Abstract:
:Increasing adult neurogenesis in the hippocampal formation (HF) has been proposed as a potential foundation for neuronal repair in Alzheimer's disease (AD), but the evidence remains controversial. We used P8 strain of senescence-accelerated mice (SAMP8) as a model of AD to investigate changes in adult neurogenesis. We examined new proliferating cells and their survival in the dentate gyrus (DG) of the HF using 5-bromodeoxyuridine (BrdU) labeling and investigated newborn cell development and differentiation with a combination of phenotype markers. In 5-month-old SAMP8, the number of BrdU(+) cells in the DG was significantly increased relative to controls, in accordance with the rising numbers of doublecortin-positive (DCX(+)) immature neurons. Some of these BrdU(+) cells migrated to cornu ammonis 1 (CA1), possibly related to the compensation of neuronal loss. However, the capacity of neurogenesis to compensate neuronal loss during neurodegeneration was limited. First, only half of the BrdU(+) cells survived 4weeks after mitosis, and even fewer developed into neuron-specific nuclear protein positive (NeuN(+)) mature neurons. Second, the number of BrdU(+) cells and DCX(+) cells was decreased in 10-month-old SAMP8, which exhibited progressive neurodegeneration. In addition, the results provided insight into astrocytes as a crucial component of the neurogenic niche. The number of newborn astrocytes and expression of glial fibrillary acidic protein (GFAP) were diminished in the DG of SAMP8 animals, possibly explaining the insufficient neurogenesis. Thus, stimulating limited neurogenesis in AD by improving the neurogenic niche may have therapeutic potential.
journal_name
Brain Resjournal_title
Brain researchauthors
Gang B,Yue C,Han N,Xue H,Li B,Sun L,Li X,Zhao Qdoi
10.1016/j.brainres.2011.03.039subject
Has Abstractpub_date
2011-05-10 00:00:00pages
183-93eissn
0006-8993issn
1872-6240pii
S0006-8993(11)00559-2journal_volume
1389pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::We investigated the projection from the infralimbic division of the prefrontal cortex (area 25) to histaminergic neurons in the posterior hypothalamic area. Phaseolus vulgaris-leucoagglutinin (PHA-L) was injected in the prefrontal cortex of rats. Frozen brain sections were subjected to combined PHA-L and histidine dec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90802-x
更新日期:1987-03-17 00:00:00
abstract::Peripheral afferent innervation appears to be required for the expression of the dopamine phenotype in the rodent main olfactory bulb. Experiments utilizing neonatal naris closure as a means of sensory deprivation also suggest that odor-induced afferent activity is required for the expression of the phenotype. These e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91023-l
更新日期:1993-06-18 00:00:00
abstract::Artificial CSF containing 12mEq/1 of potassium (4 times normal concentration) was perfused over the surface of normal neocortex in 10 locally or barbiturate anesthetized cats. Extracellular potassium concentrations ([K+]OS) were measured as a function of time to 8 h and of depth to 3 mm. Analysis of the [K+]O versus d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90265-1
更新日期:1976-01-16 00:00:00
abstract::The response of granule cells and CA1 pyramidal neurones to NMDA was studied in the presence and absence of Mg2+ using an in vitro slice preparation. In the absence of Mg2+ the depolarizing response of hippocampal neurones to NMDA is accompanied by a decrease in input resistance. In the presence of Mg2+ ions, however,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90107-0
更新日期:1984-10-08 00:00:00
abstract::Alcohols and volatile anesthetics modulate the function of cys-loop ligand-gated ion channels, binding to a putative site between transmembrane domains two and three. The extracellular linker between these two domains is important in the transduction of the gating signal from the glycine binding site to the channel ga...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.03.031
更新日期:2007-06-04 00:00:00
abstract::Percussion of the quadriceps tendon was used to test the hypothesis that knee extensor muscle spindle discharge initiates down-regulation of the gain of the soleus H reflex. Seven subjects participated. Soleus H reflex magnitude was observed for up to 15 s, following conditioning tendon taps of 60 N or 80 N force and ...
journal_title:Brain research
pub_type: 临床试验,杂志文章
doi:10.1016/0006-8993(95)00273-s
更新日期:1995-05-29 00:00:00
abstract::Previous studies have demonstrated that increased mesolimbic dopamine (DA) activity disrupts sensorimotor gating as measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. Other behavioral changes following mesolimbic DA activation are mediated through GABAergic efferent projections from ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91754-5
更新日期:1990-11-05 00:00:00
abstract::The present studies examined the hypothesis that the N-methyl-D-aspartate (NMDA) receptor-nitric oxide (NO) pathway might be involved in the acute and chronic actions of delta 9-tetrahydrocannabinol (THC). The ability of dizocilpine (MK-801), a competitive NMDA receptor antagonist and NG-monomethyl-L-arginine (L-NMMA)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91715-9
更新日期:1994-12-19 00:00:00
abstract::Aluminum (Al) concentrations of the rat frontal cortex, parietal cortex, and hippocampus were measured by atomic absorption spectroscopy 16 days after a unilateral intracerebroventricular injection of Na gluconate, Al gluconate, or the cholinotoxin AF64A. A fourth group of rats were injected with AF64A 6 days before i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90946-8
更新日期:1988-03-22 00:00:00
abstract::The potential evoked in the pyriform cortex by single-pulse stimulation of the olfactory bulb was examined before and after single and repeated elicitation of an epileptiform afterdischarge produced by stimulation of the olfactory bulb. A single afterdischarge (AD) produced a rapid (i.e. within 5 min) increase in the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91275-2
更新日期:1985-12-30 00:00:00
abstract::A major mesolimbic projection towards the hippocampal formation (HF) has been extensively described, but no clear evidence of its dopaminergic content has been demonstrated. In order to evaluate the percentage of dopaminergic (DA) cells of ventral tegmental area (VTA-A10) and adjacent substantia nigra (SN-A9) projecti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90512-6
更新日期:1994-12-30 00:00:00
abstract::The pars externa (PE) system of the anterior olfactory nucleus (AON) in a primate, Callithrix jacchus, was defined by its architecture and by its connection patterns with the main olfactory bulb (MOB) as revealed by tracing techniques. Focal, unilateral injections of wheat germ agglutinin-conjugated horseradish peroxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90071-6
更新日期:1988-08-02 00:00:00
abstract::To elucidate the intracellular mechanism of seizure discharge, phosphorylation of cellular protein during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. PTZ markedly enhanced the phosphorylation of proteins of 34,000 and 50,000 molecular weight. Similar effects were observed by a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91395-8
更新日期:1986-01-01 00:00:00
abstract::The localization of human hand primary motor area (M1) has been the object of several studies during the last decades. EEG source analysis, functional magnetic resonance imaging (fMRI) and focal transcranial magnetic stimulation (TMS) are non-invasive methods for localizing M1 with good accuracy compared to direct ele...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.10.042
更新日期:2010-01-13 00:00:00
abstract::Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.04.014
更新日期:2019-08-15 00:00:00
abstract::The effect of an 8% casein and a control 25% casein diet on the granule cells in the dorsal blade of the dentate gyrus of the rat hippocampal formation was studied at 30, 90 and 220 days of age. Female rats were fed either an 8% or 25% casein diet 5 weeks prior to conception and the litters were maintained on these re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91769-d
更新日期:1990-11-05 00:00:00
abstract::Metallothioneins (MTs) are metal-binding proteins that are expressed in many tissues including brain. MTs protect cells and organs against metal toxicity and oxidants. Among MTs, a brain-predominant subtype MT-III has prominent neuroprotective activity against various types of damage. Here we show that the expression ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02633-7
更新日期:2003-06-20 00:00:00
abstract::In an effort to further characterize the proteins of the auditory nerve, the effects of hair cell loss on rapidly transported proteins of the auditory nerve were studied. The effects were studied in the waltzing guinea pig, a genetically deaf animal which displays an age-dependent loss of sensory cells, and in normal ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90693-x
更新日期:1982-12-16 00:00:00
abstract::We observed temporal changes in NACP (precursor protein of non-Abeta component of Alzheimer's disease amyloid), a presynaptic protein a.k. a. alpha-synuclein, in the hippocampus after 5 min ischemia. Intense NACP immunoreactivity was seen transiently around cerebral blood vessels in the CA1 subfield on day 4, and NACP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00033-x
更新日期:1998-03-30 00:00:00
abstract::When rabbit retinas are exposed in vitro to specific excitatory amino acid receptor agonists certain GABAergic amacrine cells are activated to cause a release of GABA. The GABA that is not released can be detected by immunohistochemistry. Exposure of tissues to kainate or NMDA each caused a characteristic change in th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91510-5
更新日期:1994-12-26 00:00:00
abstract::The distribution of carnosine-like immunoreactivity in photoreceptors of the frog retina was studied by post-embedding electron microscope immunocytochemistry. Different fixation and embedding procedures were applied and the best results were achieved on sections from tissue embedded in the hydrophilic resin LR White....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90256-9
更新日期:1992-04-24 00:00:00
abstract::Vanilloid (capsaicin) receptors were visualized by [3H]resiniferatoxin (RTX) autoradiography in the brain of newborn as well as adult (both control and colchicine-treated) rats. Specific labelling was seen in the brain stem only, in the nucleus of the solitary tract extending into the area postrema and the spinal sens...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01094-7
更新日期:1995-12-12 00:00:00
abstract::PC12D cells, a subline of PC12 cells, extend neurites very rapidly in response to NGF, even when RNA synthesis is blocked. Several minutes after the initiation of a concentration gradient of NGF from a micropipette in the vicinity of PC12D cells, clear projections emerged from cells on the side facing the micropipette...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91387-0
更新日期:1994-09-05 00:00:00
abstract::Cannabinoids and opioids are distinct drug classes historically used in combination to treat pain. Delta(9)-THC, an active constituent in marijuana, releases endogenous dynorphin A and leucine enkephalin in the production of analgesia. The endocannabinoid, anandamide (AEA), fails to release dynorphin A. The synthetic ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01908-3
更新日期:1999-11-27 00:00:00
abstract::alpha-Bungarotoxin (alpha-BuTX) binds in a saturable and practically irreversible fashion to membrane-associated receptors in the ciliary ganglion of the adult chick. The binding of toxin to receptors is competitively inhibited by nicotinic cholinergic ligands, and for these properties the receptors are regarded as ac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)91130-7
更新日期:1978-09-15 00:00:00
abstract::The purpose of this study was to determine the ultrastructure of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in G93A SOD1 mice modeling ALS at different stages of disease. Electron microscope examination of brainstem, cervical and lumbar spinal cords was performed in ALS mice at early and late s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.044
更新日期:2007-07-09 00:00:00
abstract::Fetal exposure to diazepam (DZ), a positive modulator of GABA(A) receptors and an agonist at mitochondrial benzodiazine receptors, induces long-term neural and behavioral effects. This study evaluated whether the early manipulation influenced the normal development of brain levels of neurosteroids or altered steroid a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.10.039
更新日期:2006-01-05 00:00:00
abstract::The reactivity of dopaminergic (DA) terminals in the nucleus accumbens was investigated in male rats submitted to tail-pinch or various social interactions. The DA activity was assessed by measurement of the presynaptic metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) by using differential pulse voltammetry in free m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90646-3
更新日期:1986-11-12 00:00:00
abstract::Mammalian target of rapamycin (mTOR) controls protein translation and has an important role in the mechanism of pain hypersensitivity under persistent pain conditions. However, its expression and localization in pain-related regions of the nervous system is not completely understood. Here, we examined the expression a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.04.010
更新日期:2010-06-08 00:00:00
abstract::Inorganic mercury (Hg2+) reduced voltage-gated calcium channel currents irreversibly in two different preparations. In cultured rat dorsal root ganglion (DRG) neurons, studied with the whole cell patch clamp technique, a rapid concentration-dependent decrease in the L/N-type currents to a steady state was observed wit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91146-j
更新日期:1993-12-31 00:00:00