Inhibitory neuron produces heterosynaptic inhibition of the sensory-to-motor neuron synapse in Aplysia.

Abstract:

:We have identified an inhibitory neuron (RPL4) in the right pleural ganglion of Aplysia, which produced hyperpolarization of the sensory and motor neurons involved in the tail withdrawal reflex. Activation of RPL4 significantly reduced the amplitude of excitatory postsynaptic potentials produced in tail motor neurons by action potentials triggered in sensory neurons. This example of heterosynaptic inhibition was due, at least in part, to an increase in membrane input conductance in the motor neuron. Since the synaptic strength of the sensory-to-motor neuron connection has been associated with the strength of the tail withdrawal reflex, RPL4 may contribute to modulation of that reflex.

journal_name

Brain Res

journal_title

Brain research

authors

Buonomano DV,Cleary LJ,Byrne JH

doi

10.1016/0006-8993(92)90548-n

subject

Has Abstract

pub_date

1992-04-10 00:00:00

pages

147-50

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(92)90548-N

journal_volume

577

pub_type

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