Abstract：
:In order to study the effects of treatment with monosodium glutamate (MSG) during the neonatal period on the intrinsic circadian timekeeping system in rats, the locomotor activity of blinded MSG-treated and control (saline-treated) rats was analyzed with power spectral analysis and cross-correlation. In contrast to a robust free-running circadian rhythm in the control rats, a significant shortening of the circadian period and rapid decomposition into ultradian components were noted in the MSG-treated rats. Computer-assisted stereometry of the hypothalamic nuclei revealed that, in addition to the well-known severe damage in the arcuate nuclei (ARC), the volumes of the suprachiasmatic nuclei (SCN) and ventromedial hypothalamic nuclei (VMH) were also reduced significantly in the MSG-treated rats. Although no gross histological damage was apparent in either the SCN and VMH, neonatal MSG treatment appears to impair the function of SCN to integrate many minor oscillations in the brain into a single, definite and precise circadian period.
journal_name
Brain Resjournal_title
Brain researchauthors
Miyabo S,Yamamura I,Ooya E,Aoyagi N,Horikawa Y,Hayashi Sdoi
10.1016/0006-8993(85)90084-8subject
Has Abstractpub_date
1985-07-29 00:00:00pages
201-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(85)90084-8journal_volume
339pub_type
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