The role of plantar cutaneous mechanoreceptors in the control of compensatory stepping reactions evoked by unpredictable, multi-directional perturbation.


:The role of plantar pressure sensation in controlling compensatory stepping was explored via hypothermic anesthesia of the foot soles, in 10 healthy young adults. Stepping reactions were evoked by unpredictable platform translation in forward, backward and lateral directions. The findings suggest three specific direction- and phase-dependent roles for the plantar cutaneous afferents: (1) sensing posterior stability limits during initiation of backward steps, (2) sensing and controlling heel-contact and subsequent weight transfer during termination of forward steps, and (3) maintaining stability during the prolonged swing phase of lateral crossover steps.


Brain Res


Brain research


Perry SD,McIlroy WE,Maki BE




Has Abstract


2000-09-22 00:00:00














  • Injection of anti-neuropeptide Y gamma-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats.

    abstract::The effect of immunoneutralization of hypothalamic neuropeptide Y (NPY) on food intake was examined to clarify the involvement of NPY in the control mechanism of feeding behavior. Injection of anti-NPY gamma-globulin into the bilateral hypothalamic paraventricular nuclei of 24-h food-deprived rats significantly inhibi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shibasaki T,Oda T,Imaki T,Ling N,Demura H

    更新日期:1993-01-22 00:00:00

  • Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors.

    abstract::The main purpose of the present study was to determine whether specific lymphokines may be neurotrophic, by testing their effects on the survival of hippocampal neuronal cultures. Previous studies have shown that a variety of interleukins may be neurotrophic or neurotoxic, depending upon the culture conditions, as wel...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Araujo DM,Cotman CW

    更新日期:1993-01-08 00:00:00

  • Abnormal myelinogenesis both in the white and gray matter of the attractin-deficient mv rat.

    abstract::The myelin vacuolation (mv) rat exhibits hypomyelination and vacuole formation in the myelin throughout the CNS, caused by a null mutation in the attractin gene. Myelin alterations in the spinal cord of mv rats progress during postnatal development and are more prominent in the white matter. In contrast, microglial ac...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Izawa T,Yamate J,Franklin RJ,Kuwamura M

    更新日期:2010-02-02 00:00:00

  • Comparative effects of the antipsychotics sulpiride or risperidone in rats. I: bodyweight, food intake, body composition, hormones and glucose tolerance.

    abstract::Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Baptista T,Araujo de Baptista E,Ying Kin NM,Beaulieu S,Walker D,Joober R,Lalonde J,Richard D

    更新日期:2002-12-06 00:00:00

  • Prolonged seizure suppression by a single implantable polymeric-TRH microdisk preparation.

    abstract::Thyrotropin-releasing hormone (TRH; Protirelin) is an endogenous neuropeptide known to have anticonvulsant effects in several seizure models and in intractable epileptic patients. Like most neuropeptides, its duration of action may be limited by a lack of sustained site-specific bioavailability. To attempt to provide ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kubek MJ,Liang D,Byrd KE,Domb AJ

    更新日期:1998-11-02 00:00:00

  • Rats prefer cocaine over nicotine in a two-lever self-administration choice test.

    abstract::Smoking is considered the leading cause of preventable death in the United States, but studies in animals suggest that nicotine is only weakly reinforcing. The maintenance of a dangerous habit by a weakly reinforcing agent has been the topic of some dispute. Using a two-lever "choice" self-administration procedure dev...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Manzardo AM,Stein L,Belluzzi JD

    更新日期:2002-01-04 00:00:00

  • ROCK2 regulates bFGF-induced proliferation of SH-SY5Y cells through GSK-3β and β-catenin pathway.

    abstract::Increased neurogenesis by promoting proliferation of neural precursor cells in the adult dentate gyrus might be beneficial for the treatment of psychiatric disorders. Results demonstrate that bFGF is necessary for the proliferation of neural precursor cells and that the glycogen synthase kinase-3β (GSK-3β) and β-caten...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Boku S,Nakagawa S,Toda H,Kato A,Takamura N,Omiya Y,Inoue T,Koyama T

    更新日期:2013-01-25 00:00:00

  • Maturational changes of amino acid concentration in cerebrospinal fluid of the rat.

    abstract::The cisternal spinal fluid (CF), plasma, and brain stem concentrations of 6 amino acids were measured in suckling rats between birth and one months of age. Each of the amino acids studied had its distinctive maturational pattern of CF concentration. Presumably these amino acids have separate mechanisms of transport fr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Korobkin RK,Cutler RW

    更新日期:1977-01-01 00:00:00

  • Effects of ACTH4-10 on vestibular compensation.

    abstract::ACTH4-10, a fragment of the adrenocorticotropic hormone (ACTH) molecule, has marked effects on the compensation process following unilateral labyrinthectomy. In Rana temporaria ACTH4-10-treatment (5-250 micrograms/kg) influences both the acquisition and the maintenance of the compensated state. The compensation proces...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Flohr H,Lüneburg U

    更新日期:1982-09-23 00:00:00

  • Transplants to the cerebral cortex of nucleus basalis magnocellularis-lesioned rats: effects on deficits in latent inhibition.

    abstract::Bilateral quisqualic acid-induced lesions of the nucleus basalis magnocellularis (nbm) in rats disrupted the expression of latent inhibition, a phenomenon thought to be dependent upon selective attention processes. Since grafts of adrenal chromaffin cells to the cerebral cortex of nbm-lesioned rats have been shown to ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Welner SA,Rousse I,Rochford J

    更新日期:1995-02-13 00:00:00

  • Effects of nucleus accumbens amphetamine on lateral hypothalamic brain stimulation reward.

    abstract::The effects of amphetamine were examined in a brain stimulation reward paradigm in which response rate was measured across a range of stimulation frequencies. Both low (0.0625 and 0.125 mg/kg) and high (1.0, 2.0 and 4.0 mg/kg) doses of systemic amphetamine decreased the stimulation frequency needed to sustain low rate...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Colle LM,Wise RA

    更新日期:1988-09-06 00:00:00

  • Rab3A deletion selectively reduces spontaneous neurotransmitter release at the mouse neuromuscular synapse.

    abstract::Rab3A is a synaptic vesicle-associated GTP-binding protein thought to be involved in modulation of presynaptic transmitter release through regulation of vesicle trafficking and membrane fusion. Electrophysiological studies at central nervous system synapses of Rab3A null-mutant mice have indicated that nerve stimulati...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sons MS,Plomp JJ

    更新日期:2006-05-17 00:00:00

  • Amphetamine injected into the ventral tegmental area sensitizes the nucleus accumbens dopaminergic response to systemic amphetamine: an in vivo microdialysis study in the rat.

    abstract::Different groups of rats received three injections of either D-amphetamine (2.5 micrograms/0.5 microliters/side) or saline into the ventral tegmental area (VTA), one injection every third day. Two weeks following the last injection, dopamine (DA) neurotransmission in the nucleus accumbens (N. Acc.) was assessed with i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vezina P

    更新日期:1993-03-12 00:00:00

  • Attentional modulation of repetition attenuation is anatomically dissociable for scenes and faces.

    abstract::Repeating a stimulus generally leads to a decreased response in neural activity compared to that for novel items. This neural attenuation provides a marker for stimulus-specific perceptual encoding and memory that can be detected using functional magnetic resonance imaging (fMRI). Although previously assumed to occur ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yi DJ,Kelley TA,Marois R,Chun MM

    更新日期:2006-03-29 00:00:00

  • 5-HT3-like receptors in the rat medial prefrontal cortex: an electrophysiological study.

    abstract::In this study, we have identified and characterized 5-HT3-like receptors in the rat medial prefrontal cortex (mPFc), an area with a moderate density of 5-HT3 binding sites, using the techniques of single unit recording and microiontophoresis. The microiontophoresis of the 5-HT3 receptor agonist 2-methylserotonin (2-Me...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ashby CR Jr,Minabe Y,Edwards E,Wang RY

    更新日期:1991-06-07 00:00:00

  • Neuroprotection of inositol hexaphosphate and changes of mitochondrion mediated apoptotic pathway and α-synuclein aggregation in 6-OHDA induced parkinson's disease cell model.

    abstract::Animal and cell experiments showed that inositol hexaphosphate (IP6) was protective on neurons in parkinson's disease (PD) model, but the underlying mechanism of this action was not extensively elucidated. To address this question, we established 6-hydroxydopamine (6-OHDA) induced human dopaminergic cell line SH-SY5Y ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhang Z,Hou L,Li X,Ju C,Zhang J,Li X,Wang X,Liu C,Lv Y,Wang Y

    更新日期:2016-02-15 00:00:00

  • Regulation of nestin expression after cortical ablation in adult rat brain.

    abstract::During embryogenesis, transient expression of nestin in proliferating neuroepithelial stem cells signals the commitment of progenitor cells to differentiate. Although adult mammalian brain contains very little nestin, significant upregulation of nestin has been reported following cerebral injury, leading to speculatio...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Douen AG,Dong L,Vanance S,Munger R,Hogan MJ,Thompson CS,Hakim AM

    更新日期:2004-05-22 00:00:00

  • Effects of prostaglandin E2, forskolin and cholera toxin on cAMP production and in vitro LH-RH release from the rat hypothalamus.

    abstract::The present study attempts to elucidate the possible role of adenosine 3',5'-monophosphate (cAMP) and prostaglandin E2 (PGE2) in the function of the neural luteinizing hormone-releasing hormone (LH-RH) apparatus. To this end, in vitro LH-RH release from superfused hypothalamic fragments and cAMP production by hypothal...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kim K,Ramirez VD

    更新日期:1986-10-29 00:00:00

  • The involvement of D1 and D2 dopamine receptors in amphetamine-induced changes in striatal unit activity in behaving rats.

    abstract::Selective D1 (SCH-23390) and D2 (eticlopride and sulpiride) dopamine receptor antagonists were assessed for their ability to reverse the effects of 1.0 mg/kg D-amphetamine on excitatory motor-related neurons in the striatum of freely moving rats. SCH-23390 (0.125, 0.25, 0.5 and 1.0 mg/kg) rapidly and consistently bloc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rosa-Kenig A,Puotz JK,Rebec GV

    更新日期:1993-08-13 00:00:00

  • Delayed spontaneous alternation in weaver mutant mice.

    abstract::Weaver mutant mice alternated above chance levels but less often than normal mice in a 2-trial spontaneous alternation test. When the inter-trial (or retention) interval was manipulated, the weaver mutants alternated above chance levels only at the shortest (15 s) but not at the longest (4 or 5 min) intervals, contrar...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lalonde R

    更新日期:1986-11-19 00:00:00

  • Vagal elicitation of respiratory-type and other unit responses in basal limbic structures of squirrel monkeys.

    abstract::Basal limbic structures (insula, amygdala, hippocampus and surrounding areas) were explored for unit responses to vagal volleys in awake, sitting, squirrel monkeys. Triple shocks were applied every 4 sec to the left cervical vagus nerve. As a control for adventitious activation by extravagal somatic afferents, units r...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Radna RJ,MacLean PD

    更新日期:1981-05-25 00:00:00

  • Neuroprotective effects of the N-terminal tripeptide of IGF-1, glycine-proline-glutamate, in the immature rat brain after hypoxic-ischemic injury.

    abstract::Insulin growth factor 1 (IGF-1) has an important role in brain development and is strongly expressed during recovery after a hypoxic-ischemic injury. Some of its central actions could be mediated through the N-terminal tripeptide fragment of IGF-1: Gly-Pro-Glu (GPE). The neuroprotective properties of GPE given after a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sizonenko SV,Sirimanne ES,Williams CE,Gluckman PD

    更新日期:2001-12-13 00:00:00

  • Selective degeneration of a putative cholinergic pathway in the chinchilla cochlea following infusion with ethylcholine aziridinium ion.

    abstract::Ethylcholine aziridinium ion (AF64A) diluted in artificial perilymph, or artificial perilymph alone was infused into the cochlea of chinchillas. After a survival time of 7 days, the cochleas were fixed with aldehydes, post-fixed in osmium and embedded in epoxy resin for light and electron microscopy. The ultrastructur...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Morley BJ,Spangler KM,Schneider BL,Javel E

    更新日期:1991-03-22 00:00:00

  • Immunocytochemical study on cholera toxin binding sites by monoclonal anti-cholera toxin antibody in neuronal tissue culture.

    abstract::An indirect method of immunocytochemistry showed that cholera toxin and its B-subunit served as specific neuronal surface markers in conjunction with monoclonal anti-cholera toxin and FITC labeled anti-mouse Fab. The cell types which get specifically stained in culture were peripheral neurons from dorsal root ganglion...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Okada E,Maeda T,Watanabe T

    更新日期:1982-06-24 00:00:00

  • Dopamine effects on thermosensitive neurons in hypothalamic tissue slices.

    abstract::To understand the role of hypothalamic dopamine in thermoregulation, single unit activity was recorded in vitro, from constantly perfused tissue slices of rat preoptic area and anterior hypothalamus, PO/AH. The firing rate and thermosensitivity of individual PO/AH neurons were determined before, during and after tissu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Scott IM,Boulant JA

    更新日期:1984-07-23 00:00:00

  • Electromyographic and neuromuscular force patterns associated with unexpectedly loaded rapid limb movements.

    abstract::A series of ballistic, unidirectional arm movements were studied to evaluate the electromyographic (EMG) and neuromuscular force patterns that occur when a limb is unexpectedly perturbed. Multiple training trials were continued with a control load spring attached to the apparatus until a pre-specified criterion for le...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Richardson C,Simmons RW

    更新日期:1985-09-23 00:00:00

  • Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat neostriatum.

    abstract::The localization of immunoreactive glutamic acid decarboxylase (GAD) and enkephalin-like immunoreactivity was examined in serial, 4-micron frozen sections of the caudate nucleus from rats pretreated with colchicine. Colocalization was found in numerous caudate neurons of medium size. Cell counts of corresponding label...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Aronin N,Difiglia M,Graveland GA,Schwartz WJ,Wu JY

    更新日期:1984-05-23 00:00:00

  • Calcium channel types mediating synaptic transmission during aging.

    abstract::The effects of omega-conotoxin (CTX) GVIA, omega-agatoxin (Aga) IVA, and the dihydropyridine nicardipine were studied on synaptic transmission in the hippocampus during aging. Field excitatory postsynaptic potentials (fEPSPs) were recorded in the CA1 region in slices from young and aged Fischer 344 rats. Peptide toxin...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hall SC,Griffith WH

    更新日期:1997-01-16 00:00:00

  • Neurofilament L gene is not a genetic factor of sporadic and familial Parkinson's disease.

    abstract::Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in Lewy bodies (LB). To gain further insight into the pathogenesis of PD we investigated the role of neurofilament lig...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rahner N,Holzmann C,Krüger R,Schöls L,Berger K,Riess O

    更新日期:2002-09-27 00:00:00

  • Temporal patterns of the embryonic intermediate filaments nestin and vimentin expression in the cerebral cortex of adult rats after cryoinjury.

    abstract::The expression of two embryonic intermediate filaments, nestin and vimentin, in the rat brain at days 0 (control), 1, 4, 7 and 14 post-cryoinjury was studied to elucidate their roles in brain injury. Western blot analysis showed that both nestin and vimentin expressions in the ipsilateral cerebral cortex were signific...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Moon C,Ahn M,Kim S,Jin JK,Sim KB,Kim HM,Lee MY,Shin T

    更新日期:2004-12-03 00:00:00