Abstract:
:Social defeat is a powerful experience that often leads to drastic physiological and behavioral changes in many animal species. An example of such a change is conditioned defeat in Syrian hamsters. The neurophysiological mechanisms that underlie such changes are not yet fully understood, however, there is evidence that the amygdala plays an essential role in behavioral and emotional responses to a variety of stressors. The goal of the present study was to determine whether GABAergic neurotransmission in the amygdala is a critical component of conditioned defeat in male Syrian hamsters. Experiment 1 examined whether infusion of the GABA(A) receptor agonist, muscimol (0.0, 4.4, 8.8 nmol), into the amygdala would block the acquisition of conditioned defeat. Experiment 2 examined whether infusion of muscimol into the amygdala prior to testing would block expression of conditioned defeat. Submissive behavior during testing was significantly reduced in animals receiving infusions of muscimol immediately prior to initial defeat training. Animals that received infusions of muscimol immediately prior to being tested with a non-aggressive intruder also displayed significantly less submissive behavior than did animals receiving vehicle control. These data indicate that infusion of muscimol into the amygdala can block the acquisition and expression of conditioned defeat, a finding that indicates that GABAergic neurotransmission within the amygdala is involved in the acquisition and expression of fear or stress-induced behavioral changes. This is the first evidence indicating that the neural circuits involved in Pavlovian fear conditioning are also involved in more ethologically-relevant models examining stress-related behavioral plasticity.
journal_name
Brain Resjournal_title
Brain researchauthors
Jasnow AM,Huhman KLdoi
10.1016/s0006-8993(01)03054-2subject
Has Abstractpub_date
2001-11-30 00:00:00pages
142-50issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(01)03054-2journal_volume
920pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Microinjection of bicuculline (Bic) into the unilateral putamen (Put) of the cat resulted in periodic occurrence of contralateral movement of the head (dystonia). Corresponding to this dystonic movement, repetitive spikes of the field potential occurring in the Put of the injected side and strong inhibition of the ext...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00190-2
更新日期:1995-04-24 00:00:00
abstract::The effects of the dopamine transporter (DAT) inhibitors cocaine and GBR12909 on DAT and dopamine D(2) receptors were evaluated in the brains under awake and isoflurane-anesthetized monkeys using high-resolution positron emission tomography (PET) in combination with microdialysis. The striatal DAT availability and dop...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02018-1
更新日期:1999-12-04 00:00:00
abstract::The present study examined the behavioral effects of dopamine receptor agonists, antagonists, or N-methyl-D-aspartate (NMDA) glutamate receptor antagonist in rats with a unilateral excitotoxic lesion of the globus pallidus (GP). After the unilateral GP lesions were made by injections of the ibotenic acid, drugs were s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01241-9
更新日期:1998-01-19 00:00:00
abstract::Dopaminergic neurotoxicities of 6-hydroxydopamine (6-OHDA) and the lipopolysaccharide (LPS) were compared in rat mesencephalic cultures plated on poly-L-lysine or on glial monolayers. In the neuron-enriched cultures plated on polylysine, 6-OHDA killed 89% of the tyrosine hydroxylase (TH)-immunopositive neurons, but LP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01189-7
更新日期:1995-12-15 00:00:00
abstract::Reactive oxygen species (ROS) are supposed to be involved in neurodegenerative processes like Parkinson's or Alzheimer's disease. Beside this there are an increasing number of studies indicating an involvement of ROS in traumatic brain injury. We therefore studied the potential role of astrocytes against neurotoxic ef...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01029-3
更新日期:1996-12-16 00:00:00
abstract::Increased and sustained central delivery of L-dihydroxyphenylalanine (L-DOPA) is a desirable therapeutic strategy in Parkinson's disease. We investigated the effects of peripheral catechol-O-methyltransferase (COMT) inhibition, by the non-toxic drug nitecapone on the metabolism of 6-[18F]fluoro-L-dihydroxyphenylalanin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90556-3
更新日期:1993-10-29 00:00:00
abstract::This study was performed to investigate the mechanism how amantadine increases the extracellular dopamine (DA) levels in the striatum in vivo. Local application of amantadine (1 mM, 40 min) to the striatum through the dialysis membrane significantly increased the extracellular DA levels. Coadministration of nomifensin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90821-4
更新日期:1994-10-31 00:00:00
abstract::The involvement of endogenous serotonergic pathways in the mediation of antinociception has been indicated by electrophysiological, pharmacological and behavioral experiments. However, manipulation of the indole pathway, either by lesioning of raphe nuclei or drug intervention, often produces disparate results. In par...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90883-3
更新日期:1987-11-24 00:00:00
abstract::Using an immunocytochemical technique we have analyzed changes in substance P, somatostatin, calcitonin gene-related peptide, and galanin immunoreactivity pattern in the rat dorsal root ganglia. After 7 days of adrenalectomy, sham operated rats were compared with adrenalectomized animals either receiving a daily intra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91893-7
更新日期:1994-03-21 00:00:00
abstract::Our previous study reported that cathepsin L may contribute to the death of dopaminergic neurons in rodent model of Parkinson's disease (PD). In this study we detected the changes in the expression of lysosomal cathepsin L in cellular models of PD. In human neuroblastoma SH-SY5Y cells, treatment with 6-hydroxydopamine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.092
更新日期:2011-04-28 00:00:00
abstract::Intracellular and extracellular recordings in the arterially-perfused eye cup of pigmented and albino rabbits show the presence of blue cones, green cones and rods. Among the ganglion cells, a fraction shows spectral opponency. Two main types were found. In one, on-depolarizing responses and on-hyperpolarizing respons...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90278-0
更新日期:1978-07-14 00:00:00
abstract::A special feature of the extracellular matrix in adult brains of various species is the concentration of certain components around different sub-populations of neurones, giving rise to net-like structures termed perineuronal nets. Recently, some of these components have been identified but the function of these nets h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01596-6
更新日期:1999-07-10 00:00:00
abstract::We previously reported the presence of Erk2 type mitogen-activated protein kinase (MAPK) and enrichment of its substrates in the post-synaptic density (PSD) fraction, and suggested a role for MAPK in the synaptic transmission and its modulation [Suzuki, T., Okumura-Noji, K., Nishida, E., ERK2-type mitogen-activated pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01762-x
更新日期:1999-09-04 00:00:00
abstract::We sought to determine whether the global increase in regional cerebral blood flow (rCBF) produced by electrical stimulation of the rostral cerebellar fastigial nucleus (FN) is a consequence of excitation of intrinsic neurons of the FN or of axons of fibers passing through or projecting into it. Studies were conducted...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90312-0
更新日期:1989-10-23 00:00:00
abstract::The carrier-mediated uptake of anionic and cationic amino acids by the basolateral face (blood side) of the isolated perfused sheep choroid plexus was demonstrated using the paired-tracer dilution technique. The uptake of these two classes of amino acid was higher than at the blood-brain barrier with no cross-competit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90731-n
更新日期:1992-05-29 00:00:00
abstract::A combined retrograde transport-immunohistochemical method was used to compare the numbers of corticotropin-releasing factor (CRF) and vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus (PVH) that could be retrogradely labeled after tracer injections in the dorsomedial medulla or the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91641-6
更新日期:1987-12-29 00:00:00
abstract::The amygdala has long been implicated in conditioned fear. The mesencephalic dopaminergic system provides a rich innervation to the amygdala [J.H. Fallon, P. Ciofi, Distribution of monoamines within the amygdala, in: J.P. Aggleton (Ed.), The Amygdala: Neurobiological Aspects of Emotion, Memory and Mental Dysfunction, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01291-3
更新日期:1999-05-08 00:00:00
abstract::The nonsteroidal anti-inflammatory drugs are presumed to produce their analgesic effects by inhibiting the cyclooxygenase catalyzed metabolism of arachidonic acid to hyperalgesic prostanoids. This study examined the hyperalgesic effect of a range of prostaglandins. We found, employing the rat paw-withdrawal test, that...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90389-s
更新日期:1990-12-24 00:00:00
abstract::The effects of the possible metabolites of taurine--taurocyamine and hypotaurine--and of homotaurine on spike discharge frequency of guinea pig cerebellar Purkinje cells were investigated in comparison with taurine and GABA. Taurocyamine, hypotaurine and homotaurine all dose-dependently suppressed the spike frequency ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90538-2
更新日期:1981-02-16 00:00:00
abstract::Regional cerebral blood flow (RCBF) and local cerebral glucose utilization (LCGU) were studied in normal, awake newborn beagle puppies using quantitative autoradiography. A highly significant linear relationship between RCBF and LCGU was present for all brain structures. Special attention was directed to the subependy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90709-1
更新日期:1984-05-14 00:00:00
abstract::Amitriptyline, a representative tricyclic antidepressant, has been widely used for the treatment of neuropathic pain, such as post-herpetic and trigeminal neuralgia. In the present study, we investigated the effect of amitriptyline on glycinergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) in acute...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.03.030
更新日期:2012-05-21 00:00:00
abstract::Cortical Spreading Depression (CSD) is a well-studied model of preconditioning that provides a high degree of tolerance to a subsequent ischemic event in the brain. The present study was undertaken in order to determine whether the release of ATP during CSD could contribute to the induction of ischemic tolerance. Dire...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.070
更新日期:2007-09-07 00:00:00
abstract::The effects of subchronic administration of the antidepressant fluoxetine (15 mg/kg i.p., 14 days) on thyroid hormone metabolism were investigated in 11 regions of the CNS and three peripheral tissues in the rat. Fluoxetine significantly enhanced the activity of the 5'II-deiodinase isoenzyme (5'D-II), which catalyzes ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91424-9
更新日期:1994-01-28 00:00:00
abstract::Experiments were conducted to (1) provide further evidence of the selectivity of [D-Ala2,Leu5,Cys6]enkephalin (DALCE) as an antagonist of delta (delta) receptor ligands and (2) use DALCE as a tool to explore the possible role of delta receptors in restraint stress. Dose- and time-response curves were generated for the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90545-m
更新日期:1990-02-19 00:00:00
abstract::ATP has been recognized as an important extracellular signaling molecule and P2X receptors are membrane ion channels activated by the binding of extracellular ATP. Since both AQP4 and P2X7 receptor (P2X7R) are known to be present in astrocytes, we examined whether P2X7R activation plays a role in the regulation of AQP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.12.023
更新日期:2008-02-21 00:00:00
abstract::There are marked increases in noradrenaline (NA) release during emergence from general anesthesia induced with volatile anesthestics. These changes in NA in the posterior hypothalamus of the rat were assessed by intracranial microdialysis. Sevoflurane and halothane in equipotent concentrations were used to obtain the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01080-7
更新日期:1996-01-15 00:00:00
abstract::Opioid peptides and their receptors have been localized to the inner ear of the rat and guinea pig mammalian models. The expression of mu opioid receptor (MOR) in the human and mouse cochlea is not yet known. We present MOR protein localization by immunohistochemistry and mRNA expression by in situ hybridization in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.09.051
更新日期:2014-11-24 00:00:00
abstract::A disintegrin and metalloproteinase (ADAM) 12 represents a member of a large family of similarly structured multi-domain proteins. In the central nervous system (CNS), ADAM12 has been suggested to play a role in brain development, glioblastoma cell proliferation, and in experimental autoimmune encephalomyelitis. Furth...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.02.049
更新日期:2010-04-22 00:00:00
abstract::We have developed a sensitive enzymatic-immunoassay to quantify the level of gamma-enolase (a specific neuronal enzyme) which is released from cultured cells after exposure to various toxins. We show that this method can estimate selectively neuronal cell death without significantly interfering with glial cell death. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91264-f
更新日期:1992-10-09 00:00:00
abstract::Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. Previous MRI studies have revealed that POAG can be associated with alterations in hippocampal function. Thus, the aim of this study was to investigate a relationship between chronic high intraocular pressure (IOP) and hippocamp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.09.001
更新日期:2017-11-15 00:00:00