Abstract：
:Using in vivo microdialysis, we examined the ability of choline (Ch) chloride (120 mg/kg i.p.) to amplify basal and stimulated acetylcholine (ACh) release from rat striatum in the presence of high (10(-5) M) and low (5 x 10(-8) M) neostigmine concentration. High concentrations might suppress ACh release, and thus Ch dependence, by excessively stimulating presynaptic cholinergic receptors; alternatively, they could enhance Ch dependence by depriving the cholinergic terminals of Ch that would otherwise be formed intrasynaptically from the hydrolysis of ACh. Both basal and stimulated ACh release were found to be tetrodotoxin (TTX) sensitive. The concentration of neostigmine in the microdialysis fluid positively affected basal ACh levels, but had no effect on Ch levels. Ch administration significantly increased ACh release (to 136% of basal values; P < 0.01) in the presence of the low neostigmine concentration, but failed to significantly increase ACh release following local electrical depolarization of striatal neurons. In contrast, Ch failed to affect basal ACh release in the presence of the high neostigmine concentration, but did increase electrically evoked release to 408% of basal values, as compared with 250% in rats receiving saline instead of the Ch (P < 0.05). Ch administration significantly increased microdialysate Ch levels in the presence of both of the neostigmine concentrations. Local administration of oxotremorine, a muscarinic agonist, to animals receiving the lower neostigmine concentration reduced basal ACh release and reduced the increase in basal release produced by Ch administration.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Marshall DL,Wurtman RJdoi
10.1016/0006-8993(93)91330-usubject
Has Abstractpub_date
1993-12-03 00:00:00pages
269-74issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(93)91330-Ujournal_volume
629pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The present study using near-infrared spectroscopy (NIRS) examined prefrontal activation associated with maze-solving performance in adult humans. The participants were required to solve a plus-shaped maze, comparable to the one used for pigeons and human children to behaviorally assess planning processes, by moving a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.047
更新日期：2011-02-16 00:00:00
abstract：:Brain iron overload has a detrimental role in brain injury after intracerebral hemorrhage (ICH). Lipocalin 2 (LCN2), a siderophore-binding protein, is involved in cellular iron transport. The present study investigated changes in LCN2 expression after ICH and the role of iron in those changes. Male Sprague-Dawley rats...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.02.008
更新日期：2013-04-10 00:00:00
abstract：:The aim of this study was to describe the normal distribution of the water content in several regions of the rat brain and furthermore to determine if global ischemia results in a variable increase in water content in these regions. Water content was determined in 40 regions; in 8 unaffected brains by gravimetry and i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01165-1
更新日期：1997-02-21 00:00:00
abstract：:An in vitro radioenzymatic assay and purification procedure by thin-layer chromatography were used to study the metabolism of dihydrotestosterone (DHT) into 3 alpha- and 3 beta-androstanediols by the brain and cloacal gland of Japanese quail. Kinetic studies showed that these 2 metabolites are produced in a linear fas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91280-7
更新日期：1987-09-22 00:00:00
abstract：:In male hamsters mating behavior is dependent on chemosensory input from the main olfactory and vomeronasal systems, whose central pathways contain cell bodies and fibers of gonadotropin-releasing hormone (GnRH) neurons. In sexually naive males, vomeronasal organ removal (VNX), but not main olfactory lesions, impairs ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.078
更新日期：2010-03-04 00:00:00
abstract：:A search for vasomotor depressor sites in the lateral medullary brainstem of anesthetized cat using microinjections of AMPA has delineated a longitudinal column of sympathoinhibitory neurons consisting of the rostral depressor area, the caudal ventrolateral medulla, and a new intermediate depressor area. Systematic bl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91257-s
更新日期：1993-02-19 00:00:00
abstract：:N-stearoyltyrosine (NsTyr), a synthesized anandamide (AEA) analogue, was evaluated for the first time in the present study for the neuroprotective effect in gerbils subjected to transient global cerebral ischemia reperfusion (IR). The extent of ischemia injury was assessed behaviorally by measuring neurological functi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.070
更新日期：2009-09-01 00:00:00
abstract：:Experiments were performed in the male Wistar rat to investigate the projections from cardiovascular responsive sites in the ventrolateral medulla (VLM) to the subfornical organ (SFO). Unilateral iontophoretic injections of Phaseolus vulgaris leucoagglutinin (PHA-L) were made into either caudal VLM (CVLM) sites at whi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.12.029
更新日期：2004-04-02 00:00:00
abstract：:Venous capacitance plays an important role in the control of cardiac output. However, the central nervous system sites and neurochemical signals involved in modulating venous function remain to be fully elucidated. The hypothalamic paraventricular nucleus (PVN) is an important site modulating autonomic outflow to the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00128-5
更新日期：1997-05-09 00:00:00
abstract：:The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at mu opiate and sigma opiate/phencyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In al...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91326-x
更新日期：1984-02-27 00:00:00
abstract：:In the present study we found that mesencephalic trigeminal (Mes-V) neurons of the rat are innervated by nitrergic fibers and that nitric oxide (NO) modifies the electrophysiological properties of these cells. Mes-V neurons were surrounded by a network of fibers that contained neuronal nitric oxide synthase (nNOS); th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03776-9
更新日期：2003-01-17 00:00:00
abstract：:We examined the effects of nicotinic drugs on the metabolites of [3H]dopamine (DA) released from rat striatal synaptosomes in comparison with the effects of high K+ and methamphetamine stimulation. The pattern of outflow of [3H]DA and its metabolites induced by nicotine stimulants, acetylcholine (ACh), nicotine and lo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90204-4
更新日期：1983-11-21 00:00:00
abstract：:Murine brain cells differentiated for 19 days in culture before treatment for 5 days with 10 microM diazepam. Radioligand binding to the benzodiazepine receptors on membranes obtained from these cultures was determined by the filtration assay method. Decreased binding was observed in the membranes from treated culture...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90117-8
更新日期：1983-12-12 00:00:00
abstract：:Gonadotrophin-releasing hormone (GnRH) neurons do not express the leptin receptor (OB-R) in the medial preoptic area (MPOA) and the medial basal hypothalamus (MBH). We assessed whether the effect of leptin on the secretion of luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL) in proestrus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.001
更新日期：2015-04-16 00:00:00
abstract：:In anaesthetized, spontaneously breathing cats and dogs, extracellular recordings were made of the spontaneous activities of 28 single neurones with cardiac rhythm. It was confirmed by histological examination that the neurones were situated in the mediodorsal portion of the nucleus of the solitary tract. Different di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90049-x
更新日期：1977-09-09 00:00:00
abstract：:Ischemic stroke is caused by the interruption of cerebral blood flow that leads to brain damage with long-term sensorimotor deficits. Stem cell transplantation may recover functional deficit by replacing damaged brain. In this study, we attempted to test whether the human neural stem cells (NSCs) can improve the outco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.04.038
更新日期：2004-08-06 00:00:00
abstract：:The actions of convulsant and sedative barbiturates on responses to gamma-aminobutyric acid (GABA) application and on inhibitory postsynaptic currents were compared using voltage-clamp techniques in cultured rat hippocampal neurons. The convulsant barbiturates, 5-ethyl-5-(3-methylbut-2-enyl) barbituric acid (3M2B), an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90910-4
更新日期：1990-05-14 00:00:00
abstract：:The Harderian gland of birds, a major lacrimal gland, contains a large population of lymphoid cells that produce IgA, a significant component of tears. Using histochemical techniques, we have examined the innervation of the gland. There was an extensive acetylcholine-esterase positive fiber network throughout the glan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91331-9
更新日期：1985-02-25 00:00:00
abstract：:Enkephalin-like immunoreactive nerve fibers in the celiac ganglion of guinea pigs were characterized by a high population of large granular vesicles mixed with small clear vesicles. The immunoreactive material is confined to the large granular vesicles. The immunoreactive nerve fibers formed many axo-dendritic as well...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90987-8
更新日期：1982-12-02 00:00:00
abstract：:One hundred and four visual units of the (ventral) lateral geniculate nucleus (GL) of chicks (Gallus domesticus) were studied with extracellular microelectrodes. Most were extremely responsive to moving targets even at low speeds (0.1 degrees/sec). They were classified as follows. (1) movement-sensitive units with uni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90823-0
更新日期：1979-05-11 00:00:00
abstract：:The bioelectric activity of the rat superior cervical ganglion (SCG) infected with pseudorabies virus (PRV) was examined in vitro 30-38 h after inoculation. Simultaneous intra- and extracellular recordings on the internal (ICN) and external carotid nerves (ECN) revealed a synchronized spontaneous activity. This synchr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90642-4
更新日期：1982-05-20 00:00:00
abstract：:The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.03.010
更新日期：2016-07-01 00:00:00
abstract：:The effects of sodium valproate on extracellularly recorded spontaneous neuronal activity and its interaction with GABA-induced inhibition were assessed in the rat medial basal hypothalamus both in situ and in explant culture. In situ, valproate enhanced the spontaneous rate in 14 of 20 neurons sampled, 6 neurons were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90288-2
更新日期：1981-08-24 00:00:00
abstract：:The projections to the striatum from two cytoarchitectonically and functionally distinct subdivisions of the cat precruciate motor cortex were studied using anatomical and electrophysiological techniques. Our results indicate that the medial precruciate cortex (stimulation of which leads to movements of the axial and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90960-0
更新日期：1979-07-20 00:00:00
abstract：:By the use of anti-omega-CTx antibodies in indirect immunofluorescence we demonstrated the presence of omega-CTx binding sites in the presynaptic compartment of frog nerve-muscle preparations. The images we obtained indicate that omega-CTx-sensitive channels are clustered at discrete sites corresponding in distributio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90981-z
更新日期：1991-05-03 00:00:00
abstract：:Chronic hydrocephalus is one of the severe complications after subarachnoid hemorrhage (SAH). However, there is no efficient treatment for the prevention of chronic hydrocephalus, partially due to poor understanding of underlying pathogenesis, subarachnoid fibrosis. Transforming growth factor-β1(TGF-β1) is a potent fi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.11.004
更新日期：2016-01-01 00:00:00
abstract：:The importance of particular genes in neuronal death following global cerebral ischemia can readily be studied in genetically modified mice provided a reliable model of ischemia is available. For that purpose, we developed a mouse model of global cerebral ischemia that induces consistent damage to different regions of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03014-2
更新日期：2003-08-29 00:00:00
abstract：:The blood-brain interface in elasmobranchs was examined using physiological and anatomical techniques. Electrolyte analyses of plasma and cerebrospinal fluid (CSF) in control fish and in fish with elevated plasma cation concentration (Ca, Mg or K) demonstrated homeostasis of CSF calcium and magnesium concentrations in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91083-0
更新日期：1981-12-07 00:00:00
abstract：:The effects of acute ethanol exposure of chick spinal cord neurons were studied in tissue culture, using whole-cell voltage-clamp techniques. Results indicate that ethanol produces a persistent increase in the sensitivity of spinal neurons to GABA and glycine, with no change in input resistance or resting membrane pot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90098-4
更新日期：1988-07-12 00:00:00
abstract：BACKGROUND:Diminished dopaminergic neurotransmission contributes to decreased reward and negative eating behaviors in obesity. Bariatric surgery is the most effective therapy for obesity and rapidly reduces hunger and improves satiety through unknown mechanisms. We hypothesized that dopaminergic neurotransmission would...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.064
更新日期：2010-09-02 00:00:00
