Abstract：
:Vanilloid (capsaicin) receptors were visualized by [3H]resiniferatoxin (RTX) autoradiography in the brain of newborn as well as adult (both control and colchicine-treated) rats. Specific labelling was seen in the brain stem only, in the nucleus of the solitary tract extending into the area postrema and the spinal sensory nucleus of the trigeminal nerve. Also, a strong signal was seen in the dorsal horn, dorsal root, trigeminal and nodose ganglia. Membranes obtained from the cervical, thoracic, and lumbar segments of the spinal cord showed similar affinities for RTX and likewise for capsaicin and capsazepine; maximal receptor density was similar in the cervical and thoracic segments (approximately 70 fmol/mg protein) but was twice as high in the lumbar segment. 24 h after ligation of the vagal or the sciatic nerves, a strong accumulation of specific RTX binding sites was observed mainly proximal to the ligature, implying intraaxonal receptor transport from the nodose and dorsal root ganglia, respectively, to the periphery. Systemic (s.c.) vanilloid treatment depleted specific [3H]RTX binding sites from the brain stem, the sensory (dorsal root as well as trigeminal) ganglia, and the spinal cord. RTX was approximately 200-fold more potent than capsaicin for eliminating vanilloid receptors from the spinal cord. The present results suggest a discrete expression of vanilloid receptors in the brain stem (sensory nuclei); although intrinsic vanilloid receptor-expressing neurons are though to exist in the rat brain, they remain undetected by the present [3H]RTX autoradiography methodology.
journal_name
Brain Resjournal_title
Brain researchauthors
Szallasi A,Nilsson S,Farkas-Szallasi T,Blumberg PM,Hökfelt T,Lundberg JMdoi
10.1016/0006-8993(95)01094-7subject
Has Abstractpub_date
1995-12-12 00:00:00pages
175-83issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)01094-7journal_volume
703pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The origin of descending pathways to thoracic and cervical levels of the spinal cord has been investigated with retrograde tracing techniques in a series of pouch young and adult opossums. The opossum was chosen because it is born in a very immature state, 12-13 days after conception, and has a protracted development ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90102-0
更新日期：1984-08-01 00:00:00
abstract：:The independent and combined effects of Ca2+, Mg2+, Zn2+, Al3+ and Li+ on [3H]MK-801 binding in human cerebral cortical membranes were studied to further characterize the modulatory effects of metal ions on the N-methyl-D-aspartate (NMDA) receptor-ionophore. Glycine, in the presence of glutamate, significantly intensi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91290-0
更新日期：1989-05-01 00:00:00
abstract：:Previous work from this laboratory has documented that glutamate receptor activation and extracellular calcium entry into hippocampal neurons caused a long-lasting down-regulation of ligatin mRNA and protein. Here, we investigated whether glutamate reduced ligatin mRNA levels by decreasing the transcriptional activity...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00599-l
更新日期：1995-09-25 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity was examined in neurons of the monkey trigeminal ganglion. Moreover, CGRP- and SP-positive varicose nerve fibers were found, occasionally forming pericellular arborizations around trigeminal somata, which, at light microscopic level, suggeste...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91337-r
更新日期：1993-12-03 00:00:00
abstract：:The present study describes the time course of recovery in the fast axonal transport of 3H-labeled proteins in the nerve and the electrophysiological parameters in the extensor muscle of rats after single subperineural injection of batrachotoxin (BTX) (9.3 x 10(-12) mol) into the peroneal nerve. The fast axonal transp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90322-x
更新日期：1981-11-23 00:00:00
abstract：:The postnatal development of acetylcholinesterase (AChE, EC 3.1.1.7) and NADH-diaphorase was examined in the caudate-putamen nucleus and substantia nigra of rats ranging from 3 to 90 days in age. From 3 to 15 days post partum islands of AChE and NADH-diaphorase activity were observed in the caudate-putamen nucleus. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)91022-2
更新日期：1976-04-23 00:00:00
abstract：:The purpose of this study was to investigate autofluorescent pigment granules (lipofuscin, ceroid) in the trigeminal neurons (TN) during aging and streptozotocin-induced diabetes. Four young adult male rats were injected with streptozotocin (STZ; 50 mg/kg) to produce diabetes (DM), for comparison with four young uninj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.033
更新日期：2004-02-27 00:00:00
abstract：:It was previously reported that brain areas containing serotonin (5-hydroxytryptamine, 5-HT) receptors mediate memory consolidation as well as short (STM)- and long-term memory (LTM). Here the effects of systemic and intrahippocampal administration of 5-HT agonists and antagonists on an autoshaping learning task were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.007
更新日期：2007-05-25 00:00:00
abstract：:The 10-11-methylenedioxy (MDO) derivative of S(+)N-n-propylnorapomorphine (NPA) was prepared and tested as a possible active prodrug to S(+)NPA, which we have recently found to exert in vivo activity suggestive of selective antagonism of dopamine receptors in the limbic forebrain but not the extrapyramidal basal gangl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90083-7
更新日期：1987-02-17 00:00:00
abstract：:We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPi, there was a considerable augmentation of both neuronal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01563-1
更新日期：1998-03-16 00:00:00
abstract：:In cats ranging in age from the second week to adult, the postnatal functional development of striate cortical neurons projecting to the superior colliculus (SC) was studied by observing their visual responses, axonal conduction velocities and spontaneous activities. One-hundred-and-fifty-seven cells were identified a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90199-2
更新日期：1983-12-01 00:00:00
abstract：:Immunocytochemical localization of specific neurotransmitters in the brain is becoming increasingly important in studies of maturation. We have used the trilaminar prepyriform cortex (PC) of rats to study the distribution, patterns and relative number of cells, fibers and terminals during postnatal development using a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90208-2
更新日期：1987-08-01 00:00:00
abstract：BACKGROUND:An important part of the medical treatment of many cerebrovascular diseases is the occlusion of brain supplying arteries. Until now, the risk of this intervention can only be estimated by invasive diagnostics including the risk of cerebrovascular accidents. METHODS AND RESULTS:As a supporting tool, a comput...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.021
更新日期：2006-11-06 00:00:00
abstract：:The contribution of the activity of afferent fiber filaments to pain and hyperalgesia after administration of a plantar injection of interleukin-1 beta (IL-1 beta) to the hind-paw skin was investigated by recording action potentials of the rat dorsal root in response to mechanical and thermal stimuli. Touch stimuli we...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90960-1
更新日期：1994-09-19 00:00:00
abstract：:We previously reported that aquaporin 4 (AQP4) played a critical role in formation of brain edema and the altered expression of dystroglycan (DG) could relate with AQP4 expression after traumatic brain injury (TBI). However the mechanisms of this process remain unclear. DG was showed could act as a scaffold involved i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146347
更新日期：2019-10-15 00:00:00
abstract：:Baclofen-sensitive GABAB receptor binding to various brain regions was compared in age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rat. The specific [3H]baclofen binding was significantly higher in SHR cerebellum, hippocampus and nucleus tractus solitarii (NTS), but lower in medulla, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90941-2
更新日期：1985-12-09 00:00:00
abstract：:There is a population of neurons in the cortex in the middle and anterior part of the superior temporal sulcus (STS) of the monkey with responses which are selective for faces. If, consistent with the effects of damage to the temporal lobe, these neurons are involved in face recognition or in making appropriate social...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91356-3
更新日期：1985-09-02 00:00:00
abstract：:High affinity D-[3H]aspartate uptake and amino acid concentrations were examined in synaptosome-enriched preparations of microdissected rat ventral tegmental area 6-7 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Specific reductions were observed in the high affinity uptake of D-[3H...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90140-4
更新日期：1985-04-29 00:00:00
abstract：:Previous studies have found that the primary change in the brain of chronic alcoholics is a selective loss of white matter in cerebral hemispheres. It is unknown whether the loss of white matter is due to alcohol-induced degeneration of axons in white matter, and this hypothesis has never been tested. We used a newly ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.035
更新日期：2004-12-17 00:00:00
abstract：:Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine. Therefore, d-seri...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2011.05.039
更新日期：2011-07-15 00:00:00
abstract：:In an attempt to examine the possible role of noradrenergic (NA) and dopaminergic (DA) systems in intracranial self-stimulation (ICS), the rate-increasing effects of D- and L-amphetamine on ICS were determined in rats with nucleus accumbens electrodes (DA placement) or dorsal NA bundle electrodes (NA placement). The D...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90998-1
更新日期：1975-02-21 00:00:00
abstract：:Computer-assisted morphometrics were used to characterize mature somatodendritic architecture in Golgi-stained neurons of the entopeduncular nucleus (EN) of the adult cat. Only one form of adult EN neuron was apparent and characterized by common features including: relatively large conical somata, long aspiny and mode...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90766-3
更新日期：1986-06-11 00:00:00
abstract：:Alcohol-preferring Alko, Alcohol (AA) rats with free access to food and water were taught to voluntarily consume 10% alcohol solution during 20-min sessions. After the drinking session, rats had elevated dopamine release (as reflected by 3-methoxytyramine concentrations) in the nucleus accumbens, olfactory tubercle, a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)81705-2
更新日期：1997-11-07 00:00:00
abstract：:Abnormal increase in native long-chain ceramides (lcCer) in AD implicates roles in neuronal atrophy and cognitive dysfunction especially in view of divergent roles this second messenger plays in cell function. Since clearance is mediated by glucosylceramide synthase (GCS, EC 2.4.1.80) levels of the enzyme were compare...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.066
更新日期：2008-01-29 00:00:00
abstract：:An isoindolin-1-one derivate, JM-1232(-), was recently developed as a sedative and hypnotic agent with a strong affinity for the central benzodiazepine binding site of gamma-aminobutyric acid(A) (GABA(A)) receptors. The purpose of this study was to examine the effects of JM-1232(-) on the cardiovascular and sympatheti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.092
更新日期：2009-12-01 00:00:00
abstract：:Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (APV) blocked inductio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91337-g
更新日期：1990-08-13 00:00:00
abstract：:Recently, Somberg, in a preliminary report (1983), noted that electrical stimulation of the area postrema causes an increase in coronary vascular resistance. The increase in resistance was mediate by an increase in sympathetic activity as it was counteracted by alpha-adrenergic receptor blockade. The purpose of our st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91269-3
更新日期：1988-05-17 00:00:00
abstract：:In rats under urethane or pentobarbitone anesthesia, Ca2+ -sensitive microelectrodes were inserted into CA3 and CA1 hippocampal cells. In 23 neurons with a mean resting membrane potential (Vm) of -56.9 mV, the Ca potential (VCa) fell below Vm by an average of -22.1 mV (S.D. +/- 19.1 mV), indicating a mean intracellula...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90388-4
更新日期：1986-05-21 00:00:00
abstract：:Morphologically distinct subsets of mesotelencephalic neurons were sought following retrograde transport of Fluoro-Gold from iontophoretic injections relatively restricted to the medial shell, core or rostral pole subterritories of the nucleus accumbens. The diameter and lengths of Fluoro-Gold immunolabeled dendrites ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00556-6
更新日期：1995-08-14 00:00:00
abstract：:In kittens, but not in adult cats, depriving one eye of pattern vision by suturing the lids shut (monocular deprivation or MD) for one week reduces the proportion of binocular units in the visual cortex. A sensitivity of cortical units in adult cats to MD can be produced by infusing exogenous monoamines into the visua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90424-3
更新日期：1982-11-04 00:00:00
