Abstract:
:The effects of the dopamine transporter (DAT) inhibitors cocaine and GBR12909 on DAT and dopamine D(2) receptors were evaluated in the brains under awake and isoflurane-anesthetized monkeys using high-resolution positron emission tomography (PET) in combination with microdialysis. The striatal DAT availability and dopamine D(2) receptor binding were assayed with [11C]beta-CFT (WIN35,428) and [11C]raclopride, respectively. Cocaine or GBR12909 at a dose of 2 mg/kg was administered intravenously 30 min prior to the injection of labeled compounds. In the awake state, the in vivo binding of [11C]beta-CFT to DAT was significantly decreased by administration of cocaine or GBR12909 at a dose of 2 mg/kg. In contrast, [11C]raclopride binding to dopamine D(2) receptors was decreased only by GBR12909. Under isoflurane anesthesia, dopamine concentration in the striatal extracellular fluid (ECF), as measured by microdialysis, was markedly increased by cocaine or GBR12909 compared to the awake state. Isoflurane anesthesia more markedly enhanced the binding of [11C]beta-CFT in the saline-injected animals, and the degrees of reduction by cocaine and GBR12909 were more marked than those observed in the awake state. Under isoflurane anesthesia, the binding of [11C]raclopride was reduced not only by GBR12909 but also by cocaine which did not affect the binding in the awake state. Taken together, these observations indicated that isoflurane anesthesia enhanced not only the direct inhibitory effects of cocaine and GBR12909 on DAT, but also their indirect effects on dopamine D(2) receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Tsukada H,Nishiyama S,Kakiuchi T,Ohba H,Sato K,Harada N,Nakanishi Sdoi
10.1016/s0006-8993(99)02018-1subject
Has Abstractpub_date
1999-12-04 00:00:00pages
85-96issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)02018-1journal_volume
849pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Neonatal damage to the ventral hippocampus (VH) can lead, during adulthood, to behaviours that are believed to reflect enhanced mesocorticolimbic dopamine (DA) transmission. In the present study, the effects of neonatal excitotoxic lesions to the VH on spontaneous locomotor activity and stress-elicited increases in ex...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01477-8
更新日期:1999-06-12 00:00:00
abstract::Rat hippocampal slices were incubated with [3H]uridine in vitro to analyze the metabolism of nuclear RNA and the RNA precursor fractions. Labeling of total nuclear RNA was linear for 4 h of incubation and proportional to the concentration of labeled uridine in the incubation medium. Addition of 3.5 X 10(-8) M corticos...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90375-5
更新日期:1984-07-23 00:00:00
abstract::Patterns of proliferation and changes in non-neuronal cell number in the visual system of the goldfish have been quantitatively examined during optic axon regeneration after an optic nerve crush (ONC). In addition, in order to examine the effect of the regenerating axons on cellular responses in the visual pathways, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02339-2
更新日期:2000-01-31 00:00:00
abstract::In humans, tendon vibration evokes illusory sensations of movement that are usually associated with an excitatory tonic response in muscles antagonistic to those vibrated (antagonist vibratory response, AVR), i.e., in the muscle groups normally contracted if the illusory movement had been performed. The aim of the pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02604-4
更新日期:2000-10-27 00:00:00
abstract::The zebrafish, Danio rerio, has become an important model species for examining olfactory system structure and function, yet little is known about developmental changes in olfactory bulb morphology from embryo to adult. The present study examined both normal growth and the effects of deafferentation on the bulb from h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02412-9
更新日期:2000-02-21 00:00:00
abstract::Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive loss of cognitive function, dementia, and problems with movements. In order to find new protein biomarkers of high specificity from cerebrospinal fluid (CSF) of AD and PD patients, one-dimensiona...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.01.058
更新日期:2009-04-10 00:00:00
abstract::The effects of selective dopamine D1 (SKF 38393) and D2 (4-propyl-9-hydroxynaphthoxazine or PHNO) agonists on free-running rhythms of locomotor activity in rats were investigated under either constant light (LL) or dark (DD) condition. Rats under the DD condition exhibited clear circadian patterns of activity, while c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90445-2
更新日期:1991-01-11 00:00:00
abstract::Serotonin (5HT) systems play important roles in brain development, and early perturbations of 5HT receptor expression produce permanent changes in 5HT synaptic function and associated behaviors. We exposed pregnant Rhesus monkeys to environmental tobacco smoke (ETS) during gestation and for up to 3 months postnatally ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.06.094
更新日期:2006-09-21 00:00:00
abstract::During the middle of the subjective day, circadian activity rhythms in Syrian hamsters can be phase advanced by a variety of stimuli including microinjection of neuropeptide Y (NPY) or muscimol into the suprachiasmatic nucleus (SCN). It is not known, however, if these treatments shift activity rhythms by acting direct...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00831-7
更新日期:1997-10-24 00:00:00
abstract::Regulation of myelin protein gene expression in the presence and absence of myelin assembly can be assessed using crushed or permanently transected adult sciatic nerves of rats. The P0 glycoprotein and the myelin basic protein (MBP) are the major myelin-specific proteins of the peripheral nervous system. The steady-st...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(87)90021-0
更新日期:1987-04-01 00:00:00
abstract::Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but not in other region...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90667-0
更新日期:1986-01-15 00:00:00
abstract::In the central nervous system (CNS) insulin mediates a variety of effects including feeding, metabolism and cognition. The cognitive enhancing effects of insulin are proposed to be mediated through activation of insulin receptors in the hippocampus, an important integration center for learning and memory in the mammal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.005
更新日期:2009-11-03 00:00:00
abstract::Nitric oxide (NO) can have opposite effects on peripheral sensory neuron sensitivity depending on the concentration and source of NO, and the experimental setting. The aim of this study was to determine the role of endogenous NO production in the regulation of mechanosensitive Ca(2+) influx of dorsal root ganglion (DR...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02407-6
更新日期:2001-06-08 00:00:00
abstract::The distribution of hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) immunoreactivities in the cat brainstem was examined using immunohistochemical techniques. Hcrt-1- and hcrt-2-positive fibers with varicosities were detected in almost all brainstem regions. However, no hcrt-1- or hcrt-2-immunoreactive neuronal somata...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.10.004
更新日期:2004-01-09 00:00:00
abstract::The behaviour and cognitive abilities of marmosets with bilateral ablations of either the archicortex on the mediodorsal surface or the paleocortex on the ventrolateral surface of the frontal lobes were assessed in terms of the types of information being handled, the mode of action (inhibitory versus productive mechan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90937-i
更新日期:1993-11-19 00:00:00
abstract::The amplitude of anterior neocortical EEG slow-waves (0.5-4 Hz) measured during quiet waking, drowsy (WS) and synchronized sleep (S) states showed slow rhythmic oscillations in WS and S similar to those previously reported in midbrain reticular neurons (periods of 8-12 s). Abrupt changes in slow rhythms of unit discha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90153-1
更新日期:1983-06-20 00:00:00
abstract::Transthyretin (TTR) is mainly expressed in the liver and choroid plexus of the brain. The majority of familial amyloidotic polyneuropathy cases are caused by a mutant TTR gene. The origin of the TTR deposited in the peripheral nervous system is unknown. We studied the expression of TTR in the peripheral nerves of norm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.06.017
更新日期:2010-08-12 00:00:00
abstract::The effects of the 8-alpha-amino-ergoline CU 32-085 on central dopamine neuronal systems was investigated. Two h after administration of CU 32-085 a slight increase of dopamine levels was observed in the nucleus caudatus-putamen. Radioligand binding studies in vitro have shown that CU 32-085 has a low affinity for str...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91044-3
更新日期:1985-03-04 00:00:00
abstract::Injury of peripheral nerves often results in hyperalgesia (an increased sensitivity to painful stimuli). This hyperalgesia is mediated in part by sympathetic neurotransmitters. We examined the effect of neuropeptide Y (NPY), specific Y1 and Y2 agonists, and an NPY antagonist on peripheral hyperalgesia in rats whose sc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01265-j
更新日期:1995-01-16 00:00:00
abstract::The acute effects of ethanol on the gamma-aminobutyric acid (GABA)-activated current were studied with the rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. GABA produced an inward chloride current, which was composed of an initial transient and a subsequent sustained phas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90982-h
更新日期:1990-06-04 00:00:00
abstract::We examined the effect of the peripheral application of glutamate and capsaicin to the temporomandibular joint (TMJ) in influencing the activation and central sensitization of TMJ-responsive nociceptive neurons in the trigeminal subnucleus caudalis/upper cervical cord (Vc/UCC). The activity of single neurons activated...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.11.056
更新日期:2009-02-09 00:00:00
abstract::Manganese (Mn) is an essential trace element required for ubiquitous enzymatic reactions. Chronic overexposure to this metal may, however, promote potent neurotoxic effects. The mechanism of Mn toxicity is not well established, but several studies indicate that oxidative stress and mitochondria play major roles in the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.07.125
更新日期:2008-10-21 00:00:00
abstract::Here we describe a sustained outward potassium current (IK) in retinal horizontal cells (HCs). IK is unusually small over the range of membrane potentials normally experienced by these cells, which are chronically depolarized. We hypothesize that this unique IK will reduce the amount of neurotransmitter required to sh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90204-o
更新日期:1990-09-24 00:00:00
abstract::The localization of calcitonin gene-related peptide (CGRP)-like immunoreactive (CGRPI) structures in the cochlea was examined in the rat using immunocytochemistry. Numerous CGRPI fibers entered the organ of Corti in the intraganglionic spiral bundle and formed a dense fiber patch at the base of the inner hair cells. M...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90992-8
更新日期:1985-12-09 00:00:00
abstract::5-Hydroxytryptamine (5-HT, serotonin), synthesized in midbrain raphe nuclei and released in various hypothalamic sites, decreases food intake but the specific 5-HT receptor subtypes involved are controversial. Here, we have studied changes in the regional density of binding to 5-HT receptors and transporters and the l...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02055-7
更新日期:1999-11-13 00:00:00
abstract::It has been shown that glucagon like peptide-1 (GLP-1) acts on the central nervous system (CNS), in addition to its peripheral actions. Central administration of glucagon like peptide-1 (GLP-1) delays liquid gastric emptying via non-adrenergic, non-cholinergic neurons in rats. However, it remains unclear how central G...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.06.090
更新日期:2006-09-21 00:00:00
abstract::Neurodegenerative disorders have attracted attention in last decades due to their high incidence in the world. The p53/miR-34a axis triggers apoptosis and suppresses viability in multiple types of cells, but little is known about its role in neurodegenerative diseases. In this study, we showed that presenilin (PS)-2, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.01.034
更新日期:2017-05-01 00:00:00
abstract::Recently, this laboratory provided evidence that interleukin-1beta (IL-1beta), an immune and brain-derived cytokine, microinjected into the medial hypothalamus, potentiates defensive rage behavior in the cat elicited from the midbrain periaqueductal gray (PAG), and that such effects are blocked by a 5-HT2 receptor ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.04.086
更新日期:2005-06-28 00:00:00
abstract::Nuclear factor kappa B (NFkappaB) is a transcription factor which can be activated by some neurotrophic factors and cytokines, and then translocated into the nucleus. We examined NFkappaB immunoreactivity (IR) in L4 and L5 dorsal root ganglion (DRG) cells of normal rats, and 2 weeks after complete sciatic nerve transe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00380-1
更新日期:1998-06-29 00:00:00
abstract::The role of histamine in mediating restraint stress-induced alterations in dopaminergic neuronal activity and alpha-melanocyte-stimulating hormone (alpha MSH) secretion was evaluated in male rats. Dopaminergic neuronal activity was estimated by measuring concentrations of the dopamine metabolite 3,4-dihydroxyphenylace...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90399-9
更新日期:1994-08-08 00:00:00