Abstract：
:In the present study we investigated whether nitroflurbiprofen (NFP) or nitro-aspirin can reduce the inflammatory response induced by continuous infusion of lipopolysaccharide (LPS) into the fourth ventricular space of the rat's brain for 30 days. The chronic LPS infusion produced an extensive inflammation that was particularly evident in the hippocampus, subiculum and entorhinal and piriform cortices. Daily peripheral administration of NFP dose-dependently, and significantly, attenuated the brain inflammation as indicated by the decreased density and reactive state of microglial cells. Daily peripheral administration of nitro-aspirin also attenuated the brain inflammation, but to a much lesser degree than NFP. The results demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs) could reduce brain inflammation and that NFP is an effective anti-inflammatory agent.
journal_name
Brain Resjournal_title
Brain researchauthors
Hauss-Wegrzyniak B,Willard LB,Del Soldato P,Pepeu G,Wenk GLdoi
10.1016/s0006-8993(98)01081-6subject
Has Abstractpub_date
1999-01-02 00:00:00pages
36-43issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(98)01081-6journal_volume
815pub_type
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