Post-transcriptional regulation of gene expression in hippocampal neurons by glutamate receptor activation.

abstract：:Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...

journal_title：Brain research

authors： Baptista T,Araujo de Baptista E,Ying Kin NM,Beaulieu S,Walker D,Joober R,Lalonde J,Richard D

更新日期：2002-12-06 00:00:00

abstract：:Novel neurorehabilitative strategies are needed to improve motor outcomes following stroke. Based on the disynaptic excitatory projections of the dentatothalamocortical pathway to the motor cortex as well as to anterior and posterior cortical areas, we hypothesize that chronic electrical stimulation of the contralesio...

journal_title：Brain research

authors： Machado AG,Baker KB,Schuster D,Butler RS,Rezai A

更新日期：2009-07-14 00:00:00

abstract：:An extensive mapping of the caudate-putamen in rat for intracranial self-stimulation (ICS) site was undertaken to provide addtional support for the role of dopamine in brain-stimulation reward. Eight-seven per cent of the placements in the neostriatum supported ICS, with self-stimulation rates greater than 250/15 min ...

journal_title：Brain research

authors： Phillips AG,Carter DA,Fibiger HC

更新日期：1976-03-12 00:00:00

abstract：:We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced lea...

journal_title：Brain research

authors： Kubo KY,Iwaku F,Watanabe K,Fujita M,Onozuka M

更新日期：2005-09-28 00:00:00

abstract：:Clusters of carotid body (glomus) cells cultured from a few days to 3 weeks, maintained their morphological characteristics during this period. The resting potential (Em) and input resistance (Ro) did not change for 2 weeks but both declined afterwards. The intracellular pH (pHi) of glomus cells, measured with glass m...

journal_title：Brain research

authors： He SF,Wei JY,Eyzaguirre C

更新日期：1991-05-03 00:00:00

abstract：:To see if activation of central alpha 1-adrenergic receptors can cause facilitation of lordosis in rats, the behavioral effects of centrally administered alpha 1-agonists, methoxamine (MA) and phenylephrine (PhE), and related agents were studied. In ovariectomized rats treated with estrogen, infusion of MA, PhE, or a ...

journal_title：Brain research

authors： Kow LM,Weesner GD,Pfaff DW

更新日期：1992-08-21 00:00:00

abstract：:Met-enkephalin immunoreactive material content was found to be decreased in the cervical and thoracic segments of the spinal cord from rats aged 25 months as compared to young, 3-month-old, rats. No age-related variations were detectable at the lumbar level. Bio-Gel P 30 column chromatography of thoracic segment extra...

journal_title：Brain research

authors： Missale C,Govoni S,Castelletti L,Spano PF,Trabucchi M

更新日期：1983-02-28 00:00:00

abstract：:Olfactory bulbectomy (OBX) transects the glutamatergic efferents from the olfactory bulbs, and the changes of glutamatergic N-methyl-D-aspartate (NMDA) receptor-mediated function are though to be involved in the behavioral deficits seen in OBX rats. In the present study, irritability scores in OBX male Wistar rats wer...

journal_title：Brain research

authors： Ho Y,Liu T,Tai M,Wen Z,Chow RS,Tsai Y,Wong C

更新日期：2001-05-11 00:00:00

abstract：:In 16-week-old Sprague-Dawley rats lightly anesthetized with pentobarbital, 5-HT (3-96 micrograms/kg, i.v.; n = 6) produced distinct pseudaffective responses and a dose-dependent (slope = 17.2 +/- 6.8 s/log10 dose) inhibition of the tail-flick (TF) reflex (ED50 = 32.6 +/- 9.2 micrograms/kg). In the same rats, a 1:1 co...

journal_title：Brain research

authors： Meller ST,Lewis SJ,Brody MJ,Gebhart GF

更新日期：1991-10-04 00:00:00

abstract：:The formation of reactive oxygen species (ROS) has been suggested to be associated with excitotoxicity but the involvement of cytoplasmic enzymes in ROS formation is not clearly known. In the present study, we examined the role of xanthine oxidase (XO), nitric oxide synthase (NOS) and phospholipase A(2) (PLA(2)) in gl...

journal_title：Brain research

authors： Sanganahalli BG,Joshi PG,Joshi NB

更新日期：2005-03-10 00:00:00

abstract：:alpha-Adrenoreceptors are present in the ventricular (VZ) and subventricular (SVZ) zones of the mammalian embryonic forebrain, and contribute towards cell cycle controls in the germinal neuroepithelium [Pabbathi et al., Brain Res. 760 (1997) 22-33.]. Since noradrenaline-containing fibres from the locus coeruleus (LC) ...

journal_title：Brain research

authors： Popovik E,Haynes LW

更新日期：2000-01-24 00:00:00

abstract：:The organization of the wing component of the dorsal column-medial lemniscal pathway, and somatosensory projections from the thalamus to the Wulst, are described for an oscine member of the major group of birds, the Passeriformes. Wing primary afferents terminate throughout the cervical spinal cord, but between the br...

journal_title：Brain research

authors： Wild JM

更新日期：1997-06-06 00:00:00

abstract：:From measured effects of amino acids on synaptosomal tyrosine uptake and from published data on human CNS levels of amino acids hypothetical calculations were made to compare CNS tyrosine availability for catecholamine synthesis in the hyperphenylalaninemic and non-hyperphenylalaninemic condition. These calculations i...

journal_title：Brain research

authors： Peterson NA,Shah SN,Raghupathy E,Rhoads DE

更新日期：1983-08-01 00:00:00

abstract：:Synaptic plasma membrane preparations from brain tissue have endogenous Ca2+-dependent phospholipase A2 activity. Characterization of this activity revealed that it was maximally active at 10(-7)-10(-5) M Ca2+ and pH 7.0. The enzyme had a Km of 62.0 microM and a Vmax of 98.0 nmol/mg/h. Calmodulin and prostaglandin F2 ...

journal_title：Brain research

authors： Moskowitz N,Schook W,Puszkin S

更新日期：1984-01-09 00:00:00

abstract：:Two selectively bred lines of mice, one responding with high (HA) and the other with low analgesia (LA) to 3 min swims at 20 degrees C were compared with respect to naloxone ability to reverse such swim induced pain threshold elevation. Also, the analgesic effect of morphine was tested in both lines of mice. Naloxone ...

journal_title：Brain research

authors： Panocka I,Marek P,Sadowski B

更新日期：1986-11-05 00:00:00

abstract：:Ovarian steroid hormones influence not only seizure phenomena, but also the neuronal cell death that follows. In the present study, we applied two models of ovarian steroid loss, ovariectomy and chemically-induced ovarian failure, to evaluate kainate-induced seizure activity and the susceptibility of hippocampal neuro...

journal_title：Brain research

authors： Schauwecker PE,Wood RI,Lorenzana A

更新日期：2009-04-10 00:00:00

abstract：:We investigated the protective effect of subchronic treatment of the A2A receptor antagonist, SCH 58261 (0.01 mg/kg, i.p.), administered 5 min, 6 h and 15 h after permanent right middle cerebral artery occlusion (MCAo). Twenty-four hours after ischemia, an extensive pallid area, evaluated by cresyl violet staining, is...

journal_title：Brain research

authors： Melani A,Gianfriddo M,Vannucchi MG,Cipriani S,Baraldi PG,Giovannini MG,Pedata F

更新日期：2006-02-16 00:00:00

abstract：:A histo-enzymatic technique for visualizing and quantifying endogenous NAD(H) in brain tissue was developed, based on coupled enzymatic cycling reactions that reduce nitrotetrazolium blue chloride to produce formazan. Conditions were used where the endogenous level of nicotinamide adenine dinucleotides (NAD(H)) was th...

journal_title：Brain research

authors： Balan IS,Fiskum G,Kristian T

更新日期：2010-02-26 00:00:00

abstract：:Visual pathways (optic disc, optic nerve and pretectal regions) were electrically stimulated and evoked potentials were explored throughout the inferior olive in the anesthetized rat. Responsive areas were identified as the caudal half of the dorsal cap, nucleus beta and the most caudal region of subnucleus c of the m...

journal_title：Brain research

authors： Akaike T

更新日期：1986-03-12 00:00:00

abstract：:Although Rolling mouse Nagoya (RMN) has been considered to demonstrate cerebellar dysfunction, our previous metabolic and electrophysiological studies also revealed a dysfunction of the basal ganglia, with the presumable primary site of dysfunction being the striatum. In the present study, we investigated the neuroche...

journal_title：Brain research

authors： Taniwaki T,Shinoda H,Kaseda Y,Kato M,Goto I

更新日期：1996-04-01 00:00:00

abstract：:Mouse brain expresses three principal glucose transporters. Glut1 is an endothelial marker and is the principal glucose transporter of the blood-brain barrier. Glut3 and Glut6 are expressed in glial cells and neural cells. A mouse line with a null allele for Glut3 has been developed. The Glut3(-/-) genotype is intraut...

journal_title：Brain research

authors： Stuart CA,Ross IR,Howell ME,McCurry MP,Wood TG,Ceci JD,Kennel SJ,Wall J

更新日期：2011-04-12 00:00:00

abstract：:Converging evidence suggests that compromised motor abilities in hemiparetic cerebral palsy are not solely due to impairments in motor execution, but are also related to deficits in action planning. The present study had two aims. First, we compared grip planning in a sequential task between participants with left-sid...

journal_title：Brain research

authors： Crajé C,van der Kamp J,Steenbergen B

更新日期：2009-03-19 00:00:00

abstract：:Basic fibroblast growth factor (b-FGF) and alpha melanocyte stimulating hormone (alpha-MSH) were tested for their ability to promote axonal elongation on E14 fetal rat spinal cord cell culture, and to support cell survival. A similar development of neurite was observed in alpha-MSH treated cultures or in control cultu...

journal_title：Brain research

authors： Peulve P,Laquerriere A,Hemet J,Tadie M

更新日期：1994-08-22 00:00:00

abstract：:We evaluated the role of neuropeptide Y (NPY), a potent endogenous orexigenic signal, in the ventromedial hypothalamic (VMH) lesion-induced hyperphagia in rats. To produce hyperphagia and excessive weight gain, adult female rats received bilateral electrolytic or sham lesions in the VMH. Concurrently, a permanent intr...

journal_title：Brain research

authors： Dube MG,Kalra PS,Crowley WR,Kalra SP

更新日期：1995-09-04 00:00:00

abstract：:The present study was undertaken to confirm the dorsolateral pontomesencephalic reticular formation (an area that includes the nucleus cuneiformis (NCF) and nucleus parabrachialis (NPB)) as a sensitive site for stimulation-produced antinociception and to investigate the possibility that there are cells in this region ...

journal_title：Brain research

authors： Haws CM,Williamson AM,Fields HL

更新日期：1989-04-03 00:00:00

abstract：:Earlier studies in this laboratory have shown that partial serotonergic (5-HT) deafferentation from the hippocampus induced a homotypic sprouting. The 5-HT-denervated hippocampus was further found to be a favorable environment for the growth of grafted 5-HT, but not for norepinephrinergic neurons. In the current study...

journal_title：Brain research

authors： Zhou FC,Azmitia EC

更新日期：1990-01-22 00:00:00

abstract：:Blink movement metrics were studied in three alert cynomolgus monkeys using electromagnetic search coils attached to the eyelids bilaterally. Monkey blinks averaged approximately 24 degrees. Down-phase peak velocities were approximately twice those of the corresponding up phases. Most blinks were symmetrical with clos...

journal_title：Brain research

authors： Porter JD,Stava MW,Gaddie IB,Baker RS

更新日期：1993-04-23 00:00:00

abstract：:The amount of estradiol benzoate with progesterone required to induce lordosis in ovariectomized hamsters was determined to compare the responsiveness of hamsters to estradiol benzoate with that of rats and guinea pigs. In addition, the uptake and metabolism of tritiated estradiol in ovariectomized rats, guinea pigs...

journal_title：Brain research

authors： Feder HH,Siegel H,Wade GN

更新日期：1974-05-10 00:00:00

abstract：:Smoking is considered the leading cause of preventable death in the United States, but studies in animals suggest that nicotine is only weakly reinforcing. The maintenance of a dangerous habit by a weakly reinforcing agent has been the topic of some dispute. Using a two-lever "choice" self-administration procedure dev...

journal_title：Brain research

authors： Manzardo AM,Stein L,Belluzzi JD

更新日期：2002-01-04 00:00:00

abstract：:Event-related brain potentials were used to study the neural mechanisms underlying goal-directed object use distinguishing between processes supporting immediate and final action goals during action planning and execution. Subjects performed a grasping and transportation task in which actions were cued either with the...

journal_title：Brain research

authors： van Schie HT,Bekkering H

更新日期：2007-05-07 00:00:00