Abstract：
:Neonatal damage to the ventral hippocampus (VH) can lead, during adulthood, to behaviours that are believed to reflect enhanced mesocorticolimbic dopamine (DA) transmission. In the present study, the effects of neonatal excitotoxic lesions to the VH on spontaneous locomotor activity and stress-elicited increases in extracellular nucleus accumbens (NAcc) DA levels were examined in adult rats. Male pups received, on postnatal day 7, bilateral injections of either an ibotenic acid solution (lesioned) or vehicle (sham-lesioned) into the VH. At 3-4 months of age, animals were assessed during five daily sessions for changes in spontaneous locomotor activity associated with habituation to a novel environment. Voltammetry was used in separate groups of sham- and VH-lesioned animals to monitor the NAcc DA response to each of five once-daily exposures to tail-pinch stress. The results indicate that while VH-lesioned animals seem to habituate to novelty, they remain hyperactive relative to sham-lesioned controls. In contrast, however, stress consistently elicited in VH-lesioned animals smaller and shorter-lasting increases in NAcc DA than in sham-lesioned controls. These data suggest that neonatal excitotoxic damage to VH leads to changes in DA function that persist into adulthood. The blunted response to stress seen in VH-lesioned animals indicates that one consequence of such damage is a functional hyporeactivity in meso-NAcc DA neurons. The fact that these animals are spontaneously more active suggests compensatory changes in DA function that are efferent to DA terminals in NAcc.
journal_name
Brain Resjournal_title
Brain researchauthors
Brake WG,Sullivan RM,Flores G,Srivastava LK,Gratton Adoi
10.1016/s0006-8993(99)01477-8subject
Has Abstractpub_date
1999-06-12 00:00:00pages
25-32issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01477-8journal_volume
831pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The alpha7 nicotinic receptor agonist 3-[2,4-dimethoxybenzylidene]anabaseine (DMXB; GTS-21) was investigated for its ability to: (1) activate a variety of nicotinic receptor subtypes in Xenopus oocytes; (2) improve passive avoidance and spatial Morris water task performances in mecamylamine-sensitive manners in bilate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00536-2
更新日期：1997-09-12 00:00:00
abstract：:Oxidative stress plays an important role in the pathogenesis of neurodegeneration after the acute central nervous system injury. We reported previously that increased nitric oxide (NO) production following spinal cord hemisection tends to lead to neurodegeneration in neurons of the nucleus dorsalis (ND) that normally ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.003
更新日期：2005-09-07 00:00:00
abstract：:The distribution of cells expressing mu-receptor mRNA and mu-receptor binding sites were compared in brain and spinal cord tissue sections using a combination of in situ hybridization and receptor autoradiographic techniques. mu-Receptor mRNA was visualized with a 35S-labeled cRNA probe directed to transmembrane III-V...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90031-0
更新日期：1994-04-18 00:00:00
abstract：:In decerebrate rats, the responses of tilt-sensitive neurons in the lateral and descending vestibular nuclei were studied during constant velocity 10 degrees off-vertical axis rotations (OVAR) in the clockwise (VW) and counterclockwise (CCW) directions. Seventy three otolith-related units showed a sinusoidal position-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00687-l
更新日期：1995-09-25 00:00:00
abstract：:A histochemical stain for cytochrome oxidase (CO) activity was used to examine the maturation of a neurochemical correlate of ON and OFF channels in the retina and dorsal lateral geniculate nucleus (LGN) of the tree shrew. In the adult tree shrew, the CO staining pattern can be used as a histochemical marker of segreg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90217-3
更新日期：1987-08-01 00:00:00
abstract：:The functions of the claustrum are not well understood. Few studies explore its electrophysiological properties in awake animals. Here, we address this lacuna by recording spontaneous local field potential (LFP) activity in the anterior claustrum of rats freely exploring open field environments under differing conditi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.09.021
更新日期：2017-12-15 00:00:00
abstract：:The uptake and efflux of 36Cl in the lateral ventricle choroid plexus of 1-7-week-old rats were measured to determine if Cl transport changed with age and if such transport responded to inhibitors of CSF secretion and ion transport. The steady-state (30 min) Cl uptakes were 148 +/- 9.4 nmol.mg-1 dry weight at 1 week a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90076-y
更新日期：1993-10-08 00:00:00
abstract：:The roles of endogenous serotonin (5-HT) and 5-HT receptor subtypes in regulation of acetylcholine (ACh) release in frontal cortex of conscious rats were examined using a microdialysis technique. Systemic administration (1 and 3 mg/kg, i.p.) of the 5-HT-releasing agent p-chloroamphetamine (PCA) elevated ACh output in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00856-1
更新日期：1997-10-24 00:00:00
abstract：:The distribution of hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) immunoreactivities in the cat brainstem was examined using immunohistochemical techniques. Hcrt-1- and hcrt-2-positive fibers with varicosities were detected in almost all brainstem regions. However, no hcrt-1- or hcrt-2-immunoreactive neuronal somata...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.10.004
更新日期：2004-01-09 00:00:00
abstract：:To elucidate the intracellular mechanism of the bursting activity which is characteristic of seizure discharge, the behavior of the intracellular cyclic nucleotide and the intracellular calcium during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. Cyclic AMP was increased about 3...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90137-3
更新日期：1983-06-20 00:00:00
abstract：:Fifteen adult male Sprague-Dawley rats were implanted with a set of electrodes for standard sleep recordings. A stainless steel cannula was also implanted into the lateral ventricle of these rats. Fifteen additional rats were implanted with a cannula alone. Rats with electrodes were habituated for 3 days or more to th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90888-5
更新日期：1994-10-03 00:00:00
abstract：:Qualitative and computer-assisted analyses were performed on Golgi-impregnated neurons which were serially reconstructed in 3 dimensions. Analysis of the temporal pattern of growth indicated that the initial outgrowth, formation of the adult number of dendrites and virtually all dendritic branching occurred in the pre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90192-6
更新日期：1986-01-01 00:00:00
abstract：:The effects of selective axotomy of serotoninergic neurons produced by an intracerebroventricular injection of 5,7-dihydroxytryptamine (200 micrograms free base) on 5-HT1B binding sites labeled with S-CM-G-[125I]TNH2 were investigated by quantitative autoradiography in the rat brain. Results show, 21 days after surger...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91452-x
更新日期：1993-10-01 00:00:00
abstract：:Results from the application of a procedure that allows simultaneous estimation of the rates of glucose transport from blood and of glucose phosphorylation in discrete regions of the brain are given for groups of rats displaying chemically induced motor disturbances. The procedure is based on sequential injections of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90782-4
更新日期：1981-09-28 00:00:00
abstract：:Despite over 20 years of behavioral research, considerable disagreement remains regarding the locus of the cognitive mechanisms (e.g., stimulus encoding, response selection or response production) responsible for the acquisition and expression of learned sequences. Functional neuroimaging may prove invaluable for reso...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.09.097
更新日期：2009-01-09 00:00:00
abstract：:Various chemical and physical lesions were employed to elucidate the cellular localization of cholecystokinin (CCK) receptors in the rat caudate nucleus. A wide knife cut severing all caudal afferents reduced caudate CCK receptors by approximately 25%, indicating that some receptors lie on axons and (or) terminals of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90284-5
更新日期：1981-08-24 00:00:00
abstract：:The prognosis of patients with malignant glioma remains extremely poor despite surgery and improvements in radio- and chemo-therapies. We recently showed that marrow-isolated adult mutilineage inducible (MIAMI) cells, a subpopulation of human mesenchymal stromal cells (MSCs), can serve as cellular carriers of drug-loa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.07.030
更新日期：2012-09-14 00:00:00
abstract：:The entire set of giant interneurons (GIs) in the nerve cord of the cockroach, Periplaneta americana, was ablated using either electrolytic or surgical techniques. All animals with these lesions were capable of turning and running away from standard wind puffs. However, all animals responded much less frequently to st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91202-4
更新日期：1988-04-05 00:00:00
abstract：:The relationship between the dorsal raphe neurons projecting to the caudate-putamen and those projecting to the substantia nigra was investigated using a fluorescent retrograde double labeling technique in the rat. The majority of the dorsal raphe neurons projecting to the substantia nigra were found to project also t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90250-4
更新日期：1980-03-17 00:00:00
abstract：:We previously reported that glial fibrillary acidic protein (GFAP) levels increased significantly at 3 days after stab wounds, relative to sham-operated controls, reaching a maximum of 200% of control value at 5-7 days. They then fell to near-normal values by 21 days. To determine whether these protein changes correla...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90142-x
更新日期：1990-11-26 00:00:00
abstract：:Whole-cell patch recordings of neurons in the rostral (gustatory) nucleus tractus solitarius (rNTS) were performed in a brain slice preparation from rat medulla. Neural responses to brief applications (10-45 s) of substance P (SP), via a constant superfusion apparatus, were recorded. SP transiently depolarized 80 of 1...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91603-p
更新日期：1993-08-13 00:00:00
abstract：:Intra- and interhemispheric connections between the anterior ectosylvian visual area (AEV) and other visual cortical areas including the lateral suprasylvian (LSS) were examined in the cat using the retrograde double-label fluorescence technique. The areal and laminar distributions of labeled neurons were mapped follo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90189-1
更新日期：1985-11-18 00:00:00
abstract：:By ligating specific nerves in the cat, the central processes of the nodose ganglion (NG) cells containing substance P-like immunoreactive materials were shown, immunohistochemically, to run through the cross-anastomosis made between the cranial end of the NG and the caudal end of the superior cervical ganglion (SCG),...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90811-9
更新日期：1983-06-27 00:00:00
abstract：:It has been hypothesized on the basis of animal models of epilepsy that abnormal neural activity in epilepsy may be related to reorganized neural circuits that facilitate epileptogenesis. Little evidence of this was available for human epilepsy. This paper provides the first evidence of such reorganization of a hippoc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90234-5
更新日期：1989-08-28 00:00:00
abstract：:In most cases obesity, a major risk factor for diabetes mellitus type 2 and other associated chronic diseases, is generated by excessive eating. For a better understanding of eating behavior, it is necessary to determine how it is modulated by factors such as the calorie content of food, satiety and gender. Twelve hea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.04.030
更新日期：2010-09-02 00:00:00
abstract：:In six decerebrated and in eight alpha-chloralose anesthetized, paralyzed and mechanically ventilated beagle dogs, we have studied involvement of glutamate and glutamate receptors in transmission of excitatory inputs from the airway sensory receptors to the nucleus tractus solitarius and from this site to airway-relat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02890-0
更新日期：2000-11-10 00:00:00
abstract：:The distribution of nitric oxide synthase (NOS)-, choline acetyltransferase (ChAT)-, and vasoactive intestinal polypeptide (VIP)-immunoreactivities, and nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd)-reactivities in the sphenopalatine ganglia (SPG), and perivascular nerves in middle cerebral arteries ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00548-4
更新日期：1998-08-10 00:00:00
abstract：:The divalent cation zinc has been reported to possess several physiological properties such as blocking apoptotic cell death through an inhibitory effect on Ca(2+)-Mg2+ endonuclease activity, or modulating the neurotoxicity via glutamate receptor subtypes. In the present study, we investigated the effect of peripheral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01112-2
更新日期：1996-12-16 00:00:00
abstract：:A combined retrograde transport and immunocytochemical study was carried out to determine the projections of the large glycine-immunoreactive neurons in the ventral cochlear nucleus of the guinea pig. Horseradish peroxidase (HRP) was injected into the contralateral cochlear nucleus, and cochlear nucleus sections were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90285-x
更新日期：1987-07-07 00:00:00
abstract：:Although nitric oxide (NO) has been shown to play an important role in the pathophysiology of cerebral ischemia, its contribution to the pathogenesis of experimentally induced thromboembolic stroke is unknown. In this study, we pharmacologically manipulated NO levels in the acute post-thrombotic stage and determined t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00200-x
更新日期：1997-06-06 00:00:00
