Abstract：
:In this study, we demonstrate the involvement of left frontoparietal cortices in neural processes for task-switching between skilled movements. Functional magnetic resonance imaging was conducted while thirty-two right-handed healthy participants performed two sequential finger-movement tasks with their left hands. One group (n = 16) trained these tasks through random-practice (tasks were either switched or repeated trial by trial) on one day and blocked-practice (successive intensive practice of each task) on the next day, while the remaining participants practiced in the reverse order. On the first day, performance of both tasks improved in all participants, suggesting that the two skilful tasks can be learned in both practice schedules. However, during the random-practice, the performance in the switched trials initially deteriorated and gradually approached to that in the repeated trials as the practice proceeded. The left (mainly inferior) frontoparietal cortices showed greater preparatory activity for the switched trials compared with the repeated trials in a left-hemispheric dominant manner, and the left intraparietal activity decreased as the performance of the switched trials improved. The results indicate that neural processes for task-switching are associated with the greater preparatory activity in the left inferior frontoparietal cortices, and the efficient switching may proceed concomitantly with the left intraparietal activity reduction.
journal_name
Brain Resjournal_title
Brain researchauthors
Uehara S,Mizuguchi N,Hirose S,Yamamoto S,Naito Edoi
10.1016/j.brainres.2019.146365subject
Has Abstractpub_date
2019-11-01 00:00:00pages
146365eissn
0006-8993issn
1872-6240pii
S0006-8993(19)30419-6journal_volume
1722pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Several neurologic illnesses in which excitotoxic mechanisms may play a role increase in prevalence with age. In the present study we examined the susceptibility of rats to quinolinic acid striatal lesions at 1, 4 and 20 months of age, and susceptibility to N-methyl-D-aspartate (NMDA) at 1 and 4 months of age. The ext...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90631-5
更新日期：1991-10-25 00:00:00
abstract：:Thermoregulatory (brown adipose tissue temperature) experiments were conducted in age-matched anesthetized, male Sprague-Dawley and Long Evans rats kept at 37 degrees C given unilateral electrical stimulation of the ventromedial hypothalamic nucleus or the lateral preoptic area or after intravenous infusion of norepin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90422-6
更新日期：1992-03-13 00:00:00
abstract：:In the brain, free zinc levels are under the exquisite control of a variety of zinc-regulating systems, in which zinc transporter (ZnT) proteins play a central role. ZnT3, which is prominently expressed in the brain, facilitates the concentration of free zinc in pre-synaptic vesicles. In addition to histochemical stai...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.08.055
更新日期：2011-10-18 00:00:00
abstract：:Baclofen-sensitive GABAB receptor binding to various brain regions was compared in age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rat. The specific [3H]baclofen binding was significantly higher in SHR cerebellum, hippocampus and nucleus tractus solitarii (NTS), but lower in medulla, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90941-2
更新日期：1985-12-09 00:00:00
abstract：:In adult cats, we have investigated how nerve cross-union between slow and fast muscle affects twitch contraction and half-relaxation times in the presence and absence of motor disuse, produced by complete decerebellation. Cerebellectomy abolished the slowing of cross-innervated fast muscle and diminished the amount o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90480-2
更新日期：1982-02-18 00:00:00
abstract：:The effects of dopamine D1 and D2 selective drugs on the responses evoked in accumbens neurons by stimulation of cortical afferents were studied in an in vitro brain slice preparation. The D2-specific antagonist sulpiride (1-10 microM) increased, whereas the D2 agonist quinpirole (1-20 microM) occasionally attenuated ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90263-1
更新日期：1994-01-14 00:00:00
abstract：:Much evidence suggests that the neuropeptide cholecystokinin (CCK) functions as a neurotransmitter or neuromodulator in the central nervous system. The CCKa receptor subtype in the nucleus accumbens has been demonstrated to potentiate the behavioral and neurophysiological effects of dopamine. Since the mesolimbic dopa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00918-g
更新日期：1995-11-20 00:00:00
abstract：:The differential effects of the pyrethroid tetramethrin on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) single sodium channel currents in rat dorsal root ganglion (DRG) neurons were investigated using the outside-out configuration of patch-clamp technique. Channel conductances were 10.7 and 6.3 pS...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01449-7
更新日期：1996-03-18 00:00:00
abstract：:The CNP neuropeptides (Command Neuron Peptides) were first found in the command neurons for withdrawal behavior in the terrestrial snail. Given the fact that certain peptides can be found in various invertebrates, we examined Drosophila brains to determine if CNP-like peptides were present. Two types of antisera were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.038
更新日期：2007-06-04 00:00:00
abstract：:We previously reported that abdominal surgery induces Fos expression in specific hypothalamic and medullary nuclei and also causes gastric stasis. The gastric ileus is reduced by systemic capsaicin and abolished by central injection of corticotropin-releasing factor (CRF) antagonist. We studied the influence of system...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01281-4
更新日期：1997-02-14 00:00:00
abstract：:Saccadic adaptation maintains saccade accuracy and has been studied with targeting saccades, i.e. saccades that bring the gaze to a target, with the classical intra-saccadic step procedure in which the target systematically jumps to a new position during saccade execution. Post-saccadic visual feedback about the error...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.029
更新日期：2011-09-30 00:00:00
abstract：:Patterns of proliferation and changes in non-neuronal cell number in the visual system of the goldfish have been quantitatively examined during optic axon regeneration after an optic nerve crush (ONC). In addition, in order to examine the effect of the regenerating axons on cellular responses in the visual pathways, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02339-2
更新日期：2000-01-31 00:00:00
abstract：:It has recently been shown that the lobules 9 and 10 of the cerebellum contain high densities of dopamine D3 receptors (and almost no D2 receptors [Bouthenet, M.L., Souil, E., Martres, M.P., Sokoloff, P., Giros, B. and Schwartz, J.C., Brain Res., 564 (1991) 203-219; Sokoloff, P., Giros, B., Martres, M.P., Bouthenet, M...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00964-x
更新日期：1996-10-21 00:00:00
abstract：:Expression of the growth-associated protein GAP-43 is increased in the spinal cord of ALS patients and Wobbler (wr) mice, murine models of the disease. In this work we examined if expression of GAP-43 mRNA in control and wr mice was sensitive to steroid treatment. A group of control and wr mice received s.c. a 50 mg p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01783-7
更新日期：1999-09-11 00:00:00
abstract：:Afferents to th midbrain dorsal and median raphe nuclei in the rat were studied by means of the horseradish peroxidase (HRP) retrograde transport method. The HRP was given by means of a modified iontophoretic delivery technique. This technique permitted an efficient and localized deposition of a high concentration of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90291-8
更新日期：1977-02-18 00:00:00
abstract：:Several lines of evidence indicate that psychostimulant withdrawal can induce negative emotional symptoms, such as anhedonia and dysphoria, which may be due in part, to dysfunction of the serotonin (5-HT) system, including alterations in 5-HT receptors. For example, changes in 5-HT(2A) receptor function in prefrontal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.033
更新日期：2011-05-16 00:00:00
abstract：:Near-infrared spectroscopy (NIRS) enables noninvasive measurement of concentration changes of oxy- and deoxy-hemoglobin. The present study investigated cerebral representations of motion illusion by NIRS and examined several experimental procedures to determine an efficient procedure that can shorten the experimental ...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/j.brainres.2005.11.050
更新日期：2006-03-10 00:00:00
abstract：:Regeneration of crushed axons in rat dorsal spinal roots was measured to investigate the transganglionic influence of an additional peripheral axonal injury. The right sciatic nerve was cut at the hip and the left sciatic nerve was left intact. One week later, both fifth lumbar dorsal roots were crushed and subsequent...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91096-1
更新日期：1987-05-19 00:00:00
abstract：:Available evidence suggests that a portion of the septohippocampal pathway may form inhibitory synapses on inhibitory interneurons in the dentate gyrus. In contrast, a portion of the commissural input from the contralateral hilus may form excitatory synapses on inhibitory interneurons. To ascertain whether these pathw...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90301-5
更新日期：1987-03-10 00:00:00
abstract：:Immunohistochemical expression of the doublecortin (DCX) gene product was investigated in cerebral cortices from 33 normal developing human, aged 9 gestational weeks (GW) to 29 years, and from 26 patients with various neuronal migration disorders, aged 19 GW to 34 years. DCX immunoreactivity was detected predominantly...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02099-0
更新日期：2000-04-28 00:00:00
abstract：:Projections from the hypothalamus to cells of origin of the greater petrosal nerve were studied by the HRP and autoradiographic techniques in the rat. After an injection of [3H]amino acids into the hypothalamus and an application of HRP to the greater petrosal nerve, we found that a compact group of HRP-labeled neuron...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90744-3
更新日期：1984-01-02 00:00:00
abstract：:Increasing evidence indicates that volatile general anesthetics exert their effects by affecting various types of membrane conductance expressed in the central nervous system (CNS), such as ligand-gated receptor-channels. The most recently identified family of the receptor-channels in the CNS are the extracellular ATP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03125-0
更新日期：2001-12-07 00:00:00
abstract：:Microinjections of the substance P (SP) antagonist (D-pro2,D-phe7,D-trp9)-SP, or the gamma-aminobutyric acid (GABA) agonist, muscimol, into the entopeduncular nucleus reduced muscle tone in genetically spastic rats in a dose- and time-dependent manner. Similar injections into the ventral thalamus, zona incerta or amyg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90564-r
更新日期：1990-02-19 00:00:00
abstract：:Rat hippocampal slices were incubated with [3H]uridine in vitro to analyze the metabolism of nuclear RNA and the RNA precursor fractions. Labeling of total nuclear RNA was linear for 4 h of incubation and proportional to the concentration of labeled uridine in the incubation medium. Addition of 3.5 X 10(-8) M corticos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90375-5
更新日期：1984-07-23 00:00:00
abstract：:Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the vertebrate brain. GABA activates both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors in mammals. Whether non-mammalian vertebrates possess receptors with similar characteristics is not well understood. We used a mammalian GABA(B)-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.008
更新日期：2006-06-13 00:00:00
abstract：:Dissimilarity of the electroencephalogram (EEG) between the two hemispheres was characterized by cross-approximate entropy (C-ApEn), an information statistical parameter applicable to nonlinear, aperiodic signals. EEGs were recorded bipolarly with pairs of epidural electrodes in the left and right frontal cortices. Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03358-9
更新日期：2002-11-01 00:00:00
abstract：:We examined in the present study alterations in cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability following intrastriatal transplantation of mouse bone marrow stromal cells (BMSCs) or saline infusion in adult Sprague-Dawley rats. Laser Doppler revealed that transplanted animals exhibited near normal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.02.050
更新日期：2004-05-29 00:00:00
abstract：:Synaptosomes prepared from fresh human cerebral cortex were shown to be morphologically similar to those from other species. On incubation, they took up oxygen at a high and linear rate and accumulated potassium against a concentration gradient. In response to depolarization by raised extracellular K+ or addition of v...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90871-4
更新日期：1981-11-16 00:00:00
abstract：:Using gold-labelled somatostatin, somatostatin binding sites were predominantly found in laminae I-III, X and on motorneurones of the rat lumbar spinal cord. A comparison with immunohistochemical staining using antisera against somatostatin receptor sequences revealed that the marked binding in laminae I-III coincided...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01226-8
更新日期：1999-01-16 00:00:00
abstract：:The pretectal olivary nucleus of the squirrel monkey was examined in both normal and autoradiographic material. In the Nissl- and fiber-stained tissue the nucleus appears as a laminated structure. The distribution of retinal terminals within the nucleus was examined by the autoradiographic tracing method. These data r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91125-2
更新日期：1981-11-09 00:00:00
