Abstract:
:Immunohistochemical expression of the doublecortin (DCX) gene product was investigated in cerebral cortices from 33 normal developing human, aged 9 gestational weeks (GW) to 29 years, and from 26 patients with various neuronal migration disorders, aged 19 GW to 34 years. DCX immunoreactivity was detected predominantly in the fetal cerebral cortex. The neurons in the cortical plate (CP) exhibited positive labeling at 9 GW. Staining was the most marked intense at 12-20 GW, and gradually decreased thereafter, only relatively weak immunoreactivity remaining in pyramidal cells. Comparison of the immunohistochemical characteristics of DCX and those of nestin and vimentin indicated the early expression of DCX in neuroepithelial stem cells of the subventricular germinal layer, as well as in neurons of the CP. The most marked intense expression in the period of neuronal migration strongly indicated its role in neuronal migration. The abnormal distribution of DCX immunolabeling in the cerebral cortex was associated with a neuronal disarrangement in some migration disorders, such as Miller-Dieker syndrome and Fukuyama congenital muscular dystrophy. Decreased DCX immunolabeling was demonstrated in fetuses and infants with Zellweger syndrome, implicating DCX in the neuronal migration abnormality in this syndrome.
journal_name
Brain Resjournal_title
Brain researchauthors
Qin J,Mizuguchi M,Itoh M,Takashima Sdoi
10.1016/s0006-8993(00)02099-0subject
Has Abstractpub_date
2000-04-28 00:00:00pages
225-32issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02099-0journal_volume
863pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Neurokinins, such as substance P (SP), modulate the reflex regulation of cardiovascular and respiratory function in the CNS, particularly in the nucleus tractus solitarius (NTS). There is considerable evidence of the action of SP in the NTS, but the precise effects have not yet been determined. Voltage-dependent Ca2+ ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.06.060
更新日期:2006-09-19 00:00:00
abstract::Parkinson's disease is characterized by a progressive loss of dopaminergic neurons, likely associated with dysregulation of oxidation of catechols, such as dopamine (DA) and 6-hydroxydopamine (6-OHDA), and resulting in oxidative stress. The involvement of cyclooxygenase-2 (COX-2) in pathogenesis of Parkinson's disease...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.10.105
更新日期:2006-06-06 00:00:00
abstract::Aspartate-immunoreactivity (ir) was examined in the mouse trigeminal ganglion (TG). The ir was detected in 34% of TG neurons and their cell bodies were of various sizes (mean +/- S.D. = 1,234 +/- 543 microm(2)). A triple immunofluorescence method revealed the co-expression of aspartate with calcitonin gene-related pep...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.092
更新日期:2006-04-12 00:00:00
abstract::Diphtheria toxin (DTX) kills cells by inactivating ribosomal translocation and when used to retrogradely intoxicate cat intercostal motoneurones produces marked morphological alterations in Nissl bodies, including those specifically sited postsynaptic to C-type axon terminals. Here, qualitative examinations of 'intoxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90302-r
更新日期:1990-02-12 00:00:00
abstract::Development of noradrenergic responses in the rat dorsal motor nucleus of the vagus (DMV) from postnatal days 0 to 22 was studied by a conventional microelectrode technique using brain slice preparations. Between postnatal days 0 and 6, noradrenaline (NA) caused only alpha 1-adrenoceptor-mediated depolarizations. By p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91170-0
更新日期:1989-07-31 00:00:00
abstract::The ontogenic development of neurophysin has not been investigated so far. To study this problem, electron microscopic immunohistochemistry was performed on ultrathin sections of the posterior pituitary of foetal and newborn rats. A concomitant appearance of secretory granules and neurophysin was first noted in the po...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90007-5
更新日期:1977-07-01 00:00:00
abstract::In prion diseases, metal imbalances in brain and/or metal substitutions for copper in prion protein suggest that metal-catalyzed oxidation (MCO) and oxidative stress may affect cellular function and accumulation of protease-resistant prion protein (PrP(Sc)). We examined the effect of metal-induced oxidative stress by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.07.117
更新日期:2008-10-31 00:00:00
abstract::The present experiments were performed to demonstrate in vivo the existence of a modulatory role of Na+ in the inhibitory control of prolactin (PRL) secretion. Groups of adult male rats were either adrenalectomized (adrenex) or sham-operated (normals) and implanted in the right atrium with a chronic cannula for the in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91158-9
更新日期:1987-01-13 00:00:00
abstract::Dopamine (DA) and noradrenaline (NA) extracellular levels have been measured by microdialysis in the medial frontal cortex (MFC), nucleus accumbens (NAc) and caudate-putamen (CP) under baseline conditions in awake and halothane-anaesthetized rats, and after application of three types of stimuli which are likely to act...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90711-h
更新日期:1992-05-29 00:00:00
abstract::We evaluated the role of neuropeptide Y (NPY), a potent endogenous orexigenic signal, in the ventromedial hypothalamic (VMH) lesion-induced hyperphagia in rats. To produce hyperphagia and excessive weight gain, adult female rats received bilateral electrolytic or sham lesions in the VMH. Concurrently, a permanent intr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00644-6
更新日期:1995-09-04 00:00:00
abstract::The relationship between changes in regional brain bioamine levels and the expression of intraspecies aggressive behavior was evaluated in two murine models. In one study, normal male mice were maintained either in aggregate (i.e., normal, intraspecies social behavioral controls) or isolated (i.e., developed, non-soci...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03963-x
更新日期:2003-02-14 00:00:00
abstract::Abrupt withdrawal from chronic alcohol exposure can produce convulsions that are likely due to ethanol (EtOH) neuroadaptations. While significant efforts have focused on elucidating dependence mechanisms, the alterations contributing to EtOH withdrawal severity are less well characterized. The present studies examined...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.03.043
更新日期:2005-06-07 00:00:00
abstract::Phosphocreatine-Mg-complex acetate (PCr-Mg-CPLX) is a creatine-derived compound that in previous in vitro research was able to increase neuronal creatine independently of the creatine transporter, thus providing hope to cure the hereditary syndrome of creatine transporter deficiency. In previous research we showed tha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.009
更新日期:2009-08-18 00:00:00
abstract::The immunocytochemical localization of L-glutamate decarboxylase (GAD), the enzyme which which forms gamma-aminobutyric acid (GABA), has been studied in developing rodent cerebellum. During the first 3-4 postnatal days, GAD is distributed along non-terminal portions of axonal processes in close association with small ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90813-6
更新日期:1975-03-07 00:00:00
abstract::Intracerebral hemorrhage (ICH) is a devastating stroke often modelled in rats. Isoflurane anesthetic, commonly used in preclinical research, affects general physiology (e.g., blood pressure) and electrophysiology (e.g., burst suppression) in many ways. These physiological changes may detract from the clinical relevanc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146593
更新日期:2020-02-01 00:00:00
abstract::Plasma concentrations of beta-endorphin were measured by radioimmunoassay in cats prepared chronically for sleep-waking polygraphic recordings and blood collection. beta-Endorphin (beta-END) levels were found to be stable in baseline conditions and were used as an index of stress. After habituation of each cat to expe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91207-6
更新日期:1983-03-14 00:00:00
abstract::Oxidative stress has been suggested to play a key role in the neuropathogenesis of HIV infection. HIV proteins (gp120, Tat) and proinflammatory cytokines can trigger the production of reactive oxygen species (ROS), resulting in DNA and RNA lesions. Among all the lesions induced by ROS, one of the most abundant lesions...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.04.001
更新日期:2012-06-06 00:00:00
abstract::The purpose of this study was to investigate morphological characteristics of the synaptic relations of choline acetyltransferase (ChAT)-positive terminals that are made with a variety of post-synaptic profiles in the lateralis medialis-suprageniculate nuclear complex (LM-Sg) using ChAT, gamma-aminobutyric acid (GABA)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01208-5
更新日期:1997-01-30 00:00:00
abstract::It has been proposed that disruption of cholinergic input to the hippocampus and cortex contributes to the learning and memory deficits associated with aging. The data reviewed here, however, suggest that the oft-stated generalization that normal aging is characterized by disruption of cholinergic input to the hippoca...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/0165-0173(87)90007-5
更新日期:1987-11-01 00:00:00
abstract::In the present paper immunocytochemical analysis at the fluorescence microscopical level has been performed of neural cell adhesion. molecule (NCAM) immunoreactivity in the adult rat tel- and diencephalon in order to further substantiate the highly selective neuronal localization of NCAM immunoreactivity, using an aff...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01130-4
更新日期:1997-01-23 00:00:00
abstract::Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo)....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02263-1
更新日期:2002-03-22 00:00:00
abstract::The role of plantar pressure sensation in controlling compensatory stepping was explored via hypothermic anesthesia of the foot soles, in 10 healthy young adults. Stepping reactions were evoked by unpredictable platform translation in forward, backward and lateral directions. The findings suggest three specific direct...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02712-8
更新日期:2000-09-22 00:00:00
abstract::Hippocampal CA1 pyramidal cell neurons are sensitized to depolarization by L-2-amino-4-phosphonobutanoic acid (L-AP4) following exposure to L-quisqualic acid (QUIS). It has been proposed that induction of this 'QUIS-effect' involves uptake of L-QUIS by hippocampal cells. We have used o-phthaldialdehyde (OPA) derivatiz...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91359-z
更新日期:1993-03-05 00:00:00
abstract::Our previous study revealed that, during tonic muscle contraction, remarkable functional differences among intrinsic and extrinsic muscles were observed during two different grip movements, i.e., precision and power grips. To verify whether this evidence is true even under the phasic muscle contraction, magnetic stimu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02368-5
更新日期:2002-05-03 00:00:00
abstract::Although transsynaptic tracing with peripheral injection of pseudorabies virus (PRV) has been extensively characterized, several methodological issues related to central application of this tracer have not been addressed. In the present study, we addressed the following three issues by using microinjection of a cockta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01680-7
更新日期:1999-08-14 00:00:00
abstract::The medial septal area has been implicated in the control of the magnocellular neurosecretory cells of the hypothalamus, and in particular, in the regulation of neurons secreting oxytocin. The present study investigated the hypothesis that this medial septal pathway originates in the subfornical organ. Brief electrica...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01278-p
更新日期:1995-02-20 00:00:00
abstract::The involvement of the dopaminergic pathway from the ventral tegmental area (VTA) to the nucleus accumbens (NAcc) in the reinforcing properties of many drugs of abuse is well established. Though the prefrontal cortex (PFC) exhibits significant influence over activity in this pathway, its role in drug abuse is less def...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.003
更新日期:2006-02-23 00:00:00
abstract::We have shown that high-concentration albumin therapy is markedly neuroprotective in focal cerebral ischemia. The present study was conducted to ascertain the degree to which hemodynamic alterations are responsible for this therapeutic effect. Normothermic, physiologically regulated male Sprague-Dawley rats received a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00674-x
更新日期:1998-08-31 00:00:00
abstract::Basic fibroblast growth factor (bFGF) isolated from the brain and pituitary, has been shown to induce cell divisions in a variety of cell types. It also acts as a potent stimulator of angiogenesis, and it is important in the survival of several types of cultured neurons. Despite considerable information on the functio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90541-g
更新日期:1992-04-10 00:00:00
abstract::The density of binding sites for excitatory amino acids in the hippocampus of SDAT (senile dementia of the Alzheimer type) patients has been investigated. This was compared to that found in younger and old non-dement cases. In the SDAT hippocampi there was a significant decrease in the glutamate and kainate binding. T...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90706-8
更新日期:1988-08-09 00:00:00