Interleukin-1 beta, but not interleukin-6, impairs spatial navigation learning.

abstract：:In order to study the effects of treatment with monosodium glutamate (MSG) during the neonatal period on the intrinsic circadian timekeeping system in rats, the locomotor activity of blinded MSG-treated and control (saline-treated) rats was analyzed with power spectral analysis and cross-correlation. In contrast to a ...

journal_title：Brain research

authors： Miyabo S,Yamamura I,Ooya E,Aoyagi N,Horikawa Y,Hayashi S

更新日期：1985-07-29 00:00:00

abstract：:Pregnenolone sulfate (PS) is an endogenous neurosteroid known to antagonize GABA(A) receptor-mediated inhibitory responses and potentiate NMDA receptor-mediated excitatory responses in vitro. To assess the actions of the steroid as a modulator of seizure susceptibility in vivo, PS (30-300 nmol) was administered intrac...

journal_title：Brain research

authors： Kokate TG,Juhng KN,Kirkby RD,Llamas J,Yamaguchi S,Rogawski MA

更新日期：1999-06-12 00:00:00

abstract：:The effects of neonatal dopamine depletion on activity levels and locomotor patterns were tested in rats at 4 months of age. Measurements were taken using an activity pattern monitor. The lesioned group was significantly hypoactive in comparison to the control animals during the initial exposures to the monitor. Exami...

journal_title：Brain research

authors： Moy SS,Breese GR,Eckerman DA

更新日期：1994-05-09 00:00:00

abstract：:Temperature dysregulation is well known in generalized convulsive status epilepticus but so far has not been reported in non-convulsive forms. In order to detect possible subtle alterations, we have analyzed the capability to compensate for external cooling in an animal model of limbic status epilepticus. Rats with el...

journal_title：Brain research

authors： Holtkamp M,Schmitt FC,Buchheim K,Meierkord H

更新日期：2007-01-05 00:00:00

abstract：:The nictitating membrane response to periocular electrostimulation was investigated in anesthetized and paralyzed rabbits. Recordings from the abducens nerve, which carries the fibers innervating retractor bulbi muscles that are primarily involved in this reflex, showed two distinct volleys to effective stimulation: a...

journal_title：Brain research

authors： Berthier NE,Moore JW

更新日期：1983-01-10 00:00:00

abstract：:We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. R...

journal_title：Brain research

authors： Shimazaki K,Yoshida K,Hirose Y,Ishimori H,Katayama M,Kawase T

更新日期：2003-02-07 00:00:00

abstract：:This study was designed to evaluate the role of spinal glutamatergic receptors in the antinociception elicited by agmatine in mice. Intraperitoneal (i.p.) administration of agmatine (1.0-100.0 mg/kg) dose dependently inhibited the nociceptive response induced by intrathecal (i.t.) injection of glutamate, N-methy-D-asp...

journal_title：Brain research

authors： Gadotti VM,Tibola D,Paszcuk AF,Rodrigues AL,Calixto JB,Santos AR

更新日期：2006-06-06 00:00:00

abstract：:Phenotypic diversity is shaped by both genetic and epigenetic mechanisms that program tissue specific patterns of gene expression. Cells, including neurons, undergo massive epigenetic reprogramming during development through modifications to chromatin structure, and by covalent modifications of the DNA through methyla...

journal_title：Brain research

authors： McGowan PO,Meaney MJ,Szyf M

更新日期：2008-10-27 00:00:00

abstract：:After glucocorticoid stimulation, glucocorticoid receptors (GRs) are translocated to the nucleus to modulate transcription of glucocorticoid target genes. The subcellular distribution and trafficking of GR in cultured cells has been studied quite intensively using several techniques. However, the intracellular localiz...

journal_title：Brain research

authors： Sarabdjitsingh RA,Meijer OC,de Kloet ER

更新日期：2010-05-17 00:00:00

abstract：:The mitochondrial respiratory chain is a powerful source of reactive oxygen species (ROS) also in noise induced hearing loss (NIHL) and anti-oxidants and free-radicals scavengers have been shown to attenuate the damage. Coenzyme Q(10) (CoQ(10)) or ubiquinone has a bioenergetic role as a component of the mithocondrial ...

journal_title：Brain research

authors： Fetoni AR,Piacentini R,Fiorita A,Paludetti G,Troiani D

更新日期：2009-02-27 00:00:00

abstract：:The low, middle, and high molecular mass neurofilament subunit proteins (NF-L, NF-M, and NF-H) co-polymerize to form neurofilaments (NFs). During development, NF subunit expression is highly regulated, and in neurodegenerative disease, aberrant regulation of this expression can lead to the formation of harmful aggrega...

journal_title：Brain research

authors： Thyagarajan A,Szaro BG

更新日期：2008-01-16 00:00:00

abstract：:We previously reported that glial fibrillary acidic protein (GFAP) levels increased significantly at 3 days after stab wounds, relative to sham-operated controls, reaching a maximum of 200% of control value at 5-7 days. They then fell to near-normal values by 21 days. To determine whether these protein changes correla...

journal_title：Brain research

authors： Hozumi I,Aquino DA,Norton WT

更新日期：1990-11-26 00:00:00

abstract：:The effects of ventromedial hypothalamic (VMH) stimulation on various metabolic parameters in freely moving animals were measured using a specific indirect calorimetric chamber associated with a quantitative measurement of locomotor activity, which allows the separate measurement of locomotor energy expenditure from t...

journal_title：Brain research

authors： Ruffin M,Nicolaidis S

更新日期：1999-10-30 00:00:00

abstract：:The link between the state of energy balance and reproductive function is well known. Thus, signals denoting negative energy balance and the accompanying hyperphagic drive are likely to be factors in the suppression of gonadotropin releasing hormone (GnRH) activity. We have previously found that appetite-regulating sy...

journal_title：Brain research

authors： Williamson-Hughes PS,Grove KL,Smith MS

更新日期：2005-04-18 00:00:00

abstract：:Systemic administration of nicotinic receptor (nAChR) agonists is antinociceptive in models of acute pain whereas their intrathecal (i. t.) administration has been reported to be antinociceptive, nociceptive or without effect. It has been hypothesized that the action induced is dependent upon the subtype and location ...

journal_title：Brain research

authors： Rueter LE,Meyer MD,Decker MW

更新日期：2000-07-28 00:00:00

abstract：:Generation and persistence of tinnitus following hearing loss may be due to aberrant engagement of attention. Here, functional MRI was used to determine differences in auditory and visual attention processing in adults with tinnitus and hearing loss compared to two age-matched control groups, one with matched hearing ...

journal_title：Brain research

authors： Husain FT,Akrofi K,Carpenter-Thompson JR,Schmidt SA

更新日期：2015-09-16 00:00:00

abstract：:In decerebrate dogs, stimulation of pelvic afferent fibres and distension of the rectum, vagina and urinary bladder brought about a sustained postural change and rhythmic abdominal compression. The posture, which resulted from flexion of the back and stifle joints, extension of the hip joints and lifting of the tail, ...

journal_title：Brain research

authors： Fukuda H,Fukai K

更新日期：1986-08-20 00:00:00

abstract：:Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar a...

journal_title：Brain research

authors： Roman C,Lin JY,Reilly S

更新日期：2009-03-09 00:00:00

abstract：:Rabbits passively oscillated in the horizontal plane with a free hand tended to stabilize their head in space (re: earth-fixed surroundings) by moving the head on the trunk (neck angular deviation, NAD) opposite the passively imposed body rotation. The gain (NAD/body rotation) of head stabilization varied from 0.0 to ...

journal_title：Brain research

authors： Fuller JH

更新日期：1981-02-02 00:00:00

abstract：:Infusion of 1 microgram of carbachol, a potent cholinergic agonist, into the lateral septum of the urethane-anaesthetized rat systematically caused the induction of clear-cut hippocampal theta (theta). However, infusion of an equivalent amount of the drug into the hippocampus, close to the recording electrode, failed ...

journal_title：Brain research

authors： Monmaur P,Ayadi K,Breton P

更新日期：1993-12-24 00:00:00

abstract：:Nitric oxide (NO) has been proposed as an intercellular messenger mediating postsynaptic to presynaptic information transfer in the induction of long-term potentiation. A number of studies support the possible involvement of NO in synaptic plasticity. NO may have a role in synaptogenesis and synaptic plasticity in dev...

journal_title：Brain research

authors： Won Sohn N,Greenberg JH,Hand PJ

更新日期：1999-01-23 00:00:00

abstract：:Kindling of the ventral tegmental area (VTA), a major source of the mesolimbic dopamine pathway, was examined in rats. We applied two quantitative measurements of dopamine sensitivity before and 2 weeks after VTA kindling (20 times electrical stimulations (100 microA at 1 min intervals) delivered once per day for 14 c...

journal_title：Brain research

authors： Watanabe T,Morimoto K,Nakamura M,Hirao T,Ninomiya T,Ando N,Suwaki H

更新日期：2004-04-02 00:00:00

abstract：:Administration of sheep red blood cells (10(6) cells, i.p.) resulted in central norepinephrine (NE) and dopamine (DA) changes which corresponded with the time of the peak immune response. These amine variations, however, appeared to be specific to certain brain regions. The increased accumulation of the NE metabolite,...

journal_title：Brain research

authors： Zalcman S,Shanks N,Anisman H

更新日期：1991-08-23 00:00:00

abstract：:An investigation has been carried out into the physiological properties of tendon organs and their interactions with motor units following two types of nerve injury: nerve crush and nerve transection followed by suture repair. Recovery from nerve crush was very successful: 6 weeks after the injury 60% of the tendon or...

journal_title：Brain research

authors： Scott JJ,Davies P,Petit J

更新日期：1995-10-30 00:00:00

abstract：:An indirect method of immunocytochemistry showed that cholera toxin and its B-subunit served as specific neuronal surface markers in conjunction with monoclonal anti-cholera toxin and FITC labeled anti-mouse Fab. The cell types which get specifically stained in culture were peripheral neurons from dorsal root ganglion...

journal_title：Brain research

authors： Okada E,Maeda T,Watanabe T

更新日期：1982-06-24 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) is a 38-amino-acid polypeptide, first isolated from hypothalamus, which directly stimulates in vitro the production of cAMP as well as the release of several pituitary hormones, such as growth hormone and luteinizing hormone. In vivo, PACAP has been shown to stimu...

journal_title：Brain research

authors： Grinevich V,Fournier A,Pelletier G

更新日期：1997-10-31 00:00:00

abstract：:Stroke is one of the leading causes of unnatural death and disability. No effective therapy is available. Recombinant human granulocyte colony-stimulating factor (rhG-CSF), as a mobilizing agent for bone marrow stem cells, can promote stem cell mobilization, homing to brain after cerebral ischemia. In the present stud...

journal_title：Brain research

authors： Yanqing Z,Yu-Min L,Jian Q,Bao-Guo X,Chuan-Zhen L

更新日期：2006-07-07 00:00:00

abstract：:We here review modulation of olfactory guided behavioral tasks by noradrenaline. In this review we focus on modulation of the main olfactory system in adult rodents. We detail behavioral paradigms commonly used and discuss how sensory perception and learning can be measured using these paradigms. We then describe neur...

journal_title：Brain research

authors： Linster C,Escanilla O

更新日期：2019-04-15 00:00:00

abstract：:There was a distinct sex-related difference in the anterior pituitary level of substance P-like immunoreactivity (SP-LI) in adult rats; the anterior pituitaries of male rats contained a higher concentration of SP-LI than those of females. Neonatal castration (day 1) resulted in a marked decrease of the SP-LI level in ...

journal_title：Brain research

authors： Yoshikawa K,Hong JS

更新日期：1983-08-29 00:00:00

abstract：:Despite significant advancements in the understanding of the pathophysiological mechanisms of subarachnoid hemorrhage (SAH), little is known about the emotional consequences. The primary goal of this study was to describe the locomotor and behavioral patterns in rats following both a single-injection and double-inject...

journal_title：Brain research

authors： Boyko M,Azab AN,Kuts R,Gruenbaum BF,Gruenbaum SE,Melamed I,Brotfain E,Shapira Y,Cesnulis E,Zlotnik A

更新日期：2013-01-23 00:00:00