Abstract：
:The effect of single administrations of MK-801 (5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine) or PCP (phencyclidine) on the induction of audiogenic seizure susceptibility by noise in immature rats was examined. Treatments with these non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists resulted in increases in noise exposure-dependent susceptibility. In neonatally drug-treated rats, seizures during adulthood were found to occur with significantly higher incidence and severity. Furthermore, drug treatments were found to lengthen what is normally a restricted developmental period within which susceptibility can be induced by noise exposure. The drugs, however, had no inherent ability to induce audiogenic seizure susceptibility if given alone. Moreover, in already-susceptible rats, MK-801 exhibited predictable anticonvulsant effects. These data suggest acute PCP or MK-801 exposures may transiently exacerbate risks inherent in certain forms of trauma. The mechanism underlying these effects is unknown although certain inferences are possible and may reveal much about epileptogenesis in this model.
journal_name
Brain Resjournal_title
Brain researchauthors
Pierson M,Swann Jdoi
10.1016/0006-8993(91)91237-usubject
Has Abstractpub_date
1991-09-27 00:00:00pages
229-36issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91237-Ujournal_volume
560pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Two myelin sheaths sharing a common outer tongue process are illustrated in a thin section electron micrograph from mouse optic nerve. Although they derive from the same outer tongue process, and therefore from the same oligodendrocyte, the two sheaths are of different thicknesses (6 and 9 turns). The example demonstr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90712-6
更新日期：1983-09-12 00:00:00
abstract：:The effects of intracerebroventricular administration of 6-hydroxydopamine (6-OHDA) and 5,7-dihydroxytryptamine (5,7-DHT) on sodium-sensitive [3H]mazindol binding were investigated in the rat hypothalamus and corpus striatum. In the hypothalamus, specific [3H]mazindol binding was inhibited by low concentrations of sod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91687-9
更新日期：1989-12-04 00:00:00
abstract：:In order to identify fixed versus flexible aspects of swallowing and oromotor control, we developed a method for the concurrent analysis of swallow frequency, swallow volume, and the temporal correlation between swallowing and rhythmic orolingual movements during prolonged bouts of fluid ingestion in unanesthetized, u...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91135-9
更新日期：1989-10-09 00:00:00
abstract：:The carrier-mediated uptake of anionic and cationic amino acids by the basolateral face (blood side) of the isolated perfused sheep choroid plexus was demonstrated using the paired-tracer dilution technique. The uptake of these two classes of amino acid was higher than at the blood-brain barrier with no cross-competit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90731-n
更新日期：1992-05-29 00:00:00
abstract：:Alterations in local cerebral glucose utilization (LCGU) induced by electrical stimulation of the sensory relay nucleus (VPL) or parafascicular nucleus (Pf) of the thalamus in conscious rats were measured by the [14C]2-deoxyglucose method, the objective being to assess the mechanism of analgesia induced by electrical ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90357-x
更新日期：1987-04-07 00:00:00
abstract：:In a whole mount preparation of the hooded rat retina, stained with methylene blue, the ganglion cell density was counted over the retina. The density ranged from 6200-6500/sq.mm to 1000-1500/sq.mm. The area with a density higher than 6000/sq.mm was called the central area and was centered at about 1 mm (20 degrees) a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90314-6
更新日期：1977-01-07 00:00:00
abstract：:Glucose inhibits ∼60% of lateral hypothalamic (LH) orexin neurons. Fasting increases the activation of LH orexin glucose-inhibited (GI) neurons in low glucose. Increases in spontaneous glutamate excitatory postsynaptic currents (sEPSCs) onto putative VTA DA neurons in low glucose are orexin dependent (Sheng et al., 20...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.05.025
更新日期：2020-03-15 00:00:00
abstract：:Continuing from earlier work which demonstrated the peripheral axonal regulation of Schwann cell myelination, this study has investigated the possibility that a peripheral axon can stimulate oligodendrocyte myelination. To test this hypothesis, regenerating PNS axons were allowed to interact with uncommitted oligodend...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90289-0
更新日期：1979-02-23 00:00:00
abstract：:We studied the effects of axotomy or neurotoxin on the survival of substantia nigra pars compacta (SNpc) neurons in two strains of mice, FVB/N or C57BL/6. Fluoro gold (FG) was injected into both striata of the mice to retrogradely label the nigrostriatal neuronal population. Ten days later, these neurons were axotomiz...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.066
更新日期：2003-12-24 00:00:00
abstract：:After traumatic brain injury, extracellular K(+) in brain can dramatically increase. We studied the effects of increased K(+) on the isolated pressurized rat middle cerebral artery (MCA). MCAs (200-250 microm OD) were isolated, cannulated with glass micropipettes, and pressurized. K(+) was increased in the extralumina...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02793-1
更新日期：2000-10-13 00:00:00
abstract：:The effect of microinfusions of cholecystokinin octapeptide (CCK8) and its antagonist L364,718 on duodenal and jejunal motility were evaluated by electromyography in fasted and fed rats. The rats were chronically fitted with electrodes implanted on the duodeno-jejunal wall. Steel cannulas were placed bilaterally in ei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91124-y
更新日期：1990-01-29 00:00:00
abstract：:Glutamate is an excitatory neurotransmitter implicated in the pathogenesis of psychiatric disorders. Glutamate results in the activation of an enzyme called glycogen synthase kinase-3 (GSK-3) acting through N-methyl-d-aspartate (NMDA) receptors. Impaired expression of GSK-3 affects behavior and neurochemicals level in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.10.002
更新日期：2019-02-01 00:00:00
abstract：:Using gold-labelled somatostatin, somatostatin binding sites were predominantly found in laminae I-III, X and on motorneurones of the rat lumbar spinal cord. A comparison with immunohistochemical staining using antisera against somatostatin receptor sequences revealed that the marked binding in laminae I-III coincided...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01226-8
更新日期：1999-01-16 00:00:00
abstract：:The purpose of this study was to determine if motoneurons in the spinal ventral horn express the muscarinic m2 acetylcholine receptor. Motoneurons were retrogradely labelled in adult rats by intramuscular injection of Fluorogold and examined with confocal microscopy for evidence of immunoreactivity for the receptor. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01208-6
更新日期：1999-01-30 00:00:00
abstract：:Previous studies have demonstrated that some anticonvulsant drugs can modulate tolerance to the opioid analgesia. In the present study, the effects of lamotrigine (LTG) on the development and expression of tolerance to the morphine-induced antinociception were evaluated using tail-flick test. To assess the LTG effects...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.014
更新日期：2009-09-29 00:00:00
abstract：:The normal cellular prion protein (PrP(C)) plays an essential role in the development of prion diseases. Indirect evidence has suggested that different PrP(C) glycoforms may be expressed in different brain regions and perform distinct functions. However, due to a lack of monoclonal antibodies (Mabs) that are specific ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02050-9
更新日期：2001-03-30 00:00:00
abstract：:The rat mutant dystonic displays an autosomal recessive neurological disease characterized by slow, twisting movements of the limbs and trunk. Rats displaying clinical signs also show a decreased behavioral response to the dopaminergic blocker, haloperidol. Investigation of the development of the cataleptic response t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90920-x
更新日期：1984-08-06 00:00:00
abstract：:The possibility that gamma-aminobutyric acid (GABA) could modulate sympathetic neurotransmission in the cerebrovascular bed of the goat has been investigated by means of 3 experimental approaches: measurement of cerebral blood flow in the anesthetized animal, recording of isometric tension in isolated cerebral arterie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90887-1
更新日期：1989-07-17 00:00:00
abstract：:The participation of glutamatergic circuits of the ventral basal ganglia in feeding-related regulatory mechanisms has been extensively indicated in primate and rodent species. In avian species, it has been shown that ICV injections of MK-801 or of CNQX increase food intake and reduce the latency of feeding initiation ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04196-3
更新日期：2003-03-14 00:00:00
abstract：:Decreasing transsynaptic activity through surgical adrenal denervation or by medullary explantation, increases Leu-enkephalin immunoreactivity (Leu-Enk) and preproenkephalin mRNA (prepro-EK). Membrane depolarization prevents this rise. To determine whether depolarizing effects are mediated by intracellular movement of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91407-2
更新日期：1988-02-16 00:00:00
abstract：:Previous research has demonstrated that diabetes induces learning and memory deficits. However, the mechanism of memory impairment induced by diabetes is poorly understood. The present study investigated the effect of streptozotocin (STZ)-induced diabetes on spatial learning and memory using the Morris Water Maze. The...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.011
更新日期：2011-09-09 00:00:00
abstract：:Two-dimensional electrophoresis of proteins has allowed high resolution analysis of the protein species rapidly transported in the frog sciatic nerve. The 7th, 8th and 9th dorsal root ganglia were selectively labeled with [3H]leucine or [35S]methionine in one compartment of a lucite chamber. Transport of TCA-precipita...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90155-5
更新日期：1978-04-14 00:00:00
abstract：:The effects of the cytokines interleukin-1 and -6 (IL1 beta, IL6; 100 ng) on spatial learning were examined in the Morris water maze. Intracerebroventricular injection of IL1 or IL6 before the training on day 1 did not influence the acquisition of spatial navigation. However, IL1 administered at 60 min, but not immedi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90468-3
更新日期：1993-06-04 00:00:00
abstract：:Nitric oxide (NO) production in the sensory neurons of the rad nodose ganglion was studied by examining the distribuiotn of NO synthase (NOS) by use of NADPH diaphorase (NADPHD) histochemistry and immunohistochemistry ofr the presence of isoformes of NOS: neuronal (nNOS), endothelial (eNOS) and the inducible isoform (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03826-x
更新日期：2003-01-24 00:00:00
abstract：:This study in lightly anesthetized rats found that unilateral electrical stimulation delivered to the ventral part of the thalamic nucleus submedius (Sm), the thalamic reuniens nucleus (Re) and the hypothalamic dorsal area (DA) markedly depressed the TF reflex, and this inhibitory effect increased following increasing...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00856-l
更新日期：1995-10-23 00:00:00
abstract：:We investigated the effect of aging on the responses to thermal and mechanical stimuli in rats. Young (3-5 months old) and aged (22-24 months old) male Sprague-Dawley rats were tested in the hot plate, high- and low-intensity radiant heat tail flick, and von Frey hair assays. Compared to young rats, aged rats displaye...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)01960-0
更新日期：2000-03-10 00:00:00
abstract：:The benzomorphan sigma ligands, (+)-N-allylnormetazocine (NANM) and (+)-pentazocine, but not (+)-cyclazocine, stereospecifically stimulated dopamine synthesis in minces of rat corpus striatum by 15-23% over basal values at 0.1-1.0 microM. The effect of (+)-NANM and (+)-pentazocine was blocked by the reported sigma ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90159-s
更新日期：1991-08-23 00:00:00
abstract：:We have previously described a rodent model of brief (30 min) middle cerebral artery occlusion followed by reperfusion, in which infarction develops gradually, reaching completion more than 3 days after ischemia, accompanied by morphological, biochemical, and pharmacological evidence of apoptosis. In the present study...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02822-0
更新日期：2001-11-02 00:00:00
abstract：:We studied seizures which were induced by a microinjection of kainic acid (KA) into the unilateral olfactory bulb (OB) in the rats. The first epileptiform discharge appeared in the OB, was then propagated to the amygdala and the hippocampus unilaterally, and finally propagated to the unilateral sensori-motor cortex. C...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00626-2
更新日期：1995-09-25 00:00:00
abstract：:Horseradish peroxidase (HRP) in slow-release gel was unilaterally implanted in the transected dorsolateral funiculus (DLF) of either cervical, midthoracic, lumbar or sacral spinal cord levels of adult male rats. Cell mappings were made of all brain areas projecting through the DLF. Following cervical implants, dense l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91139-2
更新日期：1981-11-02 00:00:00
