Abstract：
:The purpose of this study was to investigate autofluorescent pigment granules (lipofuscin, ceroid) in the trigeminal neurons (TN) during aging and streptozotocin-induced diabetes. Four young adult male rats were injected with streptozotocin (STZ; 50 mg/kg) to produce diabetes (DM), for comparison with four young uninjected control rats and four aged rats (90 weeks old). Eight weeks after STZ injection, all rats were fixed with 4% paraformaldehyde, and paraffin sections of TN were prepared and observed by fluorescence microscopy. We found the number of neurons with autofluorescent pigments had increased to 30.38% of the total in DM compared to 8.98% in the control group, and 25.36% in the aged rats. The area of autofluorescence within those neurons was 16.84% in aged rats, 13.02% in DM and 4.45% in the controls. Thus, DM caused accelerated accumulation of fluorescent granules in trigeminal neurons, and this change may show that premature aging contributes to neuronal functional decline and morphological change.
journal_name
Brain Resjournal_title
Brain researchauthors
Sugaya A,Sugimioto H,Mogi N,Tsujigami H,Deguchi Sdoi
10.1016/j.brainres.2003.11.033subject
Has Abstractpub_date
2004-02-27 00:00:00pages
132-4issue
1eissn
0006-8993issn
1872-6240pii
S0006899303040782journal_volume
999pub_type
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