Abstract：
:The effects of selective axotomy of serotoninergic neurons produced by an intracerebroventricular injection of 5,7-dihydroxytryptamine (200 micrograms free base) on 5-HT1B binding sites labeled with S-CM-G-[125I]TNH2 were investigated by quantitative autoradiography in the rat brain. Results show, 21 days after surgery, an upregulation of 5-HT1B receptors in the entorhinal cortex and the dorsomedial and suprachiasmatic nuclei of the hypothalamus. The cellular localization of those 5-HT1B receptors exhibiting post-lesion plastic properties is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Manrique C,Segu L,Héry F,Héry M,Faudon M,François-Bellan AMdoi
10.1016/0006-8993(93)91452-xsubject
Has Abstractpub_date
1993-10-01 00:00:00pages
345-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(93)91452-Xjournal_volume
623pub_type
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