Hypothalamic paraventricular nucleus lesions decrease pressor responses to subfornical organ stimulation.

abstract：:One monoclonal antibody 115A10 (MAb 5A10) specifically stained a subpopulation of retinal bipolar cells in various vertebrates. In the bullfrog retina, MAb 5A10 stained the large bipolar cells, but not the small bipolar cells. Labeling of the living bipolar cells was observed in isolated cell preparation of the frog r...

journal_title：Brain research

authors： Onoda N,Fujita SC

更新日期：1987-07-28 00:00:00

abstract：:In freely-moving female rats the effects of intraventricular infusion of norepinephrine (NE) on multiunit activity (MUA) were examined in the Diagonal Band of Broca (DBB), medial preoptic area (MPOA) and anterior hypothalamic area (AHA), regions containing neurons producing luteinizing hormone-releasing hormone (LHRH)...

journal_title：Brain research

authors： Leung PC,Whitmoyer DI,Arendash GW,Sawyer CH

更新日期：1981-12-07 00:00:00

abstract：:We have examined the effects of isotonic hypovolemia on the expression of the neuronal nitric oxide synthase (nNOS) gene in the paraventricular (PVN) and supraoptic nuclei (SON) of the rat, using in situ hybridization histochemistry with a 35S-labelled oligodeoxynucleotide probe complementary to nNOS mRNA. Intraperito...

journal_title：Brain research

authors： Ueta Y,Levy A,Lightman SL,Hara Y,Serino R,Nomura M,Shibuya I,Hattori Y,Yamashita H

更新日期：1998-04-20 00:00:00

abstract：:A quantitative freeze-fracture study of perivascular astrocytic processes in rat cerebral cortex disclosed rapid disintegration of orthogonal arrays of the intramembrane particles in acute global ischemia. The process apparently preceded the development of astrocytic swelling. ...

journal_title：Brain research

authors： Suzuki M,Iwasaki Y,Yamamoto T,Konno H,Yoshimoto T,Suzuki J

更新日期：1984-05-21 00:00:00

abstract：:Alcohols and volatile anesthetics modulate the function of cys-loop ligand-gated ion channels, binding to a putative site between transmembrane domains two and three. The extracellular linker between these two domains is important in the transduction of the gating signal from the glycine binding site to the channel ga...

journal_title：Brain research

authors： Dupre ML,Broyles JM,Mihic SJ

更新日期：2007-06-04 00:00:00

abstract：:Two-day-old rats were pretreated with 50 mg/kg of capsaicin. After 3--4 months, specific binding of [3H]muscimol and [3H]strychnine was measured in membrane preparations from dorsal spinal cord. A 20-30% decrease of the number of [3H]muscimol binding sites was observed after capsaicin treatment. In contrast, [3H]stryc...

journal_title：Brain research

authors： Singer E,Placheta P

更新日期：1980-12-08 00:00:00

abstract：:In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). In the freshwater planarian Dugesia japonica, which bel...

journal_title：Brain research

authors： Itoh MT,Shinozawa T,Sumi Y

更新日期：1999-05-29 00:00:00

abstract：:Development and aging are often mirror image processes and this may be equally true in the effects of estradiol, a potent endogenous steroid regulating brain development as well as a therapeutic used to relieve the negative components of perimenopause. Both the developing and perimenopausal brain are characterized by ...

journal_title：Brain research

authors： McCarthy MM

更新日期：2011-03-16 00:00:00

abstract：:The roles of noradrenergic and serotonergic projections to the hippocampus were investigated with respect to their involvement in the intracranial self-stimulation of this structure. In the first study, 6-hydroxydopamine-induced lesions of the dorsal tegmental noradrenergic bundle, which depleted hippocampal NE by 97%...

journal_title：Brain research

authors： van der Kooy D,Fibiger HC,Phillips AG

更新日期：1977-11-04 00:00:00

abstract：:The entire set of giant interneurons (GIs) in the nerve cord of the cockroach, Periplaneta americana, was ablated using either electrolytic or surgical techniques. All animals with these lesions were capable of turning and running away from standard wind puffs. However, all animals responded much less frequently to st...

journal_title：Brain research

authors： Comer CM,Dowd JP,Stubblefield GT

更新日期：1988-04-05 00:00:00

abstract：:Experimental studies and clinical observations show that spinal cord lesions are greatly enlarged by a process called secondary cell death. A detailed understanding of the molecular and cellular processes underlying these events is still lacking. In clinical studies using methylprednisolone in spinal cord injured pati...

journal_title：Brain research

authors： Bartholdi D,Schwab ME

更新日期：1995-02-20 00:00:00

abstract：:An involvement of serotonin (5-HT) 1A receptors in the etiology of psychiatric disorders has been suggested. Hypo-responsiveness of the 5-HT1A receptor is linked to anxiety and constitutive deletion of the 5-HT1A receptor produces anxiety-like behaviors in the mouse. Evidence that 5-HT1A receptor inactivation increase...

journal_title：Brain research

authors： He M,Sibille E,Benjamin D,Toth M,Shippenberg T

更新日期：2001-05-25 00:00:00

abstract：:The outer plexiform layer (OPL) of the retina has been studied in the developing cat, from E (embryonic day) 30. Prior to E51 the layer could not be detected, the retina comprising two cell layers, an inner layer which becomes the ganglion cell layer of the adult, and an outer 'neuroblast' layer. The OPL was first det...

journal_title：Brain research

authors： Rapaport DH,Stone J

更新日期：1982-11-01 00:00:00

abstract：:The retinohypothalamic tract, a monosynaptic retinal projection to the suprachiasmatic nucleus (SCN), is the path by which light entrains the circadian system to the external photoperiod. Serotonergic neurons in the mesencephalic median raphe nucleus (MnR) also give rise to a major SCN afferent projection. The present...

journal_title：Brain research

authors： Muscat L,Tischler RC,Morin LP

更新日期：2005-05-17 00:00:00

abstract：:The present in vitro study was performed to characterize neurons within dorsal regions of the nucleus tractus solitarii (NTS), principally at the level of area postrema, and known to receive inputs predominantly from cardiovascular and respiratory afferents (i.e. cardiorespiratory NTS). This report describes 4 classes...

journal_title：Brain research

authors： Paton JF,Foster WR,Schwaber JS

更新日期：1993-02-26 00:00:00

abstract：:The aim of this study was to investigate the relationship between serum metabolomic biomarkers and brain in vivo magnetic resonance spectroscopy (MRS) biomarkers in patients with Parkinson's disease (PD) as well as to investigate compound concentration changes by comparing the results with healthy control subjects. Un...

journal_title：Brain research

authors： Toczylowska B,Zieminska E,Michałowska M,Chalimoniuk M,Fiszer U

更新日期：2020-12-01 00:00:00

abstract：:Behavioral stress is likely to contribute to the development of hypertension in susceptible individuals. We reported that hemodynamic response patterns to acute startle vary and that those patterns predict the predisposition of rats to sustained stress-induced elevations in arterial pressure. Since considerable eviden...

journal_title：Brain research

authors： Tan Y,Gan Q,Knuepfer MM

更新日期：2003-04-04 00:00:00

abstract：:Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CB1 re...

journal_title：Brain research

authors： Araujo BH,Torres LB,Cossa AC,Naffah-Mazzacoratti Mda G,Cavalheiro EA

更新日期：2010-06-04 00:00:00

abstract：:The synaptic regulatory mechanism of resting membrane potential of layer III and V pyramidal neurons was analyzed intracellularly in the slice preparation of cat sensorimotor cortex. During the tetanic stimulation of white matter, subthreshold membrane depolarization was induced, and after that, a slowly developing hy...

journal_title：Brain research

authors： Kitagawa H,Nishimura Y,Kumazawa Y,Akamine T,Yamamoto T

更新日期：2000-06-30 00:00:00

abstract：:The activity of incertohypothalamic, tuberoinfundibular, mesolimbic and nigrostriatal dopamine (DA) neurons was estimated by measuring the rate of turnover of DA (decline of DA after alpha-methyltyrosine) in brain regions containing the cell bodies and terminals of these neurons. Estradiol benzoate (25 micrograms/kg/d...

journal_title：Brain research

authors： Lookingland KJ,Moore KE

更新日期：1984-12-03 00:00:00

abstract：:Beta-amyloid (Abeta) peptides, the major component of senile plaques in brains of patients with Alzheimer's disease (AD), were found in the low pH organelles (i.e. endosome/lysosome) of cultured neuronal cells. Since acidic pH values have been shown to promote the self-assembly of Abetas, which seems to be a prerequis...

journal_title：Brain research

authors： Su Y,Chang PT

更新日期：2001-03-02 00:00:00

abstract：:Intracellular and extracellular recordings from CA3 hippocampal neurons in vitro were used to study the ability of several NMDA (N-methyl-D-aspartate) receptor antagonists to suppress epileptiform bursts induced by NMDA and convulsants not thought to act at NMDA receptors. The antagonists, APV (D-2-amino-5-phosphonova...

journal_title：Brain research

authors： Neuman R,Cherubini E,Ben-Ari Y

更新日期：1988-09-06 00:00:00

abstract：:The muscarinic cholinergic receptor of rat eccrine sweat gland was characterized using quantitative autoradiography and [3H]QNB as radioligand. The distribution of radioligand was maximal in the secretory coil. Autoradiographic competition binding studies were performed using selective antagonists to M1 (pirenzepine),...

journal_title：Brain research

authors： Torres NE,Zollman PJ,Low PA

更新日期：1991-05-31 00:00:00

abstract：:Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in Lewy bodies (LB). To gain further insight into the pathogenesis of PD we investigated the role of neurofilament lig...

journal_title：Brain research

authors： Rahner N,Holzmann C,Krüger R,Schöls L,Berger K,Riess O

更新日期：2002-09-27 00:00:00

abstract：:Perinatal overfeeding is a risk factor for overweight and diabetes during life. Underlying pathophysiological mechanisms are unclear. The peptide galanin is suggested to stimulate food intake by acting within the paraventricular hypothalamic nucleus (PVN). In early postnatally overfed rats overweight and hyperinsuline...

journal_title：Brain research

authors： Plagemann A,Harder T,Rake A,Melchior K,Rohde W,Dörner G

更新日期：1999-02-06 00:00:00

abstract：:The pleiotropic cytokine tumor necrosis factor-alpha (TNFalpha) is implicated in the development of persistent pain through its actions in the periphery and in the central nervous system (CNS). Activation of the alpha(2)-adrenergic receptor is associated with modulation of pain, possibly through its autoregulatory eff...

journal_title：Brain research

authors： Covey WC,Ignatowski TA,Knight PR,Spengler RN

更新日期：2000-03-17 00:00:00

abstract：:(2E)-(5-Hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid (NCS-382) is an antagonist for gamma-hydroxybutyric acid (GHB) at GHB receptor sites. Advantages of using [(3)H]NCS-382 over [(3)H]GHB in radioligand binding studies are that unlike GHB, NCS-382 does not appear to bind to, activate, or i...

journal_title：Brain research

authors： Gould GG,Mehta AK,Frazer A,Ticku MK

更新日期：2003-07-25 00:00:00

abstract：:The neural representation of facial expression within the human visual system is not well defined. Using an adaptation paradigm, we examined aftereffects on expression perception produced by various stimuli. Adapting to a face, which was used to create morphs between two expressions, substantially biased expression pe...

journal_title：Brain research

authors： Fox CJ,Barton JJ

更新日期：2007-01-05 00:00:00

abstract：:Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine a...

journal_title：Brain research

authors： Pérez-Otaño I,Herrero MT,Oset C,De Ceballos ML,Luquin MR,Obeso JA,Del Río J

更新日期：1991-12-13 00:00:00

abstract：:Axonal loss and degeneration in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE) have been suggested by brain imaging, pathological and axonal transport studies. Further elucidation of the processes and mechanisms of axonal degeneration in demyelinating diseases is therefore of potential impor...

journal_title：Brain research

authors： Zhu B,Moore GR,Zwimpfer TJ,Kastrukoff LF,Dyer JK,Steeves JD,Paty DW,Cynader MS

更新日期：1999-04-10 00:00:00