 9 turns). The example demonstr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90712-6
更新日期：1983-09-12 00:00:00
abstract：:The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01952-6
更新日期：1999-10-16 00:00:00
abstract：:The central nervous system of the mollusc Helix pomatia was stimulated with NO donors sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) or hydroxylamine, in the presence of a phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine (IBMX). Radioimmunoassay revealed that all of the three NO donors signi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01147-5
更新日期：1998-01-12 00:00:00
abstract：:It has recently been shown that the immunosuppressant cyclosporin A (CsA) dramatically ameliorates the selective neuronal necrosis which results from 10 min of forebrain ischemia in rats. Since CsA is a virtually specific blocker of the mitochondrial permeability transition (MPT) pore which is assembled under adverse ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00005-x
更新日期：1997-04-04 00:00:00
abstract：:Emerging evidence that autophagy serves as a sweeper for toxic materials in the brain gives us new insight into the pathophysiology of neurodegenerative diseases. Autophagy is important for maintaining cellular homeostasis associated with metabolism. Some neurodegenerative diseases such as Alzheimer׳s and Parkinson׳s ...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.02.049
更新日期：2016-10-15 00:00:00
abstract：:The effect of electrical stimulation of the prefrontal cortex (PFC) on acetylcholine (ACh) release in the dorsal striatum was investigated using on line in vivo microdialysis. ACh output was sampled before, during and after 20-min periods of 50 and 100 microA stimulation in awake, unrestrained rats. Both currents incr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91754-x
更新日期：1994-03-14 00:00:00
abstract：:Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.05.008
更新日期：2005-06-28 00:00:00
abstract：:There is a large body of evidence indicating important interactions between the adenosine and opioid systems in regulating pain at both the spinal and supraspinal level. Mice lacking the mu-opioid receptor (MOR) gene have been successfully developed and the animals show complete loss of analgesic responses to morphine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02536-2
更新日期：2002-07-05 00:00:00
abstract：:Short, high frequency stimulation bursts (4 pulses at 100 Hz) were applied to Schaffer/commissural projections to the CA1 field of rat hippocampal slices at 0.1, 0.2, 1.0 or 2.0-s intervals to assess their efficacy in eliciting long-term potentiation (LTP). Bursts repeated at 2-s intervals induced very little LTP; sho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90579-2
更新日期：1986-03-19 00:00:00
abstract：:The putative involvement of the dopaminergic innervation of the medial part of the prefrontal cortex (PFC) in short-term memory functioning was investigated by evaluating the effects of local infusions of dopaminergic drugs into the ventral part of the medial PFC of rats in an operant delayed-matching-to-position (DMT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00025-l
更新日期：1995-03-20 00:00:00
abstract：:Kindling is an experimental model for epilepsy in which repeated stimuli induce longer electrographic seizures and eventually cause behavioral convulsions. Although kindling has some features that are similar to chronic human epilepsy, it is not known whether this process plays a role in the development of chronic sei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91071-y
更新日期：1993-10-22 00:00:00
abstract：:Poor sleep and insomnia have been recognized to be strongly correlated with the development of depression. The exploration of the basic mechanism of sleep disturbance could provide the basis for improved understanding and treatment of insomnia and prevention of depression. In this study, 31 subjects with insomnia symp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.024
更新日期：2016-10-01 00:00:00
abstract：:Neonatal MK-801 treatment from postnatal day 8-19 leads to long-term effects on brain function, suggesting that exposure to this drug leads to the development of a brain with immature network properties. One aspect of this hypothesis, that the NMDA receptors preserve their immature state after the treatment, has been ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91152-5
更新日期：1994-11-28 00:00:00
abstract：:Postsynaptic potentials evoked in motoneurons innervating m. posterior biceps and semitendinosus (PBSt) and m. triceps surae (GS) by low threshold afferents from various tail muscles located at the level of the second-third caudal vertebrae were investigated in the non-anesthetized and spinalized cat. Afferent inputs ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00039-0
更新日期：1998-03-30 00:00:00
abstract：:Attempts were made to determine the cells of origin of the spinal projections to the PAG using retrograde axoplasmic transport techniques of HRP and fluorescent markers. Following injections limited to the lateroventral subnucleus of the PAG, labels were transported to the contralateral laminae I, III, V, VII and X pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91127-7
更新日期：1983-03-28 00:00:00
abstract：:Single episodes of arousal of Syrian hamsters 2 h before projected activity onset (i.e., CT 10) phase-advanced their free-running circadian rhythm of wheel-running. Serial arousal once every 23 h or once every 23.5 h for 7 days caused large composite phase-advances to the wheel-running rhythm, the latter period being ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01314-8
更新日期：1996-02-12 00:00:00
abstract：:The behavioural response following infusion of a novel, stable substance P (SP) analogue, DiMe-C7, into the ventral tegmental area (VTA) of rats was characterized and contrasted with the response to an equal dose of the parent compound SP. DiMe-C7 produced a longer-lasting behavioural stimulation than SP as evidenced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90777-6
更新日期：1982-04-22 00:00:00
abstract：:In six decerebrated and in eight alpha-chloralose anesthetized, paralyzed and mechanically ventilated beagle dogs, we have studied involvement of glutamate and glutamate receptors in transmission of excitatory inputs from the airway sensory receptors to the nucleus tractus solitarius and from this site to airway-relat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02890-0
更新日期：2000-11-10 00:00:00
abstract：:Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity and the central terminal fields of branches of the mandibular and chorda tympani nerves were visualized histochemically at the same time using transganglionic transport of wheat germ agglutinin conjugated with horseradish peroxidase. The blue NA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01210-9
更新日期：1998-01-19 00:00:00
abstract：:We identified the burst and single-spiking cells, and the repetitive bursting cells in layers III and V of the cat sensorimotor cortex with intracellular recording and staining techniques. Both types of the bursting cells were found in 22.7% of the recorded layer V neurons and in 23.1% of the recorded neurons in layer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00505-7
更新日期：1996-07-15 00:00:00
abstract：:The effects of two kinds of antibiotics, minocycline (MNC) and ampicillin (AB-PC), on human sleep were investigated on 19 healthy male students to test for a relationship between human sleep and protein synthesis. These drugs and placebos were capsulated identically in appearance and were given to the subjects using t...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/0006-8993(83)90101-4
更新日期：1983-12-12 00:00:00
abstract：:Some kinds of nociception appear to be partially mediated by the release of substance P (SP) in the spinal cord dorsal horn from terminals of primary afferent nociceptors. Only some nociceptors contain and release SP however. Specifically, SP appears to be released by unmyelinated (C) nociceptive afferents when activa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01466-7
更新日期：1997-03-28 00:00:00
abstract：:The beneficial effects of angiotensin II type 1 (AT1) receptor blockers (ARB) in cerebrovascular disease have been shown in clinical trials. However, the effects of ARBs vary based on their unique pharmacologic properties. In this study, we focused on telmisartan, a fat-soluble ARB with selective peroxisome proliferat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.101
更新日期：2010-06-22 00:00:00
abstract：:High-intensity stimulation of the supraorbital region elicits, together with a blink reflex, a reflex inhibition of the jaw-closing muscles in normal man. The response differs from the well known inhibition obtained by intra- and perioral stimulation in two main features. Firstly, it consists of a single late silent p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90366-5
更新日期：1986-04-23 00:00:00
abstract：:The contribution of glutamatergic transmission to generation of initial convulsive seizures (CS) is debated. We tested whether pretreatment with a glutamine synthetase (GS) inhibitor, methionine sulfoximine (MSO), affects the onset and progression of initial CS by cholinergic stimulus in juvenile rats. Male rats (24 d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147253
更新日期：2021-02-15 00:00:00
abstract：:Neurotensin (NT) is an endogenous brain tridecapeptide for which high affinity binding sites exist in the central nervous system. We have investigated the effects of NT incubation with rat neostriatal slices on calcium/calmodulin (Ca/CaM)-dependent protein phosphorylation. Slices were incubated with NT (5 or 50 nM) fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91311-n
更新日期：1991-04-05 00:00:00
