Abstract：
:The synaptic regulatory mechanism of resting membrane potential of layer III and V pyramidal neurons was analyzed intracellularly in the slice preparation of cat sensorimotor cortex. During the tetanic stimulation of white matter, subthreshold membrane depolarization was induced, and after that, a slowly developing hyperpolarization was induced in the normal solution. When the membrane potential showed a slow change, spike duration and input resistance did not change and evoked single synaptic response did not reveal the enhancement of slow IPSPs. However, afterhyperpolarization following action potential was enhanced. The slow hyperpolarization and the enhancement of afterhyperpolarization were not observed in the cells treated with an NMDA receptor antagonist or a calcium channel blocker Ni(2+) (50-100 microM), or the cells hyperpolarized more than -80 mV before the tetanic stimulation.
journal_name
Brain Resjournal_title
Brain researchauthors
Kitagawa H,Nishimura Y,Kumazawa Y,Akamine T,Yamamoto Tdoi
10.1016/s0006-8993(00)02353-2subject
Has Abstractpub_date
2000-06-30 00:00:00pages
69-77issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02353-2journal_volume
869pub_type
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