Abstract：
:The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the ventral hippocampus and dorsal periaqueductal gray (dPAG) were measured by in vivo microdialysis. Inescapable, but not escapable shock increased extracellular 5-HT in the ventral hippocampus relative to restrained controls. Basal levels of 5-HT were elevated 24 h after inescapable shock, and previously inescapably shocked subjects exhibited an exaggerated 5-HT response to 2 brief footshocks. In contrast, escapable, but not inescapable shock, increased extracellular 5-HT in the dPAG, increased basal 5-HT in the dPAG 24 h later, and led to an enhanced 5-HT response to subsequent brief footshock.
journal_name
Brain Resjournal_title
Brain researchauthors
Amat J,Matus-Amat P,Watkins LR,Maier SFdoi
10.1016/s0006-8993(98)00368-0subject
Has Abstractpub_date
1998-06-22 00:00:00pages
12-22issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00368-0journal_volume
797pub_type
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