Abstract：
:We have established a cell line (TB) from a cerebrospinal fluid (CSF) specimen of a patient with a primary leptomeningeal melanomatosis. TB cell line was immunoreactive with the antibodies for low molecular weight neurofilament protein, vimentin, neuron-specific enolase, chromogranin, synaptophysin and HMB-45 (an antibody sensitive and specific for melanoma). When TB cells were transplanted into nude mice, the same immunohistochemical pattern present in cultured cells was found but surprisingly, a positive staining for desmin was observed. Significant amounts of serotonin and its metabolite were detectable. Retinoic acid but not nerve growth factor was able to induce differentiation towards a neuronal phenotype. In summary, TB cells represent primitive neuroectodermal cells having the potential for neuronal, myoblastic and possibly melanoblastic differentiation.
journal_name
Brain Resjournal_title
Brain researchauthors
Sorrentino G,Monsurrò MR,Pettinato G,Vanni R,Zuddas A,Di Porzio U,Bonavita Vdoi
10.1016/s0006-8993(99)01197-xsubject
Has Abstractpub_date
1999-05-08 00:00:00pages
205-9issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01197-Xjournal_volume
827pub_type
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