Quantitative analysis of eyelid movement metrics reveals the highly stereotyped nature of monkey blinks.

Abstract:

:Blink movement metrics were studied in three alert cynomolgus monkeys using electromagnetic search coils attached to the eyelids bilaterally. Monkey blinks averaged approximately 24 degrees. Down-phase peak velocities were approximately twice those of the corresponding up phases. Most blinks were symmetrical with close temporal linkage of onset and offset between the two eyelids. Monkey blinks exhibited higher peak velocities and shorter durations than have been previously described for similar amplitude movements in humans. Peak velocity vs. amplitude plots were linear and non-saturating within a 45 degrees range for both up and down phases. The relationship between blink peak velocity and average velocity was linear with a slope of approximately 2.0. These values were very similar to those obtained by others, not only for blinks, but also for saccadic eye and ballistic limb movements. Down-phase amplitude-duration behavior could be best described by a linear function with slope < 0.7, while amplitude-duration slope of up phases was best described by a second-order polynomial. Unlike saccadic eye movements, larger amplitude blinks are obtained primarily via increases in peak velocity rather than through extension of blink duration. These data provide mathematical descriptions of monkey blink behavior that indicate the stereotypical nature of blinks. This will serve as a normative data base with which to better understand the neural processing that goes into blinks and will allow the assessment of eyelid movement disorders and evaluation of potential treatments of these disorders.

journal_name

Brain Res

journal_title

Brain research

authors

Porter JD,Stava MW,Gaddie IB,Baker RS

doi

10.1016/0006-8993(93)90869-o

subject

Has Abstract

pub_date

1993-04-23 00:00:00

pages

159-66

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(93)90869-O

journal_volume

609

pub_type

杂志文章
  • The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: effects of acute and chronic administration of the interleukin-1-receptor antagonist (IL-1ra).

    abstract::Following infection with influenza virus, animals display decreased locomotor activity and feeding behavior and loss of body weight. It has been suggested that these effects may be mediated by cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), induced by the infe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01009-3

    authors: Swiergiel AH,Smagin GN,Johnson LJ,Dunn AJ

    更新日期:1997-11-21 00:00:00

  • Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment.

    abstract::Poly(ADP-ribose) polymerase (PARP) can initiate an energy-consuming and inefficient repair cycle following cerebral ischemia/reperfusion by transferring ADP ribose units to nuclear proteins eventually leading to cellular dysfunction and neuronal death. 3-Aminobenzamide (3-AB) is a selective inhibitor of PARP that can ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02852-9

    authors: Ding Y,Zhou Y,Lai Q,Li J,Gordon V,Diaz FG

    更新日期:2001-10-12 00:00:00

  • Dependence of the histofluorescently reactive zinc pool on zinc transporter-3 in the normal brain.

    abstract::In the brain, free zinc levels are under the exquisite control of a variety of zinc-regulating systems, in which zinc transporter (ZnT) proteins play a central role. ZnT3, which is prominently expressed in the brain, facilitates the concentration of free zinc in pre-synaptic vesicles. In addition to histochemical stai...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.08.055

    authors: Lee JY,Kim JS,Byun HR,Palmiter RD,Koh JY

    更新日期:2011-10-18 00:00:00

  • Microinjection of neurotensin into the ventral tegmental area produces hypothermia: evaluation of dopaminergic mediation.

    abstract::Neurotensin-producing perikarya and fibers have been identified in the ventral tegmental area of the rat, and recent microinjection studies indicate that neurotensin may function in the ventral tegmental area to regulate body temperature. In this study, the hypothermic response produced by intraventral tegmental injec...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90031-9

    authors: Kalivas PW,Nemeroff CB,Miller JS,Prange AJ Jr

    更新日期:1985-02-11 00:00:00

  • Effects of lidocaine injection in the interpositus nucleus and red nucleus on conditioned behavioral and neuronal responses.

    abstract::The role of the cerebellum and the red nucleus in the conditioned eyeblink response was assessed, using a combination of reversible lesions and multiple-unit extracellular recording in the awake, behaving rabbit. Lesion, recording, and stimulation experiments have indicated that both of these structures are involved i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90351-b

    authors: Chapman PF,Steinmetz JE,Sears LL,Thompson RF

    更新日期:1990-12-24 00:00:00

  • The efferent vestibular neurons in the toad (Bufo bufo L.): their location and morphology. A horseradish peroxidase study.

    abstract::Retrogradely labeled neurons are observed in the central nervous system of the toad after peripheral application of peroxidase to the anterior and posterior stumps of the VIIIth nerve. These efferent vestibular neurons are localized in the brainstem only ipsilaterally to the treated nerve; they are restricted within a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91183-7

    authors: Pellegrini M,Ceccotti F,Magherini P

    更新日期:1985-09-30 00:00:00

  • Neuronal death in the lateral geniculate nucleus of young ferrets following a cortical lesion: time-course, age dependence and involvement of caspases.

    abstract::In humans and many other mammalian species, the behavioural consequences of a cortical lesion tend to be milder when it occurs early in life, and there is evidence that an important factor contributing to the behavioural sparing in the young is the formation of new thalamo-cortical connections by thalamic neurons init...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.05.063

    authors: Gautschi M,Clarke PG

    更新日期:2007-09-05 00:00:00

  • Numerical data on neocortical neurons in adult rat, with special reference to the GABA population.

    abstract::The disector method was used to estimate the numerical density of neurons (number per unit volume) and their actual number per column (number under a given area of pial surface), in the occipital (monocular segment of the primary visual area, Oc1M), the parietal (somatosensory barrelfield area, Par1) and the frontal c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90884-p

    authors: Beaulieu C

    更新日期:1993-04-23 00:00:00

  • Menstrual cycle phase modulates cognitive control over male but not female stimuli.

    abstract::Evolutionary selection pressures have been one of the factors proposed to underlie sex differences in inhibitory control. Consequently, inhibitory control may vary as a function of the menstrual cycle and may be modulated by the stimuli being processed if these stimuli are related to reproductive success. We used func...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.05.061

    authors: Roberts GM,Newell F,Simões-Franklin C,Garavan H

    更新日期:2008-08-11 00:00:00

  • Prominent binding of the dopamine D3 agonist [3H]PD 128907 in the caudate-putamen of the adult rat.

    abstract::We have analyzed the binding properties of the selective D3 receptor agonist [3H]PD 128907 in 120 days old rats. In tissue sections, we found high numbers of binding sites for [3H]PD 128907 both in the islands of Calleja and the caudate-putamen (Bmax values being 500 and 1000 fmol/mg protein, respectively). The KD val...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01138-5

    authors: Hillefors M,von Euler M,Hedlund PB,von Euler G

    更新日期:1999-03-20 00:00:00

  • Effects of sciatic nerve transplants after fimbria-fornix lesion: examination of the role of nerve growth factor.

    abstract::At two weeks post-transplantation, sciatic nerves inserted into the lesioned septo-hippocampal pathway contain NGF levels more than twice that of normal nerves. These transplanted nerves also contain regenerating cholinergic axons. Moreover, transplanted animals exhibit septal NGF levels that are significantly greater...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90147-n

    authors: Messersmith DJ,Fabrazzo M,Mocchetti I,Kromer LF

    更新日期:1991-08-23 00:00:00

  • Subdivision of primary afferents from passive cat muscle spindles based on a single slow-adaptation parameter.

    abstract::38 primary afferents originating from de-efferented cat tibialis anterior muscle spindles were investigated. Ramp-and-hold stretches of the host muscle were performed with a varying amount of muscle pre-stretch while recording the primary afferent discharges. From the discharge responses an interspike interval functio...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91650-h

    authors: Awiszus F,Schäfer SS

    更新日期:1993-05-28 00:00:00

  • Enhanced forebrain nitric oxide synthase activity in epileptic fowl.

    abstract::Nitric oxide synthase (NOS) activity was examined in forebrain, cerebellum and optic lobes of adult domestic fowl, having a hereditary primary generalized convulsive disorder. NOS was approximately 2-fold higher in only the forebrain of adult epileptic fowl compared to non-epileptic (carrier) hatchmates. A significant...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00595-1

    authors: Sandirasegarane L,Mikler JR,Tuchek JM,Sulakhe PV

    更新日期:1996-10-07 00:00:00

  • Physostigmine and acetylcholine differentially activate nicotinic receptor subpopulations in Locusta migratoria neurons.

    abstract::The effects of acetylcholine (ACh) and physostigmine (PHY) on thoracic ganglion neurons of Locusta migratoria were investigated using whole-cell and cell-attached voltage clamp. ACh activated whole-cell currents with variable amplitudes, time course and ion channel block between cells, suggesting differential expressi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00007-9

    authors: van den Beukel I,van Kleef RG,Zwart R,Oortgiesen M

    更新日期:1998-04-13 00:00:00

  • Non-random chemoreceptor activity during superfusion in vitro.

    abstract::As a means of probing the chemotransducer, impulse sequences from in vitro, superfused sinus nerve-carotid body preparations were analyzed for departures from randomness. Twelve of 17 spike trains showed interval histograms that did not differ significantly from exponential. Thus these sequences resembled a Poisson (r...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90908-9

    authors: Nolan WF,Donnelly DF,Smith EJ,Dutton RE

    更新日期:1984-01-30 00:00:00

  • Inhibition of brain 5 alpha-reductase in pregnant rats: effects on enzymatic and behavioral activity.

    abstract::Medial basal hypothalamic (MBH) 5 alpha-reductase activity was significantly blocked with a known inhibitor, Proscar (Finasteride), in pregnant rats while their open-field behavior was quantified during the last week of pregnancy. In control animals, open-field behavior significantly decreased (in a stair-step fashion...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)01068-2

    authors: Lephart ED,Ladle DR,Jacobson NA,Rhees RW

    更新日期:1996-11-11 00:00:00

  • Activating transcription factor 3 immunoreactivity identifies small populations of axotomized neurons in rat cervical sympathetic ganglia after transection of the preganglionic cervical sympathetic trunk.

    abstract::Activating transcription factor 3 (ATF3) has been proposed as a marker for injured neurons. Thus, while undetectable normally in sensory, motor, or sympathetic neurons, ATF3-like immunoreactivity (ATF3-IR) is readily detectable in such cells after axotomy. Here we examined ATF3-IR in the superior cervical ganglion (SC...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.05.019

    authors: Zigmond RE,Vaccariello SA

    更新日期:2007-07-23 00:00:00

  • Calbindin and calretinin immunoreactivity in the retina of adult and larval sea lamprey.

    abstract::The presence of calretinin and calbindin immunoreactivity is studied in the retina of larval and adult lamprey and their respective distributions are compared. Calretinin distribution is also studied in the retina of transforming stages. Western blot analysis in brain extracts showed a 29-kDa band with both polyclonal...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.11.014

    authors: Villar-Cheda B,Abalo XM,Anadón R,Rodicio MC

    更新日期:2006-01-12 00:00:00

  • Parasympathetic varicosity proliferation and synaptogenesis in rat eyelid smooth muscle after sympathectomy.

    abstract::Parasympathetic innervation to eyelid smooth muscle inhibits sympathetic neurotransmission pre-junctionally without appreciable direct post-junctional effects. However, 5 weeks after sympathectomy, parasympathetic stimulation elicits substantial cholinergically mediated contractions. This study examined ultrastructura...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01439-x

    authors: Smith PG,Marzban F

    更新日期:1998-03-09 00:00:00

  • Angiotensin II modulates the cardiovascular responses to microinjection of NPY Y1 and NPY Y2 receptor agonists into the nucleus tractus solitarii of the rat.

    abstract::The aim of this work was to investigate the modulation of the cardiovascular effects of neuropeptide Y (NPY) in the nucleus tractus solitarii (NTS) by angiotensin II (Ang II) and to determine the NPY receptor subtype involved in this modulation. Anesthesized Sprague-Dawley rats received microinjections in the NTS of A...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)03086-5

    authors: Díaz-Cabiale Z,Fuxe K,Coveñas R,González-Barón S,Narváez JA

    更新日期:2003-09-05 00:00:00

  • The prolonged hyperpolarizing afterpotential in an invertebrate photoreceptor: wavelength and ionic dependence.

    abstract::A single electrode voltage clamp was used to examine the prolonged hyperpolarizing afterpotential (PHA) which accompanies photoconversion of a substantial fraction of rhodopsin (lambda max = 500 nM) to metarhodopsin (lambda max = 575 nM) in distal photoreceptor cells in the retina of the bay scallop, Pecten irradians....

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90539-x

    authors: Cornwall MC,Gorman AL

    更新日期:1982-05-13 00:00:00

  • Reticularis thalami afferents to the ventrobasal complex of the rat thalamus: an electron microscope study.

    abstract::Afferents from the nucleus reticularis thalami (RT) to the thalamic ventrobasal complex were studied in the rat by looking for degenerating terminals after selective neurotoxic lesion of RT using injections of kainic acid. Several lines of evidence are presented indicating that RT afferents terminate in the VB by F ty...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90607-8

    authors: Peschanski M,Ralston HJ,Roudier F

    更新日期:1983-07-04 00:00:00

  • Macrolide antibiotics protect neurons in culture against the N-methyl-D-aspartate (NMDA) receptor-mediated toxicity of glutamate.

    abstract::The immunosuppressive macrolide FK-506 has been shown to protect neurons in culture against glutamate excitotoxicity. This effect was attributed to the binding of immunosuppressants to calcineurin-inhibiting immunophilins. We now report that also the non-immunosuppressive macrolide antibiotics protect neurons in cultu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90098-8

    authors: Manev H,Favaron M,Candeo P,Fadda E,Lipartiti M,Milani D

    更新日期:1993-10-08 00:00:00

  • A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.

    abstract::The neurochemical heterogeneity of the rat striatum was assessed in vivo by measuring subregional changes in extracellular dopamine and DOPAC by in vivo electrochemistry and microdialysis in response to amphetamine and the D2 antagonist, (-)-sulpiride. Both in vivo electrochemical and microdialysis experiments indicat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91256-g

    authors: Yamamoto BK,Pehek EA

    更新日期:1990-01-08 00:00:00

  • Quantitative morphological changes in the superior colliculus and the parabigeminal nucleus in the bilaterally microphthalmic rat.

    abstract::Quantitative morphological changes in the superior colliculus (SC) and the parabigeminal nucleus (PB) were studied in hereditary bilaterally microphthalmic rat, which lacks the optic nerve completely. Volumes of the retinorecipient superficial collicular layers of SC (SCS) to the central gray matter were decreased by ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(85)90012-4

    authors: Tokunaga A,Sugita S,Otani K,Terasawa K

    更新日期:1985-11-01 00:00:00

  • Neurons evaluate both the amplitude and the meaning of signals.

    abstract::The neuronal threshold, which can be determined by the level of depolarization immediately prior to spike generation, is different for responses to conditioned and discriminated stimuli after conditioning. However, it is impossible to determine excitability within a response to stimuli that failed to generate a spike....

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02868-8

    authors: Tsitolovsky LE,Babkina NV

    更新日期:2002-08-09 00:00:00

  • Using optogenetics to study habits.

    abstract::It is now well documented that optogenetics brings to neuroscience a long sought-after foothold to study the causal role of millisecond-scale activity of genetically or anatomically defined populations of neurons. Progress is rapid, and, as evidenced by the work collected in this Special Issue, the possibilities of wh...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2013.01.008

    authors: Smith KS,Graybiel AM

    更新日期:2013-05-20 00:00:00

  • Avian nucleus isthmi ventralis projects to the contralateral optic tectum.

    abstract::Injections of HRP throughout the upper tectal strata led in 4 cases to the appearance of retrogradely labeled neurons within n.isthmi ventralis, contralateral to the experimental side. An additional case proved that this projection courses through the ventral supraoptic commissure. This is the first description of a c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90501-5

    authors: Martínez S,Puelles L

    更新日期:1989-02-27 00:00:00

  • Instability of motor unit firing rates during prolonged isometric contractions in human masseter.

    abstract::The firing patterns of up to 4 concurrently active masseter motor units were studied with intramuscular electrodes during a continuous isometric contraction of 15 min duration, in which the subject maintained the mean firing rate of one selected unit at 10 Hz. With this paradigm the net excitation (i.e. mean firing ra...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90467-a

    authors: Nordstrom MA,Miles TS

    更新日期:1991-05-24 00:00:00

  • Ventral tegmental site of opiate reward: antagonism by a hydrophilic opiate receptor blocker.

    abstract::The ventral tegmental area has been suggested as a possible site of action for the rewarding effect of opiates on the basis of the fact that local morphine injections in this but not other regions are rewarding. That this is a necessary and not just a sufficient site of opiate rewarding action was suggested by the fac...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)91232-5

    authors: Britt MD,Wise RA

    更新日期:1983-01-03 00:00:00