当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Alpha 1-adrenergic agonists act on the ventromedial hypothalamus to cause neuronal excitation and lordosis facilitation: electrophysiological and behavioral evidence.

Alpha 1-adrenergic agonists act on the ventromedial hypothalamus to cause neuronal excitation and lordosis facilitation: electrophysiological and behavioral evidence.

Abstract：

:To see if activation of central alpha 1-adrenergic receptors can cause facilitation of lordosis in rats, the behavioral effects of centrally administered alpha 1-agonists, methoxamine (MA) and phenylephrine (PhE), and related agents were studied. In ovariectomized rats treated with estrogen, infusion of MA, PhE, or a beta-agonist isoproterenol, into the lateral ventricle, or bilateral infusions of MA or PhE into the ventromedial hypothalamus (VMH) facilitated lordosis. Conversely, intra-VMH infusion of the alpha 1-antagonist prazosin (PZ) inhibited lordosis. Intra-VMH infusion of isoproterenol or an alpha 2-agonist clonidine, had no effect. Neither was the intra-VMH infusion of MA effective if: (i) the rats were not primed with estrogen; (ii) the tips of the cannulae were outside the VMH; or (iii) it was preceded by an intra-VMH infusion of the alpha 1b-antagonist, chloroethylclonidine (CEC). These results not only verify implications from recent studies that alpha 1-receptors in the hypothalamus are important for lordosis facilitation, but further show that the adrenergic facilitatory effect are: (i) mediated specifically by alpha 1b-subtype of the alpha 1-receptor, (ii) estrogen-dependent, and (iii) site-specific to VMH. To investigate neural mechanisms potentially underlying the lordosis-facilitating effect of alpha 1-activation, the actions of MA and PhE on the electrical activity of single neurons of the ventromedial nucleus of the hypothalamus (VMN) in vitro were studied.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Brain Res

journal_title

Brain research

authors

Kow LM,Weesner GD,Pfaff DW

doi

10.1016/0006-8993(92)91581-x

subject

Has Abstract

pub_date

1992-08-21 00:00:00

pages

237-45

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(92)91581-X

journal_volume

588

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Influences of hyperthermia-induced seizures on learning, memory and phosphorylative state of CaMKIIα in rat hippocampus.

    abstract：:Febrile seizure (FS) remains the most common childhood neurological emergency. Although many studies have been done, controversy exists as to whether these seizures are associated with a significant risk for cognitive impairment. The aim of our study is to check whether there is a spatial learning and memory deficit i...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2014.02.026

    authors： Xiong Y,Zhou H,Zhang L

    更新日期：2014-04-04 00:00:00

  • Mouse strain differences in the effects of corticotropin releasing hormone (CRH) on sleep and wakefulness.

    abstract：:Corticotropin releasing hormone (CRH) plays a major role in central nervous system responses to stressors and has been implicated in stress-induced alterations in sleep. In the absence of stressors, CRH contributes to the regulation of spontaneous waking. We examined the effects of CRH and astressin (AST), a non-speci...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2007.11.007

    authors： Sanford LD,Yang L,Wellman LL,Dong E,Tang X

    更新日期：2008-01-23 00:00:00

  • Heat shock protein 72 restores cyclic AMP accumulation after heat shock in N18TG2 cells.

    abstract：:Although there are several reports on the alteration of intracellular signal transduction during heat shock in somatic cells, the long term effects of heat shock on neuronal cells remain unknown. In this report, we investigated cyclic AMP (cAMP) accumulation and the expression of heat shock proteins following heat sho...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(98)00072-9

    authors： Zensho H,Nishida A,Shimizu M,Uchitomi Y,Yamawaki S

    更新日期：1998-04-20 00:00:00

  • Substrate for rapid feedforward inhibition of the auditory forebrain.

    abstract：:A sizeable, feedforward, GABAergic projection exists from the inferior colliculus to the medial geniculate body in cats. We compared the dimensions of GABA-immunoreactive and non-immunoreactive axons in the brachium of the cat inferior colliculus, and demonstrate that GABA-immunoreactive axons are among the largest of...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(97)00654-9

    authors： Saint Marie RL,Stanforth DA,Jubelier EM

    更新日期：1997-08-08 00:00:00

  • Blunted brain metabolic response to ketamine in mice lacking D(1A) dopamine receptors.

    abstract：:The interaction of glutamatergic and dopamine neurotransmission is thought to have relevance to both the pathophysiology and pharmacotherapy of schizophrenia. For example, subanesthetic doses of the N-methyl-D-aspartate receptor (NMDA-R) antagonist ketamine induce schizophrenia-like behavioral effects in humans and bo...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(01)01991-6

    authors： Miyamoto S,Mailman RB,Lieberman JA,Duncan GE

    更新日期：2001-03-16 00:00:00

  • Kindling causes changes in the composition of the astrocytic cytoskeleton.

    abstract：:Changes in the astrocytic cytoskeleton were examined in amygdala kindled rats using immunocytochemical techniques. One week following kindling, there was a dramatic increase in immunoreactivity to glial fibrillary acidic protein and vimentin in astrocytes throughout amygdala, pyriform cortex and hippocampus bilaterall...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)91694-a

    authors： Khurgel M,Racine RJ,Ivy GO

    更新日期：1992-10-02 00:00:00

  • GABA-receptor stimulation enhances norepinephrine-induced polyphosphoinositide metabolism in rat hippocampal slices.

    abstract：:The effect of gamma-aminobutyric acid (GABA)receptor stimulation on norepinephrine (NE)-induced metabolism of polyphosphoinositides (PIPs) was studied in rat hippocampal slices. Inositol phosphates (IPs), PIPs, and phosphatidic acid were measured. NE induced formation of IPs and phosphatidic acid in a dose-dependent m...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(87)90701-3

    authors： Corradetti R,Ruggiero M,Chiarugi VP,Pepeu G

    更新日期：1987-05-12 00:00:00

  • Quantitative immunoelectron microscopy and tannic acid study of dynamics of neurohaemal and non-synaptic peptide release by the caudodorsal cells of Lymnaea stagnalis.

    abstract：:The caudodorsal cells (CDCs) of the freshwater snail Lymnaea stagnalis control egg laying and egg-laying associated behaviours by releasing various peptides including the ovulation hormone CDCH. Previously it has been shown that release occurs (1) into the haemolymph from neurohaemal axon terminals in the outer compar...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)90866-4

    authors： Schmidt ED,Roubos EW

    更新日期：1989-06-12 00:00:00

  • Protein tyrosine kinase and mitogen-activated protein kinase activation contribute to K(ATP) and K(ca) channel impairment after brain injury.

    abstract：:Previous studies have observed that pial artery dilation to activators of the ATP sensitive K (K(ATP)) and calcium sensitive K (K(ca)) channel was blunted following fluid percussion brain injury (FPI) in the piglet. In recent studies in the rat, protein tyrosine kinase (PTK) activation was observed to contribute to K(...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(02)02703-8

    authors： Armstead WM

    更新日期：2002-07-12 00:00:00

  • Increased density of perivascular nerves to the major cerebral vessels of the spontaneously hypertensive rat: differential changes in noradrenaline and neuropeptide Y during development.

    abstract：:Fluorescence and immunohistochemical techniques were used to study the pattern and density of perivascular nerves containing noradrenaline (NA) and neuropeptide Y (NPY) supplying the major cerebral arteries of 4-, 6-, 8- and 12-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar (WIS) controls. Leve...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(88)90910-9

    authors： Dhital KK,Gerli R,Lincoln J,Milner P,Tanganelli P,Weber G,Fruschelli C,Burnstock G

    更新日期：1988-03-15 00:00:00

  • TRH immunoreactivity in rat brain regions, spinal cord and pancreas: validation by high-pressure liquid chromatography and thin-layer chromatography.

    abstract：:Thyrotropin-releasing hormone (TRH) immunoreactivity in rat tissue was assayed using a new reversed-phase, ion-pair, high-pressure liquid chromatography (HPLC) method for separating TRH from its analogs. Virtually all of the TRH immunoreactivity in hypothalamus, brain stem, preoptic area, septum, striatum, frontal cor...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(80)91036-7

    authors： Spindel E,Wurtman RJ

    更新日期：1980-11-17 00:00:00

  • Neurochemical studies on the mesolimbic circuitry of antinociception.

    abstract：:Previous studies using the technique of microinjection into brain nuclei indicated that the periaqueductal gray (PAG), nucleus accumbens, habenula and amygdala play an essential role in pain modulation and that these nuclei possibly act through a 'mesolimbic neural loop' to exert an analgesic effect, in which Met-enke...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(91)91685-t

    authors： Ma QP,Han JS

    更新日期：1991-12-06 00:00:00

  • Effects of palatability-induced hyperphagia and food restriction on mRNA levels of neuropeptide-Y in the arcuate nucleus.

    abstract：:This study examined the effect of feeding either a bland cornstarch-based diet (BCD) or a highly palatable, high fat diet containing sucrose (HPD) on hypothalamic arcuate nucleus (ARC) gene expression for neuropeptide-Y (NPY). Male Sprague-Dawley rats received either BCD ad libitum, HPD ad libitum, HPD pair-fed to the...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(98)00755-0

    authors： Kim EM,Welch CC,Grace MK,Billington CJ,Levine AS

    更新日期：1998-09-21 00:00:00

  • Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia.

    abstract：BACKGROUND:Metabolites involved in one-carbon metabolism (OCM) may predict cognitive prognosis in dementia. The link between OCM, apolipoprotein E (APOE), and DNA methylation creates a biologically plausible mechanism of interaction. AIM:To assess OCM metabolites as predictors of 5-year cognitive prognosis in patients...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2019.146519

    authors： Hildre AS,Solvang SH,Aarsland D,Midtun Ø,McCann A,Ervik AO,Nygård O,Ueland PM,Nordrehaug JE,Giil LM

    更新日期：2020-01-01 00:00:00

  • Effects of kainic acid lesions in rat ventral lateral geniculate nucleus upon field potentials of the superior colliculus: correlation between morphological and physiological observations.

    abstract：:Morphological and physiological effects of kainic acid (KA) lesions in rat ventral lateral geniculate nucleus (LGV) were studied 1.5 and 6 h after KA injection. Morphological changes were examined mainly by electron micrographs. At 1.5 h after KA injection dendrites were dilated and some vacuolations occurred in both ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)90033-4

    authors： Nagata T,Tsukamoto Y,Matsuno K,Hayashi Y

    更新日期：1989-03-27 00:00:00

  • Real-time monitoring of endogenous noradrenaline release in rat brain slices using fast cyclic voltammetry. 2. Operational characteristics of the alpha 2 autoreceptor in the bed nucleus of stria terminalis, pars ventralis.

    abstract：:Fast cyclic voltammetry (FCV) at carbon fibre microelectrodes was used to monitor stimulated noradrenaline (NA) efflux in slices of the ventral part of the rat bed nucleus of stria terminalis (BSTV) superfused with artificial cerebrospinal fluid at 32 degrees C. NA efflux was evoked by local electrical stimulation (tr...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(93)91498-h

    authors： Palij P,Stamford JA

    更新日期：1993-04-02 00:00:00

  • The effects of intracranial administration of the dopamine agonist apomorphine on penile reflexes and seminal emission in the rat.

    abstract：:Previous studies employing systemic administration of the dopamine agonist apomorphine have shown that the dose response curves for apomorphine's effects on penile reflexes and seminal emission differ, suggesting that experimentally separable populations of dopamine receptors regulate these two responses. The present ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)90328-4

    authors： Pehek EA,Thompson JT,Hull EM

    更新日期：1989-10-23 00:00:00

  • Motor neuron cell death in a mouse model of FALS is not mediated by the p53 cell survival regulator.

    abstract：:Mutant Cu/Zn superoxide dismutase (SOD1) associated with familial amyotrophic lateral sclerosis (FALS) causes selective motor neuron loss through unknown mechanisms of cell damage. Damaged neurons frequently undergo apoptosis mediated by the p53 cell survival regulator. We therefore studied whether motor neuron diseas...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)02745-1

    authors： Prudlo J,Koenig J,Gräser J,Burckhardt E,Mestres P,Menger M,Roemer K

    更新日期：2000-10-06 00:00:00

  • Effect of auditory neocortex ablation on identification of click rates in cats.

    abstract：:Six experimental and 3 unoperated cats were trained with a go, no-go shock avoidance procedure to discriminate increases from decreases in the rate of presentation of all auditory cortex between the suprasylvian sulcus and rhinal fissure while 3 cats had bilateral auditory cortex lesions plus ablation of the cortex of...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(76)90249-3

    authors： Cranford JL,Igarashi M,Stramler JH

    更新日期：1976-10-29 00:00:00

  • The development and restriction of the ipsilateral retinofugal projection in the chick.

    abstract：:Although it is generally believed that the central projections of the retina in birds are entirely crossed, using wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) as an anterograde tracer, we have found that in normal posthatched chicks there is a small ipsilateral retinofugal projection to the dience...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0165-3806(83)90124-4

    authors： O'Leary DM,Gerfen CR,Cowan WM

    更新日期：1983-10-01 00:00:00

  • Non-random chemoreceptor activity during superfusion in vitro.

    abstract：:As a means of probing the chemotransducer, impulse sequences from in vitro, superfused sinus nerve-carotid body preparations were analyzed for departures from randomness. Twelve of 17 spike trains showed interval histograms that did not differ significantly from exponential. Thus these sequences resembled a Poisson (r...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(84)90908-9

    authors： Nolan WF,Donnelly DF,Smith EJ,Dutton RE

    更新日期：1984-01-30 00:00:00

  • Modeling complex responses of FM-sensitive cells in the auditory midbrain using a committee machine.

    abstract：:Frequency modulation (FM) is an important building block of complex sounds that include speech signals. Exploring the neural mechanisms of FM coding with computer modeling could help understand how speech sounds are processed in the brain. Here, we modeled the single unit responses of auditory neurons recorded from th...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2013.04.058

    authors： Chang TR,Chiu TW,Sun X,Poon PW

    更新日期：2013-11-06 00:00:00

  • Postnatal reorganization of F-actin in the central canal of the spinal cord in the rat.

    abstract：:The ependymocytes lining the central canal of the spinal cord in rats have prominent F-actin networks in the apical cytoplasm, exhibiting significant regional heterogeneity between differing spinal levels. It is not clear when and how this regional heterogeneity develops. We examined F-actin in the central canal durin...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2008.08.045

    authors： Li YC,Bai WZ,Hashikawa T

    更新日期：2008-11-06 00:00:00

  • Serotonin depletion in rat hippocampus attenuates L-NAME-induced spatial learning deficits.

    abstract：:Inhibition of nitric oxide (NO) synthesis has been found to produce learning deficits in spatial tasks. Recent studies also suggest a regulatory effect of endogenous NO on hippocampal serotonin (5-HT) release and have shown that NO-synthase (NOS) inhibitors increased extracellular levels of serotonin (5-HT) in the rat...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(02)03987-2

    authors： Majlessi N,Kadkhodaee M,Parviz M,Naghdi N

    更新日期：2003-02-14 00:00:00

  • In vitro discrimination of the role of LRP1 at the BBB cellular level: focus on brain capillary endothelial cells and brain pericytes.

    abstract：:Several studies have demonstrated that the blood-brain barrier (BBB) (dynamic cellular complex composed by brain capillary endothelial cells (BCECs) and surrounded by astrocytic end feet and pericytes) regulates the exchanges of amyloid β (Aβ) peptide between the blood and the brain. Deregulation of these exchanges se...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2014.10.047

    authors： Candela P,Saint-Pol J,Kuntz M,Boucau MC,Lamartiniere Y,Gosselet F,Fenart L

    更新日期：2015-01-12 00:00:00

  • Intermuscular co-ordination during fast contact control leg tasks in man.

    abstract：:From previous inverse dynamic analyses of human leg extensions, it was hypothesized that the underlying processes for the activation of mono- and biarticular muscles are different; the mono-articular muscles being activated when they shortened, whereas the biarticular muscles appeared responsible for the control of th...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(96)01327-3

    authors： Doorenbosch CA,Welter TG,van Ingen Schenau GJ

    更新日期：1997-03-21 00:00:00

  • Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development.

    abstract：:Niemann-Pick Type C (NPC) disease is an autosomal recessive neurodegenerative disorder with abnormal lipid storage as the major cellular pathologic hallmark. Genetic analyses have identified mutations in NPC1 gene in the great majority of cases, while mutations in NPC2 account for the remainders. Yet little is known r...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.02.019

    authors： Liao G,Wen Z,Irizarry K,Huang Y,Mitsouras K,Darmani M,Leon T,Shi L,Bi X

    更新日期：2010-04-14 00:00:00

  • Effect of phencyclidine (PCP) on blood pressure and catecholamine levels in discrete brain nuclei.

    abstract：:PCP (10 mg/kg, s.c.) causes hypertension that is associated with decrease or tendency to decrease the levels of epinephrine and norepinephrine in the hypothalamus and the brainstem regions. If this represents a decreased catecholaminergic activity, then this may enhance sympathetic activity and contribute to the PCP-i...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(84)90184-7

    authors： Bayorh MA,Zukowska-Grojec Z,Palkovits M,Kopin IJ

    更新日期：1984-11-12 00:00:00

  • Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation.

    abstract：:Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifi...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2005.05.008

    authors： Zhang RX,Wang L,Liu B,Qiao JT,Ren K,Berman BM,Lao L

    更新日期：2005-06-28 00:00:00

  • Two forms of striatal tyrosine hydroxylase from DEAE-cellulose chromatography.

    abstract：:Tyrosine hydroxylase (TH) in freshly prepared 45,000 g supernatant from rat striatum was fractionated by DEAE-cellulose chromatography. The elution was made with 2 vols. of buffer (50 mM Tris, pH 7.4; 2 mM dithiothreitol) followed by 4 vols. of a linear NaCl gradient (0 0.3 M) in the same buffer. TH activity was elute...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(83)90397-9

    authors： Sze PY,Alderson RF,Hedrick BJ

    更新日期：1983-05-23 00:00:00