Abstract:
:The effects of two kinds of antibiotics, minocycline (MNC) and ampicillin (AB-PC), on human sleep were investigated on 19 healthy male students to test for a relationship between human sleep and protein synthesis. These drugs and placebos were capsulated identically in appearance and were given to the subjects using the single blind method. MNC has been proven to prevent protein synthesis whereas AB-PC does not inhibit protein synthesis, and both antibiotics are commonly used in clinical practice. With the administration of a single dose of 200 mg of MNC, an apparent decrease in slow wave sleep (SWS) was revealed on the drug night and the effects lasted through the following two consecutive nights being given a placebo. REM sleep was not reduced on all the recording nights. On the other hand, both SWS and REM sleep were not reduced with the administration of a single dose of 500 mg of AB-PC. These results are different from those previously obtained from animal experiments since many kinds of protein synthesis inhibitors have been proven to suppress mainly REM sleep in animals. It might be supposed that the species difference may be responsible for this difference, and that some proteins or polypeptides induce human sleep, especially SWS.
journal_name
Brain Resjournal_title
Brain researchauthors
Nonaka K,Nakazawa Y,Kotorii Tdoi
10.1016/0006-8993(83)90101-4subject
Has Abstractpub_date
1983-12-12 00:00:00pages
253-9issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(83)90101-4journal_volume
288pub_type
临床试验,杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Repeated odorant or electrical stimulation of the frog olfactory nerve leads to long-lasting reduction of excitability of the receptor neurons. In the turtle olfactory nerve electrical stimulation causes an increase in extracellular potassium concentration due to the efflux of potassium from active axons. Elevated pot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90340-h
更新日期:1990-12-24 00:00:00
abstract::Ramified microglial cells were investigated in primary cultures of dissociated cerebral cortical tissue from rats. The identification of these cells was confirmed through immunohistochemical staining with 7 monoclonal antibodies selective for microglia. While there was significant variation in staining intensity with ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91118-k
更新日期:1991-05-10 00:00:00
abstract::The present study demonstrates changes in rat brain glial metabolism during the acute phase of epilepsy. Status epilepticus (SE) was induced using the lithium-pilocarpine model. Glial metabolism was measured with (14)C-acetate. Local cerebral blood flow and glucose metabolism were also measured using (14)C-N-isopropyl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.10.074
更新日期:2010-01-22 00:00:00
abstract::The present study investigated the hypothesis that social isolation increases aggression by increasing the number of V1a vasopressin receptors in the anterior hypothalamus (AH). Male hamsters were randomly assigned to a group that was allowed to interact with a small nonaggressive hamster three times each week for 3 w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.081
更新日期:2006-02-16 00:00:00
abstract::The distribution of agmatine (decarboxylated arginine) was mapped in the central nervous system (CNS) in the rat. Agmatine-like immunoreactivity was identified by light microscopy, exclusively in the cytoplasm of neuronal perikarya. Immunoreactive neurons were present in the cerebral cortex, predominantly within lamin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01200-6
更新日期:1998-03-16 00:00:00
abstract::Mice with reduced expression of the NR1 subunit of the NMDA receptor (NR1 hypomorphic mice) display altered behavioral phenotypes that may relate to behavioral characteristics of schizophrenia. Altered phenotypes in the NR1 hypomorphs include marked deficits in species-typical behavioral interactions in tests of socia...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.02.002
更新日期:2009-04-10 00:00:00
abstract::Trisomy 21 (Down syndrome) results in abnormalities in electrical membrane properties of cultured human fetal dorsal root ganglion (DRG) neurons. Action potentials have faster rates of depolarization and repolarization, with decreased spike duration, compared to diploid neurons. In order to analyze the faster depolari...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91372-n
更新日期:1990-03-05 00:00:00
abstract::Electrical stimulation of the subfornical organ (SFO) in urethane anesthetized male Sprague-Dawley rats was associated with intensity and frequency dependent increases in arterial blood pressure. Stimulation in the hypothalamic paraventricular nucleus (PVN) also evoked increases in arterial blood pressure. Electrolyti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90443-8
更新日期:1984-07-09 00:00:00
abstract::In this study, we investigated the modulatory effect of 5alpha-pregnan-3alpha-ol-20-one, a neurosteroid, on the binding characteristics of [3H]flunitrazepam (2 nM), [3H]muscimol (5 nM), and 4 nM [35S]t-butylbicyclophosphorothionate (TBPS) in cerebral cortex, cerebellum, and hippocampus of control, ethanol-dependent, a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00649-0
更新日期:1998-09-14 00:00:00
abstract::In the present study, we assessed the beneficial synergistic effects of concurrent treatment with low doses of cilostazol and probucol against focal cerebral ischemic infarct in rats. The ischemic infarct induced by 2-h occlusion of middle cerebral artery (MCA) and 22-h reperfusion was significantly reduced in rat bra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.051
更新日期:2007-07-09 00:00:00
abstract::Up to today, the neuronal bases of activating and establishing a memory trace are not well understood. Several findings point towards the idea that the activation of an engram is mirrored in induced oscillatory bursts in the gamma frequency range (> 20 Hz; induced gamma band responses; iGBRs). In the present study, we...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.069
更新日期:2006-06-30 00:00:00
abstract::Delta-9-tetrahydrocannabinol (Delta(9)-THC), the main psychoactive component of marijuana, is known to dysregulate various immune responses. Cannabinoid (CB)-1 and -2 receptors are expressed mainly on cells of the central nervous system (CNS) and the immune system. The CNS is the primary target of cannabinoids and ast...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.062
更新日期:2008-01-29 00:00:00
abstract::The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adeno...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91604-q
更新日期:1993-08-13 00:00:00
abstract::Immunofluorescence on primary dissociated rat neuronal cultures (cortical, hippocampal, and cerebellar) and organotypic hippocampal cultures was used to investigate the pattern of distribution of cell-surface amyloid protein (APP). Antibodies directed against the extracellular (N-terminal) portion of APP or against th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00608-7
更新日期:1996-10-07 00:00:00
abstract::Effects of iontophoretically applied dopamine were investigated in prefrontal neurons of the monkey which showed activity changes during a visual reaction time task. The task consisted of an initial waiting phase (3.0 s), a warning phase (green lamp, 1.5-3.5 s), a lever-release GO phase (red lamp) and a reward phase. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90385-9
更新日期:1986-04-23 00:00:00
abstract::In the present research the role of gender in MDMA-induced hyperthermia and serotonin depletion is studied by injecting male and female male rats with MDMA or saline 3 times (i.p.) with 3h interval at dosages of 0.3, 1, 3 or 9 mg/kg at an ambient temperature of 25°C. The acute hyperthermia following the higher dosages...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.04.039
更新日期:2011-06-29 00:00:00
abstract::Fluoro-Jade B is known as a high affinity fluorescent marker for the localization of neuronal degeneration during acute neuronal distress. However, one study suggested that fluoro-Jade B stains reactive astroglia in the primate cerebral cortex. In this study, we analyzed the staining of fluoro-Jade B alone or combined...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.050
更新日期:2007-01-12 00:00:00
abstract::A growth hormone (GH) injection is able to induce the phosphorylated form of the signal transducer and activator of transcription 5 (pSTAT5) in a large number of cells throughout the mouse brain. The present study had the objective to map the distribution of GH-responsive cells in the brain of rats that received an in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147189
更新日期:2021-01-15 00:00:00
abstract::A rabbit polyclonal antibody (91-01) was raised against recombinant human glia maturation factor beta (r-hGMF-beta). The antibody did not cross-react with a number of other growth factors on ELISA test. When compared with the monoclonal antibody G2-09 previously obtained, 91-01 immunoblotted the same protein band in r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90971-b
更新日期:1992-09-18 00:00:00
abstract::Morphological, electrophysiological and behavioral studies were carried out in cats after unilateral kainic acid injection in the substantia nigra. A forced contralateral head turning and compulsive circling was observed after surgery. Fifteen days after, when asymmetry disappeared, apomorphine induced an ipsilateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91002-x
更新日期:1987-03-03 00:00:00
abstract::Opioid peptides and their receptors have been localized to the inner ear of the rat and guinea pig mammalian models. The expression of mu opioid receptor (MOR) in the human and mouse cochlea is not yet known. We present MOR protein localization by immunohistochemistry and mRNA expression by in situ hybridization in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.09.051
更新日期:2014-11-24 00:00:00
abstract::Contradictory results have been reported with regard to the effects of various models of hepatic encephalopathy on the blood-brain barrier (BBB) permeability, which may be due partly to the use of brain concentrations of BBB markers without attention to their peripheral pharmacokinetics. The purpose of the current stu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.07.040
更新日期:2013-09-19 00:00:00
abstract::The ability to adapt a variety of motor acts to compensate for persistent natural or artificially induced errors in movement accuracy requires the cerebellum. For adaptation of the rapid shifts in the direction of gaze called saccades, the oculomotor vermis (OMV) of the cerebellum must be intact. We disrupted the neur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.05.027
更新日期:2011-07-15 00:00:00
abstract::Nuclear factor one X (NFIX) has been shown to play a pivotal role during the development of many regions of the brain, including the neocortex, the hippocampus and the cerebellum. Mechanistically, NFIX has been shown to promote neural stem cell differentiation through the activation of astrocyte-specific genes and via...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.04.057
更新日期:2015-08-07 00:00:00
abstract::In adult rodents, neuroblasts originating from the subventricular zone migrate tangentially through the rostral migratory stream (RMS) toward the olfactory bulb where they differentiate into interneurons. Neuroblasts in the RMS migrate in chains for a long distance along specifically arranged blood vessels which promo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.08.010
更新日期:2018-11-01 00:00:00
abstract::Parkinson's disease (PD) is characterized by progressive degeneration of nigrostriatal dopaminergic neurons. Several factors such as inhibition of the mitochondrial respiration, generation of hydroxyl radicals and reduced free radical defense mechanisms causing oxidative stress, have been postulated to contribute to t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02994-2
更新日期:2001-02-23 00:00:00
abstract::In the preceding series of articles, the history of vertebrate motoneuron and motor unit neurobiological studies has been discussed. In this article, we select a few examples of recent advances in neuroscience and discuss their application or potential application to the study of motoneurons and the control of movemen...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2011.06.008
更新日期:2011-08-29 00:00:00
abstract::The neural connections from the ventral pallidum (VP) through the mediodorsal nucleus of the thalamus (MD) to the medial prefrontal cortex (MPC) were investigated. Extracellular recordings were made from 219 neurons in the medial and lateral portions of the MD and the VP and the MPC were stimulated. The most frequent ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90811-x
更新日期:1985-10-07 00:00:00
abstract::In the adult central nervous system (CNS), GABA and glycine (Gly) are predominant inhibitory neurotransmitters, negatively regulating glutamatergic transmission. In the immature CNS, on the other hand, they act as trophic factors, mediating morphogenesis. In the present study, to investigate their involvement in axona...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.01.048
更新日期:2012-03-29 00:00:00
abstract::Astaxanthin (AST) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. Much experimental evidence has proved that AST has the function of eliminating oxygen free radicals and can protect organisms from oxidative damage. The present study was carried out to further investigate the neur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.09.016
更新日期:2010-11-11 00:00:00