Met-enkephalin-like immunoreactivity in microdialysates from nucleus tractus solitarii in piglets during normoxia and hypoxia.

Abstract:

:Met-enkephalin-like immunoreactivity in microdialysates from the respiratory-related nucleus tractus solitarii was determined simultaneously with ventilatory responses in seven, spontaneously breathing, developing swine under conditions of normoxia, hypoxia and recovery from hypoxia for 30 min each. Assayed levels of Met-enkephalin-like immunoreactivity in normoxia were 0.89 +/- 0.23 pg/microliters. These levels increased to 203.6 +/- 32.2% and 283.1 +/- 55.8% of control during hypoxia and recovery, respectively. Hyperventilation during hypoxia was not sustained, comprising brief stimulation followed by return to near-control level. Taken together, these results provide further evidence that opioid release may contribute to the suppression of ventilation in hypoxia during development.

journal_name

Brain Res

journal_title

Brain research

authors

Yan S,Zhang C,Laferrière,Moss IR

doi

10.1016/0006-8993(95)00541-w

subject

Has Abstract

pub_date

1995-07-31 00:00:00

pages

217-20

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(95)00541-W

journal_volume

687

pub_type

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