Abstract:
:Met-enkephalin-like immunoreactivity in microdialysates from the respiratory-related nucleus tractus solitarii was determined simultaneously with ventilatory responses in seven, spontaneously breathing, developing swine under conditions of normoxia, hypoxia and recovery from hypoxia for 30 min each. Assayed levels of Met-enkephalin-like immunoreactivity in normoxia were 0.89 +/- 0.23 pg/microliters. These levels increased to 203.6 +/- 32.2% and 283.1 +/- 55.8% of control during hypoxia and recovery, respectively. Hyperventilation during hypoxia was not sustained, comprising brief stimulation followed by return to near-control level. Taken together, these results provide further evidence that opioid release may contribute to the suppression of ventilation in hypoxia during development.
journal_name
Brain Resjournal_title
Brain researchauthors
Yan S,Zhang C,Laferrière,Moss IRdoi
10.1016/0006-8993(95)00541-wsubject
Has Abstractpub_date
1995-07-31 00:00:00pages
217-20issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)00541-Wjournal_volume
687pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The potential shifts (delta Vo) associated with spreading depression (SD) were analysed with the help of multiple extracellular recording and ion-selective microelectrodes in the CA1 region of the dorsal hippocampus of anesthetized rats. Recurrent waves of SD were induced by perfusing high K+ solution through microdia...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91412-l
更新日期:1993-05-07 00:00:00
abstract::There is a sizeable literature concerning basal ganglia (BG) functioning that is based on data from experiments employing a method of analysis that is traditionally used with other motor areas. A brief review of this literature is presented and the following conclusion is reached: as compared to the success of traditi...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/0165-0173(85)90010-4
更新日期:1985-06-01 00:00:00
abstract::The development of bombesin-like peptides and their receptors was determined in 9 different rat brain regions. The concentration of immunoreactive bombesin increased dramatically in all brain regions examined during the third week after birth. In contrast, the density of [125I-Tyr4]bombesin binding sites was near maxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90107-x
更新日期:1984-08-01 00:00:00
abstract::Ibotenic acid lesions of the vertical limb of the diagonal band of Broca (VDB) in marmosets produced significant depletions in choline acetyltransferase (ChAT) activity and a decrease in acetylcholinesterase (AChE) staining in the hippocampal formation and entorhinal cortex (to which the cholinergic neurones of the VD...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90348-4
更新日期:1988-07-19 00:00:00
abstract::Experiments were conducted to (1) provide further evidence of the selectivity of [D-Ala2,Leu5,Cys6]enkephalin (DALCE) as an antagonist of delta (delta) receptor ligands and (2) use DALCE as a tool to explore the possible role of delta receptors in restraint stress. Dose- and time-response curves were generated for the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90545-m
更新日期:1990-02-19 00:00:00
abstract::Dopaminergic neurotoxicities of 6-hydroxydopamine (6-OHDA) and the lipopolysaccharide (LPS) were compared in rat mesencephalic cultures plated on poly-L-lysine or on glial monolayers. In the neuron-enriched cultures plated on polylysine, 6-OHDA killed 89% of the tyrosine hydroxylase (TH)-immunopositive neurons, but LP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01189-7
更新日期:1995-12-15 00:00:00
abstract::Estrogen effects on tyrosine hydroxylase (TH), monoamine oxidase types A and B (MAO), and dopamine (DA) in microdissected regions of the hypothalamus, preoptic area and substantia nigra (SNR) of the female rat brain were investigated. Ovariectomized (OVX) young adult female rats were implanted with single silastic cap...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90730-y
更新日期:1990-02-26 00:00:00
abstract::This work describes the change in an active electrogenesis of the command neurons responsible for defensive closure of a snail's pneumostome during elaborating, extinction and restoration of a classical conditioned defensive reflex to a tactile stimulus. Tactile stimulations applied to different parts of a snail's bod...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91453-l
更新日期:1992-11-06 00:00:00
abstract::Peripheral axotomy in neonatal rats induces neuronal death. We studied the anti-apoptotic protein Bcl-2 and cell death promoter Bax in spinal cord of neonatal rats after sciatic transection and treatment with melatonin, a neuroprotective substance. Pups were unilaterally axotomized at P2 and received melatonin (1 mg/k...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.07.021
更新日期:2006-09-27 00:00:00
abstract::The effects of intracerebroventricular injections of 8-OH-DPAT (a 5-HT1A agonist; 3, 15 or 30 nmol) or GR46611 (a 5-HT1B/1D agonist; 3, 15 or 30 nmol) on feeding, drinking, preening and sleep-like behaviors were investigated in free-feeding (FF) pigeons. The effects of these 5-HT agonists on blood glucose and free fat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.08.031
更新日期:2004-11-12 00:00:00
abstract::For the purpose of obtaining chemical information about the physiological role of N-acetylaspartylglutamate (NAAG), the release of endogenous NAAG from and the uptake of [3H]NAAG by Guinea pig cerebellar slices were investigated in comparison with L-aspartate (Asp) and L-glutamate (Glu). Although endogenous NAAG was f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90544-1
更新日期:1989-03-13 00:00:00
abstract::The purpose of this study was to investigate autofluorescent pigment granules (lipofuscin, ceroid) in the trigeminal neurons (TN) during aging and streptozotocin-induced diabetes. Four young adult male rats were injected with streptozotocin (STZ; 50 mg/kg) to produce diabetes (DM), for comparison with four young uninj...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.033
更新日期:2004-02-27 00:00:00
abstract::Several studies, using electrical stimulation of parts of the hypothalamus, have shown, that different parts of the hypothalamus yield different behavioural responses upon stimulation. In order to differentiate between stimulation of neuronal cell bodies and passing fibres and to investigate the role of GABA in hypoth...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91122-9
更新日期:1993-06-25 00:00:00
abstract::The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the basolateral amygdala were measured by in vivo microdialysis. Inescapable, but not escapable, shock increased extracellular 5-HT in the amygdala relative to restrained controls. Basal levels of 5-HT wer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00960-3
更新日期:1998-11-23 00:00:00
abstract::Recently, a novel method for detection of DNA synthesis has been developed based on the incorporation of 5-ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, into cellular DNA and the subsequent reaction of EdU with a fluorescent azide in a copper-catalyzed [3+2] cycloaddition ("Click" reaction). In the present stud...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.12.092
更新日期:2010-03-10 00:00:00
abstract::A common feature of many neurodegenerative disorders is an abundance of activated glial cells (astrocytes and microglia). In Alzheimer's disease (AD), activated astrocytes are in close apposition to and surrounding the amyloid plaques. The mechanisms by which the astrocytes become activated in AD and the consequences ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01318-8
更新日期:1998-03-02 00:00:00
abstract::To account for deficits in interval timing observed in Parkinson's Disease (PD) patients, we develop a model based on the accumulating firing rate of a neural population with recurrent excitation. This model naturally produces the curvilinear accumulation of neural activity introduced to timing psychophysics by Miall ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.10.070
更新日期:2006-01-27 00:00:00
abstract::Cerebellar explants derived from neonatal mice were exposed to cytosine arabinoside, an inhibitor of DNA synthesis. Following such exposure, the cortical regions of the explants contained numerous closely packed large neurons with few intervening elements and without lamination. The surviving large cortical neurons in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90984-1
更新日期:1980-03-31 00:00:00
abstract::Intra- and interhemispheric connections between the anterior ectosylvian visual area (AEV) and other visual cortical areas including the lateral suprasylvian (LSS) were examined in the cat using the retrograde double-label fluorescence technique. The areal and laminar distributions of labeled neurons were mapped follo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90189-1
更新日期:1985-11-18 00:00:00
abstract::Purkinje cell dendritic arborizations were studied in HRP intracellularly stained mature neurons grown during 30-50 days in organotypic cerebellar cultures from newborn kittens. The effects of afferent fiber depletions on the final dendritic topological parameters were investigated by computer assisted methods. Three ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90051-3
更新日期:1983-12-05 00:00:00
abstract::Previous studies have shown that one of the genetic variants BDNF val66met polymorphism is associated with drug addiction. Age at onset for drugs abuse has also been regularly cited as a factor associated with high genetic predispositions. We conducted an exploratory research to investigate the association of BDNF val...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.022
更新日期:2010-09-24 00:00:00
abstract::Because the occurrence of rapid eye movement (REM) sleep is critically dependent upon an animal's thermal balance, acute pharmacological treatments may effect REM sleep through effects on thermoregulation. We describe how manipulating ambient temperature (T(a)) alters the REM sleep-suppressing effects of systemically-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90184-8
更新日期:1994-02-04 00:00:00
abstract::Time-course expression of Bax and Bcl-2 proteins, identified as apoptosis-regulating molecules, was assessed in gerbil hippocampus following transient forebrain ischemia. Brain sections from animals sacrificed at 48, 72, 96 h and 7 days following 5 min ischemia were immunohistochemically evaluated using polyclonal ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01436-5
更新日期:1996-03-04 00:00:00
abstract::A single electrode voltage clamp was used to examine the prolonged hyperpolarizing afterpotential (PHA) which accompanies photoconversion of a substantial fraction of rhodopsin (lambda max = 500 nM) to metarhodopsin (lambda max = 575 nM) in distal photoreceptor cells in the retina of the bay scallop, Pecten irradians....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90539-x
更新日期:1982-05-13 00:00:00
abstract::It has recently been shown that the lobules 9 and 10 of the cerebellum contain high densities of dopamine D3 receptors (and almost no D2 receptors [Bouthenet, M.L., Souil, E., Martres, M.P., Sokoloff, P., Giros, B. and Schwartz, J.C., Brain Res., 564 (1991) 203-219; Sokoloff, P., Giros, B., Martres, M.P., Bouthenet, M...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00964-x
更新日期:1996-10-21 00:00:00
abstract::In order to analyze the mechanism of burst discharges intracellular recordings were made from 27 somatosensory thalamic reticular (S-TR) neurons in urethane-anesthetized rats. Burst discharges, composed of 2-7 spikes, were always superposed on a slow depolarization (SD) lasting for 40-60 ms, which appeared only when t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90539-8
更新日期:1989-03-13 00:00:00
abstract::The effects of the serotonin precursor 5-HTP, were determined in a behavioral DNIC paradigm (increase in vocalization threshold after intraperitoneal injection of the algogenic agent, phenylbenzoquinone). This counter-irritation phenomenon was strongly potentiated by 5-HTP, such potentiation being blocked by the 5-HT ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90384-5
更新日期:1982-01-14 00:00:00
abstract::The neurons that produce gonadotrophin-releasing hormone (GnRH) are mainly found in the medial preoptic area (MPOA) and constitute a common final pathway to the control of luteinizing hormone (LH) surge on proestrus. The control of GnRH secretion depends on several neurotransmitters, such as serotonin (5-HT), noradren...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.045
更新日期:2007-04-20 00:00:00
abstract::Astrocytes produce and bind endothelins (ETs), suggesting that these cells have ET autoregulatory and eliminatory functions. To further investigate these functions in primary rat astrocytes, ET-1 levels in the cell culture media (RIA/HPLC) and intracellular content of ET-1 mRNA (RT PCR) were measured under basal and s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01368-1
更新日期:1998-03-02 00:00:00
abstract::We have examined the influence of reducing conditions on the activity of group-I or -II metabotropic glutamate receptors. In cultured cerebellar granule cells or in hippocampal slices, the reducing agent dithiothreitol (DTT) inhibited the stimulation of polyphosphoinositide (PPI) hydrolysis elicited by group-I mGlu re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02293-9
更新日期:2000-06-09 00:00:00