Abstract:
:The role of plantar pressure sensation in controlling compensatory stepping was explored via hypothermic anesthesia of the foot soles, in 10 healthy young adults. Stepping reactions were evoked by unpredictable platform translation in forward, backward and lateral directions. The findings suggest three specific direction- and phase-dependent roles for the plantar cutaneous afferents: (1) sensing posterior stability limits during initiation of backward steps, (2) sensing and controlling heel-contact and subsequent weight transfer during termination of forward steps, and (3) maintaining stability during the prolonged swing phase of lateral crossover steps.
journal_name
Brain Resjournal_title
Brain researchauthors
Perry SD,McIlroy WE,Maki BEdoi
10.1016/s0006-8993(00)02712-8subject
Has Abstractpub_date
2000-09-22 00:00:00pages
401-6issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02712-8journal_volume
877pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The effect of immunoneutralization of hypothalamic neuropeptide Y (NPY) on food intake was examined to clarify the involvement of NPY in the control mechanism of feeding behavior. Injection of anti-NPY gamma-globulin into the bilateral hypothalamic paraventricular nuclei of 24-h food-deprived rats significantly inhibi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91727-a
更新日期:1993-01-22 00:00:00
abstract::The main purpose of the present study was to determine whether specific lymphokines may be neurotrophic, by testing their effects on the survival of hippocampal neuronal cultures. Previous studies have shown that a variety of interleukins may be neurotrophic or neurotoxic, depending upon the culture conditions, as wel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90400-h
更新日期:1993-01-08 00:00:00
abstract::The myelin vacuolation (mv) rat exhibits hypomyelination and vacuole formation in the myelin throughout the CNS, caused by a null mutation in the attractin gene. Myelin alterations in the spinal cord of mv rats progress during postnatal development and are more prominent in the white matter. In contrast, microglial ac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.11.027
更新日期:2010-02-02 00:00:00
abstract::Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03616-8
更新日期:2002-12-06 00:00:00
abstract::Thyrotropin-releasing hormone (TRH; Protirelin) is an endogenous neuropeptide known to have anticonvulsant effects in several seizure models and in intractable epileptic patients. Like most neuropeptides, its duration of action may be limited by a lack of sustained site-specific bioavailability. To attempt to provide ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00860-9
更新日期:1998-11-02 00:00:00
abstract::Smoking is considered the leading cause of preventable death in the United States, but studies in animals suggest that nicotine is only weakly reinforcing. The maintenance of a dangerous habit by a weakly reinforcing agent has been the topic of some dispute. Using a two-lever "choice" self-administration procedure dev...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03215-2
更新日期:2002-01-04 00:00:00
abstract::Increased neurogenesis by promoting proliferation of neural precursor cells in the adult dentate gyrus might be beneficial for the treatment of psychiatric disorders. Results demonstrate that bFGF is necessary for the proliferation of neural precursor cells and that the glycogen synthase kinase-3β (GSK-3β) and β-caten...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.11.034
更新日期:2013-01-25 00:00:00
abstract::The cisternal spinal fluid (CF), plasma, and brain stem concentrations of 6 amino acids were measured in suckling rats between birth and one months of age. Each of the amino acids studied had its distinctive maturational pattern of CF concentration. Presumably these amino acids have separate mechanisms of transport fr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90098-1
更新日期:1977-01-01 00:00:00
abstract::ACTH4-10, a fragment of the adrenocorticotropic hormone (ACTH) molecule, has marked effects on the compensation process following unilateral labyrinthectomy. In Rana temporaria ACTH4-10-treatment (5-250 micrograms/kg) influences both the acquisition and the maintenance of the compensated state. The compensation proces...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)91158-1
更新日期:1982-09-23 00:00:00
abstract::Bilateral quisqualic acid-induced lesions of the nucleus basalis magnocellularis (nbm) in rats disrupted the expression of latent inhibition, a phenomenon thought to be dependent upon selective attention processes. Since grafts of adrenal chromaffin cells to the cerebral cortex of nbm-lesioned rats have been shown to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01364-n
更新日期:1995-02-13 00:00:00
abstract::The effects of amphetamine were examined in a brain stimulation reward paradigm in which response rate was measured across a range of stimulation frequencies. Both low (0.0625 and 0.125 mg/kg) and high (1.0, 2.0 and 4.0 mg/kg) doses of systemic amphetamine decreased the stimulation frequency needed to sustain low rate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90653-1
更新日期:1988-09-06 00:00:00
abstract::Rab3A is a synaptic vesicle-associated GTP-binding protein thought to be involved in modulation of presynaptic transmitter release through regulation of vesicle trafficking and membrane fusion. Electrophysiological studies at central nervous system synapses of Rab3A null-mutant mice have indicated that nerve stimulati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.03.055
更新日期:2006-05-17 00:00:00
abstract::Different groups of rats received three injections of either D-amphetamine (2.5 micrograms/0.5 microliters/side) or saline into the ventral tegmental area (VTA), one injection every third day. Two weeks following the last injection, dopamine (DA) neurotransmission in the nucleus accumbens (N. Acc.) was assessed with i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91761-g
更新日期:1993-03-12 00:00:00
abstract::Repeating a stimulus generally leads to a decreased response in neural activity compared to that for novel items. This neural attenuation provides a marker for stimulus-specific perceptual encoding and memory that can be detected using functional magnetic resonance imaging (fMRI). Although previously assumed to occur ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.090
更新日期:2006-03-29 00:00:00
abstract::In this study, we have identified and characterized 5-HT3-like receptors in the rat medial prefrontal cortex (mPFc), an area with a moderate density of 5-HT3 binding sites, using the techniques of single unit recording and microiontophoresis. The microiontophoresis of the 5-HT3 receptor agonist 2-methylserotonin (2-Me...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91316-s
更新日期:1991-06-07 00:00:00
abstract::Animal and cell experiments showed that inositol hexaphosphate (IP6) was protective on neurons in parkinson's disease (PD) model, but the underlying mechanism of this action was not extensively elucidated. To address this question, we established 6-hydroxydopamine (6-OHDA) induced human dopaminergic cell line SH-SY5Y ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.12.035
更新日期:2016-02-15 00:00:00
abstract::During embryogenesis, transient expression of nestin in proliferating neuroepithelial stem cells signals the commitment of progenitor cells to differentiate. Although adult mammalian brain contains very little nestin, significant upregulation of nestin has been reported following cerebral injury, leading to speculatio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.08.070
更新日期:2004-05-22 00:00:00
abstract::The present study attempts to elucidate the possible role of adenosine 3',5'-monophosphate (cAMP) and prostaglandin E2 (PGE2) in the function of the neural luteinizing hormone-releasing hormone (LH-RH) apparatus. To this end, in vitro LH-RH release from superfused hypothalamic fragments and cAMP production by hypothal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90162-9
更新日期:1986-10-29 00:00:00
abstract::Selective D1 (SCH-23390) and D2 (eticlopride and sulpiride) dopamine receptor antagonists were assessed for their ability to reverse the effects of 1.0 mg/kg D-amphetamine on excitatory motor-related neurons in the striatum of freely moving rats. SCH-23390 (0.125, 0.25, 0.5 and 1.0 mg/kg) rapidly and consistently bloc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91633-4
更新日期:1993-08-13 00:00:00
abstract::Weaver mutant mice alternated above chance levels but less often than normal mice in a 2-trial spontaneous alternation test. When the inter-trial (or retention) interval was manipulated, the weaver mutants alternated above chance levels only at the shortest (15 s) but not at the longest (4 or 5 min) intervals, contrar...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91265-5
更新日期:1986-11-19 00:00:00
abstract::Basal limbic structures (insula, amygdala, hippocampus and surrounding areas) were explored for unit responses to vagal volleys in awake, sitting, squirrel monkeys. Triple shocks were applied every 4 sec to the left cervical vagus nerve. As a control for adventitious activation by extravagal somatic afferents, units r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91247-6
更新日期:1981-05-25 00:00:00
abstract::Insulin growth factor 1 (IGF-1) has an important role in brain development and is strongly expressed during recovery after a hypoxic-ischemic injury. Some of its central actions could be mediated through the N-terminal tripeptide fragment of IGF-1: Gly-Pro-Glu (GPE). The neuroprotective properties of GPE given after a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03148-1
更新日期:2001-12-13 00:00:00
abstract::Ethylcholine aziridinium ion (AF64A) diluted in artificial perilymph, or artificial perilymph alone was infused into the cochlea of chinchillas. After a survival time of 7 days, the cochleas were fixed with aldehydes, post-fixed in osmium and embedded in epoxy resin for light and electron microscopy. The ultrastructur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90889-4
更新日期:1991-03-22 00:00:00
abstract::An indirect method of immunocytochemistry showed that cholera toxin and its B-subunit served as specific neuronal surface markers in conjunction with monoclonal anti-cholera toxin and FITC labeled anti-mouse Fab. The cell types which get specifically stained in culture were peripheral neurons from dorsal root ganglion...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90305-5
更新日期:1982-06-24 00:00:00
abstract::To understand the role of hypothalamic dopamine in thermoregulation, single unit activity was recorded in vitro, from constantly perfused tissue slices of rat preoptic area and anterior hypothalamus, PO/AH. The firing rate and thermosensitivity of individual PO/AH neurons were determined before, during and after tissu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90364-0
更新日期:1984-07-23 00:00:00
abstract::A series of ballistic, unidirectional arm movements were studied to evaluate the electromyographic (EMG) and neuromuscular force patterns that occur when a limb is unexpectedly perturbed. Multiple training trials were continued with a control load spring attached to the apparatus until a pre-specified criterion for le...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90741-3
更新日期:1985-09-23 00:00:00
abstract::The localization of immunoreactive glutamic acid decarboxylase (GAD) and enkephalin-like immunoreactivity was examined in serial, 4-micron frozen sections of the caudate nucleus from rats pretreated with colchicine. Colocalization was found in numerous caudate neurons of medium size. Cell counts of corresponding label...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90850-3
更新日期:1984-05-23 00:00:00
abstract::The effects of omega-conotoxin (CTX) GVIA, omega-agatoxin (Aga) IVA, and the dihydropyridine nicardipine were studied on synaptic transmission in the hippocampus during aging. Field excitatory postsynaptic potentials (fEPSPs) were recorded in the CA1 region in slices from young and aged Fischer 344 rats. Peptide toxin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01234-6
更新日期:1997-01-16 00:00:00
abstract::Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in Lewy bodies (LB). To gain further insight into the pathogenesis of PD we investigated the role of neurofilament lig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03138-4
更新日期:2002-09-27 00:00:00
abstract::The expression of two embryonic intermediate filaments, nestin and vimentin, in the rat brain at days 0 (control), 1, 4, 7 and 14 post-cryoinjury was studied to elucidate their roles in brain injury. Western blot analysis showed that both nestin and vimentin expressions in the ipsilateral cerebral cortex were signific...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.09.022
更新日期:2004-12-03 00:00:00