Abstract：
:38 primary afferents originating from de-efferented cat tibialis anterior muscle spindles were investigated. Ramp-and-hold stretches of the host muscle were performed with a varying amount of muscle pre-stretch while recording the primary afferent discharges. From the discharge responses an interspike interval function was estimated. This revealed a slow adaptation during the hold phase of stretch which could be approximated quite well by a power function. The slow-adaptation power function exponent (SAE) was found to be rather independent of the amount of pre-stretch applied to the host muscle and grouped around a value characteristic for each afferent. These 'characteristic SAEs' showed a clearly bimodal distribution within the population of primaries studied. Moreover, the distribution around both modes was narrow enough to justify the subdivision of the primary afferents according to their characteristic SAE as either high-SAE (10 afferents; 26%) or low-SAE (28 afferents; 74%) afferents. The most likely explanation for this bimodality of slow-adaptation behavior in primary afferents is given by the assumption that the afferent discharge of the passive spindle is mainly provided from a branch innervating either the bag1 (for high-SAE units) or the bag2 and chain (for low-SAE units) intrafusal fibers.
journal_name
Brain Resjournal_title
Brain researchauthors
Awiszus F,Schäfer SSdoi
10.1016/0006-8993(93)91650-hsubject
Has Abstractpub_date
1993-05-28 00:00:00pages
110-4issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)91650-Hjournal_volume
612pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Rats were trained on a radial maze and then given electrolytic lesions of the MS followed by a single intraseptal injection of 5 micrograms of NGF. Three days later they were re-tested on the maze. They were also post-operatively tested for hyperemotionality. MS lesions severely impaired performance on the radial maze...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00242-i
更新日期：1995-05-08 00:00:00
abstract：:A commissural-associational entorhino-entorhinal projection in the guinea pig was analyzed using anterograde and retrograde axonal tracing techniques. The projection originated in layer II and terminated in layer Ia of both the medial entorhinal area (MEA) and the lateral entorhinal area (LEA). A few cells in other la...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90117-0
更新日期：1989-12-25 00:00:00
abstract：:Samples of 14 brains of autopsied patients suffering from dementia of the Alzheimer type were examined. In Congo red-hemalum stained 14-microns-thick sections of the hippocampus 15 tangle-bearing and 25-30 unaffected nerve cells of area CA1 per case were measured for cell size and nucleolar size utilizing an interacti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90843-3
更新日期：1989-05-22 00:00:00
abstract：:Infection and inflammation leading to injury or death of pre-oligodendrocytes (preOLs) is one of the principal initiating mechanisms in the pathogenesis of preterm periventricular leukomalacia (PVL). The present study explores the possible protective effect of curcumin against the toxicity of lipopolysaccharide (LPS)-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.04.014
更新日期：2010-06-21 00:00:00
abstract：:We investigated the effect of aging on the responses to thermal and mechanical stimuli in rats. Young (3-5 months old) and aged (22-24 months old) male Sprague-Dawley rats were tested in the hot plate, high- and low-intensity radiant heat tail flick, and von Frey hair assays. Compared to young rats, aged rats displaye...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)01960-0
更新日期：2000-03-10 00:00:00
abstract：:In 22 squirrel monkeys (Saimiri sciureus) vocalization-eliciting electrodes were implanted into the amygdala and along the trajectory of the stria terminalis. Then, lesions were placed in the stria terminalis, its bed nucleus, the ventral amygdalofugal pathway and several di- and mesencephalic structures in order to f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91055-1
更新日期：1982-06-10 00:00:00
abstract：:Few clinical or experimental studies have carried out systematic investigations of cutaneous and deep sensibility in areas with referred muscle pain. Therefore, no clear signs of increased or decreased psychophysical responses to various somatosensory stimuli are found in referred pain areas. In the present study, a t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01077-3
更新日期：1997-01-02 00:00:00
abstract：:Enkephalin immunoreactive neurons within the nucleus tractus solitarius (NTS) were found to project to the parabrachial nucleus of the cat with the use of a combination of immunohistochemistry and retrograde transport of horseradish peroxidase. Double labelled neurons were located in the medial, parvocellular and comm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91521-1
更新日期：1988-03-01 00:00:00
abstract：:The distribution of the regulatory (RII beta) subunits of type II cAMP-dependent protein kinase in cortical and subcortical areas was examined in human control and Alzheimer's disease (AD) brains. Four monoclonal antibodies generated against bovine brain RII, which cross-reacted with human brain RII beta, detected RII...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90230-7
更新日期：1992-04-24 00:00:00
abstract：:Quantitative in vitro autoradiography was used to examine [3H]D-Ala2, MePhe4, Gly-015 enkephalin (DAGO) (mu-agonist) and [3H]diprenorphine (general opiate antagonist) binding sites in the hippocampal formation of young (6-8 months) and aged (25-28 months) Long-Evans rats. Age-related changes in these binding sites wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01211-7
更新日期：1996-01-22 00:00:00
abstract：:The functions of the claustrum are not well understood. Few studies explore its electrophysiological properties in awake animals. Here, we address this lacuna by recording spontaneous local field potential (LFP) activity in the anterior claustrum of rats freely exploring open field environments under differing conditi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.09.021
更新日期：2017-12-15 00:00:00
abstract：:The purpose of this paper is to investigate the involvement of various auditory localization mechanisms in the improvement of auditory spatial sensitivity in the case of partial visual deprivation. We compared sensitivity to binaural, monaural, and echo cues between normal-sighted and myopic subjects. In an auditory t...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/j.brainres.2005.01.101
更新日期：2005-04-11 00:00:00
abstract：:The present study demonstrates changes in rat brain glial metabolism during the acute phase of epilepsy. Status epilepticus (SE) was induced using the lithium-pilocarpine model. Glial metabolism was measured with (14)C-acetate. Local cerebral blood flow and glucose metabolism were also measured using (14)C-N-isopropyl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.074
更新日期：2010-01-22 00:00:00
abstract：:Tuberohypophysial dopamine (DA) neurons terminate in the intermediate and neural lobes of the posterior pituitary. The objective of this study was to determine if concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC), a major metabolite of DA in these regions, reflect the activity of tuberohypophysial DA neurons. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91209-y
更新日期：1990-01-01 00:00:00
abstract：:The effects of acetylcholine (ACh) and physostigmine (PHY) on thoracic ganglion neurons of Locusta migratoria were investigated using whole-cell and cell-attached voltage clamp. ACh activated whole-cell currents with variable amplitudes, time course and ion channel block between cells, suggesting differential expressi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00007-9
更新日期：1998-04-13 00:00:00
abstract：:The second messenger cyclic GMP (cGMP) plays a role in the anxiolytic-like behavioral response of mice to nitrous oxide (N2O). This study was conducted to determine whether this behavioral effect of N2O is affected by inhibition of cGMP-dependent protein kinase (PKG). N2O-induced behavior in the light/dark exploration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.015
更新日期：2005-03-15 00:00:00
abstract：:The globus pallidus plays a critical role in movement regulation. Morphological studies have shown that group I mGluRs including mGluR1 and mGluR5 are expressed in the globus pallidus. Up to now, little is known about the in vivo electrophysiological effects of group I mGluRs on the pallidal neurons. The present study...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.08.027
更新日期：2012-10-05 00:00:00
abstract：:The cholinergic neurotoxin, AF64A-picrylsulfonate, was unilaterally infused into the dorsal hippocampus of Wistar rats (2 nmol/2 microliters/4 min; A 6.2, Ls 1.5, H 6.5, Paxinos and Watson). After 19 days the for immunohistochemical staining of choline acetyltransferase (ChAT). Morphometry and counting of ChAT-immunor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91125-x
更新日期：1986-04-02 00:00:00
abstract：:The endocrine disruptor Bisphenol-A (BPA) has been shown to modulate estrogenic, androgenic, and anti-androgenic effects. The effects of BPA exposure during early organizational periods of development have been well documented. The current study focuses on the effects of short term, low-dose BPA exposure on anxiety, s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.07.018
更新日期：2013-09-05 00:00:00
abstract：:The localization of vasoactive intestinal peptide (VIP)-like immunoreactivity was investigated in the brain, olfactory system and retina of the zebrafish, Danio rerio, during development and in juvenile specimens, by using the indirect immunofluorescence and the peroxidase-antiperoxidase methods. In 24 h post fertiliz...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03065-1
更新日期：2001-01-12 00:00:00
abstract：:The retinal spreading depression has been used as a tool to investigate the action of nitric oxide (NO) as a diffusible neurotransmitter which in many cases acts by raising the cGMP level in target cells. The role of NO as a vasodilating agents has been well-established and it has been suggested that the vasodilatatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00737-b
更新日期：1995-09-11 00:00:00
abstract：:Previous studies indicate that 3-acetylpyridine (3-AP) intoxication produces discrete lesions of the inferior olive (IO) and other central structures in rats and mice. As a result, it has been widely employed in investigations of the influences of climbing fibers on cerebellar function. This study examines the central...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-0173(85)90017-7
更新日期：1985-04-01 00:00:00
abstract：:Studies were undertaken to characterize the binding of [3H]estradiol ([3H]E2) to blood plasma and to brain cytosols collected from perinatal ferrets of both sexes. A dialysis experiment showed that the binding capacity of plasma for [3H]E2 was low in neonatal ferrets. Saturable, high-affinity binding of [3H]E2 to cyto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90075-5
更新日期：1983-03-01 00:00:00
abstract：:A comparison was made of the effects of left and right cerebral decortication on cytotoxic activity of natural killer and natural cytotoxic lymphocytes in the mouse. Natural killer cytotoxic activity was significantly reduced after right decortication, whereas left decortication led to a less pronounced, though still ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90704-f
更新日期：1990-08-06 00:00:00
abstract：:The present study examines the effects of ibotenic acid lesions of the medial amygdala, the bed nucleus of the stria terminalis and the medial preoptic area on the display of paced mating behavior in female rats. Lesions of either the medial amygdala or the bed nucleus of the stria terminalis have no effect on the dis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.10.056
更新日期：2004-02-27 00:00:00
abstract：:2-Deoxy-d-glucose (2DG) is a glucose analogue that inhibits intracellular utilization of glucose and produces a characteristic behavioral response known as glucoprivic feeding. The area postrema (AP) is a caudal hindbrain structure shown previously to be involved in 2DG-induced glucoprivic feeding. In addition, periph...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00528-9
更新日期：1998-08-10 00:00:00
abstract：:Tumor necrosis factor-alpha (TNFalpha) affects several CNS functions such as regulation of sleep, body temperature, and feeding during pathology. There is also evidence for TNFalpha involvement in physiological sleep regulation, e.g., TNFalpha induces sleep and brain levels of TNFalpha increase during prolonged wakefu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.06.044
更新日期：2005-08-16 00:00:00
abstract：:Stroke is the major cause of acquired epilepsy in the adult population. The mechanisms of ischemia-induced epileptogenesis are not completely understood, but glutamate is associated with both ischemia-induced injury and epileptogenesis. The objective of this study was to develop an in vitro model of epileptogenesis in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.065
更新日期：2011-01-31 00:00:00
abstract：:The effect of single administrations of MK-801 (5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine) or PCP (phencyclidine) on the induction of audiogenic seizure susceptibility by noise in immature rats was examined. Treatments with these non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists resul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91237-u
更新日期：1991-09-27 00:00:00
abstract：:The regional distribution of FLFQPQRFamide binding sites on fresh unfixed cryostate sections from post mortem specimens of human spinal cord and lower medulla oblongata was studied by quantitative autoradiographic methods using [125I]YLFQPQRFamide as ligand. Samples were taken from five cases who had died with no hist...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91531-8
更新日期：1994-01-07 00:00:00
