Presynaptic modulation of the release of dopamine from striatal synaptosomes: differences in the effects of high K+ stimulation, methamphetamine and nicotinic drugs.

abstract：:This study investigated the effects of antidromically conducted nerve impulses on the transmission of orthodromic volleys in primary afferents of the hindlimb in decerebrated paralyzed cats. Two protocols were used: (A) Single skin and muscle afferents (N=20) isolated from the distal part of cut dorsal rootlets (L7-S1...

journal_title：Brain research

authors： Gossard JP,Bouyer L,Rossignol S

更新日期：1999-04-17 00:00:00

abstract：:Administration of sheep red blood cells (10(6) cells, i.p.) resulted in central norepinephrine (NE) and dopamine (DA) changes which corresponded with the time of the peak immune response. These amine variations, however, appeared to be specific to certain brain regions. The increased accumulation of the NE metabolite,...

journal_title：Brain research

authors： Zalcman S,Shanks N,Anisman H

更新日期：1991-08-23 00:00:00

abstract：:Pentobarbital reversibly increased Na+-dependent GABA binding to bovine cerebral cortex membranes. This effect was chloride-dependent. Kinetic analysis of [3H]GABA binding revealed an increase of the apparent number of binding sites. Pretreatment of the membranes with Triton X-100 extremely diminished the effect of pe...

journal_title：Brain research

authors： Asano T,Ogasawara N

更新日期：1981-11-23 00:00:00

abstract：:The purpose of this study was to determine the effects of aging and gender on the volumes of total brain, brainstem, cerebellum and lateral ventricle of healthy Koreans by magnetic resonance imaging (MRI). Using three-dimensional MRI volumetry, we compared the volumes of various brain regions according to age and gend...

journal_title：Brain research

authors： Lee NJ,Park IS,Koh I,Jung TW,Rhyu IJ

更新日期：2009-06-18 00:00:00

abstract：:We consider a random synaptic pruning in an initially highly interconnected network. It is proved that a random network can maintain a self-sustained activity level for some parameters. For such a set of parameters a pruning is constructed so that in the resulting network each neuron/node has almost equal numbers of i...

journal_title：Brain research

authors： Turova TS

更新日期：2012-01-24 00:00:00

abstract：:It has been suggested that thiolic groups are essential for cytochrome c oxidase (COX) activity and other respiratory mitochondrial enzymes. Recent experiments showed that the thiolic antioxidant N-acetylcysteine (NAC) can protect against age-related impairment in COX activity in mice hepatic mitochondria. The present...

journal_title：Brain research

authors： Martínez Banaclocha M,Martínez N

更新日期：1999-09-18 00:00:00

abstract：:The ability of membrane-associated peptidases from the brains of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats to metabolize iodinated angiotensin (125I-Ang II) and 125I-Ang III was compared. 125I-Ang II was metabolized to 125I-Ang III and other fragments exclusively by membrane-assoc...

journal_title：Brain research

authors： Cook VI,Wright JW,Wright SA,Harding JW

更新日期：1990-10-08 00:00:00

abstract：:ATP has been recognized as an important extracellular signaling molecule and P2X receptors are membrane ion channels activated by the binding of extracellular ATP. Since both AQP4 and P2X7 receptor (P2X7R) are known to be present in astrocytes, we examined whether P2X7R activation plays a role in the regulation of AQP...

journal_title：Brain research

authors： Lee M,Lee SJ,Choi HJ,Jung YW,Frøkiaer J,Nielsen S,Kwon TH

更新日期：2008-02-21 00:00:00

abstract：:Inoculation of the tail base of rats with Mycobacterium butyricum led to an arthritic swelling and inflammation of the limbs which displayed a hyperalgesia to noxious pressure: these effects peaked at 3 weeks postinoculation. In vitro autoradiography of coronal sections of rat brain was used for a parallel determinati...

journal_title：Brain research

authors： Millan MJ,Morris BJ,Colpaert FC,Herz A

更新日期：1987-07-28 00:00:00

abstract：:Chronic intermittent hypoxia (CIH) may cause sustained systemic hypertension by increasing sympathetic neural discharge (SND). We hypothesized that CIH alters brainstem circuits modulating SND. After 30 days of CIH exposure in rats, increased c-fos labeling was seen in the nucleus of the solitary tract and ventrolater...

journal_title：Brain research

authors： Greenberg HE,Sica AL,Scharf SM,Ruggiero DA

更新日期：1999-01-23 00:00:00

abstract：:Intracellular recordings were performed in vitro from both pars compacta and pars reticulata neurones of the substantia nigra, and their postsynaptic responses to electrical stimulation within the nucleus were analysed. Intracellular staining by biocytin was used to reveal the morphology and location of the recorded n...

journal_title：Brain research

authors： Hajós M,Greenfield SA

更新日期：1994-10-17 00:00:00

abstract：:Excitotoxic neuronal death underlies many neurodegenerative disorders. Because cannabinoid receptor agonists act presynaptically to inhibit glutamate release, we examined the effects of Win 55212-2, a full agonist at CB(1) receptors, and Delta(9)-tetrahydrocannabinol (THC), a partial agonist, on the survival of neuron...

journal_title：Brain research

authors： Gilbert GL,Kim HJ,Waataja JJ,Thayer SA

更新日期：2007-01-12 00:00:00

abstract：:Plectin is associated with intermediate filaments, such as glial fibrillary acidic protein (GFAP) and vimentin, which have an important role in the glial reactions after lesions. The present study investigates the plectin immunoreactivity following stab wounds in the cortex and the underlying white matter of adult rat...

journal_title：Brain research

authors： Kálmán M,Szabó A

更新日期：2000-02-28 00:00:00

abstract：:The cholinergic innervation of the mediodorsal (MD) nucleus of the thalamus was visualized immunohistochemically in human brain postmortem, using an antibody against human choline acetyltransferase (ChAT). The ChAT staining of the MD nucleus was more intense than in the surrounding thalamic nuclei but weaker than that...

journal_title：Brain research

authors： Brandel JP,Hirsch EC,Hersh LB,Javoy-Agid F

更新日期：1990-05-07 00:00:00

abstract：:Previous research has demonstrated that diabetes induces learning and memory deficits. However, the mechanism of memory impairment induced by diabetes is poorly understood. The present study investigated the effect of streptozotocin (STZ)-induced diabetes on spatial learning and memory using the Morris Water Maze. The...

journal_title：Brain research

authors： Ye L,Wang F,Yang RH

更新日期：2011-09-09 00:00:00

abstract：:Adaptation in aging may become impaired from abnormal expression of corticotropin-releasing factor (CRF) and altered CRF receptor function. In this study, we measured CRF mRNA levels in Fischer 344 rats at various ages. The brains of these rats were processed for in situ hybridization. Relative to 3-month-old rats, le...

journal_title：Brain research

authors： Kasckow JW,Regmi A,Mulchahey JJ,Plotsky PM,Hauger RL

更新日期：1999-03-20 00:00:00

abstract：:Amphetamine-induced locomotion and stereotypy were concurrently evaluated in order to determine if pretreatment with para-chlorophenylalanine (PCPA) (which is reported to facilitate some of the effects of amphetamine) results in a behavioral pattern similar to the augmentation previously reported to occur with repeate...

journal_title：Brain research

authors： Segal DS

更新日期：1976-11-05 00:00:00

abstract：:An acute pain animal model for fMRI study would provide useful spatial and temporal information for studying the supraspinal nociceptive neuronal responses. The aim of the present study was to investigate whether the nociceptive responses in different brain areas can be differentiated by using functional magnetic reso...

journal_title：Brain research

authors： Chang C,Shyu BC

更新日期：2001-04-06 00:00:00

abstract：:Amphetamine releases dopamine through a transporter-mediated mechanism. The purpose of this report was to further our understanding of the intracellular pool from which amphetamine releases dopamine: the cytoplasmic pool, the vesicular pool, or both. Rats were treated with D-amphetamine (AMPH) (1.0 or 10.0 mg/kg) or a...

journal_title：Brain research

authors： Sabol KE,Seiden LS

更新日期：1998-09-21 00:00:00

abstract：:We investigated the effects of a novel Na(+)/H(+) exchanger-1 (NHE-1) inhibitor KR-33028 on glutamate excitotoxicity in cultured neuron cells in vitro and cerebral infarct in vivo by comparing its potency with that of zoniporide, a well-known, highly potent NHE-1 inhibitor. KR-33028 inhibited NHE-1 activation in a con...

journal_title：Brain research

authors： Lee BK,Lee DH,Park S,Park SL,Yoon JS,Lee MG,Lee S,Yi KY,Yoo SE,Lee KH,Kim YS,Lee SH,Baik EJ,Moon CH,Jung YS

更新日期：2009-01-12 00:00:00

abstract：:Ouabain (5 X 10(-4) M) induced a 6-fold increase in intracellular Na+ and a 65% loss of cellular K+ in C6 glial cells which was accompanied by a 12 mV decrease in the resting membrane potential. Following ouabain washout intracellular ion concentrations and the membrane potential returned to control levels suggesting...

journal_title：Brain research

authors： Kukes G,De Vellis J,Elul R

更新日期：1976-03-05 00:00:00

abstract：:Noxious heat applied to the footpad evokes the expression of fos protein-like immunoreactivity in the rat spinal cord lumbar dorsal horn. Electrical stimulation in the medullary nucleus raphe magnus (NRM) while not evoking fos-like immunoreactivity itself, reduced significantly the number of neurons (to 50% of control...

journal_title：Brain research

authors： Jones SL,Light AR

更新日期：1990-10-22 00:00:00

abstract：:We have identified an inhibitory neuron (RPL4) in the right pleural ganglion of Aplysia, which produced hyperpolarization of the sensory and motor neurons involved in the tail withdrawal reflex. Activation of RPL4 significantly reduced the amplitude of excitatory postsynaptic potentials produced in tail motor neurons ...

journal_title：Brain research

authors： Buonomano DV,Cleary LJ,Byrne JH

更新日期：1992-04-10 00:00:00

abstract：:The administration of alpha 2-adrenoreceptor antagonists SKF 64139 or SKF 72223 (TIQ derivatives) elicits an increase in striatal DOPA synthesis. The findings that the enhanced DOPA synthesis is reversed by pretreatment of the animals with clonidine or with the D beta H inhibitor FLA-63 suggest that action of the TIQ ...

journal_title：Brain research

authors： Rabey JM,Passeltiner P,Bystritsky A,Engel J,Goldstein M

更新日期：1981-12-28 00:00:00

abstract：:Our recent results showed that angiotensin II or III (AII, AIII) microinjected into the zona incerta (ZI) significantly increased water intake. The most effective doses of AII and AIII were also defined. The two neuropeptides had their effects differently on drinking via different receptors. AII bound to AT(1) that wa...

journal_title：Brain research

authors： Bagi EE,Fekete E,Bányai D,Lénárd L

更新日期：2004-03-26 00:00:00

abstract：:Growth hormone releasing factor (GRF) applied by iontophoresis, pressure, and in the perfusate, increased (14.81%) or decreased (45.92%) the firing of paraventricular neurons extracellularly recorded from guinea-pig hypothalamic slices. Effects were similar whatever the mode of application and were elicited in the nan...

journal_title：Brain research

authors： Poulain P,Carette B

更新日期：1986-04-23 00:00:00

abstract：:We investigated the electrophysiological properties of the area postrema neurons in acutely prepared rat brain slices using the whole-cell patch-clamp technique. Two different types of transient outward potassium current (I(to)), fast and slow, were found in the area postrema. Both the decay time constant and rise tim...

journal_title：Brain research

authors： Funahashi M,Mitoh Y,Matsuo R

更新日期：2002-06-28 00:00:00

abstract：:Bilateral removal of the cortical visual area in newborn cats produces degeneration of retinal ganglion cells. Measurements of over 4,000 cells and calculation of neuron densities from sample areas of retina in the adult show that the medium sized cell population in peripheral retina is reduced by 68%, whereas the pop...

journal_title：Brain research

authors： Pearson HE,Labar DR,Payne BR,Cornwell P,Aggarwal N

更新日期：1981-05-18 00:00:00

abstract：:The BE (2)-M17 human neuroblastoma has previously been shown to express corticotropin-releasing factor (CRF) mRNA following retinoic acid treatment. It is demonstrated in this report that both cell extracts and cell incubation medium of retinoic acid-treated BE (2)-M17 cells were shown to contain CRF-like immunoreacti...

journal_title：Brain research

authors： Kasckow JW,Parkes DG,Owens MJ,Stipetic MD,Han JH,Nemeroff CB,Vale WW

更新日期：1994-08-15 00:00:00

abstract：:(1)The brain stem of anaesthetized cats has been mapped between Horsley-Clark planes APO and P8.5 with electrical stimuli of low intensity in order to determine the areas which can produce excitatory of inhibitory influences on the spontaneously contracting, sympathetically denervated, urinary bladder. (2) Two inhibit...

journal_title：Brain research

authors： McMahon SB,Spillane K

更新日期：1982-02-25 00:00:00