Abstract：
:N-stearoyltyrosine (NsTyr), a synthesized anandamide (AEA) analogue, was evaluated for the first time in the present study for the neuroprotective effect in gerbils subjected to transient global cerebral ischemia reperfusion (IR). The extent of ischemia injury was assessed behaviorally by measuring neurological functions, passive avoidance test and Morris water maze; and histopathologically by evaluating hippocampal CA1 pyramidal damage. In addition, ischemia-induced apoptosis was examined using the terminal deoxynucleotidyl transferase-mediated UTP nick end labeling (TUNEL) method. Furthermore, in order to understand the mechanism of NsTyr's neuroprotective effect, we examined antioxidative enzymes, such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and non-enzymatic scavenger glutathione (GSH) and measured the levels of malondialdehyde (MDA) in hippocampus. The administration of NsTyr led to attenuation of ischemia-induced neural deficits both behaviorally and histopathologically, reduced the level of MDA, significantly increased the activity of antioxidants GSH and GSH-PX, and obviously elevated the activities of SOD and CAT. Our results suggest that NsTyr shows neuroprotective effect on global cerebral IR injury and its neuroprotective effects may be attributed to restraining DNA fragmentation, suppressing the production of free radicals and elevating antioxidant capacity.
journal_name
Brain Resjournal_title
Brain researchauthors
Zhang YB,Kan MY,Yang ZH,Ding WL,Yi J,Chen HZ,Lu Ydoi
10.1016/j.brainres.2009.06.070subject
Has Abstractpub_date
2009-09-01 00:00:00pages
146-56eissn
0006-8993issn
1872-6240pii
S0006-8993(09)01287-6journal_volume
1287pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The effects of the serotonin precursor 5-HTP, were determined in a behavioral DNIC paradigm (increase in vocalization threshold after intraperitoneal injection of the algogenic agent, phenylbenzoquinone). This counter-irritation phenomenon was strongly potentiated by 5-HTP, such potentiation being blocked by the 5-HT ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90384-5
更新日期：1982-01-14 00:00:00
abstract：:We compared changes in levels of substance P-like immunoreactivity (SPLI) in L4-6 dorsal root ganglia (DRG), L4-6 dorsal roots, sciatic nerve, tibial nerve and hind foot skin in rats following resection or crush injury of the sciatic nerve. The initial depletion of SPLI, which occurred in all areas sampled, was simila...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90725-0
更新日期：1986-02-12 00:00:00
abstract：:The effects of repetitive pilocarpine-induced status epilepticus (SE) in the hippocampal Na(+)/K(+)ATPase activity were studied in developing rat. Na(+)/K(+)ATPase is a membrane-bound enzyme responsible for the active transport of sodium and potassium ions through the membrane. It is necessary to maintain neuronal exc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.12.068
更新日期：2007-03-23 00:00:00
abstract：:To provide evidence to support the calcium hypothesis of cerebral ischemia, we examined the effects of extracellular calcium and calcium antagonists (verapamil, flunarizine, nicardipine) on in vitro 'ischemia' using guinea pig hippocampal slices. As a model of in vivo ischemia we used a state of both glucose and oxyge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90242-4
更新日期：1990-08-27 00:00:00
abstract：:Pretreatment with the alpha(2)-adrenoceptor agonist clonidine (31.25, 62.5, or 125 microg/kg, i.p.) dose-dependently reduced long-term potentiation (LTP) elicited in vivo in the occipital cortex of anesthetized rats, whereas pretreatment with the alpha(2)-adrenoceptor antagonist yohimbine (0.133, 0.4, or 1.2 mg/kg, i....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.020
更新日期：2004-09-24 00:00:00
abstract：:Opioid receptor subtype antagonists differentially alter food intake under deprivation (24 h), glucoprivic (2-deoxy-D-glucose, 500 mg/kg, i.p.) or palatable (10% sucrose) conditions with mu (beta-funaltrexamine) and kappa (nor-binaltorphamine), but not delta1 ([D-Ala2,Leu5,Cys6]enkephalin) opioid antagonists reducing ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00539-8
更新日期：1997-08-29 00:00:00
abstract：:Homer1a is implicated in depression in humans and depression-like behavior in mice. To further understand the role of Homer1a in stress-induced emotional changes, we applied very mild stress to Homer1a knockout (H1a KO) mice. The wild-type (WT) and H1a KO mice were restrained for 2h daily for 7 consecutive days at the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.008
更新日期：2015-04-24 00:00:00
abstract：:We report the localization of angiotensin-converting enzyme (kininase II, EC 3.4.15.1) in discrete nuclei and areas of the rat brain by a quantitative autoradiographic technique using image processing coupled to computerized microdensitometry, after incubation of brain sections with the specific converting enzyme inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90746-8
更新日期：1986-06-11 00:00:00
abstract：:Stanniocalcin (STC-1), a 50 kDa glycoprotein hormone that regulates calcium/phosphate homeostasis in bony fish and mammals, has been shown to be expressed in central neurons and choroid plexus, and to exert a protective effect against hypercalcemic and hypoxic damage to neurons. Circumventricular organs are known to f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.070
更新日期：2008-07-07 00:00:00
abstract：:An enriched environment has been shown to improve cognitive, behavioral and histopathological outcome after focal cerebral ischemia and head trauma. The purpose of this study was to determine the effect of an enriched environment on histopathology following global cerebral ischemia. Wistar rats (21 weeks of age) were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04089-1
更新日期：2003-02-21 00:00:00
abstract：:In the vertebrate retina excitatory transmission seems to be mediated mainly by excitatory amino acids; glutamate and/or aspartate are the most viable candidates to subserve this function. Postsynaptic receptors for N-methyl-D-aspartate (NMDA), kainate (KA), quisqualate (QA) and 2-amino-4-phosphonobutyric acid have be...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91330-8
更新日期：1987-06-23 00:00:00
abstract：:GABA-A receptors mediate both phasic synaptic inhibition and more recently appreciated tonic currents in the vertebrate central nervous system. We addressed discrepancies in the literature regarding the pharmacology of tonic currents by examining tonic currents in a controlled environment of dissociated, solitary glut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.033
更新日期：2006-11-06 00:00:00
abstract：:During aerobic incubation at 37 degrees C, active uptake of labeled non-metabolizable alpha-aminoisobutyric acid (AIB) into isolated nodose ganglia (NG) excised from adult rats was accelerated to nearly twice that of the control, by the addition of glia maturation factor (GMF, 5 micrograms/ml) in a dose-dependent mann...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90350-1
更新日期：1986-05-14 00:00:00
abstract：:The [14C]2-deoxy-D-glucose technique was used to test the effects of central muscarinic stimulation on local cerebral glucose utilization (LCGU) in rats. Systemic administration of the muscarinic agonist oxotremorine (OXO, 0.7 mg/kg, ip) increased LCGU in brain regions involved in motor function: the sensorimotor cort...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91100-8
更新日期：1981-12-07 00:00:00
abstract：:Brevetoxins (PbTx) are potent allosteric enhancers of voltage-gated sodium channel (VGSC) function and are associated with periodic "red tide" blooms. These neurotoxins produce neuronal injury and death in cerebellar granule cells (CGC) following acute exposure. In murine neocortical neurons, brevetoxin induces Ca(2+)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.10.018
更新日期：2005-01-07 00:00:00
abstract：:The GABAB agonist, baclofen, causes a dose-dependent decrease in lordosis, and this effect is attenuated following hypothalamic serotonin, (5-HT) lesions. Baclofen administration is associated with decreased 5-HT activity in the medial preoptic (mPOA) and ventromedial nuclei and enhanced 5-HT activity in the midbrain ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90564-c
更新日期：1991-08-09 00:00:00
abstract：:Bone marrow-derived mesenchymal stem cells (BMSCs) are a promising source for cell-based treatment of brain injury, but the therapy of BMSCs is restricted by low cell survival. We examined whether nerve growth factor (NGF) improve BMSCs viability in the brain with Fimbria-Fornix lesion (FF). After transduction of NGF ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.010
更新日期：2009-01-19 00:00:00
abstract：:Studies with radioactive antipyrene and deoxyglucose indicated that both blood flow and metabolism are enhanced in the goldfish optic tectum following a brief visual stimulation. It is concluded that the brain of cold-blooded animals demonstrates regionally regulated physiological alterations, previously reported only...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90195-1
更新日期：1979-01-26 00:00:00
abstract：:As in many humans suffering from lupus erythematosus, the development of systemic autoimmunity and inflammation in Fas-deficient MRL-lpr mice is accompanied by CNS dysfunction of unknown etiology. Experimental studies revealed infiltration of lymphoid cells into the choroid plexus, reduced neuronal complexity, retarde...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03980-x
更新日期：2003-02-28 00:00:00
abstract：:Studies have demonstrated defects of DA and 5HT neurotransmission in dietary fat induced obese animals. In the present study, we used a perfusion system to assay the release of DA and 5HT from striatal slices preloaded with [(3)H]-DA or [(3)H]-5HT. The release of both DA and 5HT from striatal slices of rats fed a high...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.06.036
更新日期：2010-08-19 00:00:00
abstract：:In neuronal cultures, glycogen synthase kinase 3(GSK3) is truncated at the N-terminal end by calpain downstream of activated glutamate receptors. However, the in vivo biological significance of that truncation has not been explored. In an attempt to elucidate if GSK3 truncation has a pathophysiological relevance, we h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.03.016
更新日期：2015-06-22 00:00:00
abstract：:The impact of hyperglycemia after traumatic brain injury (TBI), and even the administration of glucose-containing solutions to head injured patients, remains controversial. In the current study adult male Sprague-Dawley rats were tested on behavioral tasks and then underwent surgery to induce sham injury or unilateral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.04.022
更新日期：2015-07-21 00:00:00
abstract：:The effect of perinatal androgen exposure on the sexually dimorphic distribution of serotonin (5-HT)-immunoreactive fibers in the medial preoptic nucleus (MPN) of the rat was evaluated with an indirect immunohistochemical method. Female animals treated with testosterone propionate (TP) perinatally, postnatally or with...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90777-2
更新日期：1985-08-05 00:00:00
abstract：:Electrical stimulation in the dorsal acoustic stria (DAS) and the posterior and dorsal part of the ventral cochlear nucleus (VCN) was used to identify the response properties of efferent axons from the dorsal cochlear nucleus (DCN) in unanesthetized, decerebrate cats. Responses recorded in the DCN of this preparation ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91091-4
更新日期：1980-10-27 00:00:00
abstract：:Microinfusions of the benzodiazepine anxiolytic midazolam into the central or basolateral amygdaloid nuclei produced different anxiolytic effects in two tests of rat 'anxiety'. Infusions into the basolateral nucleus impaired open-arm avoidance in the elevated plus-maze test, but did not impair shock-probe avoidance in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01318-c
更新日期：1995-02-13 00:00:00
abstract：:The role of calcium and protein kinases in rhythmic activity induced by muscarinic receptor activation in the CA1 area in rat hippocampal slices was investigated. Extracellular recording showed that carbachol (20 microM) induced synchronized field potential activity with a dominant frequency of 7.39+/-0.68 Hz. Pretrea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02331-3
更新日期：2000-07-28 00:00:00
abstract：:The effect of the xanthine derivative propentofylline (HWA 285) on metabolic and functional recovery in rabbit spinal cord after 20 and 30 min ischemia and 4 days of reperfusion was investigated. Pre-treatment with 20 mg/kg significantly improved recovery of the energy state in the spinal cord, however, without signif...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91114-t
更新日期：1992-09-11 00:00:00
abstract：:The ependymocytes lining the central canal of the spinal cord in rats have prominent F-actin networks in the apical cytoplasm, exhibiting significant regional heterogeneity between differing spinal levels. It is not clear when and how this regional heterogeneity develops. We examined F-actin in the central canal durin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.08.045
更新日期：2008-11-06 00:00:00
abstract：:The present experiments were designed to assess whether brain hypothermia can reduce the behavioral and histopathological deficits associated with global forebrain ischemia. Animals were subjected to 12.5 min of four vessel occlusion (4VO) with moderate hypotension, and brain temperature maintained at either 37 degree...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90945-6
更新日期：1992-05-15 00:00:00
abstract：:Alteration of blood-brain barrier (BBB) permeability by 2450 MHz CW microwaves was assessed semi-quantitatively after intravenous injection of horseradish peroxidase (HRP) and exposure of conscious, unrestrained rats to incident power densities of 0, 20 or 65 mW/cm2 for 30, 90 or 180 min. Additional rats were exposed ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-0173(84)90022-5
更新日期：1984-05-01 00:00:00
